Incidental Mutation 'R6752:Irgm1'
ID530842
Institutional Source Beutler Lab
Gene Symbol Irgm1
Ensembl Gene ENSMUSG00000046879
Gene Nameimmunity-related GTPase family M member 1
SynonymsIfi1, LRG-47, Irgm, Iigp3
MMRRC Submission
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R6752 (G1)
Quality Score225.009
Status Validated
Chromosome11
Chromosomal Location48861968-48871683 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 48866463 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 174 (T174A)
Ref Sequence ENSEMBL: ENSMUSP00000094870 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049519] [ENSMUST00000097271]
Predicted Effect probably damaging
Transcript: ENSMUST00000049519
AA Change: T190A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000050446
Gene: ENSMUSG00000046879
AA Change: T190A

DomainStartEndE-ValueType
Pfam:IIGP 42 399 5.5e-169 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000097271
AA Change: T174A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000094870
Gene: ENSMUSG00000046879
AA Change: T174A

DomainStartEndE-ValueType
Pfam:IIGP 26 288 2.5e-131 PFAM
Pfam:MMR_HSR1 62 175 2.8e-6 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147151
Meta Mutation Damage Score 0.6288 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency 98% (55/56)
MGI Phenotype PHENOTYPE: In the absence of infection, mice show no overt phenotype. Resistance to protozoan parasitic infection and bacterial infection is impaired in homozygous mutant mice, whereas resistance to viral infection is normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T C 11: 84,195,483 L45S probably benign Het
Agbl2 G A 2: 90,803,074 C518Y probably damaging Het
Akt3 A T 1: 177,050,190 Y337* probably null Het
Aox1 T C 1: 58,047,239 I101T probably benign Het
Arhgap23 T C 11: 97,452,248 F241S probably damaging Het
Asmt A G X: 170,676,361 M202V probably benign Het
Atp6v0a2 A G 5: 124,641,514 E189G probably damaging Het
Birc3 G A 9: 7,857,344 A376V probably benign Het
Ccbe1 C T 18: 66,076,307 probably null Het
Chst2 C A 9: 95,404,749 E515* probably null Het
Col12a1 A T 9: 79,633,424 N2426K possibly damaging Het
Dmrt2 A G 19: 25,678,342 N435S probably damaging Het
Dnah14 A G 1: 181,593,452 K123E probably benign Het
Dock4 T A 12: 40,820,617 L1452Q probably damaging Het
Galnt7 G A 8: 57,652,951 R10C probably damaging Het
Gm16506 A G 14: 43,727,419 I22T unknown Het
H2-Q6 A G 17: 35,428,127 T292A probably damaging Het
Ifne A G 4: 88,880,082 M33T probably benign Het
Igf2r G A 17: 12,714,944 R808W probably damaging Het
Igfbp5 T C 1: 72,863,909 E169G probably damaging Het
Inppl1 G A 7: 101,832,542 R198* probably null Het
Itih3 C T 14: 30,923,489 G21S possibly damaging Het
Klra4 G T 6: 130,062,028 Q134K probably benign Het
Mfsd1 T A 3: 67,596,603 Y309* probably null Het
Mrps10 A G 17: 47,377,815 N162S probably damaging Het
Mtmr14 T C 6: 113,240,397 F90S probably damaging Het
Myh15 A G 16: 49,182,927 D1783G probably damaging Het
Myo3b A G 2: 70,289,512 E972G probably damaging Het
Myt1 G T 2: 181,801,082 V455F probably damaging Het
Nbea T A 3: 55,968,309 T1647S probably benign Het
Nbea A T 3: 56,037,219 S575T probably benign Het
Ntn4 A G 10: 93,734,175 N466S probably benign Het
Olfr1113 A G 2: 87,213,044 M51V probably benign Het
Olfr1468-ps1 T A 19: 13,375,526 L188H unknown Het
Olfr197 T A 16: 59,186,331 N51Y probably damaging Het
Pcdhgb4 T A 18: 37,720,651 I33N probably damaging Het
Pi4ka A G 16: 17,376,982 L184P possibly damaging Het
Pom121l2 T G 13: 21,981,769 F70C probably damaging Het
Psmb5 T C 14: 54,616,755 T89A probably benign Het
Rab11fip2 T C 19: 59,907,043 D471G probably damaging Het
Rnh1 A G 7: 141,163,441 V207A probably benign Het
Sh3tc2 C A 18: 61,961,037 T49N probably benign Het
Skint4 T C 4: 112,119,863 M158T possibly damaging Het
Skint7 T A 4: 111,980,266 H80Q probably benign Het
Smg1 A G 7: 118,163,316 probably benign Het
Sostdc1 T C 12: 36,314,412 V40A probably benign Het
Sptlc1 C A 13: 53,335,358 K437N possibly damaging Het
Stat2 T C 10: 128,283,753 F503L probably damaging Het
Syt16 A T 12: 74,229,213 probably null Het
Tspyl1 T C 10: 34,282,587 S103P probably benign Het
Ube4a A T 9: 44,925,948 S1053R probably damaging Het
Vipr1 A G 9: 121,653,893 N58S probably damaging Het
Zfp184 C A 13: 21,959,408 A428E probably damaging Het
Zfp292 A C 4: 34,808,593 F1484V possibly damaging Het
Zfp599 G A 9: 22,249,544 H442Y probably damaging Het
Zfp944 G A 17: 22,339,519 T249I probably benign Het
Zkscan14 T A 5: 145,195,506 H405L probably damaging Het
Other mutations in Irgm1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00418:Irgm1 APN 11 48866005 nonsense probably null
IGL01821:Irgm1 APN 11 48866526 missense probably damaging 1.00
IGL02043:Irgm1 APN 11 48866815 missense probably damaging 0.98
IGL02252:Irgm1 APN 11 48866154 missense possibly damaging 0.92
IGL03153:Irgm1 APN 11 48866267 missense probably damaging 1.00
igraine UTSW 11 48866613 missense probably benign 0.33
R0487:Irgm1 UTSW 11 48866327 missense probably damaging 0.98
R1808:Irgm1 UTSW 11 48866432 missense probably damaging 0.99
R1809:Irgm1 UTSW 11 48866613 missense probably benign 0.33
R1878:Irgm1 UTSW 11 48866070 missense probably benign 0.07
R2971:Irgm1 UTSW 11 48866590 nonsense probably null
R4492:Irgm1 UTSW 11 48866128 synonymous silent
R4962:Irgm1 UTSW 11 48866332 missense possibly damaging 0.93
R5186:Irgm1 UTSW 11 48866217 missense probably benign 0.00
R5794:Irgm1 UTSW 11 48866237 missense probably damaging 0.99
R6224:Irgm1 UTSW 11 48866886 missense probably benign 0.02
R6487:Irgm1 UTSW 11 48865950 missense probably benign 0.21
R6766:Irgm1 UTSW 11 48866101 missense possibly damaging 0.80
R8005:Irgm1 UTSW 11 48866390 missense probably damaging 1.00
R8418:Irgm1 UTSW 11 48866339 missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- CAGCACCTGATGTTGGAGAG -3'
(R):5'- ACTTTCCCAATGTGGTGCTGTG -3'

Sequencing Primer
(F):5'- CTTTATGAAGTGTGTCCCTAAGC -3'
(R):5'- CAATGTGGTGCTGTGGGACTTAC -3'
Posted On2018-08-01