Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01143:Vmn2r108'

53123

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r108

Ensembl Gene

ENSMUSG00000091805

Gene Name

vomeronasal 2, receptor 108

Synonyms

EG627805

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL01143

Quality Score

Status

Chromosome

Chromosomal Location

20682635-20701498 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 20682727 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Serine at position 826 (A826S)

Ref Sequence

ENSEMBL: ENSMUSP00000130373 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167314]

AlphaFold

E9PYS0

Predicted Effect

possibly damaging
Transcript: ENSMUST00000167314
AA Change: A826S

PolyPhen 2 Score 0.824 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: A826S

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	6e-33	PFAM
Pfam:NCD3G	510	563	9.2e-22	PFAM
Pfam:7tm_3	593	831	2.2e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abtb3	A	T	10: 85,490,335 (GRCm39)		probably benign	Het
Adgrl4	A	G	3: 151,205,866 (GRCm39)		probably null	Het
Adgrv1	A	C	13: 81,567,470 (GRCm39)	D5234E	probably benign	Het
Bmp7	G	T	2: 172,721,275 (GRCm39)	H267N	probably benign	Het
Ccdc113	T	C	8: 96,260,888 (GRCm39)	V30A	probably damaging	Het
Ccdc185	A	T	1: 182,575,417 (GRCm39)	L424Q	probably damaging	Het
Cep192	T	A	18: 67,937,445 (GRCm39)	D58E	probably damaging	Het
Ces1f	C	T	8: 93,998,458 (GRCm39)		probably null	Het
Chaf1a	T	A	17: 56,370,336 (GRCm39)	D600E	possibly damaging	Het
Cndp2	A	G	18: 84,695,442 (GRCm39)		probably null	Het
Dnah11	T	A	12: 117,976,475 (GRCm39)	D2727V	probably damaging	Het
Dync1li2	T	C	8: 105,156,085 (GRCm39)	D252G	probably damaging	Het
Ephx2	C	T	14: 66,326,971 (GRCm39)	R408Q	probably damaging	Het
Fat1	C	A	8: 45,488,569 (GRCm39)	T3427K	possibly damaging	Het
Gal3st4	A	G	5: 138,269,664 (GRCm39)	M1T	probably null	Het
Gm5828	T	C	1: 16,840,172 (GRCm39)		noncoding transcript	Het
Gm7694	C	T	1: 170,130,394 (GRCm39)	M1I	probably null	Het
Gpatch1	A	G	7: 35,000,997 (GRCm39)		probably benign	Het
Grik1	G	T	16: 87,754,488 (GRCm39)		probably null	Het
Gtf2ird2	A	G	5: 134,225,394 (GRCm39)	T161A	possibly damaging	Het
Hk2	T	C	6: 82,706,533 (GRCm39)	I790V	possibly damaging	Het
Ints9	G	A	14: 65,274,870 (GRCm39)	V609I	probably benign	Het
Kcnq4	T	G	4: 120,555,820 (GRCm39)	D585A	probably damaging	Het
Large2	T	C	2: 92,196,684 (GRCm39)	Y464C	probably damaging	Het
Lpar6	G	A	14: 73,476,077 (GRCm39)	D13N	probably damaging	Het
Morn1	T	C	4: 155,176,761 (GRCm39)	Y132H	probably damaging	Het
Nphp1	C	T	2: 127,622,056 (GRCm39)	V24I	probably benign	Het
Or5b104	A	T	19: 13,072,476 (GRCm39)	F179I	probably damaging	Het
Or5w17	T	C	2: 87,584,278 (GRCm39)	N20D	probably benign	Het
Or8b1c	G	T	9: 38,384,338 (GRCm39)	M98I	possibly damaging	Het
Pcdhb13	T	C	18: 37,575,690 (GRCm39)	W23R	probably benign	Het
Plekhg3	T	C	12: 76,611,756 (GRCm39)		probably null	Het
Slx4	T	C	16: 3,808,752 (GRCm39)	K396R	probably benign	Het
Snx13	A	G	12: 35,182,159 (GRCm39)	D736G	probably damaging	Het
Spag17	A	G	3: 99,846,614 (GRCm39)	D46G	probably benign	Het
Spata31	T	G	13: 65,068,630 (GRCm39)	Y259*	probably null	Het
Synj1	T	C	16: 90,748,864 (GRCm39)	E1064G	probably damaging	Het
Tom1	A	G	8: 75,785,085 (GRCm39)	T81A	probably benign	Het
Ttc23l	A	G	15: 10,530,775 (GRCm39)	I279T	probably damaging	Het
Ttc39a	T	C	4: 109,300,010 (GRCm39)		probably null	Het
Zyg11b	A	T	4: 108,102,191 (GRCm39)	V510E	possibly damaging	Het

Other mutations in Vmn2r108

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00903:Vmn2r108	APN	17	20,682,774 (GRCm39)	missense	probably damaging	0.98
IGL01311:Vmn2r108	APN	17	20,682,939 (GRCm39)	nonsense	probably null
IGL01411:Vmn2r108	APN	17	20,691,282 (GRCm39)	missense	probably benign	0.01
IGL01414:Vmn2r108	APN	17	20,691,942 (GRCm39)	missense	probably benign	0.00
IGL01536:Vmn2r108	APN	17	20,683,543 (GRCm39)	missense	probably damaging	1.00
IGL01748:Vmn2r108	APN	17	20,683,476 (GRCm39)	missense	probably benign	0.03
IGL01769:Vmn2r108	APN	17	20,691,280 (GRCm39)	missense	probably benign	0.02
IGL02022:Vmn2r108	APN	17	20,691,987 (GRCm39)	missense	possibly damaging	0.77
IGL02041:Vmn2r108	APN	17	20,683,398 (GRCm39)	missense	probably damaging	1.00
IGL02049:Vmn2r108	APN	17	20,691,608 (GRCm39)	missense	probably benign	0.00
IGL02344:Vmn2r108	APN	17	20,689,405 (GRCm39)	missense	probably damaging	1.00
IGL02939:Vmn2r108	APN	17	20,691,545 (GRCm39)	missense	probably benign	0.05
IGL03202:Vmn2r108	APN	17	20,691,319 (GRCm39)	nonsense	probably null
PIT4498001:Vmn2r108	UTSW	17	20,683,279 (GRCm39)	missense	probably damaging	1.00
R0112:Vmn2r108	UTSW	17	20,691,897 (GRCm39)	missense	probably benign	0.07
R0505:Vmn2r108	UTSW	17	20,683,096 (GRCm39)	missense	possibly damaging	0.77
R0833:Vmn2r108	UTSW	17	20,691,721 (GRCm39)	missense	probably benign
R0836:Vmn2r108	UTSW	17	20,691,721 (GRCm39)	missense	probably benign
R0943:Vmn2r108	UTSW	17	20,691,397 (GRCm39)	nonsense	probably null
R1411:Vmn2r108	UTSW	17	20,683,107 (GRCm39)	missense	probably damaging	0.98
R1442:Vmn2r108	UTSW	17	20,692,623 (GRCm39)	nonsense	probably null
R1587:Vmn2r108	UTSW	17	20,692,383 (GRCm39)	missense	probably damaging	1.00
R1751:Vmn2r108	UTSW	17	20,682,786 (GRCm39)	missense	probably damaging	1.00
R1773:Vmn2r108	UTSW	17	20,689,335 (GRCm39)	missense	probably damaging	1.00
R2021:Vmn2r108	UTSW	17	20,691,252 (GRCm39)	missense	probably benign	0.00
R2159:Vmn2r108	UTSW	17	20,689,363 (GRCm39)	missense	probably benign	0.41
R2224:Vmn2r108	UTSW	17	20,701,295 (GRCm39)	nonsense	probably null
R2226:Vmn2r108	UTSW	17	20,701,295 (GRCm39)	nonsense	probably null
R2517:Vmn2r108	UTSW	17	20,692,577 (GRCm39)	missense	probably damaging	1.00
R3710:Vmn2r108	UTSW	17	20,682,932 (GRCm39)	missense	probably benign
R4470:Vmn2r108	UTSW	17	20,682,990 (GRCm39)	missense	probably damaging	1.00
R4686:Vmn2r108	UTSW	17	20,691,636 (GRCm39)	missense	probably damaging	0.99
R4729:Vmn2r108	UTSW	17	20,692,632 (GRCm39)	missense	probably damaging	0.99
R4799:Vmn2r108	UTSW	17	20,682,891 (GRCm39)	missense	probably damaging	1.00
R4993:Vmn2r108	UTSW	17	20,701,449 (GRCm39)	missense	probably benign	0.04
R5088:Vmn2r108	UTSW	17	20,690,454 (GRCm39)	missense	possibly damaging	0.46
R5213:Vmn2r108	UTSW	17	20,691,755 (GRCm39)	missense	probably benign	0.00
R5289:Vmn2r108	UTSW	17	20,691,866 (GRCm39)	missense	probably damaging	1.00
R5290:Vmn2r108	UTSW	17	20,691,665 (GRCm39)	missense	probably benign	0.00
R5713:Vmn2r108	UTSW	17	20,691,290 (GRCm39)	missense	probably damaging	1.00
R5753:Vmn2r108	UTSW	17	20,683,179 (GRCm39)	missense	probably damaging	0.99
R5792:Vmn2r108	UTSW	17	20,683,398 (GRCm39)	missense	probably damaging	0.99
R5798:Vmn2r108	UTSW	17	20,692,545 (GRCm39)	missense	probably benign	0.39
R5897:Vmn2r108	UTSW	17	20,691,580 (GRCm39)	missense	probably benign	0.01
R6018:Vmn2r108	UTSW	17	20,683,268 (GRCm39)	missense	possibly damaging	0.83
R6093:Vmn2r108	UTSW	17	20,701,402 (GRCm39)	missense	probably benign	0.00
R6156:Vmn2r108	UTSW	17	20,692,447 (GRCm39)	missense	probably benign	0.03
R6199:Vmn2r108	UTSW	17	20,682,644 (GRCm39)	missense	probably benign	0.01
R6259:Vmn2r108	UTSW	17	20,683,371 (GRCm39)	missense	possibly damaging	0.95
R6309:Vmn2r108	UTSW	17	20,691,660 (GRCm39)	missense	probably damaging	0.98
R6324:Vmn2r108	UTSW	17	20,691,977 (GRCm39)	nonsense	probably null
R6364:Vmn2r108	UTSW	17	20,691,260 (GRCm39)	missense	probably benign	0.00
R6446:Vmn2r108	UTSW	17	20,692,609 (GRCm39)	nonsense	probably null
R6541:Vmn2r108	UTSW	17	20,701,480 (GRCm39)	missense	probably benign	0.02
R7025:Vmn2r108	UTSW	17	20,691,345 (GRCm39)	missense	possibly damaging	0.67
R7063:Vmn2r108	UTSW	17	20,701,410 (GRCm39)	missense	probably damaging	1.00
R7092:Vmn2r108	UTSW	17	20,701,338 (GRCm39)	missense	probably benign	0.10
R7096:Vmn2r108	UTSW	17	20,682,762 (GRCm39)	missense	probably damaging	1.00
R7203:Vmn2r108	UTSW	17	20,683,038 (GRCm39)	missense	probably benign	0.12
R7458:Vmn2r108	UTSW	17	20,692,532 (GRCm39)	missense	probably benign	0.17
R7619:Vmn2r108	UTSW	17	20,692,457 (GRCm39)	missense	probably benign	0.02
R7841:Vmn2r108	UTSW	17	20,690,305 (GRCm39)	critical splice donor site	probably null
R7944:Vmn2r108	UTSW	17	20,691,890 (GRCm39)	missense	probably damaging	0.99
R8048:Vmn2r108	UTSW	17	20,691,762 (GRCm39)	missense	probably benign	0.29
R8213:Vmn2r108	UTSW	17	20,690,350 (GRCm39)	missense	probably benign	0.03
R8218:Vmn2r108	UTSW	17	20,683,465 (GRCm39)	missense	probably damaging	1.00
R8507:Vmn2r108	UTSW	17	20,683,195 (GRCm39)	nonsense	probably null
R8708:Vmn2r108	UTSW	17	20,682,687 (GRCm39)	missense	probably damaging	0.98
R8845:Vmn2r108	UTSW	17	20,691,361 (GRCm39)	missense	probably benign	0.03
R9030:Vmn2r108	UTSW	17	20,690,312 (GRCm39)	missense	probably benign	0.01
R9226:Vmn2r108	UTSW	17	20,691,330 (GRCm39)	missense	probably benign
R9278:Vmn2r108	UTSW	17	20,692,561 (GRCm39)	missense	probably benign	0.11
X0022:Vmn2r108	UTSW	17	20,691,371 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r108	UTSW	17	20,691,375 (GRCm39)	missense	probably benign	0.01
Z1177:Vmn2r108	UTSW	17	20,691,219 (GRCm39)	missense	probably damaging	0.99

Posted On

2013-06-21