Incidental Mutation 'R6778:Usp32'
ID 531381
Institutional Source Beutler Lab
Gene Symbol Usp32
Ensembl Gene ENSMUSG00000000804
Gene Name ubiquitin specific peptidase 32
Synonyms 6430526O11Rik, 2900074J03Rik
MMRRC Submission 044894-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6778 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 84984442-85140161 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85025686 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 811 (I811V)
Ref Sequence ENSEMBL: ENSMUSP00000103710 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108075]
AlphaFold F8VPZ3
Predicted Effect unknown
Transcript: ENSMUST00000000821
AA Change: I109V
SMART Domains Protein: ENSMUSP00000000821
Gene: ENSMUSG00000000804
AA Change: I109V

DomainStartEndE-ValueType
Pfam:UCH 32 260 4.1e-51 PFAM
Pfam:UCH_1 33 228 1.7e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108075
AA Change: I811V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000103710
Gene: ENSMUSG00000000804
AA Change: I811V

DomainStartEndE-ValueType
EFh 232 260 4.66e0 SMART
EFh 268 296 5.8e-1 SMART
Blast:EFh 318 346 5e-7 BLAST
DUSP 389 588 2.32e-16 SMART
Pfam:Ubiquitin_3 628 711 2.4e-9 PFAM
Pfam:UCH 733 1564 2.4e-83 PFAM
Pfam:UCH_1 1202 1547 2.9e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000174602
SMART Domains Protein: ENSMUSP00000134476
Gene: ENSMUSG00000000804

DomainStartEndE-ValueType
Pfam:DUSP 1 65 6.5e-17 PFAM
Pfam:Ubiquitin_3 122 216 8e-10 PFAM
Pfam:UCH 238 257 1.2e-7 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts14 T A 10: 61,225,452 (GRCm38) N403Y probably damaging Het
Akap6 A G 12: 53,025,816 (GRCm38) E989G probably damaging Het
Aoc2 A G 11: 101,325,361 (GRCm38) N90S probably damaging Het
Apol9a T C 15: 77,404,333 (GRCm38) Y278C probably benign Het
Casq2 T A 3: 102,127,931 (GRCm38) probably null Het
Ccdc7a T A 8: 128,821,120 (GRCm38) T1284S possibly damaging Het
Dlat A G 9: 50,650,857 (GRCm38) L289P probably damaging Het
Dnah8 C T 17: 30,635,666 (GRCm38) P101S probably benign Het
Dzip3 C A 16: 48,982,083 (GRCm38) A28S probably benign Het
Fam205c T C 4: 42,868,522 (GRCm38) K367R possibly damaging Het
Ffar4 A G 19: 38,113,664 (GRCm38) E249G possibly damaging Het
Fubp3 A T 2: 31,598,673 (GRCm38) K180N possibly damaging Het
Gm7489 T A 15: 53,885,952 (GRCm38) probably benign Het
Ifitm6 A T 7: 141,016,143 (GRCm38) M59K possibly damaging Het
Igkv4-80 A T 6: 69,016,561 (GRCm38) Y115* probably null Het
Igsf21 G T 4: 140,034,648 (GRCm38) R240S probably benign Het
Kank4 A T 4: 98,761,505 (GRCm38) N942K probably benign Het
Man2a1 C A 17: 64,714,635 (GRCm38) T35K possibly damaging Het
Mvk T A 5: 114,452,380 (GRCm38) D193E probably benign Het
Npas2 T A 1: 39,325,300 (GRCm38) M241K possibly damaging Het
Npsr1 T A 9: 24,254,618 (GRCm38) I100N possibly damaging Het
Olfml2b A G 1: 170,645,070 (GRCm38) D50G probably damaging Het
Olfr961 T A 9: 39,646,747 (GRCm38) V7E probably damaging Het
Pcnx A G 12: 81,918,871 (GRCm38) D604G probably damaging Het
Pitx2 C T 3: 129,218,743 (GRCm38) P254L probably damaging Het
Rdh10 T C 1: 16,106,184 (GRCm38) F56S probably damaging Het
Rin1 T C 19: 5,054,886 (GRCm38) L647P probably damaging Het
Sgk3 T A 1: 9,886,144 (GRCm38) probably null Het
Sgpp1 A G 12: 75,716,294 (GRCm38) I371T probably benign Het
Slc12a9 T C 5: 137,315,081 (GRCm38) Y872C possibly damaging Het
Syne1 A G 10: 5,102,406 (GRCm38) F7487L probably damaging Het
Tars T C 15: 11,389,699 (GRCm38) N375S probably benign Het
Tbc1d31 A G 15: 57,938,029 (GRCm38) Y320C probably damaging Het
Tbl1xr1 T A 3: 22,189,782 (GRCm38) F73L probably benign Het
Tmem145 G A 7: 25,311,376 (GRCm38) V378I probably benign Het
Tmprss11d T C 5: 86,309,350 (GRCm38) H150R probably benign Het
Tnc T G 4: 63,995,598 (GRCm38) I1326L probably benign Het
Trpc7 T C 13: 56,804,687 (GRCm38) Y502C probably damaging Het
Vmn1r71 C T 7: 10,748,216 (GRCm38) A182T probably benign Het
Wdr47 T A 3: 108,633,096 (GRCm38) N602K probably benign Het
Other mutations in Usp32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00529:Usp32 APN 11 84,994,426 (GRCm38) missense probably damaging 1.00
IGL00701:Usp32 APN 11 85,059,125 (GRCm38) splice site probably null
IGL00848:Usp32 APN 11 85,051,181 (GRCm38) splice site probably benign
IGL00934:Usp32 APN 11 85,007,076 (GRCm38) missense probably damaging 1.00
IGL01019:Usp32 APN 11 85,039,265 (GRCm38) missense probably damaging 0.97
IGL01302:Usp32 APN 11 84,988,482 (GRCm38) missense probably benign 0.05
IGL01444:Usp32 APN 11 85,059,164 (GRCm38) missense probably damaging 0.97
IGL01575:Usp32 APN 11 85,022,802 (GRCm38) missense probably damaging 1.00
IGL01981:Usp32 APN 11 85,036,524 (GRCm38) missense probably benign 0.02
IGL02118:Usp32 APN 11 85,032,177 (GRCm38) nonsense probably null
IGL02159:Usp32 APN 11 85,005,802 (GRCm38) splice site probably null
IGL02227:Usp32 APN 11 84,986,481 (GRCm38) missense probably damaging 1.00
IGL02363:Usp32 APN 11 85,044,787 (GRCm38) missense probably benign 0.01
IGL02524:Usp32 APN 11 85,010,011 (GRCm38) nonsense probably null
IGL02613:Usp32 APN 11 85,040,070 (GRCm38) missense probably damaging 0.99
IGL02720:Usp32 APN 11 85,006,991 (GRCm38) critical splice donor site probably null
IGL02738:Usp32 APN 11 85,083,806 (GRCm38) missense probably damaging 1.00
IGL02929:Usp32 APN 11 84,988,372 (GRCm38) missense probably benign 0.01
IGL03303:Usp32 APN 11 85,022,832 (GRCm38) missense probably damaging 1.00
BB010:Usp32 UTSW 11 85,007,059 (GRCm38) missense probably damaging 1.00
BB020:Usp32 UTSW 11 85,007,059 (GRCm38) missense probably damaging 1.00
PIT4812001:Usp32 UTSW 11 85,010,074 (GRCm38) missense probably damaging 1.00
R0026:Usp32 UTSW 11 85,032,074 (GRCm38) missense possibly damaging 0.48
R0295:Usp32 UTSW 11 85,053,692 (GRCm38) missense probably damaging 0.98
R1320:Usp32 UTSW 11 85,017,793 (GRCm38) missense probably damaging 0.98
R1712:Usp32 UTSW 11 85,042,580 (GRCm38) missense probably benign 0.12
R1922:Usp32 UTSW 11 85,007,004 (GRCm38) nonsense probably null
R1973:Usp32 UTSW 11 85,103,931 (GRCm38) missense probably benign 0.09
R2010:Usp32 UTSW 11 85,040,004 (GRCm38) missense probably damaging 0.98
R2082:Usp32 UTSW 11 85,030,512 (GRCm38) missense probably damaging 0.99
R2355:Usp32 UTSW 11 85,005,909 (GRCm38) missense probably benign 0.34
R3147:Usp32 UTSW 11 85,029,087 (GRCm38) missense probably damaging 1.00
R3160:Usp32 UTSW 11 85,025,536 (GRCm38) missense probably damaging 0.97
R3162:Usp32 UTSW 11 85,025,536 (GRCm38) missense probably damaging 0.97
R3716:Usp32 UTSW 11 85,042,563 (GRCm38) missense probably damaging 1.00
R3816:Usp32 UTSW 11 84,994,384 (GRCm38) critical splice donor site probably null
R3870:Usp32 UTSW 11 85,007,055 (GRCm38) nonsense probably null
R3871:Usp32 UTSW 11 85,081,156 (GRCm38) missense probably null 0.81
R4041:Usp32 UTSW 11 85,017,739 (GRCm38) missense probably benign 0.40
R4079:Usp32 UTSW 11 85,039,229 (GRCm38) missense probably damaging 0.98
R4332:Usp32 UTSW 11 85,103,978 (GRCm38) missense possibly damaging 0.79
R4396:Usp32 UTSW 11 85,053,975 (GRCm38) missense probably benign
R4580:Usp32 UTSW 11 85,059,127 (GRCm38) critical splice donor site probably null
R4620:Usp32 UTSW 11 85,059,127 (GRCm38) critical splice donor site probably null
R4744:Usp32 UTSW 11 84,994,393 (GRCm38) missense probably damaging 1.00
R4909:Usp32 UTSW 11 85,055,772 (GRCm38) nonsense probably null
R5056:Usp32 UTSW 11 85,026,795 (GRCm38) missense probably benign 0.07
R5111:Usp32 UTSW 11 85,077,331 (GRCm38) missense possibly damaging 0.95
R5213:Usp32 UTSW 11 85,022,259 (GRCm38) missense probably damaging 1.00
R5308:Usp32 UTSW 11 85,017,718 (GRCm38) missense probably benign 0.12
R5381:Usp32 UTSW 11 85,059,127 (GRCm38) critical splice donor site probably benign
R5538:Usp32 UTSW 11 85,017,786 (GRCm38) missense possibly damaging 0.65
R5659:Usp32 UTSW 11 85,077,414 (GRCm38) missense possibly damaging 0.94
R6006:Usp32 UTSW 11 84,992,451 (GRCm38) critical splice donor site probably null
R6011:Usp32 UTSW 11 85,032,097 (GRCm38) missense possibly damaging 0.70
R6029:Usp32 UTSW 11 85,025,582 (GRCm38) missense probably damaging 0.99
R6074:Usp32 UTSW 11 84,994,573 (GRCm38) missense probably benign 0.00
R6331:Usp32 UTSW 11 84,986,576 (GRCm38) missense possibly damaging 0.92
R6353:Usp32 UTSW 11 85,022,281 (GRCm38) missense probably benign
R6714:Usp32 UTSW 11 85,026,870 (GRCm38) missense probably damaging 0.99
R6988:Usp32 UTSW 11 85,010,143 (GRCm38) missense probably benign 0.35
R6992:Usp32 UTSW 11 85,032,088 (GRCm38) missense probably damaging 0.99
R7182:Usp32 UTSW 11 85,040,170 (GRCm38) missense probably benign 0.34
R7186:Usp32 UTSW 11 85,051,234 (GRCm38) missense probably benign 0.45
R7198:Usp32 UTSW 11 85,022,855 (GRCm38) frame shift probably null
R7201:Usp32 UTSW 11 85,022,855 (GRCm38) frame shift probably null
R7469:Usp32 UTSW 11 84,988,553 (GRCm38) missense possibly damaging 0.94
R7502:Usp32 UTSW 11 85,022,898 (GRCm38) missense possibly damaging 0.48
R7513:Usp32 UTSW 11 85,027,112 (GRCm38) nonsense probably null
R7629:Usp32 UTSW 11 85,019,855 (GRCm38) frame shift probably null
R7703:Usp32 UTSW 11 85,077,327 (GRCm38) missense probably damaging 0.99
R7741:Usp32 UTSW 11 84,987,281 (GRCm38) missense probably damaging 0.99
R7765:Usp32 UTSW 11 84,994,408 (GRCm38) missense probably damaging 1.00
R7933:Usp32 UTSW 11 85,007,059 (GRCm38) missense probably damaging 1.00
R7973:Usp32 UTSW 11 85,022,808 (GRCm38) missense probably damaging 0.99
R7989:Usp32 UTSW 11 85,034,300 (GRCm38) missense
R7998:Usp32 UTSW 11 84,994,426 (GRCm38) missense probably damaging 1.00
R8292:Usp32 UTSW 11 85,077,401 (GRCm38) missense probably damaging 0.99
R8305:Usp32 UTSW 11 85,032,185 (GRCm38) missense possibly damaging 0.83
R8548:Usp32 UTSW 11 85,017,827 (GRCm38) missense possibly damaging 0.52
R8924:Usp32 UTSW 11 85,025,544 (GRCm38) missense probably damaging 0.98
R9002:Usp32 UTSW 11 85,053,951 (GRCm38) missense probably damaging 0.96
R9145:Usp32 UTSW 11 85,022,292 (GRCm38) missense probably damaging 1.00
R9209:Usp32 UTSW 11 85,040,012 (GRCm38) missense probably damaging 0.98
R9211:Usp32 UTSW 11 85,022,733 (GRCm38) missense probably damaging 1.00
R9296:Usp32 UTSW 11 85,017,652 (GRCm38) missense probably damaging 1.00
R9310:Usp32 UTSW 11 85,051,202 (GRCm38) missense probably benign 0.29
R9417:Usp32 UTSW 11 84,994,543 (GRCm38) missense probably damaging 1.00
R9514:Usp32 UTSW 11 85,022,734 (GRCm38) missense probably damaging 0.99
R9652:Usp32 UTSW 11 85,030,491 (GRCm38) missense probably damaging 0.97
R9723:Usp32 UTSW 11 85,044,710 (GRCm38) nonsense probably null
R9757:Usp32 UTSW 11 85,077,329 (GRCm38) nonsense probably null
X0028:Usp32 UTSW 11 84,992,606 (GRCm38) missense probably benign 0.05
Z1177:Usp32 UTSW 11 84,988,612 (GRCm38) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CCCAGCTAAGTAGGTAGAACACAAG -3'
(R):5'- GATGGTATCAATGGCCAAAATGC -3'

Sequencing Primer
(F):5'- TCAAAACTAACAAACCTCTGCAG -3'
(R):5'- GCCAAAATGCCTCTTATTTTTCTGG -3'
Posted On 2018-08-29