Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01145:Dus3l'

53128

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dus3l

Ensembl Gene

ENSMUSG00000007603

Gene Name

dihydrouridine synthase 3-like (S. cerevisiae)

Synonyms

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.482) question?

Stock #

IGL01145

Quality Score

Status

Chromosome

Chromosomal Location

56764751-56770092 bp(+) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

T to C at 56767627 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000127457 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000007747] [ENSMUST00000168666]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000007747

SMART Domains

Protein: ENSMUSP00000007747
Gene: ENSMUSG00000007603

Domain	Start	End	E-Value	Type
low complexity region	2	18	N/A	INTRINSIC
Blast:ZnF_C3H1	109	136	2e-6	BLAST
Blast:ZnF_C3H1	146	172	6e-9	BLAST
Pfam:Dus	295	566	2e-60	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000168666

SMART Domains

Protein: ENSMUSP00000127457
Gene: ENSMUSG00000090273

Domain	Start	End	E-Value	Type
low complexity region	22	35	N/A	INTRINSIC
Pfam:PRR22	58	422	2.3e-169	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000187612

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acan	A	C	7: 79,099,282	D1267A	probably damaging	Het
AI314180	A	C	4: 58,811,501	D1467E	probably null	Het
Ankrd44	A	G	1: 54,762,259		probably null	Het
Arap3	T	C	18: 37,989,179	M619V	probably benign	Het
C8b	A	T	4: 104,780,580	Y83F	probably benign	Het
Capn15	A	G	17: 25,963,050	V595A	probably damaging	Het
Cbx1	A	T	11: 96,801,566	D93V	probably benign	Het
Cyp2c66	G	T	19: 39,170,961	E285D	probably benign	Het
Dkk4	T	A	8: 22,625,386	V84D	probably damaging	Het
Dnah17	T	A	11: 118,047,173	I3343F	possibly damaging	Het
Eif6	A	G	2: 155,826,435		probably benign	Het
Eya3	A	G	4: 132,709,995	I389V	probably damaging	Het
Gm5868	A	T	5: 72,586,204		probably null	Het
Gm5916	A	T	9: 36,120,702	D95E	unknown	Het
Gucy2d	T	A	7: 98,449,963	S329T	probably benign	Het
Hook3	C	T	8: 26,059,344	M157I	probably benign	Het
Iapp	C	A	6: 142,303,364	R48S	probably damaging	Het
Ints11	A	G	4: 155,885,126	Y153C	probably damaging	Het
Layn	G	A	9: 51,074,046	T62I	probably benign	Het
Llgl2	A	G	11: 115,853,805	H876R	probably benign	Het
Lrp4	T	C	2: 91,487,051	I840T	probably damaging	Het
Myo9a	T	A	9: 59,855,375	F796L	probably benign	Het
Naip1	A	G	13: 100,409,121	S1300P	probably benign	Het
Nfat5	T	A	8: 107,367,215	I602N	probably damaging	Het
Omt2a	T	C	9: 78,312,956	M64V	probably benign	Het
Pcnx	T	C	12: 81,992,035	S2025P	probably damaging	Het
Pemt	A	G	11: 59,983,467	L62P	probably damaging	Het
Polrmt	A	G	10: 79,741,137	V399A	probably benign	Het
Rasgrp4	T	C	7: 29,151,473	S77P	possibly damaging	Het
Rrm2b	G	A	15: 37,944,560	P111L	probably damaging	Het
Thap12	A	G	7: 98,712,903	*121W	probably null	Het
Tnik	A	G	3: 28,604,167		probably benign	Het
Trio	G	A	15: 27,818,167		probably benign	Het
Zfhx4	A	G	3: 5,245,347	E930G	probably damaging	Het
Zfp335	G	T	2: 164,907,502	T299K	probably benign	Het

Other mutations in Dus3l

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02164:Dus3l	APN	17	56767943	unclassified	probably benign
IGL02903:Dus3l	APN	17	56768363	missense	probably damaging	1.00
IGL02979:Dus3l	APN	17	56768140	missense	possibly damaging	0.91
R0532:Dus3l	UTSW	17	56769308	missense	probably damaging	0.98
R1668:Dus3l	UTSW	17	56766912	missense	possibly damaging	0.73
R3151:Dus3l	UTSW	17	56768899	missense	probably benign	0.12
R4671:Dus3l	UTSW	17	56768566	missense	probably benign	0.02
R4737:Dus3l	UTSW	17	56767868	missense	probably damaging	1.00
R5198:Dus3l	UTSW	17	56769574	missense	probably benign	0.03
R5613:Dus3l	UTSW	17	56767882	missense	possibly damaging	0.89
R5930:Dus3l	UTSW	17	56769579	missense	probably damaging	0.97
R6198:Dus3l	UTSW	17	56767858	missense	possibly damaging	0.46
R7206:Dus3l	UTSW	17	56767807	missense	probably damaging	0.98
R7316:Dus3l	UTSW	17	56765551	missense	possibly damaging	0.90
R8139:Dus3l	UTSW	17	56767058	nonsense	probably null
R9682:Dus3l	UTSW	17	56769770	missense	probably benign	0.00

Posted On

2013-06-21