Mutagenetix > Incidental Mutations

Incidental Mutation 'R6750:Tas2r117'

530693

Institutional Source

Beutler Lab

Gene Symbol

Tas2r117

Ensembl Gene

ENSMUSG00000058349

Gene Name

taste receptor, type 2, member 117

Synonyms

Tas2r17, T2R17, mt2r54, mGR17

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

R6750 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

132802818-132803975 bp(+) (GRCm38)

Type of Mutation

start gained

DNA Base Change (assembly)

A to G at 132802854 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000069768 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068302]

Predicted Effect

probably benign
Transcript: ENSMUST00000068302

SMART Domains

Protein: ENSMUSP00000069768
Gene: ENSMUSG00000058349

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	307	1.2e-85	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.6%
20x: 92.7%

Validation Efficiency

100% (75/75)

Allele List at MGI

Other mutations in this stock

Total: 73 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921501E09Rik	A	T	17: 33,066,398	S477T	possibly damaging	Het
5430419D17Rik	T	A	7: 131,288,245		probably benign	Het
Adal	A	T	2: 121,142,649	L62F	probably damaging	Het
Akap13	C	T	7: 75,739,458	P2375S	probably benign	Het
Apob	T	A	12: 7,997,853	L931Q	probably damaging	Het
Arcn1	A	G	9: 44,750,394	V391A	possibly damaging	Het
Ccdc162	A	T	10: 41,561,226	I1729N	possibly damaging	Het
Cd24a	T	C	10: 43,582,725	L86P	unknown	Het
Churc1	C	A	12: 76,775,631	H71Q	probably damaging	Het
Clcn3	A	G	8: 60,914,775	L780P	possibly damaging	Het
Cldn17	C	T	16: 88,506,307	G178E	possibly damaging	Het
Cmah	A	G	13: 24,464,252	Y345C	probably damaging	Het
Cntnap5b	C	T	1: 100,274,499	S357L	probably damaging	Het
Col6a6	A	G	9: 105,783,680	I410T	probably damaging	Het
Crmp1	T	C	5: 37,265,322		probably null	Het
Csmd2	A	C	4: 128,197,225	N186H	possibly damaging	Het
Cyp1a1	A	T	9: 57,700,256	M56L	probably benign	Het
D2hgdh	G	C	1: 93,826,407	R56P	probably benign	Het
Dapk2	A	G	9: 66,220,752	E104G	probably damaging	Het
Dld	T	C	12: 31,332,214	N498S	probably benign	Het
Dyrk4	G	T	6: 126,898,955	Q106K	probably benign	Het
Eif2b4	T	C	5: 31,189,960	I333V	probably damaging	Het
F5	A	G	1: 164,193,507	T1184A	possibly damaging	Het
Fbxl6	C	T	15: 76,538,412	G102D	probably damaging	Het
Foxa1	C	T	12: 57,542,610	G275R	probably benign	Het
Fryl	A	G	5: 73,022,232	I2944T	probably damaging	Het
Gm597	C	A	1: 28,777,414	E512D	probably damaging	Het
Gna15	T	C	10: 81,514,283	D95G	probably benign	Het
Greb1	T	A	12: 16,688,583	M1460L	probably benign	Het
Herc1	TCCC	TCC	9: 66,501,188		probably null	Het
Herc2	T	C	7: 56,097,447	I444T	probably damaging	Het
Ifngr1	T	A	10: 19,609,351	M366K	probably benign	Het
Krt27	C	T	11: 99,348,980	E253K	probably damaging	Het
Micalcl	C	T	7: 112,381,839	T406I	probably damaging	Het
Mocs2	T	G	13: 114,826,248	D156E	probably damaging	Het
Mprip	A	T	11: 59,696,131	K43N	probably damaging	Het
Myo5b	A	T	18: 74,617,035	T190S	possibly damaging	Het
Naa25	C	T	5: 121,408,309	T86M	probably damaging	Het
Ncam1	T	C	9: 49,567,339	D163G	probably damaging	Het
Nlrp4f	A	T	13: 65,181,654	Y908*	probably null	Het
Nlrp9b	T	A	7: 20,023,234	L132*	probably null	Het
Nrg1	A	C	8: 31,818,096	S679A	probably damaging	Het
Olfr3	C	A	2: 36,812,942	R50M	possibly damaging	Het
Olfr656	C	T	7: 104,618,113	R145C	probably damaging	Het
Paqr9	A	T	9: 95,560,997	T347S	probably damaging	Het
Pcdhb21	T	C	18: 37,514,448	L210P	probably damaging	Het
Pdzd7	T	G	19: 45,027,748	D978A	probably benign	Het
Pkd1l1	A	T	11: 8,973,217	S17T	unknown	Het
Plcz1	T	C	6: 140,028,438	K93E	possibly damaging	Het
Pom121l2	G	C	13: 21,981,937	R126P	probably damaging	Het
Prkg1	C	T	19: 31,764,561	E88K	probably benign	Het
Psme4	A	T	11: 30,853,203	D15V	probably damaging	Het
Ptprf	A	G	4: 118,231,731	V625A	probably benign	Het
Rab27a	G	A	9: 73,085,008	S106N	probably damaging	Het
Rasa4	A	G	5: 136,100,948	T261A	probably benign	Het
Sardh	T	C	2: 27,228,257	D487G	probably benign	Het
Sec16a	A	G	2: 26,440,018	Y662H	probably benign	Het
Sema3d	T	A	5: 12,585,100	L711*	probably null	Het
Sept14	T	A	5: 129,696,117	Y152F	probably damaging	Het
Smc5	A	G	19: 23,242,640	L411P	probably damaging	Het
Spg7	T	A	8: 123,073,911	V39E	probably damaging	Het
Tle1	A	T	4: 72,122,450	I631N	probably damaging	Het
Tmed3	T	A	9: 89,699,790	S207C	probably damaging	Het
Tmem59l	G	A	8: 70,486,372	P51S	probably benign	Het
Trpc3	A	G	3: 36,624,393	Y848H	probably damaging	Het
Tsen2	T	C	6: 115,549,920	F66S	probably damaging	Het
Ttll5	T	A	12: 85,956,610	S216R	probably damaging	Het
Usp22	A	T	11: 61,157,216	V426E	probably damaging	Het
Vmn2r76	T	C	7: 86,225,906	N621S	probably damaging	Het
Wdr75	A	G	1: 45,817,379	T521A	probably damaging	Het
Wrnip1	T	A	13: 32,802,756	D173E	probably damaging	Het
Zfp317	G	A	9: 19,647,804	G438D	probably damaging	Het
Zscan10	T	A	17: 23,607,190	S109T	possibly damaging	Het

Other mutations in Tas2r117

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01611:Tas2r117	APN	6	132803484	missense	probably benign	0.00
IGL01611:Tas2r117	APN	6	132803487	missense	probably damaging	0.96
IGL02140:Tas2r117	APN	6	132803595	missense	probably benign	0.15
IGL02154:Tas2r117	APN	6	132803715	missense	probably benign	0.00
IGL02466:Tas2r117	APN	6	132803000	missense	probably benign	0.12
IGL02942:Tas2r117	APN	6	132803694	missense	probably benign	0.00
IGL03328:Tas2r117	APN	6	132803078	missense	probably benign	0.40
PIT4480001:Tas2r117	UTSW	6	132803051	missense	possibly damaging	0.91
R0380:Tas2r117	UTSW	6	132803588	nonsense	probably null
R0456:Tas2r117	UTSW	6	132803391	missense	probably benign	0.12
R0699:Tas2r117	UTSW	6	132803198	missense	probably damaging	1.00
R2118:Tas2r117	UTSW	6	132803166	missense	probably damaging	0.96
R2265:Tas2r117	UTSW	6	132803225	missense	probably benign	0.06
R4420:Tas2r117	UTSW	6	132803349	nonsense	probably null
R4861:Tas2r117	UTSW	6	132803129	missense	probably benign	0.00
R4861:Tas2r117	UTSW	6	132803129	missense	probably benign	0.00
R5233:Tas2r117	UTSW	6	132803622	missense	possibly damaging	0.95
R5384:Tas2r117	UTSW	6	132803154	missense	probably benign	0.04
R6852:Tas2r117	UTSW	6	132802929	missense	probably benign	0.00
R6902:Tas2r117	UTSW	6	132803325	missense	probably damaging	0.98
R6946:Tas2r117	UTSW	6	132803325	missense	probably damaging	0.98
R7129:Tas2r117	UTSW	6	132803387	missense	probably benign	0.01
R7412:Tas2r117	UTSW	6	132803229	missense	probably damaging	1.00
R7733:Tas2r117	UTSW	6	132803175	missense	probably benign	0.02
R7768:Tas2r117	UTSW	6	132803522	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CAGAAAATTCTACAGGAGCTGTGTG -3'
(R):5'- TCTTAACCCAGTCCATACAGTG -3'

Sequencing Primer
(F):5'- AAGAATTCTGGTCTGGCACCC -3'
(R):5'- CATACAGTGGACCAGGACCATG -3'

Posted On

2018-08-01