Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01098:Vmn2r104'

53060

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r104

Ensembl Gene

ENSMUSG00000090315

Gene Name

vomeronasal 2, receptor 104

Synonyms

V2r7

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.108) question?

Stock #

IGL01098

Quality Score

Status

Chromosome

Chromosomal Location

20249687-20268467 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20268358 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 37 (E37G)

Ref Sequence

ENSEMBL: ENSMUSP00000129895 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168050]

AlphaFold

E9Q2J5

Predicted Effect

probably benign
Transcript: ENSMUST00000168050
AA Change: E37G

PolyPhen 2 Score 0.270 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: E37G

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	85	457	4e-38	PFAM
Pfam:NCD3G	512	565	2.1e-20	PFAM
Pfam:7tm_3	598	833	1.7e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921509C19Rik	T	C	2: 151,315,453 (GRCm39)	D75G	possibly damaging	Het
Brip1	G	T	11: 85,999,688 (GRCm39)	R765S	possibly damaging	Het
Btbd16	T	C	7: 130,424,975 (GRCm39)	I452T	probably damaging	Het
Cdc42ep4	T	G	11: 113,620,328 (GRCm39)	D21A	probably damaging	Het
Cdx2	T	A	5: 147,243,792 (GRCm39)	M1L	possibly damaging	Het
Cfap206	C	T	4: 34,721,562 (GRCm39)	S162N	probably damaging	Het
Csmd2	C	T	4: 127,952,845 (GRCm39)	T98M	probably damaging	Het
Cyp26a1	A	T	19: 37,688,450 (GRCm39)	Q324L	probably benign	Het
Etaa1	A	G	11: 17,896,059 (GRCm39)	V686A	probably damaging	Het
Gpr6	G	A	10: 40,946,739 (GRCm39)	T281I	probably damaging	Het
Herc1	T	A	9: 66,369,204 (GRCm39)		probably null	Het
Lama2	A	T	10: 26,907,108 (GRCm39)	I2351N	possibly damaging	Het
Lman1	A	G	18: 66,124,711 (GRCm39)	F343L	probably damaging	Het
Lmo1	A	G	7: 108,742,657 (GRCm39)		probably benign	Het
Lrrc17	T	A	5: 21,780,269 (GRCm39)	F414L	probably benign	Het
Man2b2	A	T	5: 36,972,900 (GRCm39)	L538Q	probably damaging	Het
Map3k9	A	G	12: 81,770,928 (GRCm39)	S910P	probably damaging	Het
Mapk1ip1	G	A	7: 138,438,191 (GRCm39)	P80S	probably damaging	Het
Mindy4	G	T	6: 55,261,727 (GRCm39)		probably benign	Het
Msh4	A	T	3: 153,583,619 (GRCm39)		probably benign	Het
Mta2	A	G	19: 8,924,081 (GRCm39)	D187G	probably damaging	Het
Olfml2a	A	G	2: 38,837,226 (GRCm39)		probably null	Het
Pink1	A	T	4: 138,047,408 (GRCm39)		probably null	Het
Plekha6	T	C	1: 133,209,903 (GRCm39)	F575L	possibly damaging	Het
Rpe	C	A	1: 66,745,674 (GRCm39)	D71E	probably benign	Het
Slc5a7	C	T	17: 54,599,988 (GRCm39)	A142T	probably benign	Het
Sptbn1	C	T	11: 30,109,385 (GRCm39)	R70K	probably damaging	Het
Taf1c	G	T	8: 120,329,580 (GRCm39)	Q159K	probably damaging	Het
Tgfb1i1	T	C	7: 127,851,693 (GRCm39)	F311S	probably damaging	Het
Tmc8	T	C	11: 117,683,389 (GRCm39)	V648A	possibly damaging	Het
Tmed8	G	T	12: 87,223,445 (GRCm39)	A98E	probably benign	Het
Tmem200a	A	G	10: 25,870,041 (GRCm39)	I76T	probably damaging	Het
Vmn2r18	A	T	5: 151,496,296 (GRCm39)	V474E	probably damaging	Het
Vps52	C	T	17: 34,181,704 (GRCm39)	T510I	possibly damaging	Het
Wwox	G	T	8: 115,172,118 (GRCm39)	G71*	probably null	Het
Zer1	C	T	2: 29,998,232 (GRCm39)		probably null	Het
Zfp296	A	T	7: 19,311,845 (GRCm39)	K117N	possibly damaging	Het

Other mutations in Vmn2r104

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn2r104	APN	17	20,258,501 (GRCm39)	missense	probably damaging	0.98
IGL01333:Vmn2r104	APN	17	20,263,055 (GRCm39)	missense	probably benign	0.17
IGL01527:Vmn2r104	APN	17	20,263,158 (GRCm39)	missense	possibly damaging	0.82
IGL01773:Vmn2r104	APN	17	20,260,930 (GRCm39)	missense	probably benign	0.10
IGL01939:Vmn2r104	APN	17	20,250,187 (GRCm39)	missense	probably damaging	0.99
IGL02121:Vmn2r104	APN	17	20,262,056 (GRCm39)	nonsense	probably null
IGL02305:Vmn2r104	APN	17	20,263,118 (GRCm39)	missense	probably benign	0.09
IGL02374:Vmn2r104	APN	17	20,263,048 (GRCm39)	missense	probably benign	0.34
IGL03260:Vmn2r104	APN	17	20,263,083 (GRCm39)	missense	probably benign	0.05
IGL03366:Vmn2r104	APN	17	20,249,866 (GRCm39)	missense	probably damaging	1.00
R0091:Vmn2r104	UTSW	17	20,262,075 (GRCm39)	missense	possibly damaging	0.79
R0125:Vmn2r104	UTSW	17	20,250,069 (GRCm39)	missense	probably damaging	0.98
R0257:Vmn2r104	UTSW	17	20,249,889 (GRCm39)	missense	probably damaging	1.00
R0381:Vmn2r104	UTSW	17	20,268,264 (GRCm39)	nonsense	probably null
R0709:Vmn2r104	UTSW	17	20,263,166 (GRCm39)	missense	probably damaging	1.00
R0786:Vmn2r104	UTSW	17	20,262,987 (GRCm39)	missense	probably benign
R1575:Vmn2r104	UTSW	17	20,262,477 (GRCm39)	missense	probably damaging	1.00
R1827:Vmn2r104	UTSW	17	20,262,497 (GRCm39)	missense	probably damaging	0.97
R1932:Vmn2r104	UTSW	17	20,261,031 (GRCm39)	missense	probably damaging	1.00
R1956:Vmn2r104	UTSW	17	20,262,313 (GRCm39)	missense	probably damaging	0.98
R2203:Vmn2r104	UTSW	17	20,250,083 (GRCm39)	missense	probably benign	0.05
R2205:Vmn2r104	UTSW	17	20,250,083 (GRCm39)	missense	probably benign	0.05
R2859:Vmn2r104	UTSW	17	20,268,455 (GRCm39)	missense	possibly damaging	0.82
R3701:Vmn2r104	UTSW	17	20,249,818 (GRCm39)	missense	probably damaging	1.00
R3834:Vmn2r104	UTSW	17	20,250,183 (GRCm39)	missense	probably benign	0.02
R4151:Vmn2r104	UTSW	17	20,250,147 (GRCm39)	missense	probably damaging	1.00
R4470:Vmn2r104	UTSW	17	20,262,503 (GRCm39)	missense	probably damaging	1.00
R4625:Vmn2r104	UTSW	17	20,268,443 (GRCm39)	missense	probably benign	0.00
R4754:Vmn2r104	UTSW	17	20,261,030 (GRCm39)	nonsense	probably null
R4911:Vmn2r104	UTSW	17	20,250,288 (GRCm39)	missense	probably benign	0.00
R5270:Vmn2r104	UTSW	17	20,258,528 (GRCm39)	missense	probably damaging	1.00
R5279:Vmn2r104	UTSW	17	20,262,146 (GRCm39)	missense	probably benign	0.07
R5311:Vmn2r104	UTSW	17	20,250,163 (GRCm39)	missense	probably damaging	1.00
R5370:Vmn2r104	UTSW	17	20,250,450 (GRCm39)	missense	probably damaging	0.97
R5461:Vmn2r104	UTSW	17	20,250,343 (GRCm39)	missense	probably damaging	1.00
R5683:Vmn2r104	UTSW	17	20,260,981 (GRCm39)	nonsense	probably null
R5795:Vmn2r104	UTSW	17	20,250,372 (GRCm39)	missense	probably benign	0.02
R5795:Vmn2r104	UTSW	17	20,250,544 (GRCm39)	missense	possibly damaging	0.89
R5970:Vmn2r104	UTSW	17	20,249,733 (GRCm39)	missense	probably benign	0.01
R5983:Vmn2r104	UTSW	17	20,261,970 (GRCm39)	missense	probably damaging	1.00
R5992:Vmn2r104	UTSW	17	20,249,747 (GRCm39)	missense	probably damaging	1.00
R6066:Vmn2r104	UTSW	17	20,258,573 (GRCm39)	missense	possibly damaging	0.69
R6156:Vmn2r104	UTSW	17	20,261,909 (GRCm39)	missense	probably damaging	1.00
R6182:Vmn2r104	UTSW	17	20,250,507 (GRCm39)	missense	probably benign	0.16
R6245:Vmn2r104	UTSW	17	20,261,829 (GRCm39)	missense	possibly damaging	0.69
R6333:Vmn2r104	UTSW	17	20,249,848 (GRCm39)	missense	probably benign	0.30
R6573:Vmn2r104	UTSW	17	20,262,487 (GRCm39)	missense	probably damaging	1.00
R7101:Vmn2r104	UTSW	17	20,250,358 (GRCm39)	missense	possibly damaging	0.65
R7123:Vmn2r104	UTSW	17	20,261,088 (GRCm39)	missense	probably benign	0.12
R7485:Vmn2r104	UTSW	17	20,249,737 (GRCm39)	missense	probably benign	0.01
R7514:Vmn2r104	UTSW	17	20,249,791 (GRCm39)	missense	probably damaging	1.00
R7634:Vmn2r104	UTSW	17	20,261,971 (GRCm39)	missense	possibly damaging	0.48
R7958:Vmn2r104	UTSW	17	20,262,988 (GRCm39)	missense	probably benign
R8031:Vmn2r104	UTSW	17	20,263,048 (GRCm39)	missense	probably benign	0.34
R8094:Vmn2r104	UTSW	17	20,250,483 (GRCm39)	missense	possibly damaging	0.77
R8191:Vmn2r104	UTSW	17	20,250,465 (GRCm39)	missense	possibly damaging	0.89
R8308:Vmn2r104	UTSW	17	20,261,040 (GRCm39)	missense	possibly damaging	0.55
R8691:Vmn2r104	UTSW	17	20,262,110 (GRCm39)	missense	probably damaging	0.98
R8795:Vmn2r104	UTSW	17	20,262,988 (GRCm39)	missense	probably benign
R8900:Vmn2r104	UTSW	17	20,261,924 (GRCm39)	missense	probably damaging	0.99
R8913:Vmn2r104	UTSW	17	20,249,968 (GRCm39)	missense	probably damaging	1.00
R9180:Vmn2r104	UTSW	17	20,263,087 (GRCm39)	missense	probably benign	0.00
R9199:Vmn2r104	UTSW	17	20,262,097 (GRCm39)	missense	probably damaging	0.99
R9282:Vmn2r104	UTSW	17	20,261,098 (GRCm39)	missense	probably damaging	1.00
R9303:Vmn2r104	UTSW	17	20,268,439 (GRCm39)	missense	possibly damaging	0.90
R9305:Vmn2r104	UTSW	17	20,268,439 (GRCm39)	missense	possibly damaging	0.90
R9322:Vmn2r104	UTSW	17	20,263,087 (GRCm39)	missense	probably benign	0.00
R9325:Vmn2r104	UTSW	17	20,268,433 (GRCm39)	missense	possibly damaging	0.95
R9414:Vmn2r104	UTSW	17	20,250,250 (GRCm39)	missense	probably damaging	0.99
R9785:Vmn2r104	UTSW	17	20,268,409 (GRCm39)	missense	probably benign
RF007:Vmn2r104	UTSW	17	20,268,302 (GRCm39)	missense	probably benign	0.36
Z1177:Vmn2r104	UTSW	17	20,250,051 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-06-21