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|Institutional Source||Beutler Lab|
|Gene Name||polo like kinase 2|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R6776 (G1)|
|Chromosomal Location||110395046-110400844 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 110399791 bp|
|Amino Acid Change||Isoleucine to Threonine at position 592 (I592T)|
|Ref Sequence||ENSEMBL: ENSMUSP00000022212 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000022212]|
|Predicted Effect||probably benign
AA Change: I592T
PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
AA Change: I592T
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
PHENOTYPE: Inactivation of this gene results in impaired embryonic growth and placental defects due to increased cell proliferation. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Plk2||
(F):5'- ATCTTAGATGCAGTGCAGAGAGTC -3'
(R):5'- CACAGACATTAGAACTTGCTAAGC -3'
(F):5'- GTCAGCATCTCTTTGAGATAGAGCC -3'
(R):5'- CAAGAAGTAATCAAGGTTCTGCC -3'