Incidental Mutation 'IGL01145:Dus3l'
ID53128
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dus3l
Ensembl Gene ENSMUSG00000007603
Gene Namedihydrouridine synthase 3-like (S. cerevisiae)
Synonyms
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.405) question?
Stock #IGL01145
Quality Score
Status
Chromosome17
Chromosomal Location56764751-56770092 bp(+) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) T to C at 56767627 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000127457 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000007747] [ENSMUST00000168666]
Predicted Effect probably benign
Transcript: ENSMUST00000007747
SMART Domains Protein: ENSMUSP00000007747
Gene: ENSMUSG00000007603

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
Blast:ZnF_C3H1 109 136 2e-6 BLAST
Blast:ZnF_C3H1 146 172 6e-9 BLAST
Pfam:Dus 295 566 2e-60 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168666
SMART Domains Protein: ENSMUSP00000127457
Gene: ENSMUSG00000090273

DomainStartEndE-ValueType
low complexity region 22 35 N/A INTRINSIC
Pfam:PRR22 58 422 2.3e-169 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000187612
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan A C 7: 79,099,282 D1267A probably damaging Het
AI314180 A C 4: 58,811,501 D1467E probably null Het
Ankrd44 A G 1: 54,762,259 probably null Het
Arap3 T C 18: 37,989,179 M619V probably benign Het
C8b A T 4: 104,780,580 Y83F probably benign Het
Capn15 A G 17: 25,963,050 V595A probably damaging Het
Cbx1 A T 11: 96,801,566 D93V probably benign Het
Cyp2c66 G T 19: 39,170,961 E285D probably benign Het
Dkk4 T A 8: 22,625,386 V84D probably damaging Het
Dnah17 T A 11: 118,047,173 I3343F possibly damaging Het
Eif6 A G 2: 155,826,435 probably benign Het
Eya3 A G 4: 132,709,995 I389V probably damaging Het
Gm5868 A T 5: 72,586,204 probably null Het
Gm5916 A T 9: 36,120,702 D95E unknown Het
Gucy2d T A 7: 98,449,963 S329T probably benign Het
Hook3 C T 8: 26,059,344 M157I probably benign Het
Iapp C A 6: 142,303,364 R48S probably damaging Het
Ints11 A G 4: 155,885,126 Y153C probably damaging Het
Layn G A 9: 51,074,046 T62I probably benign Het
Llgl2 A G 11: 115,853,805 H876R probably benign Het
Lrp4 T C 2: 91,487,051 I840T probably damaging Het
Myo9a T A 9: 59,855,375 F796L probably benign Het
Naip1 A G 13: 100,409,121 S1300P probably benign Het
Nfat5 T A 8: 107,367,215 I602N probably damaging Het
Omt2a T C 9: 78,312,956 M64V probably benign Het
Pcnx T C 12: 81,992,035 S2025P probably damaging Het
Pemt A G 11: 59,983,467 L62P probably damaging Het
Polrmt A G 10: 79,741,137 V399A probably benign Het
Rasgrp4 T C 7: 29,151,473 S77P possibly damaging Het
Rrm2b G A 15: 37,944,560 P111L probably damaging Het
Thap12 A G 7: 98,712,903 *121W probably null Het
Tnik A G 3: 28,604,167 probably benign Het
Trio G A 15: 27,818,167 probably benign Het
Zfhx4 A G 3: 5,245,347 E930G probably damaging Het
Zfp335 G T 2: 164,907,502 T299K probably benign Het
Other mutations in Dus3l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02164:Dus3l APN 17 56767943 unclassified probably benign
IGL02903:Dus3l APN 17 56768363 missense probably damaging 1.00
IGL02979:Dus3l APN 17 56768140 missense possibly damaging 0.91
R0532:Dus3l UTSW 17 56769308 missense probably damaging 0.98
R1668:Dus3l UTSW 17 56766912 missense possibly damaging 0.73
R3151:Dus3l UTSW 17 56768899 missense probably benign 0.12
R4671:Dus3l UTSW 17 56768566 missense probably benign 0.02
R4737:Dus3l UTSW 17 56767868 missense probably damaging 1.00
R5198:Dus3l UTSW 17 56769574 missense probably benign 0.03
R5613:Dus3l UTSW 17 56767882 missense possibly damaging 0.89
R5930:Dus3l UTSW 17 56769579 missense probably damaging 0.97
R6198:Dus3l UTSW 17 56767858 missense possibly damaging 0.46
R7206:Dus3l UTSW 17 56767807 missense probably damaging 0.98
R7316:Dus3l UTSW 17 56765551 missense possibly damaging 0.90
Posted On2013-06-21