Incidental Mutation 'R6757:Or10g3'
ID 531096
Institutional Source Beutler Lab
Gene Symbol Or10g3
Ensembl Gene ENSMUSG00000094140
Gene Name olfactory receptor family 10 subfamily G member 3
Synonyms GA_x6K02T2RJGY-622120-623061, MOR223-5, Olfr1512
MMRRC Submission 044873-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.113) question?
Stock # R6757 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 52609567-52610508 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 52610172 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 113 (C113R)
Ref Sequence ENSEMBL: ENSMUSP00000149717 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071221] [ENSMUST00000214980]
AlphaFold Q8VF72
Predicted Effect probably damaging
Transcript: ENSMUST00000071221
AA Change: C113R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000071208
Gene: ENSMUSG00000094140
AA Change: C113R

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2.1e-48 PFAM
Pfam:7tm_1 41 290 2.9e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192537
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200261
Predicted Effect probably damaging
Transcript: ENSMUST00000214980
AA Change: C113R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik A T 1: 11,666,558 (GRCm39) *288Y probably null Het
Art2a G T 7: 101,204,221 (GRCm39) L106I probably benign Het
Bmi1 C T 2: 18,688,840 (GRCm39) T203M probably damaging Het
Cpm A G 10: 117,507,543 (GRCm39) D220G probably damaging Het
Cyp2a22 A C 7: 26,638,629 (GRCm39) D52E probably benign Het
Dag1 A C 9: 108,095,216 (GRCm39) I92S probably damaging Het
Dntt A T 19: 41,025,601 (GRCm39) H73L probably damaging Het
Epha5 A C 5: 84,253,737 (GRCm39) I716S probably damaging Het
Fpr-rs4 C T 17: 18,242,394 (GRCm39) Q134* probably null Het
Fzd8 T A 18: 9,213,238 (GRCm39) C107S possibly damaging Het
Garre1 G A 7: 33,938,502 (GRCm39) A799V possibly damaging Het
Gnptab T C 10: 88,273,364 (GRCm39) L1047P probably damaging Het
Gstt1 A T 10: 75,634,217 (GRCm39) probably null Het
Kdm2a T C 19: 4,369,271 (GRCm39) R1115G probably damaging Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Myo1b C T 1: 51,852,207 (GRCm39) E179K probably damaging Het
Nrp1 T A 8: 129,152,349 (GRCm39) I186N probably damaging Het
Pole T C 5: 110,451,476 (GRCm39) V835A probably damaging Het
Shprh A G 10: 11,057,252 (GRCm39) probably null Het
Slc39a14 A T 14: 70,548,333 (GRCm39) L238Q probably damaging Het
Spata31e5 A C 1: 28,819,191 (GRCm39) I30S probably damaging Het
Usp40 A T 1: 87,907,759 (GRCm39) I619N probably damaging Het
Other mutations in Or10g3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01328:Or10g3 APN 14 52,609,967 (GRCm39) missense probably damaging 1.00
IGL01375:Or10g3 APN 14 52,609,865 (GRCm39) missense probably damaging 0.99
IGL02343:Or10g3 APN 14 52,609,934 (GRCm39) missense probably damaging 1.00
R1443:Or10g3 UTSW 14 52,610,408 (GRCm39) missense probably damaging 1.00
R1902:Or10g3 UTSW 14 52,610,174 (GRCm39) missense possibly damaging 0.81
R1903:Or10g3 UTSW 14 52,610,174 (GRCm39) missense possibly damaging 0.81
R3115:Or10g3 UTSW 14 52,610,397 (GRCm39) missense probably damaging 1.00
R4752:Or10g3 UTSW 14 52,609,764 (GRCm39) missense probably damaging 1.00
R5345:Or10g3 UTSW 14 52,609,725 (GRCm39) nonsense probably null
R5689:Or10g3 UTSW 14 52,610,214 (GRCm39) missense possibly damaging 0.83
R6185:Or10g3 UTSW 14 52,610,019 (GRCm39) missense possibly damaging 0.91
R6287:Or10g3 UTSW 14 52,609,748 (GRCm39) missense probably damaging 1.00
R8751:Or10g3 UTSW 14 52,610,420 (GRCm39) missense probably benign 0.03
R8855:Or10g3 UTSW 14 52,610,196 (GRCm39) missense probably damaging 1.00
R8866:Or10g3 UTSW 14 52,610,196 (GRCm39) missense probably damaging 1.00
R9038:Or10g3 UTSW 14 52,609,716 (GRCm39) missense probably damaging 0.99
R9450:Or10g3 UTSW 14 52,610,110 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACCTGATTGGGACCACAGTAGG -3'
(R):5'- AACGCGCTCATCCTGATCAC -3'

Sequencing Primer
(F):5'- CCACAGTAGGGCAAGCG -3'
(R):5'- ATCCTGATCACCGTCTGCG -3'
Posted On 2018-08-01