Mutagenetix > Incidental Mutation

Incidental Mutation 'R6759:Or51a10'

531142

Institutional Source

Beutler Lab

Gene Symbol

Or51a10

Ensembl Gene

ENSMUSG00000049797

Gene Name

olfactory receptor family 51 subfamily A member 10

Synonyms

MOR13-6, GA_x6K02T2PBJ9-6784380-6783436, Olfr642

MMRRC Submission

044875-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

R6759 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

103698615-103699559 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 103699334 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 76 (S76P)

Ref Sequence

ENSEMBL: ENSMUSP00000148961 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052660] [ENSMUST00000074064] [ENSMUST00000138055] [ENSMUST00000214299]

AlphaFold

Q924X8

Predicted Effect

probably damaging
Transcript: ENSMUST00000052660
AA Change: S76P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000061462
Gene: ENSMUSG00000049797
AA Change: S76P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	312	8.5e-119	PFAM
Pfam:7TM_GPCR_Srsx	37	309	1.7e-7	PFAM
Pfam:7tm_1	43	294	4.1e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000074064

SMART Domains

Protein: ENSMUSP00000073707
Gene: ENSMUSG00000090219

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	312	2.6e-124	PFAM
Pfam:7TM_GPCR_Srsx	37	255	3.1e-7	PFAM
Pfam:7tm_1	43	294	3.2e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000138055

SMART Domains

Protein: ENSMUSP00000139240
Gene: ENSMUSG00000109824

Domain	Start	End	E-Value	Type
transmembrane domain	29	51	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000214299
AA Change: S76P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.5%
20x: 95.9%

Validation Efficiency

98% (49/50)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2900026A02Rik	T	C	5: 113,331,692 (GRCm39)	S841G	probably benign	Het
4933427I04Rik	G	T	4: 123,753,879 (GRCm39)		probably benign	Het
Aak1	A	G	6: 86,921,399 (GRCm39)	T199A	probably damaging	Het
Acnat2	C	A	4: 49,380,254 (GRCm39)	V375L	probably benign	Het
Aldh1a7	T	C	19: 20,677,320 (GRCm39)	T434A	possibly damaging	Het
Aldh3a2	T	C	11: 61,156,088 (GRCm39)	T63A	probably benign	Het
Anxa2	T	C	9: 69,391,103 (GRCm39)	S97P	probably damaging	Het
Apip	T	C	2: 102,922,191 (GRCm39)	S186P	probably benign	Het
Apob	A	G	12: 8,061,049 (GRCm39)	K3177R	probably benign	Het
Atm	C	T	9: 53,429,859 (GRCm39)	W392*	probably null	Het
Atp8b1	T	A	18: 64,679,161 (GRCm39)	R773S	probably benign	Het
Bicdl2	T	A	17: 23,885,718 (GRCm39)		probably null	Het
Bltp1	C	T	3: 37,042,234 (GRCm39)	T2740I	possibly damaging	Het
Cacng3	G	A	7: 122,361,547 (GRCm39)		probably null	Het
Clca3a1	G	T	3: 144,455,450 (GRCm39)	L448M	probably damaging	Het
Clk4	A	G	11: 51,166,401 (GRCm39)	I94M	possibly damaging	Het
Cnot3	G	T	7: 3,654,918 (GRCm39)	V124F	probably damaging	Het
Cyp4a30b	C	T	4: 115,318,571 (GRCm39)	A426V	probably benign	Het
Dact1	T	A	12: 71,364,911 (GRCm39)	L564*	probably null	Het
Dnah8	T	A	17: 30,882,266 (GRCm39)		probably null	Het
Dock5	T	A	14: 68,033,445 (GRCm39)	T975S	probably benign	Het
Dock8	C	A	19: 25,104,848 (GRCm39)	H739Q	probably damaging	Het
Efr3b	T	A	12: 4,034,613 (GRCm39)	N186Y	probably damaging	Het
Enam	G	A	5: 88,649,550 (GRCm39)	G278D	probably damaging	Het
Fgl2	A	G	5: 21,578,256 (GRCm39)	D181G	probably benign	Het
Gfra3	G	T	18: 34,828,926 (GRCm39)	S156*	probably null	Het
Jam3	G	C	9: 27,013,276 (GRCm39)	T98S	probably benign	Het
Ltbp2	A	T	12: 84,834,184 (GRCm39)	I1435N	probably damaging	Het
Man2a1	G	A	17: 64,932,383 (GRCm39)	A157T	probably benign	Het
Mcm3ap	T	A	10: 76,337,148 (GRCm39)	V1361E	probably benign	Het
Nobox	A	T	6: 43,284,538 (GRCm39)	L36Q	possibly damaging	Het
Or2ag12	T	A	7: 106,277,100 (GRCm39)	M198L	probably benign	Het
Parp4	G	A	14: 56,857,947 (GRCm39)	V860I	probably benign	Het
Pim3	T	A	15: 88,747,296 (GRCm39)		probably null	Het
Ptpn13	A	T	5: 103,713,121 (GRCm39)	N1748I	possibly damaging	Het
Rad51ap2	A	G	12: 11,507,145 (GRCm39)	T356A	possibly damaging	Het
Ranbp2	C	T	10: 58,293,559 (GRCm39)	R310*	probably null	Het
Rassf5	C	T	1: 131,109,988 (GRCm39)	V190I	probably benign	Het
Rgl1	T	G	1: 152,409,281 (GRCm39)	Q481P	probably damaging	Het
Rrp1b	A	G	17: 32,276,063 (GRCm39)	T537A	probably benign	Het
Smok3c	T	A	5: 138,063,699 (GRCm39)	S395R	probably benign	Het
St3gal1	A	G	15: 66,983,195 (GRCm39)	V187A	possibly damaging	Het
Strn4	A	T	7: 16,556,978 (GRCm39)	E145V	probably damaging	Het
Tex21	T	A	12: 76,251,086 (GRCm39)		probably null	Het
Usp37	G	A	1: 74,534,908 (GRCm39)	R13*	probably null	Het
Uty	G	T	Y: 1,174,735 (GRCm39)	L222I	probably damaging	Homo
Wwp2	A	G	8: 108,267,314 (GRCm39)	T309A	probably damaging	Het
Zfp40	C	T	17: 23,395,510 (GRCm39)	R359H	possibly damaging	Het

Other mutations in Or51a10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01457:Or51a10	APN	7	103,699,376 (GRCm39)	missense	probably damaging	1.00
IGL01933:Or51a10	APN	7	103,699,021 (GRCm39)	missense	probably damaging	1.00
IGL01980:Or51a10	APN	7	103,699,300 (GRCm39)	missense	probably benign	0.21
IGL02161:Or51a10	APN	7	103,698,797 (GRCm39)	missense	possibly damaging	0.66
IGL02639:Or51a10	APN	7	103,698,988 (GRCm39)	missense	probably damaging	0.99
I2289:Or51a10	UTSW	7	103,698,961 (GRCm39)	missense	probably damaging	1.00
R0418:Or51a10	UTSW	7	103,698,979 (GRCm39)	missense	probably benign	0.00
R1647:Or51a10	UTSW	7	103,699,376 (GRCm39)	missense	probably damaging	1.00
R1648:Or51a10	UTSW	7	103,699,376 (GRCm39)	missense	probably damaging	1.00
R1701:Or51a10	UTSW	7	103,699,402 (GRCm39)	missense	possibly damaging	0.95
R2142:Or51a10	UTSW	7	103,699,507 (GRCm39)	missense	probably damaging	1.00
R2165:Or51a10	UTSW	7	103,698,845 (GRCm39)	missense	probably benign	0.22
R2655:Or51a10	UTSW	7	103,698,638 (GRCm39)	missense	probably benign	0.03
R6216:Or51a10	UTSW	7	103,698,902 (GRCm39)	missense	probably damaging	1.00
R6925:Or51a10	UTSW	7	103,698,947 (GRCm39)	missense	probably benign	0.16
R7243:Or51a10	UTSW	7	103,698,962 (GRCm39)	missense	probably damaging	1.00
R7684:Or51a10	UTSW	7	103,698,667 (GRCm39)	missense	probably damaging	0.99
R7699:Or51a10	UTSW	7	103,699,800 (GRCm39)	start gained	probably benign
R8316:Or51a10	UTSW	7	103,698,829 (GRCm39)	missense	probably damaging	1.00
R8458:Or51a10	UTSW	7	103,698,875 (GRCm39)	missense	possibly damaging	0.93
R8836:Or51a10	UTSW	7	103,699,055 (GRCm39)	missense	probably benign	0.07
R9161:Or51a10	UTSW	7	103,699,725 (GRCm39)	start gained	probably benign
R9519:Or51a10	UTSW	7	103,698,636 (GRCm39)	missense	probably benign	0.00
Z1176:Or51a10	UTSW	7	103,699,480 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- ATGATGATGGACATACCCATGTG -3'
(R):5'- TTCCCAGAGATGCAGAGTCTG -3'

Sequencing Primer
(F):5'- ACGGGCATCAGTAAGCAC -3'
(R):5'- TGCAGAGTCTGGAGCACTG -3'

Posted On

2018-08-01