Incidental Mutation 'R6752:Klra4'
ID 530828
Institutional Source Beutler Lab
Gene Symbol Klra4
Ensembl Gene ENSMUSG00000079852
Gene Name killer cell lectin-like receptor, subfamily A, member 4
Synonyms ly49r<129>, Ly49d, Chok
MMRRC Submission 044869-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R6752 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 130020694-130044234 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 130038991 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 134 (Q134K)
Ref Sequence ENSEMBL: ENSMUSP00000114004 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000119096]
AlphaFold Q60651
Predicted Effect probably benign
Transcript: ENSMUST00000119096
AA Change: Q134K

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000114004
Gene: ENSMUSG00000079852
AA Change: Q134K

DomainStartEndE-ValueType
CLECT 140 255 1.78e-16 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency 98% (55/56)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T C 11: 84,086,309 (GRCm39) L45S probably benign Het
Agbl2 G A 2: 90,633,418 (GRCm39) C518Y probably damaging Het
Akt3 A T 1: 176,877,756 (GRCm39) Y337* probably null Het
Aox1 T C 1: 58,086,398 (GRCm39) I101T probably benign Het
Arhgap23 T C 11: 97,343,074 (GRCm39) F241S probably damaging Het
Asmt A G X: 169,110,096 (GRCm39) M202V probably benign Het
Atp6v0a2 A G 5: 124,779,452 (GRCm39) E189G probably damaging Het
Birc2 G A 9: 7,857,345 (GRCm39) A376V probably benign Het
Ccbe1 C T 18: 66,209,378 (GRCm39) probably null Het
Chst2 C A 9: 95,286,802 (GRCm39) E515* probably null Het
Col12a1 A T 9: 79,540,706 (GRCm39) N2426K possibly damaging Het
Dmrt2 A G 19: 25,655,706 (GRCm39) N435S probably damaging Het
Dnah14 A G 1: 181,421,017 (GRCm39) K123E probably benign Het
Dock4 T A 12: 40,870,616 (GRCm39) L1452Q probably damaging Het
Galnt7 G A 8: 58,105,985 (GRCm39) R10C probably damaging Het
Gm16506 A G 14: 43,964,876 (GRCm39) I22T unknown Het
H2-Q6 A G 17: 35,647,103 (GRCm39) T292A probably damaging Het
Ifne A G 4: 88,798,319 (GRCm39) M33T probably benign Het
Igf2r G A 17: 12,933,831 (GRCm39) R808W probably damaging Het
Igfbp5 T C 1: 72,903,068 (GRCm39) E169G probably damaging Het
Inppl1 G A 7: 101,481,749 (GRCm39) R198* probably null Het
Irgm1 T C 11: 48,757,290 (GRCm39) T174A probably damaging Het
Itih3 C T 14: 30,645,446 (GRCm39) G21S possibly damaging Het
Mfsd1 T A 3: 67,503,936 (GRCm39) Y309* probably null Het
Mrps10 A G 17: 47,688,740 (GRCm39) N162S probably damaging Het
Mtmr14 T C 6: 113,217,358 (GRCm39) F90S probably damaging Het
Myh15 A G 16: 49,003,290 (GRCm39) D1783G probably damaging Het
Myo3b A G 2: 70,119,856 (GRCm39) E972G probably damaging Het
Myt1 G T 2: 181,442,875 (GRCm39) V455F probably damaging Het
Nbea A T 3: 55,944,640 (GRCm39) S575T probably benign Het
Nbea T A 3: 55,875,730 (GRCm39) T1647S probably benign Het
Ntn4 A G 10: 93,570,037 (GRCm39) N466S probably benign Het
Or10ag52 A G 2: 87,043,388 (GRCm39) M51V probably benign Het
Or5b114-ps1 T A 19: 13,352,890 (GRCm39) L188H unknown Het
Or5h27 T A 16: 59,006,694 (GRCm39) N51Y probably damaging Het
Pcdhgb4 T A 18: 37,853,704 (GRCm39) I33N probably damaging Het
Pi4ka A G 16: 17,194,846 (GRCm39) L184P possibly damaging Het
Pom121l2 T G 13: 22,165,939 (GRCm39) F70C probably damaging Het
Psmb5 T C 14: 54,854,212 (GRCm39) T89A probably benign Het
Rab11fip2 T C 19: 59,895,475 (GRCm39) D471G probably damaging Het
Rnh1 A G 7: 140,743,354 (GRCm39) V207A probably benign Het
Sh3tc2 C A 18: 62,094,108 (GRCm39) T49N probably benign Het
Skint4 T C 4: 111,977,060 (GRCm39) M158T possibly damaging Het
Skint7 T A 4: 111,837,463 (GRCm39) H80Q probably benign Het
Smg1 A G 7: 117,762,539 (GRCm39) probably benign Het
Sostdc1 T C 12: 36,364,411 (GRCm39) V40A probably benign Het
Sptlc1 C A 13: 53,489,394 (GRCm39) K437N possibly damaging Het
Stat2 T C 10: 128,119,622 (GRCm39) F503L probably damaging Het
Syt16 A T 12: 74,275,987 (GRCm39) probably null Het
Tspyl1 T C 10: 34,158,583 (GRCm39) S103P probably benign Het
Ube4a A T 9: 44,837,246 (GRCm39) S1053R probably damaging Het
Vipr1 A G 9: 121,482,959 (GRCm39) N58S probably damaging Het
Zfp184 C A 13: 22,143,578 (GRCm39) A428E probably damaging Het
Zfp292 A C 4: 34,808,593 (GRCm39) F1484V possibly damaging Het
Zfp599 G A 9: 22,160,840 (GRCm39) H442Y probably damaging Het
Zfp944 G A 17: 22,558,500 (GRCm39) T249I probably benign Het
Zkscan14 T A 5: 145,132,316 (GRCm39) H405L probably damaging Het
Other mutations in Klra4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01322:Klra4 APN 6 130,038,985 (GRCm39) missense probably benign 0.18
IGL02189:Klra4 APN 6 130,021,105 (GRCm39) missense possibly damaging 0.68
IGL02510:Klra4 APN 6 130,036,506 (GRCm39) missense probably damaging 1.00
IGL02887:Klra4 APN 6 130,021,033 (GRCm39) missense probably damaging 1.00
R1388:Klra4 UTSW 6 130,039,198 (GRCm39) splice site probably benign
R1933:Klra4 UTSW 6 130,042,207 (GRCm39) missense possibly damaging 0.83
R3121:Klra4 UTSW 6 130,040,141 (GRCm39) missense probably benign 0.00
R5205:Klra4 UTSW 6 130,039,080 (GRCm39) missense probably damaging 0.99
R5223:Klra4 UTSW 6 130,039,110 (GRCm39) missense probably damaging 1.00
R5589:Klra4 UTSW 6 130,039,117 (GRCm39) missense probably benign 0.41
R5930:Klra4 UTSW 6 130,030,016 (GRCm39) missense possibly damaging 0.95
R5931:Klra4 UTSW 6 130,030,016 (GRCm39) missense possibly damaging 0.95
R5932:Klra4 UTSW 6 130,030,016 (GRCm39) missense possibly damaging 0.95
R6452:Klra4 UTSW 6 130,042,329 (GRCm39) splice site probably null
R6789:Klra4 UTSW 6 130,039,182 (GRCm39) missense probably damaging 1.00
R6841:Klra4 UTSW 6 130,042,162 (GRCm39) missense probably benign 0.01
R7255:Klra4 UTSW 6 130,036,605 (GRCm39) missense probably damaging 0.99
R7901:Klra4 UTSW 6 130,040,113 (GRCm39) missense probably damaging 1.00
R8284:Klra4 UTSW 6 130,042,243 (GRCm39) missense possibly damaging 0.49
R8340:Klra4 UTSW 6 130,042,257 (GRCm39) missense probably benign 0.27
R8560:Klra4 UTSW 6 130,042,235 (GRCm39) missense probably benign 0.05
R8832:Klra4 UTSW 6 130,021,019 (GRCm39) missense probably benign 0.05
R9076:Klra4 UTSW 6 130,039,107 (GRCm39) missense possibly damaging 0.81
R9333:Klra4 UTSW 6 130,021,080 (GRCm39) missense probably damaging 1.00
R9434:Klra4 UTSW 6 130,040,083 (GRCm39) missense possibly damaging 0.50
Predicted Primers PCR Primer
(F):5'- AACTTCTGAGTTTCCAGACCCC -3'
(R):5'- GTGAGGTTACTTCCACCGTAATTTTC -3'

Sequencing Primer
(F):5'- GAGTTTCCAGACCCCTACATG -3'
(R):5'- GGTGTCAACATGAAGCTTTTTCTC -3'
Posted On 2018-08-01