Incidental Mutation 'R6752:Olfr197'
ID530856
Institutional Source Beutler Lab
Gene Symbol Olfr197
Ensembl Gene ENSMUSG00000061501
Gene Nameolfactory receptor 197
SynonymsMOR183-3, GA_x54KRFPKG5P-55400292-55399363
MMRRC Submission
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.281) question?
Stock #R6752 (G1)
Quality Score225.009
Status Validated
Chromosome16
Chromosomal Location59185556-59186481 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 59186331 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Tyrosine at position 51 (N51Y)
Ref Sequence ENSEMBL: ENSMUSP00000146916 (fasta)
Predicted Effect probably damaging
Transcript: ENSMUST00000080031
AA Change: N51Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000207772
AA Change: N51Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency 98% (55/56)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T C 11: 84,195,483 L45S probably benign Het
Agbl2 G A 2: 90,803,074 C518Y probably damaging Het
Akt3 A T 1: 177,050,190 Y337* probably null Het
Aox1 T C 1: 58,047,239 I101T probably benign Het
Arhgap23 T C 11: 97,452,248 F241S probably damaging Het
Asmt A G X: 170,676,361 M202V probably benign Het
Atp6v0a2 A G 5: 124,641,514 E189G probably damaging Het
Birc3 G A 9: 7,857,344 A376V probably benign Het
Ccbe1 C T 18: 66,076,307 probably null Het
Chst2 C A 9: 95,404,749 E515* probably null Het
Col12a1 A T 9: 79,633,424 N2426K possibly damaging Het
Dmrt2 A G 19: 25,678,342 N435S probably damaging Het
Dnah14 A G 1: 181,593,452 K123E probably benign Het
Dock4 T A 12: 40,820,617 L1452Q probably damaging Het
Galnt7 G A 8: 57,652,951 R10C probably damaging Het
Gm16506 A G 14: 43,727,419 I22T unknown Het
H2-Q6 A G 17: 35,428,127 T292A probably damaging Het
Ifne A G 4: 88,880,082 M33T probably benign Het
Igf2r G A 17: 12,714,944 R808W probably damaging Het
Igfbp5 T C 1: 72,863,909 E169G probably damaging Het
Inppl1 G A 7: 101,832,542 R198* probably null Het
Irgm1 T C 11: 48,866,463 T174A probably damaging Het
Itih3 C T 14: 30,923,489 G21S possibly damaging Het
Klra4 G T 6: 130,062,028 Q134K probably benign Het
Mfsd1 T A 3: 67,596,603 Y309* probably null Het
Mrps10 A G 17: 47,377,815 N162S probably damaging Het
Mtmr14 T C 6: 113,240,397 F90S probably damaging Het
Myh15 A G 16: 49,182,927 D1783G probably damaging Het
Myo3b A G 2: 70,289,512 E972G probably damaging Het
Myt1 G T 2: 181,801,082 V455F probably damaging Het
Nbea T A 3: 55,968,309 T1647S probably benign Het
Nbea A T 3: 56,037,219 S575T probably benign Het
Ntn4 A G 10: 93,734,175 N466S probably benign Het
Olfr1113 A G 2: 87,213,044 M51V probably benign Het
Olfr1468-ps1 T A 19: 13,375,526 L188H unknown Het
Pcdhgb4 T A 18: 37,720,651 I33N probably damaging Het
Pi4ka A G 16: 17,376,982 L184P possibly damaging Het
Pom121l2 T G 13: 21,981,769 F70C probably damaging Het
Psmb5 T C 14: 54,616,755 T89A probably benign Het
Rab11fip2 T C 19: 59,907,043 D471G probably damaging Het
Rnh1 A G 7: 141,163,441 V207A probably benign Het
Sh3tc2 C A 18: 61,961,037 T49N probably benign Het
Skint4 T C 4: 112,119,863 M158T possibly damaging Het
Skint7 T A 4: 111,980,266 H80Q probably benign Het
Smg1 A G 7: 118,163,316 probably benign Het
Sostdc1 T C 12: 36,314,412 V40A probably benign Het
Sptlc1 C A 13: 53,335,358 K437N possibly damaging Het
Stat2 T C 10: 128,283,753 F503L probably damaging Het
Syt16 A T 12: 74,229,213 probably null Het
Tspyl1 T C 10: 34,282,587 S103P probably benign Het
Ube4a A T 9: 44,925,948 S1053R probably damaging Het
Vipr1 A G 9: 121,653,893 N58S probably damaging Het
Zfp184 C A 13: 21,959,408 A428E probably damaging Het
Zfp292 A C 4: 34,808,593 F1484V possibly damaging Het
Zfp599 G A 9: 22,249,544 H442Y probably damaging Het
Zfp944 G A 17: 22,339,519 T249I probably benign Het
Zkscan14 T A 5: 145,195,506 H405L probably damaging Het
Other mutations in Olfr197
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4612:Olfr197 UTSW 16 59186311 missense probably damaging 1.00
R5777:Olfr197 UTSW 16 59185903 missense unknown
R5945:Olfr197 UTSW 16 59185728 missense unknown
R6045:Olfr197 UTSW 16 59186091 missense probably benign 0.07
R7284:Olfr197 UTSW 16 59185968 makesense probably null
R7327:Olfr197 UTSW 16 59186013 missense unknown
R7387:Olfr197 UTSW 16 59186336 missense probably damaging 1.00
R8089:Olfr197 UTSW 16 59185710 missense unknown
R8420:Olfr197 UTSW 16 59185754 missense unknown
Z1176:Olfr197 UTSW 16 59186485 start gained probably benign
Z1177:Olfr197 UTSW 16 59186000 missense unknown
Predicted Primers PCR Primer
(F):5'- ACATTCCATAGTTGCACACATC -3'
(R):5'- TCTTTGCGGTAACAGTGAGTC -3'

Sequencing Primer
(F):5'- TTCCATAGTTGCACACATCACAAATG -3'
(R):5'- CAGTGAGTCTATGATGCAGATACTG -3'
Posted On2018-08-01