Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01107:Vmn2r100'

53068

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r100

Ensembl Gene

ENSMUSG00000091859

Gene Name

vomeronasal 2, receptor 100

Synonyms

EG627537

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL01107

Quality Score

Status

Chromosome

Chromosomal Location

19504732-19535231 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19521356 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 110 (Y110C)

Ref Sequence

ENSEMBL: ENSMUSP00000156263 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166081] [ENSMUST00000231465]

AlphaFold

E9QAZ9

Predicted Effect

probably damaging
Transcript: ENSMUST00000166081
AA Change: Y110C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000128350
Gene: ENSMUSG00000091859
AA Change: Y110C

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	83	456	7.4e-41	PFAM
Pfam:NCD3G	510	563	1.9e-21	PFAM
Pfam:7tm_3	594	831	2.6e-51	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000231465
AA Change: Y110C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001O22Rik	A	T	2: 30,797,936	F215Y	probably damaging	Het
2700049A03Rik	T	C	12: 71,194,468		probably null	Het
Akip1	C	T	7: 109,711,838	T195M	probably damaging	Het
Arhgef16	T	C	4: 154,280,244	N631S	probably benign	Het
Brat1	C	T	5: 140,717,177	S544L	probably damaging	Het
Cfap65	C	T	1: 74,919,183		probably null	Het
D17Wsu92e	A	T	17: 27,786,069		probably null	Het
Defa22	T	A	8: 21,163,037		probably null	Het
Dnajc4	C	T	19: 6,989,501	R153H	probably benign	Het
Dusp11	A	G	6: 85,952,370		probably benign	Het
E2f4	T	A	8: 105,304,177		probably benign	Het
Ece1	T	A	4: 137,938,658	L271Q	probably damaging	Het
Fcgrt	T	C	7: 45,093,328	D343G	probably damaging	Het
Igsf10	T	C	3: 59,331,524	E412G	probably damaging	Het
Il4ra	G	T	7: 125,575,914	L431F	possibly damaging	Het
Krt86	T	A	15: 101,475,425	L200Q	probably damaging	Het
Lpcat1	T	A	13: 73,494,828	F126I	probably damaging	Het
Prag1	A	G	8: 36,099,931	T79A	probably benign	Het
Pramef12	A	T	4: 144,393,094	I301N	probably benign	Het
Psg29	G	T	7: 17,204,925	L41F	probably benign	Het
Rai14	C	T	15: 10,599,711		probably benign	Het
Reg3a	A	G	6: 78,383,245	D136G	probably benign	Het
Rif1	A	G	2: 52,111,303	T1590A	probably benign	Het
Rorb	A	T	19: 18,957,328	L300*	probably null	Het
Sin3b	T	C	8: 72,731,105	C150R	possibly damaging	Het
Smarcc1	C	A	9: 110,221,937	H942N	probably damaging	Het
Tas2r105	A	G	6: 131,687,111	V118A	probably benign	Het
Tmem131	T	C	1: 36,829,581	S388G	probably damaging	Het
Ttll9	C	A	2: 153,002,889		probably benign	Het
Ush1c	A	G	7: 46,209,901	L498P	probably damaging	Het
Zbtb11	T	C	16: 56,006,007	Y800H	probably damaging	Het
Zdhhc20	T	A	14: 57,865,589	E101V	probably damaging	Het

Other mutations in Vmn2r100

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00904:Vmn2r100	APN	17	19526000	missense	probably damaging	1.00
IGL00912:Vmn2r100	APN	17	19531392	missense	possibly damaging	0.95
IGL01517:Vmn2r100	APN	17	19521963	missense	probably benign	0.37
IGL01594:Vmn2r100	APN	17	19531233	missense	possibly damaging	0.52
IGL01657:Vmn2r100	APN	17	19525916	missense	possibly damaging	0.89
IGL01822:Vmn2r100	APN	17	19504838	missense	probably null	0.00
IGL02020:Vmn2r100	APN	17	19504938	missense	possibly damaging	0.78
IGL02060:Vmn2r100	APN	17	19521254	missense	possibly damaging	0.79
IGL02126:Vmn2r100	APN	17	19521242	splice site	probably benign
IGL02142:Vmn2r100	APN	17	19522321	missense	probably damaging	1.00
IGL02308:Vmn2r100	APN	17	19521335	missense	possibly damaging	0.90
IGL02407:Vmn2r100	APN	17	19521508	missense	probably damaging	0.98
IGL02469:Vmn2r100	APN	17	19531285	nonsense	probably null
IGL03088:Vmn2r100	APN	17	19522039	missense	probably benign	0.27
IGL03181:Vmn2r100	APN	17	19531945	missense	probably damaging	1.00
IGL03405:Vmn2r100	APN	17	19531924	missense	probably damaging	1.00
H8562:Vmn2r100	UTSW	17	19521490	missense	possibly damaging	0.87
R0012:Vmn2r100	UTSW	17	19504874	missense	probably benign
R0012:Vmn2r100	UTSW	17	19526034	missense	probably damaging	0.99
R0044:Vmn2r100	UTSW	17	19522179	missense	possibly damaging	0.46
R0109:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0111:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0112:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0149:Vmn2r100	UTSW	17	19521247	critical splice acceptor site	probably null
R0355:Vmn2r100	UTSW	17	19531320	missense	probably benign	0.00
R0395:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0396:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0453:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0465:Vmn2r100	UTSW	17	19531530	missense	probably damaging	0.98
R0477:Vmn2r100	UTSW	17	19522514	missense	probably benign	0.00
R0510:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0512:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0514:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0518:Vmn2r100	UTSW	17	19521916	missense	probably damaging	1.00
R0521:Vmn2r100	UTSW	17	19521916	missense	probably damaging	1.00
R0555:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0608:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0959:Vmn2r100	UTSW	17	19523524	missense	possibly damaging	0.95
R1114:Vmn2r100	UTSW	17	19531999	missense	probably damaging	1.00
R2027:Vmn2r100	UTSW	17	19522072	missense	probably benign	0.02
R2049:Vmn2r100	UTSW	17	19522050	missense	probably benign	0.00
R2224:Vmn2r100	UTSW	17	19522372	missense	probably benign	0.03
R2226:Vmn2r100	UTSW	17	19522372	missense	probably benign	0.03
R3618:Vmn2r100	UTSW	17	19523430	missense	probably benign
R3715:Vmn2r100	UTSW	17	19532010	missense	probably damaging	0.99
R4120:Vmn2r100	UTSW	17	19531953	missense	probably damaging	1.00
R4152:Vmn2r100	UTSW	17	19523419	frame shift	probably null
R4153:Vmn2r100	UTSW	17	19523419	frame shift	probably null
R4154:Vmn2r100	UTSW	17	19523419	frame shift	probably null
R4200:Vmn2r100	UTSW	17	19522535	missense	probably benign	0.29
R4632:Vmn2r100	UTSW	17	19531954	missense	probably damaging	1.00
R4720:Vmn2r100	UTSW	17	19522526	missense	probably benign	0.02
R4761:Vmn2r100	UTSW	17	19521368	missense	possibly damaging	0.47
R4831:Vmn2r100	UTSW	17	19521410	missense	probably benign	0.28
R4951:Vmn2r100	UTSW	17	19532038	missense	probably benign	0.01
R5211:Vmn2r100	UTSW	17	19525995	missense	possibly damaging	0.67
R5553:Vmn2r100	UTSW	17	19504848	missense	possibly damaging	0.64
R5657:Vmn2r100	UTSW	17	19504916	missense	probably benign	0.31
R5883:Vmn2r100	UTSW	17	19523524	missense	probably benign
R5912:Vmn2r100	UTSW	17	19531809	missense	probably damaging	0.99
R6141:Vmn2r100	UTSW	17	19522314	missense	probably benign	0.07
R6146:Vmn2r100	UTSW	17	19522260	missense	probably benign	0.04
R6500:Vmn2r100	UTSW	17	19522093	missense	probably damaging	1.00
R6575:Vmn2r100	UTSW	17	19521409	missense	probably benign	0.12
R6647:Vmn2r100	UTSW	17	19522523	missense	probably benign	0.00
R7038:Vmn2r100	UTSW	17	19505001	missense	possibly damaging	0.76
R7052:Vmn2r100	UTSW	17	19531294	missense	possibly damaging	0.95
R7170:Vmn2r100	UTSW	17	19531971	missense	probably benign	0.00
R7209:Vmn2r100	UTSW	17	19531314	missense	not run
R7312:Vmn2r100	UTSW	17	19522034	missense	probably benign	0.01
R7734:Vmn2r100	UTSW	17	19522034	missense	probably benign	0.01
R7750:Vmn2r100	UTSW	17	19522464	missense	probably benign
R8103:Vmn2r100	UTSW	17	19531153	splice site	probably null
R8193:Vmn2r100	UTSW	17	19504840	nonsense	probably null
R8267:Vmn2r100	UTSW	17	19522490	nonsense	probably null
R8290:Vmn2r100	UTSW	17	19531350	missense	probably damaging	0.99
R8531:Vmn2r100	UTSW	17	19522197	missense	possibly damaging	0.66
R8786:Vmn2r100	UTSW	17	19522576	missense	probably damaging	1.00
R8920:Vmn2r100	UTSW	17	19521358	missense	probably damaging	1.00
R8938:Vmn2r100	UTSW	17	19531563	missense	probably benign	0.00
X0062:Vmn2r100	UTSW	17	19531390	missense	possibly damaging	0.89
Z1176:Vmn2r100	UTSW	17	19521530	missense	probably benign	0.00
Z1177:Vmn2r100	UTSW	17	19504989	missense	probably benign	0.00

Posted On

2013-06-21