|List |< first << previous [record 41 of 50] next >> last >||
|Institutional Source||Beutler Lab|
|Gene Name||Son DNA binding protein|
|Is this an essential gene?||Probably essential (E-score: 0.955)|
|Stock #||R6371 (G1)|
|Chromosomal Location||91647506-91679221 bp(+) (GRCm38)|
|Type of Mutation|
|DNA Base Change (assembly)||T to C at 91674741 bp|
|Amino Acid Change|
|Coding Region Coverage||
|Validation Efficiency||98% (50/51)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequence found in the human hepatitis B virus (HBV) and represses HBV core promoter activity. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Son||
(F):5'- ACAGTTGTGCAGCTTAGGAC -3'
(R):5'- TCCCCACTCTATTATAAGGCAAG -3'
(F):5'- CAGTTGTGCAGCTTAGGACATTAAG -3'
(R):5'- GCACATGAAACACCCTGTA -3'