Incidental Mutation 'R6777:Trgv3'
ID 531344
Institutional Source Beutler Lab
Gene Symbol Trgv3
Ensembl Gene ENSMUSG00000076750
Gene Name T cell receptor gamma, variable 3
Synonyms vgamma3, Tcrg-V3
MMRRC Submission 044893-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R6777 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 19427015-19427471 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 19427450 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 111 (Y111C)
Ref Sequence ENSEMBL: ENSMUSP00000142927 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103559] [ENSMUST00000198663]
AlphaFold A0A075B5Z1
Predicted Effect probably damaging
Transcript: ENSMUST00000103559
AA Change: Y110C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000100339
Gene: ENSMUSG00000076750
AA Change: Y110C

DomainStartEndE-ValueType
IGv 34 114 4.92e-12 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000198663
AA Change: Y111C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000142927
Gene: ENSMUSG00000076750
AA Change: Y111C

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IGv 35 115 2e-14 SMART
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 96.1%
Validation Efficiency 100% (32/32)
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900092C05Rik A T 7: 12,246,756 (GRCm39) L45F probably benign Het
Adam7 T C 14: 68,762,784 (GRCm39) Y147C probably damaging Het
Adss2 A T 1: 177,603,902 (GRCm39) probably null Het
Atp2c1 T A 9: 105,295,799 (GRCm39) I812L possibly damaging Het
Capn2 A G 1: 182,297,742 (GRCm39) probably null Het
Crybg3 A G 16: 59,378,678 (GRCm39) probably benign Het
Cux1 C G 5: 136,594,422 (GRCm39) probably benign Het
Dkk2 T A 3: 131,879,572 (GRCm39) C84S probably damaging Het
Eml3 T C 19: 8,914,086 (GRCm39) V128A probably benign Het
Fzr1 A G 10: 81,206,327 (GRCm39) Y148H probably damaging Het
Galnt9 G A 5: 110,768,465 (GRCm39) R587H probably damaging Het
Ganc A G 2: 120,274,630 (GRCm39) T584A probably damaging Het
Gldc T C 19: 30,110,912 (GRCm39) T564A probably damaging Het
Gm49359 A T 13: 62,603,006 (GRCm39) C65S probably benign Het
Hspa12a A G 19: 58,810,519 (GRCm39) Y175H probably benign Het
Ly6g A G 15: 75,030,431 (GRCm39) D60G probably benign Het
Or11j4 A T 14: 50,631,115 (GRCm39) M301L probably damaging Het
Pex1 T A 5: 3,672,358 (GRCm39) C694S probably benign Het
Pkd1l3 T C 8: 110,353,446 (GRCm39) F676L probably benign Het
Pla2g2c T C 4: 138,470,976 (GRCm39) V119A probably benign Het
Ralgps2 A G 1: 156,715,515 (GRCm39) probably null Het
Rbp3 C A 14: 33,676,230 (GRCm39) H59Q probably benign Het
Serpina3c T C 12: 104,118,069 (GRCm39) K90E probably benign Het
Slc24a3 A G 2: 145,482,202 (GRCm39) Y620C probably damaging Het
Smg1 C A 7: 117,788,340 (GRCm39) probably benign Het
Srp68 A T 11: 116,153,730 (GRCm39) V198E probably damaging Het
Ssx2ip C T 3: 146,144,476 (GRCm39) T580M possibly damaging Het
Terf2 A G 8: 107,797,169 (GRCm39) V434A possibly damaging Het
Tmem242 G A 17: 5,483,830 (GRCm39) P71S probably damaging Het
Tmprss13 C T 9: 45,247,399 (GRCm39) R254* probably null Het
Other mutations in Trgv3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Trgv3 APN 13 19,427,381 (GRCm39) missense probably benign 0.44
IGL02458:Trgv3 APN 13 19,427,423 (GRCm39) missense probably damaging 0.99
IGL03146:Trgv3 APN 13 19,427,337 (GRCm39) nonsense probably null
R7275:Trgv3 UTSW 13 19,427,188 (GRCm39) missense probably benign 0.20
R7491:Trgv3 UTSW 13 19,427,016 (GRCm39) start codon destroyed probably null 0.99
R8434:Trgv3 UTSW 13 19,427,036 (GRCm39) missense probably benign
R8965:Trgv3 UTSW 13 19,427,180 (GRCm39) missense probably damaging 1.00
R9307:Trgv3 UTSW 13 19,427,441 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ATGAGAGTGCGCAAATATCCTG -3'
(R):5'- CAGTATGTTCCCTGGAAGCC -3'

Sequencing Primer
(F):5'- AGCTATACATTGGTACCGGC -3'
(R):5'- GTATGTTCCCTGGAAGCCCAAAAAG -3'
Posted On 2018-08-29