Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01120:Vmn2r103'

53082

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL01120

Quality Score

Status

Chromosome

Chromosomal Location

19773363-19812536 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 19792997 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 127 (T127S)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

AlphaFold

E9PWW0

Predicted Effect

probably benign
Transcript: ENSMUST00000172203
AA Change: T127S

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: T127S

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210010C04Rik	A	T	6: 41,031,673	Y236N	probably damaging	Het
5830411N06Rik	T	C	7: 140,296,559	L648P	probably benign	Het
Abhd11	T	A	5: 135,011,475		probably null	Het
Armcx5	T	C	X: 135,746,363	I396T	probably damaging	Het
Atm	T	C	9: 53,461,122		probably null	Het
Atp6v1c2	C	T	12: 17,308,293	E88K	probably damaging	Het
Caskin1	A	G	17: 24,505,369	T1044A	possibly damaging	Het
Ccdc155	G	T	7: 45,184,198	S560Y	probably damaging	Het
Cyp3a59	T	A	5: 146,102,861	S315T	probably damaging	Het
Dnaja1	T	A	4: 40,730,248	I240N	probably damaging	Het
Dnttip2	C	T	3: 122,278,737		probably benign	Het
Elavl2	A	T	4: 91,264,072	M136K	probably damaging	Het
Eml5	C	T	12: 98,844,019	V893I	probably benign	Het
Fbxw4	G	T	19: 45,640,516	A2E	probably benign	Het
Flg2	T	G	3: 93,201,168	S168A	probably damaging	Het
Fndc3a	G	A	14: 72,556,662	T857I	probably benign	Het
Gria1	A	G	11: 57,317,669	K797E	probably damaging	Het
Herc1	T	C	9: 66,428,880	F1569S	probably benign	Het
Lrrc45	T	C	11: 120,720,010	V524A	probably benign	Het
Myo19	T	C	11: 84,907,278	L708P	probably damaging	Het
Nup107	A	G	10: 117,770,241		probably benign	Het
Olfr479	T	G	7: 108,055,567	M195R	probably damaging	Het
Olfr651	T	C	7: 104,553,345	V142A	probably benign	Het
Palm	A	G	10: 79,816,787		probably benign	Het
Phf14	T	C	6: 11,962,740	V462A	probably damaging	Het
Pkhd1l1	G	A	15: 44,505,312		probably null	Het
Pkp3	T	A	7: 141,084,182	L424*	probably null	Het
Prss29	A	G	17: 25,322,133	K184E	probably benign	Het
Ptcd1	C	T	5: 145,152,243		probably benign	Het
Pth1r	T	C	9: 110,727,130	H225R	probably damaging	Het
Rffl	C	T	11: 82,806,022	V332I	probably damaging	Het
Rsl1	T	C	13: 67,177,166		probably benign	Het
Scn9a	T	C	2: 66,526,972	K986R	probably benign	Het
Slc22a15	A	G	3: 101,897,166	L181P	probably damaging	Het
Slc34a1	T	A	13: 55,409,071	L241H	probably damaging	Het
Slc4a4	C	A	5: 89,132,379	H354Q	probably damaging	Het
Sorcs2	T	C	5: 36,021,252	E1131G	probably damaging	Het
Ssc4d	C	A	5: 135,967,963	D95Y	probably damaging	Het
Tcte1	A	T	17: 45,539,668	D290V	probably damaging	Het
Thyn1	T	A	9: 27,003,774	M74K	probably benign	Het
Tlr4	C	T	4: 66,840,425	T485I	probably benign	Het
Trem1	A	G	17: 48,237,249	T101A	probably benign	Het
Ttc17	T	C	2: 94,371,796	E387G	probably damaging	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	19793102	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	19794965	missense	probably benign	0.00
IGL01403:Vmn2r103	APN	17	19792967	missense	probably benign
IGL01404:Vmn2r103	APN	17	19812434	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	19794068	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	19799208	missense	probably benign
IGL02251:Vmn2r103	APN	17	19793969	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19773369	missense	probably benign
IGL02555:Vmn2r103	APN	17	19811611	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	19794127	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	19793956	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	19812248	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19773520	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	19811979	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	19811641	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	19792859	missense	probably benign	0.06
R0375:Vmn2r103	UTSW	17	19793464	missense	probably benign	0.12
R0755:Vmn2r103	UTSW	17	19773568	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	19793927	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	19794247	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	19792968	missense	probably benign
R1488:Vmn2r103	UTSW	17	19793660	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19773400	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	19794234	missense	probably benign
R1928:Vmn2r103	UTSW	17	19811767	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	19812300	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	19793794	missense	probably benign
R2219:Vmn2r103	UTSW	17	19793647	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19773531	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	19793600	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	19812149	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	19794233	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	19811815	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	19811769	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	19812171	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	19793642	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	19792989	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	19794939	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	19812453	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	19794216	nonsense	probably null
R6114:Vmn2r103	UTSW	17	19812325	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	19812144	missense	probably benign
R6292:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	19794082	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	19811904	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	19811977	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	19793477	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	19812052	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	19794214	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	19793123	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	19799249	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	19793497	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	19811796	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	19811943	missense	probably damaging	1.00
R8559:Vmn2r103	UTSW	17	19812384	missense	probably benign	0.01
R9413:Vmn2r103	UTSW	17	19811896	missense	possibly damaging	0.54
R9591:Vmn2r103	UTSW	17	19811659	missense	possibly damaging	0.70
R9652:Vmn2r103	UTSW	17	19793765	missense	probably benign	0.01
R9680:Vmn2r103	UTSW	17	19799263	nonsense	probably null
R9743:Vmn2r103	UTSW	17	19812213	missense	probably damaging	1.00
Z1088:Vmn2r103	UTSW	17	19795047	missense	probably benign	0.08

Posted On

2013-06-21