Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01118:Wdr90'

53081

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Wdr90

Ensembl Gene

ENSMUSG00000073434

Gene Name

WD repeat domain 90

Synonyms

3230401M21Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.142) question?

Stock #

IGL01118

Quality Score

Status

Chromosome

Chromosomal Location

25844771-25861501 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 25854687 bp

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 762 (L762Q)

Ref Sequence

ENSEMBL: ENSMUSP00000078426 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079461] [ENSMUST00000176923]

Predicted Effect

probably damaging
Transcript: ENSMUST00000079461
AA Change: L762Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000078426
Gene: ENSMUSG00000073434
AA Change: L762Q

Domain	Start	End	E-Value	Type
low complexity region	32	53	N/A	INTRINSIC
Pfam:DUF667	60	183	5e-26	PFAM
Pfam:DUF667	210	271	3.7e-9	PFAM
low complexity region	381	396	N/A	INTRINSIC
WD40	478	519	5.94e0	SMART
WD40	522	565	3.2e0	SMART
WD40	572	612	3.3e1	SMART
WD40	687	725	1.15e1	SMART
WD40	728	766	5.75e-1	SMART
WD40	768	808	9.24e-4	SMART
WD40	811	850	4.13e0	SMART
WD40	853	892	4.62e-1	SMART
WD40	950	993	1.07e1	SMART
WD40	996	1035	5.75e-1	SMART
WD40	1040	1077	1.58e-2	SMART
WD40	1290	1334	5.23e-3	SMART
WD40	1337	1378	1.27e-1	SMART
WD40	1384	1419	1.83e2	SMART
WD40	1422	1469	3.08e0	SMART
WD40	1472	1509	9.9e0	SMART
WD40	1568	1607	9.02e-7	SMART
WD40	1610	1655	5.75e-1	SMART
WD40	1659	1697	2.98e-1	SMART
WD40	1700	1749	6.14e1	SMART
WD40	1850	1888	1.92e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176170

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176575

Predicted Effect

probably benign
Transcript: ENSMUST00000176678

Predicted Effect

probably damaging
Transcript: ENSMUST00000176923
AA Change: L744Q

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000135420
Gene: ENSMUSG00000073434
AA Change: L744Q

Domain	Start	End	E-Value	Type
low complexity region	32	53	N/A	INTRINSIC
Pfam:DUF667	60	252	5.1e-14	PFAM
low complexity region	363	378	N/A	INTRINSIC
WD40	460	501	5.94e0	SMART
WD40	504	547	3.2e0	SMART
WD40	554	594	3.3e1	SMART
WD40	669	707	1.15e1	SMART
WD40	710	748	5.75e-1	SMART
WD40	750	790	9.24e-4	SMART
WD40	793	832	4.13e0	SMART
WD40	835	874	4.62e-1	SMART
WD40	932	975	1.07e1	SMART
WD40	978	1017	5.75e-1	SMART
WD40	1022	1059	1.58e-2	SMART
WD40	1272	1316	5.23e-3	SMART
WD40	1319	1360	1.27e-1	SMART
WD40	1366	1401	1.83e2	SMART
WD40	1404	1451	3.08e0	SMART
WD40	1454	1491	9.9e0	SMART
WD40	1550	1589	9.02e-7	SMART
WD40	1592	1637	5.75e-1	SMART
WD40	1641	1679	2.98e-1	SMART
WD40	1682	1731	6.14e1	SMART
WD40	1832	1870	1.92e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176963

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177017

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177031

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177170

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177340

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000180868

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700006A11Rik	C	T	3: 124,401,409	R539Q	probably benign	Het
Abcb1a	G	A	5: 8,674,687	R40H	probably damaging	Het
Acan	T	A	7: 79,098,653	S1057R	possibly damaging	Het
Ahnak	A	T	19: 9,012,578	D3742V	probably damaging	Het
Amdhd1	A	T	10: 93,531,568	D241E	probably benign	Het
Cntn5	T	C	9: 9,831,560	Y605C	possibly damaging	Het
Dgcr14	A	T	16: 17,902,932	I350N	probably damaging	Het
Dnmt3l	T	C	10: 78,057,286	F299S	probably damaging	Het
G6pd2	A	T	5: 61,810,063	M394L	probably benign	Het
Gm21319	T	A	12: 87,773,442	N116Y	probably damaging	Het
Gm9839	A	T	1: 32,519,843	M386K	probably benign	Het
Gtf2h3	T	C	5: 124,595,668	V268A	probably damaging	Het
Hgs	T	C	11: 120,475,214	V195A	probably damaging	Het
Igkv3-2	A	T	6: 70,698,994	S96C	probably damaging	Het
Mgl2	A	G	11: 70,134,189	E12G	probably benign	Het
Mup11	A	T	4: 60,659,780	F153I	probably damaging	Het
Nf1	T	A	11: 79,546,986	C2057S	probably damaging	Het
Nkrf	A	G	X: 36,888,757	F624S	probably damaging	Het
Noto	T	C	6: 85,424,210	S74P	probably benign	Het
Olfr1090	A	G	2: 86,753,970	I256T	probably benign	Het
Pax8	T	C	2: 24,442,932		probably benign	Het
Psg28	A	T	7: 18,428,092	V162D	probably damaging	Het
Rai1	T	C	11: 60,187,438	F776S	probably damaging	Het
Taar8a	A	T	10: 24,076,861	H121L	probably damaging	Het
Tas2r113	A	G	6: 132,893,315	N102S	probably benign	Het
Trpm1	A	G	7: 64,235,824	T863A	probably benign	Het
Ttf2	A	G	3: 100,967,097		probably benign	Het
Wdr62	T	C	7: 30,242,781	H611R	probably damaging	Het
Yeats2	T	G	16: 20,186,304	S364A	probably damaging	Het
Zdhhc15	G	T	X: 104,598,106	Q82K	probably benign	Het

Other mutations in Wdr90

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00418:Wdr90	APN	17	25849364	missense	probably damaging	1.00
IGL01964:Wdr90	APN	17	25848409	missense	probably benign
IGL02116:Wdr90	APN	17	25859492	missense	probably benign	0.12
IGL02172:Wdr90	APN	17	25850434	missense	probably benign	0.22
IGL02716:Wdr90	APN	17	25857220	missense	probably damaging	0.96
IGL02961:Wdr90	APN	17	25848675	nonsense	probably null
IGL03229:Wdr90	APN	17	25845463	splice site	probably benign
IGL03367:Wdr90	APN	17	25847791	splice site	probably benign
IGL03098:Wdr90	UTSW	17	25859987	intron	probably benign
R0111:Wdr90	UTSW	17	25848444	splice site	probably benign
R0454:Wdr90	UTSW	17	25860049	missense	probably damaging	0.96
R0457:Wdr90	UTSW	17	25860485	missense	probably benign	0.00
R0488:Wdr90	UTSW	17	25848617	missense	probably damaging	1.00
R0622:Wdr90	UTSW	17	25855658	missense	probably damaging	1.00
R0671:Wdr90	UTSW	17	25846393	missense	probably benign	0.04
R0799:Wdr90	UTSW	17	25860130	missense	probably benign	0.38
R1177:Wdr90	UTSW	17	25846054	missense	possibly damaging	0.85
R1460:Wdr90	UTSW	17	25860448	missense	possibly damaging	0.82
R1468:Wdr90	UTSW	17	25854053	missense	probably damaging	1.00
R1468:Wdr90	UTSW	17	25854053	missense	probably damaging	1.00
R1544:Wdr90	UTSW	17	25849310	missense	possibly damaging	0.69
R2057:Wdr90	UTSW	17	25855199	missense	probably benign	0.05
R2087:Wdr90	UTSW	17	25846603	missense	probably damaging	1.00
R2159:Wdr90	UTSW	17	25851741	missense	probably benign
R2208:Wdr90	UTSW	17	25860388	missense	probably damaging	1.00
R2345:Wdr90	UTSW	17	25859162	missense	probably benign	0.05
R2391:Wdr90	UTSW	17	25851455	missense	probably damaging	1.00
R2394:Wdr90	UTSW	17	25851455	missense	probably damaging	1.00
R2520:Wdr90	UTSW	17	25855352	missense	probably damaging	1.00
R3798:Wdr90	UTSW	17	25850498	missense	probably benign	0.01
R3979:Wdr90	UTSW	17	25859278	missense	probably benign	0.00
R4111:Wdr90	UTSW	17	25849368	missense	possibly damaging	0.94
R4326:Wdr90	UTSW	17	25853731	missense	probably benign	0.25
R4459:Wdr90	UTSW	17	25861002	missense	possibly damaging	0.95
R4697:Wdr90	UTSW	17	25855363	missense	probably benign	0.03
R4735:Wdr90	UTSW	17	25859450	missense	probably benign
R4907:Wdr90	UTSW	17	25860650	intron	probably benign
R5070:Wdr90	UTSW	17	25846333	missense	probably damaging	1.00
R5230:Wdr90	UTSW	17	25855303	missense	probably benign	0.01
R5268:Wdr90	UTSW	17	25850845	missense	probably damaging	1.00
R5287:Wdr90	UTSW	17	25861467	utr 5 prime	probably benign
R5382:Wdr90	UTSW	17	25845598	missense	probably damaging	1.00
R5511:Wdr90	UTSW	17	25845021	unclassified	probably benign
R5545:Wdr90	UTSW	17	25845856	missense	probably damaging	1.00
R5707:Wdr90	UTSW	17	25857192	missense	probably benign	0.00
R5973:Wdr90	UTSW	17	25845133	missense	probably damaging	0.99
R5973:Wdr90	UTSW	17	25846407	missense	probably damaging	1.00
R6385:Wdr90	UTSW	17	25848530	missense	probably damaging	1.00
R6481:Wdr90	UTSW	17	25845911	missense	probably damaging	0.99
R7078:Wdr90	UTSW	17	25849649	missense	probably damaging	1.00
R7214:Wdr90	UTSW	17	25845393	missense	probably benign	0.00
R7288:Wdr90	UTSW	17	25846312	missense	probably benign	0.03
R7304:Wdr90	UTSW	17	25851506	missense	probably benign	0.10
R7309:Wdr90	UTSW	17	25860702	missense	probably benign	0.02
R7391:Wdr90	UTSW	17	25846528	missense	probably benign	0.08
R7622:Wdr90	UTSW	17	25854109	missense	probably benign	0.00
R7646:Wdr90	UTSW	17	25860130	missense	probably benign	0.38
R7772:Wdr90	UTSW	17	25861491	start gained	probably benign
R7779:Wdr90	UTSW	17	25846326	missense	probably damaging	1.00
R7780:Wdr90	UTSW	17	25846326	missense	probably damaging	1.00
R7781:Wdr90	UTSW	17	25846326	missense	probably damaging	1.00
R7782:Wdr90	UTSW	17	25846326	missense	probably damaging	1.00
R7812:Wdr90	UTSW	17	25852558	missense	probably damaging	1.00
X0064:Wdr90	UTSW	17	25848563	missense	probably damaging	1.00

Posted On

2013-06-21