Incidental Mutation 'IGL01132:Tcte1'
ID53104
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tcte1
Ensembl Gene ENSMUSG00000023949
Gene Namet-complex-associated testis expressed 1
SynonymsTcte-1, D17Sil1
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01132
Quality Score
Status
Chromosome17
Chromosomal Location45523434-45542679 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 45539862 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Serine at position 355 (A355S)
Ref Sequence ENSEMBL: ENSMUSP00000109175 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000113547] [ENSMUST00000180252]
Predicted Effect possibly damaging
Transcript: ENSMUST00000113547
AA Change: A355S

PolyPhen 2 Score 0.929 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000109175
Gene: ENSMUSG00000023949
AA Change: A355S

DomainStartEndE-ValueType
low complexity region 6 17 N/A INTRINSIC
low complexity region 28 47 N/A INTRINSIC
low complexity region 206 222 N/A INTRINSIC
Blast:LRR 235 274 7e-14 BLAST
LRR 304 331 5.02e-6 SMART
LRR 332 358 1.28e-3 SMART
LRR 359 386 5.81e-2 SMART
LRR 387 414 2.05e-2 SMART
LRR 415 442 1.13e-4 SMART
Blast:LRR 443 470 3e-8 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000180252
SMART Domains Protein: ENSMUSP00000136337
Gene: ENSMUSG00000096847

DomainStartEndE-ValueType
low complexity region 2 27 N/A INTRINSIC
Pfam:TMEM151 40 486 2e-213 PFAM
low complexity region 511 518 N/A INTRINSIC
low complexity region 542 556 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,950,275 V124I probably damaging Het
Adcy6 T C 15: 98,597,851 N619S probably benign Het
Adgrf5 G T 17: 43,422,509 D75Y possibly damaging Het
Aldh1a7 T C 19: 20,727,040 H30R possibly damaging Het
Birc6 T C 17: 74,603,060 S1483P probably damaging Het
Cd209e T C 8: 3,851,274 T127A probably benign Het
Clmn T A 12: 104,774,551 probably null Het
Dcc A T 18: 71,682,174 Y376* probably null Het
Dscaml1 C T 9: 45,752,328 R1950* probably null Het
Eml2 A T 7: 19,200,539 S388C probably damaging Het
Ext2 C T 2: 93,791,073 M370I probably benign Het
Foxo1 C T 3: 52,345,159 R248W probably damaging Het
Gan T A 8: 117,196,444 probably benign Het
Klra1 A T 6: 130,364,274 C245* probably null Het
Myh10 A T 11: 68,768,268 M491L possibly damaging Het
Myrf A G 19: 10,223,205 Y343H probably damaging Het
Olfr1084 A T 2: 86,639,166 C181S probably benign Het
Olfr790 T C 10: 129,501,646 V254A probably damaging Het
Olfr859 G A 9: 19,808,654 S112N probably damaging Het
Oplah C T 15: 76,300,957 S852N probably benign Het
Prag1 T C 8: 36,146,357 V1021A probably damaging Het
Rassf4 C T 6: 116,659,607 probably benign Het
Sf3b3 T C 8: 110,842,781 I102V probably benign Het
Slc27a4 T C 2: 29,804,302 I46T probably benign Het
Slc5a12 T C 2: 110,597,822 V74A probably damaging Het
St5 A G 7: 109,570,005 probably null Het
Tas2r134 G T 2: 51,627,659 C50F probably damaging Het
Other mutations in Tcte1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Tcte1 APN 17 45534928 missense probably damaging 1.00
IGL00945:Tcte1 APN 17 45541189 missense probably benign 0.15
IGL01120:Tcte1 APN 17 45539668 missense probably damaging 0.99
IGL01884:Tcte1 APN 17 45539809 unclassified probably null
IGL02418:Tcte1 APN 17 45541202 missense probably benign 0.37
IGL02731:Tcte1 APN 17 45539886 missense probably benign 0.00
IGL03130:Tcte1 APN 17 45533296 missense probably damaging 1.00
R0358:Tcte1 UTSW 17 45535285 missense probably benign 0.34
R1519:Tcte1 UTSW 17 45535252 missense probably damaging 1.00
R2013:Tcte1 UTSW 17 45541311 missense probably benign 0.30
R2014:Tcte1 UTSW 17 45541311 missense probably benign 0.30
R3744:Tcte1 UTSW 17 45539671 missense probably damaging 0.99
R4250:Tcte1 UTSW 17 45539691 missense probably benign 0.04
R4976:Tcte1 UTSW 17 45534928 missense probably damaging 1.00
R5398:Tcte1 UTSW 17 45539826 nonsense probably null
R6169:Tcte1 UTSW 17 45535070 missense probably benign 0.01
R6251:Tcte1 UTSW 17 45535159 missense probably benign
R6279:Tcte1 UTSW 17 45533289 missense possibly damaging 0.69
R6300:Tcte1 UTSW 17 45533289 missense possibly damaging 0.69
R6316:Tcte1 UTSW 17 45534860 missense probably benign
R6417:Tcte1 UTSW 17 45535130 missense probably damaging 0.97
R6892:Tcte1 UTSW 17 45533157 missense probably benign
R7047:Tcte1 UTSW 17 45533368 missense possibly damaging 0.52
R7645:Tcte1 UTSW 17 45534989 missense probably benign 0.00
Z1176:Tcte1 UTSW 17 45535071 missense probably benign
Z1177:Tcte1 UTSW 17 45535012 missense possibly damaging 0.93
Posted On2013-06-21