Incidental Mutation 'R6759:Fgl2'
ID 531133
Institutional Source Beutler Lab
Gene Symbol Fgl2
Ensembl Gene ENSMUSG00000039899
Gene Name fibrinogen-like protein 2
Synonyms
MMRRC Submission 044875-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.295) question?
Stock # R6759 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 21577671-21583384 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21578256 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 181 (D181G)
Ref Sequence ENSEMBL: ENSMUSP00000046131 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030552] [ENSMUST00000035799] [ENSMUST00000115245]
AlphaFold P12804
Predicted Effect probably benign
Transcript: ENSMUST00000030552
SMART Domains Protein: ENSMUSP00000030552
Gene: ENSMUSG00000064280

DomainStartEndE-ValueType
coiled coil region 1 33 N/A INTRINSIC
low complexity region 120 130 N/A INTRINSIC
coiled coil region 194 320 N/A INTRINSIC
low complexity region 333 342 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000035799
AA Change: D181G

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000046131
Gene: ENSMUSG00000039899
AA Change: D181G

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
low complexity region 54 70 N/A INTRINSIC
coiled coil region 71 158 N/A INTRINSIC
FBG 201 428 1.6e-131 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115245
SMART Domains Protein: ENSMUSP00000110900
Gene: ENSMUSG00000064280

DomainStartEndE-ValueType
coiled coil region 1 33 N/A INTRINSIC
low complexity region 120 130 N/A INTRINSIC
coiled coil region 194 320 N/A INTRINSIC
low complexity region 333 342 N/A INTRINSIC
coiled coil region 438 477 N/A INTRINSIC
coiled coil region 549 595 N/A INTRINSIC
coiled coil region 617 663 N/A INTRINSIC
coiled coil region 690 720 N/A INTRINSIC
coiled coil region 770 793 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.9%
Validation Efficiency 98% (49/50)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice for one allele have unaltered type 1 immunity responses. Homozygous null mice for another allele show partial embryonic lethality, hemorrhage at implantation sites, decreased susceptibility to hepatitis virus infection and prolongedsurvival of heart grafts. [provided by MGI curators]
Allele List at MGI

All alleles(2) : Targeted, knock-out(1) Targeted, other(1)

Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900026A02Rik T C 5: 113,331,692 (GRCm39) S841G probably benign Het
4933427I04Rik G T 4: 123,753,879 (GRCm39) probably benign Het
Aak1 A G 6: 86,921,399 (GRCm39) T199A probably damaging Het
Acnat2 C A 4: 49,380,254 (GRCm39) V375L probably benign Het
Aldh1a7 T C 19: 20,677,320 (GRCm39) T434A possibly damaging Het
Aldh3a2 T C 11: 61,156,088 (GRCm39) T63A probably benign Het
Anxa2 T C 9: 69,391,103 (GRCm39) S97P probably damaging Het
Apip T C 2: 102,922,191 (GRCm39) S186P probably benign Het
Apob A G 12: 8,061,049 (GRCm39) K3177R probably benign Het
Atm C T 9: 53,429,859 (GRCm39) W392* probably null Het
Atp8b1 T A 18: 64,679,161 (GRCm39) R773S probably benign Het
Bicdl2 T A 17: 23,885,718 (GRCm39) probably null Het
Bltp1 C T 3: 37,042,234 (GRCm39) T2740I possibly damaging Het
Cacng3 G A 7: 122,361,547 (GRCm39) probably null Het
Clca3a1 G T 3: 144,455,450 (GRCm39) L448M probably damaging Het
Clk4 A G 11: 51,166,401 (GRCm39) I94M possibly damaging Het
Cnot3 G T 7: 3,654,918 (GRCm39) V124F probably damaging Het
Cyp4a30b C T 4: 115,318,571 (GRCm39) A426V probably benign Het
Dact1 T A 12: 71,364,911 (GRCm39) L564* probably null Het
Dnah8 T A 17: 30,882,266 (GRCm39) probably null Het
Dock5 T A 14: 68,033,445 (GRCm39) T975S probably benign Het
Dock8 C A 19: 25,104,848 (GRCm39) H739Q probably damaging Het
Efr3b T A 12: 4,034,613 (GRCm39) N186Y probably damaging Het
Enam G A 5: 88,649,550 (GRCm39) G278D probably damaging Het
Gfra3 G T 18: 34,828,926 (GRCm39) S156* probably null Het
Jam3 G C 9: 27,013,276 (GRCm39) T98S probably benign Het
Ltbp2 A T 12: 84,834,184 (GRCm39) I1435N probably damaging Het
Man2a1 G A 17: 64,932,383 (GRCm39) A157T probably benign Het
Mcm3ap T A 10: 76,337,148 (GRCm39) V1361E probably benign Het
Nobox A T 6: 43,284,538 (GRCm39) L36Q possibly damaging Het
Or2ag12 T A 7: 106,277,100 (GRCm39) M198L probably benign Het
Or51a10 A G 7: 103,699,334 (GRCm39) S76P probably damaging Het
Parp4 G A 14: 56,857,947 (GRCm39) V860I probably benign Het
Pim3 T A 15: 88,747,296 (GRCm39) probably null Het
Ptpn13 A T 5: 103,713,121 (GRCm39) N1748I possibly damaging Het
Rad51ap2 A G 12: 11,507,145 (GRCm39) T356A possibly damaging Het
Ranbp2 C T 10: 58,293,559 (GRCm39) R310* probably null Het
Rassf5 C T 1: 131,109,988 (GRCm39) V190I probably benign Het
Rgl1 T G 1: 152,409,281 (GRCm39) Q481P probably damaging Het
Rrp1b A G 17: 32,276,063 (GRCm39) T537A probably benign Het
Smok3c T A 5: 138,063,699 (GRCm39) S395R probably benign Het
St3gal1 A G 15: 66,983,195 (GRCm39) V187A possibly damaging Het
Strn4 A T 7: 16,556,978 (GRCm39) E145V probably damaging Het
Tex21 T A 12: 76,251,086 (GRCm39) probably null Het
Usp37 G A 1: 74,534,908 (GRCm39) R13* probably null Het
Uty G T Y: 1,174,735 (GRCm39) L222I probably damaging Homo
Wwp2 A G 8: 108,267,314 (GRCm39) T309A probably damaging Het
Zfp40 C T 17: 23,395,510 (GRCm39) R359H possibly damaging Het
Other mutations in Fgl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01622:Fgl2 APN 5 21,578,175 (GRCm39) missense possibly damaging 0.57
IGL01623:Fgl2 APN 5 21,578,175 (GRCm39) missense possibly damaging 0.57
IGL02056:Fgl2 APN 5 21,580,543 (GRCm39) missense probably damaging 0.99
IGL03128:Fgl2 APN 5 21,578,291 (GRCm39) missense probably benign
A4554:Fgl2 UTSW 5 21,577,776 (GRCm39) missense probably benign 0.01
R0049:Fgl2 UTSW 5 21,580,661 (GRCm39) missense possibly damaging 0.95
R0049:Fgl2 UTSW 5 21,580,661 (GRCm39) missense possibly damaging 0.95
R0052:Fgl2 UTSW 5 21,580,347 (GRCm39) missense probably damaging 1.00
R0052:Fgl2 UTSW 5 21,580,347 (GRCm39) missense probably damaging 1.00
R0149:Fgl2 UTSW 5 21,580,783 (GRCm39) missense probably damaging 1.00
R0316:Fgl2 UTSW 5 21,580,521 (GRCm39) missense possibly damaging 0.82
R1336:Fgl2 UTSW 5 21,578,181 (GRCm39) missense possibly damaging 0.52
R1703:Fgl2 UTSW 5 21,577,730 (GRCm39) missense possibly damaging 0.89
R1893:Fgl2 UTSW 5 21,580,669 (GRCm39) missense probably benign 0.01
R2371:Fgl2 UTSW 5 21,580,816 (GRCm39) missense probably damaging 1.00
R4803:Fgl2 UTSW 5 21,580,918 (GRCm39) missense probably benign 0.00
R5250:Fgl2 UTSW 5 21,580,521 (GRCm39) missense possibly damaging 0.82
R5422:Fgl2 UTSW 5 21,580,808 (GRCm39) missense probably damaging 1.00
R7808:Fgl2 UTSW 5 21,578,229 (GRCm39) missense possibly damaging 0.53
R7812:Fgl2 UTSW 5 21,577,896 (GRCm39) missense probably benign 0.01
R7838:Fgl2 UTSW 5 21,577,752 (GRCm39) missense probably benign 0.01
R8177:Fgl2 UTSW 5 21,578,307 (GRCm39) critical splice donor site probably null
R8725:Fgl2 UTSW 5 21,580,677 (GRCm39) nonsense probably null
R8727:Fgl2 UTSW 5 21,580,677 (GRCm39) nonsense probably null
R9114:Fgl2 UTSW 5 21,580,363 (GRCm39) missense probably damaging 1.00
R9198:Fgl2 UTSW 5 21,577,920 (GRCm39) missense probably damaging 0.96
R9513:Fgl2 UTSW 5 21,580,790 (GRCm39) nonsense probably null
R9606:Fgl2 UTSW 5 21,577,991 (GRCm39) missense possibly damaging 0.87
X0017:Fgl2 UTSW 5 21,580,650 (GRCm39) missense probably damaging 0.98
X0026:Fgl2 UTSW 5 21,580,711 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TAAGTTGCAGGCTGACGACC -3'
(R):5'- TCCTGCCATAACTTAACAGGTG -3'

Sequencing Primer
(F):5'- AGGCTGACGACCATCGAGATC -3'
(R):5'- GAAAGTCTGACTAACTTATGCTCCC -3'
Posted On 2018-08-01