Incidental Mutation 'R6750:Tas2r117'
ID530693
Institutional Source Beutler Lab
Gene Symbol Tas2r117
Ensembl Gene ENSMUSG00000058349
Gene Nametaste receptor, type 2, member 117
SynonymsTas2r17, T2R17, mt2r54, mGR17
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.054) question?
Stock #R6750 (G1)
Quality Score225.009
Status Validated
Chromosome6
Chromosomal Location132802818-132803975 bp(+) (GRCm38)
Type of Mutationstart gained
DNA Base Change (assembly) A to G at 132802854 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000069768 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068302]
Predicted Effect probably benign
Transcript: ENSMUST00000068302
SMART Domains Protein: ENSMUSP00000069768
Gene: ENSMUSG00000058349

DomainStartEndE-ValueType
Pfam:TAS2R 8 307 1.2e-85 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.7%
Validation Efficiency 100% (75/75)
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921501E09Rik A T 17: 33,066,398 S477T possibly damaging Het
5430419D17Rik T A 7: 131,288,245 probably benign Het
Adal A T 2: 121,142,649 L62F probably damaging Het
Akap13 C T 7: 75,739,458 P2375S probably benign Het
Apob T A 12: 7,997,853 L931Q probably damaging Het
Arcn1 A G 9: 44,750,394 V391A possibly damaging Het
Ccdc162 A T 10: 41,561,226 I1729N possibly damaging Het
Cd24a T C 10: 43,582,725 L86P unknown Het
Churc1 C A 12: 76,775,631 H71Q probably damaging Het
Clcn3 A G 8: 60,914,775 L780P possibly damaging Het
Cldn17 C T 16: 88,506,307 G178E possibly damaging Het
Cmah A G 13: 24,464,252 Y345C probably damaging Het
Cntnap5b C T 1: 100,274,499 S357L probably damaging Het
Col6a6 A G 9: 105,783,680 I410T probably damaging Het
Crmp1 T C 5: 37,265,322 probably null Het
Csmd2 A C 4: 128,197,225 N186H possibly damaging Het
Cyp1a1 A T 9: 57,700,256 M56L probably benign Het
D2hgdh G C 1: 93,826,407 R56P probably benign Het
Dapk2 A G 9: 66,220,752 E104G probably damaging Het
Dld T C 12: 31,332,214 N498S probably benign Het
Dyrk4 G T 6: 126,898,955 Q106K probably benign Het
Eif2b4 T C 5: 31,189,960 I333V probably damaging Het
F5 A G 1: 164,193,507 T1184A possibly damaging Het
Fbxl6 C T 15: 76,538,412 G102D probably damaging Het
Foxa1 C T 12: 57,542,610 G275R probably benign Het
Fryl A G 5: 73,022,232 I2944T probably damaging Het
Gm597 C A 1: 28,777,414 E512D probably damaging Het
Gna15 T C 10: 81,514,283 D95G probably benign Het
Greb1 T A 12: 16,688,583 M1460L probably benign Het
Herc1 TCCC TCC 9: 66,501,188 probably null Het
Herc2 T C 7: 56,097,447 I444T probably damaging Het
Ifngr1 T A 10: 19,609,351 M366K probably benign Het
Krt27 C T 11: 99,348,980 E253K probably damaging Het
Micalcl C T 7: 112,381,839 T406I probably damaging Het
Mocs2 T G 13: 114,826,248 D156E probably damaging Het
Mprip A T 11: 59,696,131 K43N probably damaging Het
Myo5b A T 18: 74,617,035 T190S possibly damaging Het
Naa25 C T 5: 121,408,309 T86M probably damaging Het
Ncam1 T C 9: 49,567,339 D163G probably damaging Het
Nlrp4f A T 13: 65,181,654 Y908* probably null Het
Nlrp9b T A 7: 20,023,234 L132* probably null Het
Nrg1 A C 8: 31,818,096 S679A probably damaging Het
Olfr3 C A 2: 36,812,942 R50M possibly damaging Het
Olfr656 C T 7: 104,618,113 R145C probably damaging Het
Paqr9 A T 9: 95,560,997 T347S probably damaging Het
Pcdhb21 T C 18: 37,514,448 L210P probably damaging Het
Pdzd7 T G 19: 45,027,748 D978A probably benign Het
Pkd1l1 A T 11: 8,973,217 S17T unknown Het
Plcz1 T C 6: 140,028,438 K93E possibly damaging Het
Pom121l2 G C 13: 21,981,937 R126P probably damaging Het
Prkg1 C T 19: 31,764,561 E88K probably benign Het
Psme4 A T 11: 30,853,203 D15V probably damaging Het
Ptprf A G 4: 118,231,731 V625A probably benign Het
Rab27a G A 9: 73,085,008 S106N probably damaging Het
Rasa4 A G 5: 136,100,948 T261A probably benign Het
Sardh T C 2: 27,228,257 D487G probably benign Het
Sec16a A G 2: 26,440,018 Y662H probably benign Het
Sema3d T A 5: 12,585,100 L711* probably null Het
Sept14 T A 5: 129,696,117 Y152F probably damaging Het
Smc5 A G 19: 23,242,640 L411P probably damaging Het
Spg7 T A 8: 123,073,911 V39E probably damaging Het
Tle1 A T 4: 72,122,450 I631N probably damaging Het
Tmed3 T A 9: 89,699,790 S207C probably damaging Het
Tmem59l G A 8: 70,486,372 P51S probably benign Het
Trpc3 A G 3: 36,624,393 Y848H probably damaging Het
Tsen2 T C 6: 115,549,920 F66S probably damaging Het
Ttll5 T A 12: 85,956,610 S216R probably damaging Het
Usp22 A T 11: 61,157,216 V426E probably damaging Het
Vmn2r76 T C 7: 86,225,906 N621S probably damaging Het
Wdr75 A G 1: 45,817,379 T521A probably damaging Het
Wrnip1 T A 13: 32,802,756 D173E probably damaging Het
Zfp317 G A 9: 19,647,804 G438D probably damaging Het
Zscan10 T A 17: 23,607,190 S109T possibly damaging Het
Other mutations in Tas2r117
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01611:Tas2r117 APN 6 132803484 missense probably benign 0.00
IGL01611:Tas2r117 APN 6 132803487 missense probably damaging 0.96
IGL02140:Tas2r117 APN 6 132803595 missense probably benign 0.15
IGL02154:Tas2r117 APN 6 132803715 missense probably benign 0.00
IGL02466:Tas2r117 APN 6 132803000 missense probably benign 0.12
IGL02942:Tas2r117 APN 6 132803694 missense probably benign 0.00
IGL03328:Tas2r117 APN 6 132803078 missense probably benign 0.40
PIT4480001:Tas2r117 UTSW 6 132803051 missense possibly damaging 0.91
R0380:Tas2r117 UTSW 6 132803588 nonsense probably null
R0456:Tas2r117 UTSW 6 132803391 missense probably benign 0.12
R0699:Tas2r117 UTSW 6 132803198 missense probably damaging 1.00
R2118:Tas2r117 UTSW 6 132803166 missense probably damaging 0.96
R2265:Tas2r117 UTSW 6 132803225 missense probably benign 0.06
R4420:Tas2r117 UTSW 6 132803349 nonsense probably null
R4861:Tas2r117 UTSW 6 132803129 missense probably benign 0.00
R4861:Tas2r117 UTSW 6 132803129 missense probably benign 0.00
R5233:Tas2r117 UTSW 6 132803622 missense possibly damaging 0.95
R5384:Tas2r117 UTSW 6 132803154 missense probably benign 0.04
R6852:Tas2r117 UTSW 6 132802929 missense probably benign 0.00
R6902:Tas2r117 UTSW 6 132803325 missense probably damaging 0.98
R6946:Tas2r117 UTSW 6 132803325 missense probably damaging 0.98
R7129:Tas2r117 UTSW 6 132803387 missense probably benign 0.01
R7412:Tas2r117 UTSW 6 132803229 missense probably damaging 1.00
R7733:Tas2r117 UTSW 6 132803175 missense probably benign 0.02
R7768:Tas2r117 UTSW 6 132803522 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGAAAATTCTACAGGAGCTGTGTG -3'
(R):5'- TCTTAACCCAGTCCATACAGTG -3'

Sequencing Primer
(F):5'- AAGAATTCTGGTCTGGCACCC -3'
(R):5'- CATACAGTGGACCAGGACCATG -3'
Posted On2018-08-01