Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01121:Vmn2r101'

53088

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r101

Ensembl Gene

ENSMUSG00000094892

Gene Name

vomeronasal 2, receptor 101

Synonyms

EG627576

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.102) question?

Stock #

IGL01121

Quality Score

Status

Chromosome

Chromosomal Location

19797493-19832579 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 19809936 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Cysteine at position 241 (G241C)

Ref Sequence

ENSEMBL: ENSMUSP00000131583 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171914]

AlphaFold

E9PZS9

Predicted Effect

probably damaging
Transcript: ENSMUST00000171914
AA Change: G241C

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000131583
Gene: ENSMUSG00000094892
AA Change: G241C

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	466	1.6e-36	PFAM
Pfam:NCD3G	509	562	6.4e-22	PFAM
Pfam:7tm_3	595	830	1.4e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700046A07Rik	G	A	18: 62,888,219 (GRCm39)		noncoding transcript	Het
4930432E11Rik	A	T	7: 29,273,426 (GRCm39)		noncoding transcript	Het
Alg3	T	C	16: 20,429,397 (GRCm39)	E31G	probably damaging	Het
Arhgap29	A	G	3: 121,803,512 (GRCm39)	E764G	probably damaging	Het
Atp5mf	C	A	5: 145,121,378 (GRCm39)	V68L	probably benign	Het
Birc6	T	A	17: 74,938,033 (GRCm39)	I2645K	probably benign	Het
Capn11	A	G	17: 45,950,058 (GRCm39)	S369P	probably benign	Het
Car4	A	T	11: 84,855,172 (GRCm39)		probably null	Het
Ccdc185	C	T	1: 182,576,222 (GRCm39)	V156I	probably benign	Het
Cpsf2	G	T	12: 101,954,965 (GRCm39)	E245D	probably damaging	Het
Dnah11	T	C	12: 118,014,430 (GRCm39)	D2019G	probably benign	Het
Dscc1	A	G	15: 54,945,721 (GRCm39)		probably benign	Het
Dzip3	T	C	16: 48,765,244 (GRCm39)	D490G	probably benign	Het
E2f8	G	A	7: 48,517,569 (GRCm39)	Q745*	probably null	Het
Fat3	T	A	9: 15,909,697 (GRCm39)	T2102S	probably benign	Het
Fgf7	C	T	2: 125,930,152 (GRCm39)		probably benign	Het
Fstl4	T	C	11: 52,705,464 (GRCm39)	F47L	probably benign	Het
Gm15097	A	T	X: 148,587,324 (GRCm39)	R129S	possibly damaging	Het
Gm4297	C	T	X: 24,418,854 (GRCm39)	D200N	probably benign	Het
Itgb5	G	T	16: 33,740,359 (GRCm39)	D490Y	probably benign	Het
Kansl1	A	G	11: 104,226,422 (GRCm39)	S912P	probably benign	Het
Kcnq3	A	T	15: 65,877,826 (GRCm39)		probably benign	Het
Kctd6	A	G	14: 8,222,656 (GRCm38)	H166R	possibly damaging	Het
Kel	T	C	6: 41,679,343 (GRCm39)	D140G	probably benign	Het
Lrif1	C	A	3: 106,642,980 (GRCm39)	S177*	probably null	Het
Lrp1	A	T	10: 127,419,722 (GRCm39)	C962*	probably null	Het
Lypd5	A	T	7: 24,050,976 (GRCm39)	Y29F	probably benign	Het
Mmrn1	A	G	6: 60,952,928 (GRCm39)	D403G	possibly damaging	Het
Nhsl1	T	G	10: 18,387,458 (GRCm39)	V244G	probably damaging	Het
Or6c35	T	C	10: 129,168,804 (GRCm39)	I18T	probably benign	Het
Ptprd	A	T	4: 75,872,438 (GRCm39)		probably benign	Het
Rcan2	A	T	17: 44,328,775 (GRCm39)	I69L	probably damaging	Het
Rprd2	A	G	3: 95,683,862 (GRCm39)	L373P	probably damaging	Het
Slc10a4	T	C	5: 73,164,929 (GRCm39)	C174R	probably damaging	Het
Tas2r134	C	T	2: 51,518,001 (GRCm39)	T160I	probably damaging	Het
Tbc1d19	T	A	5: 54,054,404 (GRCm39)	L464*	probably null	Het
Tmem45a2	C	T	16: 56,861,153 (GRCm39)	D225N	possibly damaging	Het
Unc79	G	A	12: 103,131,890 (GRCm39)	C2139Y	probably damaging	Het
Vmn2r91	T	C	17: 18,356,766 (GRCm39)	V811A	possibly damaging	Het
Wdr11	T	C	7: 129,229,746 (GRCm39)	Y844H	probably benign	Het
Wdr70	T	C	15: 7,902,655 (GRCm39)	K656E	possibly damaging	Het
Zfp579	C	A	7: 4,996,246 (GRCm39)	C555F	possibly damaging	Het

Other mutations in Vmn2r101

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02125:Vmn2r101	APN	17	19,809,963 (GRCm39)	missense	possibly damaging	0.95
IGL02300:Vmn2r101	APN	17	19,832,199 (GRCm39)	missense	probably damaging	1.00
IGL02682:Vmn2r101	APN	17	19,832,507 (GRCm39)	missense	possibly damaging	0.82
IGL02825:Vmn2r101	APN	17	19,810,132 (GRCm39)	missense	probably benign	0.00
IGL02862:Vmn2r101	APN	17	19,831,867 (GRCm39)	missense	probably damaging	1.00
IGL02943:Vmn2r101	APN	17	19,831,666 (GRCm39)	missense	probably damaging	0.99
R0371:Vmn2r101	UTSW	17	19,810,394 (GRCm39)	missense	probably benign	0.07
R0462:Vmn2r101	UTSW	17	19,810,431 (GRCm39)	missense	probably benign	0.04
R0492:Vmn2r101	UTSW	17	19,809,245 (GRCm39)	missense	probably damaging	1.00
R0654:Vmn2r101	UTSW	17	19,810,373 (GRCm39)	missense	probably benign	0.01
R1120:Vmn2r101	UTSW	17	19,797,723 (GRCm39)	splice site	probably benign
R1323:Vmn2r101	UTSW	17	19,832,313 (GRCm39)	missense	probably damaging	1.00
R1323:Vmn2r101	UTSW	17	19,832,313 (GRCm39)	missense	probably damaging	1.00
R1676:Vmn2r101	UTSW	17	19,832,184 (GRCm39)	missense	probably benign	0.00
R2023:Vmn2r101	UTSW	17	19,810,368 (GRCm39)	nonsense	probably null
R2149:Vmn2r101	UTSW	17	19,809,225 (GRCm39)	missense	probably benign	0.00
R2350:Vmn2r101	UTSW	17	19,810,045 (GRCm39)	missense	probably benign	0.01
R2760:Vmn2r101	UTSW	17	19,809,901 (GRCm39)	missense	probably benign	0.14
R3085:Vmn2r101	UTSW	17	19,809,077 (GRCm39)	splice site	probably null
R3086:Vmn2r101	UTSW	17	19,809,077 (GRCm39)	splice site	probably null
R3719:Vmn2r101	UTSW	17	19,809,811 (GRCm39)	missense	possibly damaging	0.50
R3771:Vmn2r101	UTSW	17	19,809,919 (GRCm39)	missense	probably benign
R3773:Vmn2r101	UTSW	17	19,809,919 (GRCm39)	missense	probably benign
R4225:Vmn2r101	UTSW	17	19,831,951 (GRCm39)	missense	probably damaging	1.00
R4248:Vmn2r101	UTSW	17	19,809,376 (GRCm39)	missense	probably damaging	1.00
R4290:Vmn2r101	UTSW	17	19,832,303 (GRCm39)	missense	probably damaging	1.00
R4291:Vmn2r101	UTSW	17	19,832,303 (GRCm39)	missense	probably damaging	1.00
R4293:Vmn2r101	UTSW	17	19,832,303 (GRCm39)	missense	probably damaging	1.00
R4307:Vmn2r101	UTSW	17	19,810,423 (GRCm39)	missense	probably damaging	1.00
R4721:Vmn2r101	UTSW	17	19,832,287 (GRCm39)	missense	probably damaging	0.99
R4829:Vmn2r101	UTSW	17	19,832,229 (GRCm39)	missense	probably benign	0.03
R5022:Vmn2r101	UTSW	17	19,831,649 (GRCm39)	critical splice acceptor site	probably null
R5110:Vmn2r101	UTSW	17	19,831,897 (GRCm39)	missense	possibly damaging	0.92
R5244:Vmn2r101	UTSW	17	19,831,788 (GRCm39)	missense	probably damaging	1.00
R5397:Vmn2r101	UTSW	17	19,809,104 (GRCm39)	missense	probably damaging	1.00
R5875:Vmn2r101	UTSW	17	19,809,092 (GRCm39)	missense	probably damaging	0.99
R5944:Vmn2r101	UTSW	17	19,809,769 (GRCm39)	missense	probably benign	0.00
R6216:Vmn2r101	UTSW	17	19,811,267 (GRCm39)	missense	probably benign	0.00
R6334:Vmn2r101	UTSW	17	19,810,112 (GRCm39)	missense	possibly damaging	0.83
R6512:Vmn2r101	UTSW	17	19,809,146 (GRCm39)	missense	probably damaging	1.00
R6607:Vmn2r101	UTSW	17	19,832,296 (GRCm39)	missense	probably damaging	1.00
R6965:Vmn2r101	UTSW	17	19,811,284 (GRCm39)	missense	probably benign	0.00
R7101:Vmn2r101	UTSW	17	19,809,350 (GRCm39)	missense	probably null	0.14
R7183:Vmn2r101	UTSW	17	19,832,440 (GRCm39)	missense	probably damaging	1.00
R7344:Vmn2r101	UTSW	17	19,832,059 (GRCm39)	missense	probably benign	0.38
R7375:Vmn2r101	UTSW	17	19,831,652 (GRCm39)	missense	probably damaging	1.00
R7574:Vmn2r101	UTSW	17	19,831,899 (GRCm39)	missense	possibly damaging	0.91
R7575:Vmn2r101	UTSW	17	19,831,654 (GRCm39)	missense	probably benign	0.01
R7592:Vmn2r101	UTSW	17	19,811,443 (GRCm39)	splice site	probably null
R7626:Vmn2r101	UTSW	17	19,832,192 (GRCm39)	nonsense	probably null
R7715:Vmn2r101	UTSW	17	19,832,177 (GRCm39)	missense	probably damaging	1.00
R7730:Vmn2r101	UTSW	17	19,831,950 (GRCm39)	missense	possibly damaging	0.81
R8078:Vmn2r101	UTSW	17	19,810,507 (GRCm39)	missense	probably benign	0.07
R8228:Vmn2r101	UTSW	17	19,811,284 (GRCm39)	missense	probably benign	0.00
R8283:Vmn2r101	UTSW	17	19,832,253 (GRCm39)	missense	probably damaging	1.00
R8712:Vmn2r101	UTSW	17	19,811,397 (GRCm39)	missense	probably benign	0.24
R8765:Vmn2r101	UTSW	17	19,809,245 (GRCm39)	missense	probably damaging	1.00
R9091:Vmn2r101	UTSW	17	19,810,244 (GRCm39)	missense	probably benign
R9092:Vmn2r101	UTSW	17	19,809,807 (GRCm39)	missense	probably benign	0.07
R9113:Vmn2r101	UTSW	17	19,811,288 (GRCm39)	missense	possibly damaging	0.56
R9158:Vmn2r101	UTSW	17	19,809,161 (GRCm39)	missense	probably benign	0.00
R9168:Vmn2r101	UTSW	17	19,809,138 (GRCm39)	missense	probably damaging	1.00
R9235:Vmn2r101	UTSW	17	19,810,238 (GRCm39)	missense	probably damaging	0.99
R9270:Vmn2r101	UTSW	17	19,810,244 (GRCm39)	missense	probably benign
R9290:Vmn2r101	UTSW	17	19,811,395 (GRCm39)	missense	probably benign	0.05
R9296:Vmn2r101	UTSW	17	19,810,047 (GRCm39)	missense	probably damaging	0.98
R9602:Vmn2r101	UTSW	17	19,831,780 (GRCm39)	nonsense	probably null
R9706:Vmn2r101	UTSW	17	19,809,925 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r101	UTSW	17	19,809,237 (GRCm39)	missense	possibly damaging	0.78

Posted On

2013-06-21