Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01121:Vmn2r91'

53087

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r91

Ensembl Gene

ENSMUSG00000091206

Gene Name

vomeronasal 2, receptor 91

Synonyms

EG665210

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL01121

Quality Score

Status

Chromosome

Chromosomal Location

18085057-18136643 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 18136504 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 811 (V811A)

Ref Sequence

ENSEMBL: ENSMUSP00000127465 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172359]

AlphaFold

E9Q2U5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000172359
AA Change: V811A

PolyPhen 2 Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000127465
Gene: ENSMUSG00000091206
AA Change: V811A

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	83	462	2.2e-38	PFAM
Pfam:NCD3G	510	564	6.7e-20	PFAM
Pfam:7tm_3	597	832	2.1e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700046A07Rik	G	A	18: 62,755,148		noncoding transcript	Het
4930432E11Rik	A	T	7: 29,574,001		noncoding transcript	Het
Alg3	T	C	16: 20,610,647	E31G	probably damaging	Het
Arhgap29	A	G	3: 122,009,863	E764G	probably damaging	Het
Atp5j2	C	A	5: 145,184,568	V68L	probably benign	Het
Birc6	T	A	17: 74,631,038	I2645K	probably benign	Het
Capn11	A	G	17: 45,639,132	S369P	probably benign	Het
Car4	A	T	11: 84,964,346		probably null	Het
Ccdc185	C	T	1: 182,748,657	V156I	probably benign	Het
Cpsf2	G	T	12: 101,988,706	E245D	probably damaging	Het
Dnah11	T	C	12: 118,050,695	D2019G	probably benign	Het
Dscc1	A	G	15: 55,082,325		probably benign	Het
Dzip3	T	C	16: 48,944,881	D490G	probably benign	Het
E2f8	G	A	7: 48,867,821	Q745*	probably null	Het
Fat3	T	A	9: 15,998,401	T2102S	probably benign	Het
Fgf7	C	T	2: 126,088,232		probably benign	Het
Fstl4	T	C	11: 52,814,637	F47L	probably benign	Het
Gm15097	A	T	X: 149,804,328	R129S	possibly damaging	Het
Gm4297	C	T	X: 24,552,615	D200N	probably benign	Het
Itgb5	G	T	16: 33,919,989	D490Y	probably benign	Het
Kansl1	A	G	11: 104,335,596	S912P	probably benign	Het
Kcnq3	A	T	15: 66,005,977		probably benign	Het
Kctd6	A	G	14: 8,222,656	H166R	possibly damaging	Het
Kel	T	C	6: 41,702,409	D140G	probably benign	Het
Lrif1	C	A	3: 106,735,664	S177*	probably null	Het
Lrp1	A	T	10: 127,583,853	C962*	probably null	Het
Lypd5	A	T	7: 24,351,551	Y29F	probably benign	Het
Mmrn1	A	G	6: 60,975,944	D403G	possibly damaging	Het
Nhsl1	T	G	10: 18,511,710	V244G	probably damaging	Het
Olfr781	T	C	10: 129,332,935	I18T	probably benign	Het
Ptprd	A	T	4: 75,954,201		probably benign	Het
Rcan2	A	T	17: 44,017,884	I69L	probably damaging	Het
Rprd2	A	G	3: 95,776,550	L373P	probably damaging	Het
Slc10a4	T	C	5: 73,007,586	C174R	probably damaging	Het
Tas2r134	C	T	2: 51,627,989	T160I	probably damaging	Het
Tbc1d19	T	A	5: 53,897,062	L464*	probably null	Het
Tmem45a2	C	T	16: 57,040,790	D225N	possibly damaging	Het
Unc79	G	A	12: 103,165,631	C2139Y	probably damaging	Het
Vmn2r101	G	T	17: 19,589,674	G241C	probably damaging	Het
Wdr11	T	C	7: 129,628,022	Y844H	probably benign	Het
Wdr70	T	C	15: 7,873,174	K656E	possibly damaging	Het
Zfp579	C	A	7: 4,993,247	C555F	possibly damaging	Het

Other mutations in Vmn2r91

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00983:Vmn2r91	APN	17	18105558	missense	probably benign	0.00
IGL01464:Vmn2r91	APN	17	18107602	missense	probably null	0.00
IGL02003:Vmn2r91	APN	17	18107659	missense	probably benign
IGL02709:Vmn2r91	APN	17	18105449	missense	possibly damaging	0.74
IGL02795:Vmn2r91	APN	17	18085277	missense	probably benign	0.01
IGL02813:Vmn2r91	APN	17	18136086	missense	possibly damaging	0.91
IGL02830:Vmn2r91	APN	17	18136622	missense	probably benign	0.01
IGL03130:Vmn2r91	APN	17	18110111	splice site	probably benign
BB006:Vmn2r91	UTSW	17	18107644	missense	probably damaging	1.00
BB016:Vmn2r91	UTSW	17	18107644	missense	probably damaging	1.00
R0164:Vmn2r91	UTSW	17	18106137	missense	probably benign	0.00
R0164:Vmn2r91	UTSW	17	18106137	missense	probably benign	0.00
R0393:Vmn2r91	UTSW	17	18105450	missense	probably damaging	1.00
R1142:Vmn2r91	UTSW	17	18136443	missense	probably damaging	1.00
R1603:Vmn2r91	UTSW	17	18106143	missense	probably benign	0.04
R1992:Vmn2r91	UTSW	17	18135880	missense	probably damaging	1.00
R2182:Vmn2r91	UTSW	17	18105429	missense	possibly damaging	0.94
R2424:Vmn2r91	UTSW	17	18136169	nonsense	probably null
R2512:Vmn2r91	UTSW	17	18135786	missense	probably benign
R2885:Vmn2r91	UTSW	17	18105366	missense	probably benign	0.00
R2909:Vmn2r91	UTSW	17	18136399	missense	probably damaging	1.00
R3009:Vmn2r91	UTSW	17	18105455	missense	probably benign	0.11
R3079:Vmn2r91	UTSW	17	18135711	splice site	probably null
R3080:Vmn2r91	UTSW	17	18135711	splice site	probably null
R3434:Vmn2r91	UTSW	17	18110108	splice site	probably benign
R3723:Vmn2r91	UTSW	17	18085278	critical splice donor site	probably null
R3829:Vmn2r91	UTSW	17	18105497	missense	probably damaging	1.00
R3845:Vmn2r91	UTSW	17	18107598	missense	probably benign	0.00
R3846:Vmn2r91	UTSW	17	18107598	missense	probably benign	0.00
R4118:Vmn2r91	UTSW	17	18110096	missense	probably damaging	1.00
R4285:Vmn2r91	UTSW	17	18135768	missense	probably benign	0.00
R4729:Vmn2r91	UTSW	17	18107644	missense	probably damaging	1.00
R4793:Vmn2r91	UTSW	17	18105396	missense	probably damaging	1.00
R4932:Vmn2r91	UTSW	17	18136489	missense	possibly damaging	0.84
R5016:Vmn2r91	UTSW	17	18110060	nonsense	probably null
R5018:Vmn2r91	UTSW	17	18136438	missense	probably damaging	1.00
R5605:Vmn2r91	UTSW	17	18136501	missense	probably damaging	1.00
R5815:Vmn2r91	UTSW	17	18106202	missense	probably benign	0.01
R6146:Vmn2r91	UTSW	17	18136256	missense	probably benign	0.07
R6187:Vmn2r91	UTSW	17	18106626	missense	probably benign	0.05
R6426:Vmn2r91	UTSW	17	18135603	splice site	probably null
R6450:Vmn2r91	UTSW	17	18085265	missense	probably damaging	0.98
R6767:Vmn2r91	UTSW	17	18107545	missense	probably damaging	0.98
R6986:Vmn2r91	UTSW	17	18136009	missense	probably benign	0.10
R7112:Vmn2r91	UTSW	17	18105618	missense	possibly damaging	0.83
R7178:Vmn2r91	UTSW	17	18136162	missense	probably damaging	1.00
R7330:Vmn2r91	UTSW	17	18106167	missense	probably damaging	1.00
R7368:Vmn2r91	UTSW	17	18136278	missense	possibly damaging	0.75
R7380:Vmn2r91	UTSW	17	18136576	nonsense	probably null
R7397:Vmn2r91	UTSW	17	18135798	missense	probably benign	0.02
R7625:Vmn2r91	UTSW	17	18105431	missense	probably damaging	1.00
R7739:Vmn2r91	UTSW	17	18135818	missense	probably benign	0.00
R7749:Vmn2r91	UTSW	17	18136278	missense	possibly damaging	0.75
R7755:Vmn2r91	UTSW	17	18110049	missense	possibly damaging	0.88
R7929:Vmn2r91	UTSW	17	18107644	missense	probably damaging	1.00
R7981:Vmn2r91	UTSW	17	18107625	missense	probably benign	0.02
R8211:Vmn2r91	UTSW	17	18106500	missense	probably damaging	1.00
R8325:Vmn2r91	UTSW	17	18136363	missense	probably damaging	1.00
R8781:Vmn2r91	UTSW	17	18085061	missense	possibly damaging	0.78
R8974:Vmn2r91	UTSW	17	18105374	missense	probably benign	0.27
R9047:Vmn2r91	UTSW	17	18106034	missense	probably benign	0.00
R9048:Vmn2r91	UTSW	17	18135860	missense	probably benign	0.00
R9109:Vmn2r91	UTSW	17	18107643	missense	probably damaging	1.00
R9211:Vmn2r91	UTSW	17	18136557	nonsense	probably null

Posted On

2013-06-21