Mutagenetix > Incidental Mutation

Incidental Mutation 'R6782:Vmn2r107'

531491

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r107

Ensembl Gene

ENSMUSG00000056910

Gene Name

vomeronasal 2, receptor 107

Synonyms

V2r6

MMRRC Submission

Accession Numbers

Genbank: NM_001104569; MGI: 1316664

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R6782 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

20345425-20375772 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20356879 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 380 (S380P)

Ref Sequence

ENSEMBL: ENSMUSP00000048706 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042090]

AlphaFold

E9PZJ7

Predicted Effect

probably damaging
Transcript: ENSMUST00000042090
AA Change: S380P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: S380P

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	466	3.6e-40	PFAM
Pfam:NCD3G	509	562	5.1e-21	PFAM
Pfam:7tm_3	593	830	8e-51	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.4%
20x: 95.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca14	C	T	7: 120,248,085	A724V	probably damaging	Het
Abcc3	A	T	11: 94,358,950	F1055L	probably damaging	Het
Akt3	A	T	1: 177,050,190	Y337*	probably null	Het
Ankrd17	T	C	5: 90,254,738	K1488R	possibly damaging	Het
Ano1	G	A	7: 144,621,687	T498I	probably damaging	Het
Arhgap42	T	A	9: 9,115,720	K118N	probably damaging	Het
Arl5b	A	G	2: 15,073,182	E106G	probably damaging	Het
Atp5g3	C	T	2: 73,909,328	R56Q	probably benign	Het
Bbx	T	C	16: 50,200,565	R749G	probably benign	Het
Cacna1g	A	G	11: 94,459,550	S490P	probably damaging	Het
Ccdc63	A	T	5: 122,111,014	Y417*	probably null	Het
Cep162	A	T	9: 87,211,684	N880K	probably benign	Het
Chd2	G	A	7: 73,475,379	Q77*	probably null	Het
Cntrl	T	G	2: 35,170,646	M1397R	possibly damaging	Het
Dcaf7	A	G	11: 106,054,755	Y310C	probably damaging	Het
Dnah5	T	A	15: 28,449,156	S4235T	possibly damaging	Het
Dot1l	C	T	10: 80,789,390	P1157L	probably damaging	Het
Esco2	T	C	14: 65,820,016	T577A	probably benign	Het
Foxp1	T	C	6: 98,930,145	D624G	probably damaging	Het
Gfi1	A	T	5: 107,725,953		probably null	Het
Gm10985	TTCTCTCTCTCTCTCTCT	TTCTCTCTCTCTCTCT	3: 53,845,205		probably null	Het
Gm5113	G	A	7: 30,178,753	V89I	probably benign	Het
Gtf3c2	A	C	5: 31,169,836	L382R	probably benign	Het
Hhip	T	C	8: 80,051,604	N99S	probably damaging	Het
Hist1h3b	T	C	13: 23,752,410	S11P	probably benign	Het
Htr5b	T	C	1: 121,510,498	I335V	probably benign	Het
Ifi206	A	G	1: 173,481,357	S358P	unknown	Het
Loxhd1	T	A	18: 77,431,177	V1893D	probably damaging	Het
Mical2	A	G	7: 112,346,761	R11G	probably damaging	Het
Mrc1	T	C	2: 14,261,337		probably null	Het
Npr1	T	C	3: 90,456,253	N821S	probably benign	Het
Olfr1279	A	G	2: 111,306,745	D180G	probably damaging	Het
Olfr487	T	C	7: 108,212,463	D22G	probably benign	Het
Olfr495	T	G	7: 108,395,537	M139R	probably damaging	Het
Olfr628	A	G	7: 103,732,342	T139A	possibly damaging	Het
Pi4ka	T	A	16: 17,325,988	D739V	probably damaging	Het
Pi4ka	A	G	16: 17,376,982	L184P	possibly damaging	Het
Ptprd	T	C	4: 76,325,140		probably null	Het
Ralgapb	G	A	2: 158,436,566	G5R	probably damaging	Het
Ric8b	T	C	10: 84,947,527	V83A	probably damaging	Het
Sdc2	C	A	15: 33,028,135	T133K	probably damaging	Het
Slc12a7	T	A	13: 73,798,969	V592D	probably damaging	Het
Sorcs1	G	T	19: 50,176,122	Y990*	probably null	Het
Spata13	G	T	14: 60,691,463	G157W	probably damaging	Het
Tada1	A	G	1: 166,389,972	N226S	probably benign	Het
Tenm3	A	G	8: 48,646,256		probably null	Het
Tll1	A	G	8: 64,071,281	V457A	probably benign	Het
Tmem232	T	C	17: 65,500,124	K25E	possibly damaging	Het
Tnrc18	T	C	5: 142,787,308	S406G	unknown	Het
Ush2a	A	G	1: 188,356,834	M329V	probably benign	Het
Vmn2r73	A	G	7: 85,870,355	M465T	probably benign	Het
Wwc2	A	G	8: 47,900,791	Y103H	possibly damaging	Het
Zfp217	T	C	2: 170,116,258	D463G	probably damaging	Het
Zfp345	T	C	2: 150,473,354	S88G	probably damaging	Het
Zfp975	A	C	7: 42,662,030	N386K	probably benign	Het

Other mutations in Vmn2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01402:Vmn2r107	APN	17	20375747	missense	probably damaging	0.98
IGL01768:Vmn2r107	APN	17	20345606	missense	probably benign	0.32
IGL02086:Vmn2r107	APN	17	20357800	missense	probably benign	0.00
IGL02136:Vmn2r107	APN	17	20374906	missense	probably benign	0.02
IGL02266:Vmn2r107	APN	17	20356777	missense	probably damaging	1.00
IGL02285:Vmn2r107	APN	17	20375561	missense	probably damaging	1.00
IGL02724:Vmn2r107	APN	17	20356744	missense	possibly damaging	0.49
IGL02998:Vmn2r107	APN	17	20357755	missense	probably damaging	0.99
IGL03089:Vmn2r107	APN	17	20375712	missense	probably benign	0.05
IGL03284:Vmn2r107	APN	17	20356911	missense	probably benign	0.07
IGL03307:Vmn2r107	APN	17	20356776	missense	probably benign	0.09
IGL03399:Vmn2r107	APN	17	20357958	splice site	probably benign
3-1:Vmn2r107	UTSW	17	20345504	missense	probably benign
BB006:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
BB016:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R0285:Vmn2r107	UTSW	17	20345611	missense	probably benign	0.00
R0455:Vmn2r107	UTSW	17	20374823	splice site	probably benign
R0497:Vmn2r107	UTSW	17	20375132	missense	probably damaging	1.00
R0506:Vmn2r107	UTSW	17	20357759	missense	probably benign
R0621:Vmn2r107	UTSW	17	20374990	missense	probably benign	0.01
R0667:Vmn2r107	UTSW	17	20355654	missense	possibly damaging	0.91
R1118:Vmn2r107	UTSW	17	20356598	missense	probably benign	0.03
R1204:Vmn2r107	UTSW	17	20357769	missense	probably benign
R1237:Vmn2r107	UTSW	17	20356685	nonsense	probably null
R1485:Vmn2r107	UTSW	17	20374847	missense	possibly damaging	0.95
R1783:Vmn2r107	UTSW	17	20356513	missense	possibly damaging	0.51
R1873:Vmn2r107	UTSW	17	20345578	missense	probably benign	0.10
R1974:Vmn2r107	UTSW	17	20355617	splice site	probably null
R2009:Vmn2r107	UTSW	17	20375467	missense	probably benign	0.01
R2029:Vmn2r107	UTSW	17	20375287	missense	probably benign	0.01
R2164:Vmn2r107	UTSW	17	20375642	missense	probably damaging	1.00
R2269:Vmn2r107	UTSW	17	20375555	missense	possibly damaging	0.58
R3087:Vmn2r107	UTSW	17	20360345	missense	probably benign	0.03
R3740:Vmn2r107	UTSW	17	20374889	missense	probably benign	0.00
R3961:Vmn2r107	UTSW	17	20375455	missense	probably damaging	1.00
R4031:Vmn2r107	UTSW	17	20375221	missense	probably benign	0.00
R4270:Vmn2r107	UTSW	17	20355779	missense	probably benign
R4963:Vmn2r107	UTSW	17	20375141	missense	probably damaging	1.00
R5121:Vmn2r107	UTSW	17	20355753	missense	probably benign	0.01
R5640:Vmn2r107	UTSW	17	20375164	missense	probably damaging	1.00
R6007:Vmn2r107	UTSW	17	20375054	missense	probably benign	0.19
R6238:Vmn2r107	UTSW	17	20345587	missense	probably benign	0.43
R6298:Vmn2r107	UTSW	17	20355782	missense	probably benign	0.00
R6467:Vmn2r107	UTSW	17	20375677	missense	probably damaging	0.99
R6726:Vmn2r107	UTSW	17	20375375	missense	probably damaging	0.96
R7299:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7301:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7375:Vmn2r107	UTSW	17	20355876	missense	probably benign
R7448:Vmn2r107	UTSW	17	20375732	missense	probably benign	0.00
R7495:Vmn2r107	UTSW	17	20375009	missense	possibly damaging	0.71
R7589:Vmn2r107	UTSW	17	20375372	missense	probably benign	0.05
R7594:Vmn2r107	UTSW	17	20360373	missense	probably benign	0.03
R7678:Vmn2r107	UTSW	17	20356639	missense	probably benign	0.01
R7929:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R7974:Vmn2r107	UTSW	17	20357008	missense	probably benign	0.00
R8040:Vmn2r107	UTSW	17	20375546	missense	probably damaging	1.00
R8263:Vmn2r107	UTSW	17	20360352	missense	probably damaging	1.00
R8426:Vmn2r107	UTSW	17	20356977	missense	possibly damaging	0.91
R9175:Vmn2r107	UTSW	17	20356789	missense	possibly damaging	0.79
R9537:Vmn2r107	UTSW	17	20374887	missense	probably benign	0.00
R9642:Vmn2r107	UTSW	17	20360399	missense	probably damaging	1.00
R9711:Vmn2r107	UTSW	17	20357000	missense	probably damaging	1.00
X0022:Vmn2r107	UTSW	17	20356968	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- TGGGTCATGAACATTGAACCC -3'
(R):5'- CCTGCCATGGAAAGAACTCC -3'

Sequencing Primer
(F):5'- TCATGTTAGATTCATTCCATGGAAG -3'
(R):5'- GGAAAGAACTCCATCCCTTCTTC -3'

Posted On

2018-08-29