Incidental Mutation 'R6784:Or51t4'
ID 531561
Institutional Source Beutler Lab
Gene Symbol Or51t4
Ensembl Gene ENSMUSG00000045824
Gene Name olfactory receptor family 51 subfamily T member 4
Synonyms GA_x6K02T2PBJ9-5659738-5660748, MOR14-9, Olfr574
MMRRC Submission 044898-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.175) question?
Stock # R6784 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 102597674-102598714 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 102597722 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 17 (T17S)
Ref Sequence ENSEMBL: ENSMUSP00000095815 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052997] [ENSMUST00000211329] [ENSMUST00000213477] [ENSMUST00000216420]
AlphaFold F8VQ18
Predicted Effect possibly damaging
Transcript: ENSMUST00000052997
AA Change: T17S

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000095815
Gene: ENSMUSG00000045824
AA Change: T17S

DomainStartEndE-ValueType
low complexity region 14 31 N/A INTRINSIC
Pfam:7tm_4 44 323 3.8e-96 PFAM
Pfam:7TM_GPCR_Srsx 48 195 1.2e-8 PFAM
Pfam:7tm_1 54 305 2e-17 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000211329
AA Change: T7S
Predicted Effect probably benign
Transcript: ENSMUST00000213477
Predicted Effect probably benign
Transcript: ENSMUST00000216420
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 96.2%
Validation Efficiency 98% (46/47)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass C T 6: 23,093,895 (GRCm39) S142N probably null Het
Aida A G 1: 183,103,346 (GRCm39) Y275C probably damaging Het
Arrdc4 A G 7: 68,398,594 (GRCm39) I74T probably benign Het
C1ql4 A G 15: 98,985,290 (GRCm39) V107A probably benign Het
Ccnh T C 13: 85,360,884 (GRCm39) V284A probably benign Het
Cd180 A G 13: 102,839,213 (GRCm39) E32G probably damaging Het
Chd6 T C 2: 160,808,174 (GRCm39) D1680G probably damaging Het
Cog7 A T 7: 121,563,516 (GRCm39) probably null Het
Cyp2j6 T A 4: 96,423,741 (GRCm39) Q209L possibly damaging Het
Dars1 A T 1: 128,319,084 (GRCm39) V116E probably damaging Het
Dnah10 A G 5: 124,854,890 (GRCm39) K1932E probably damaging Het
Dock9 A G 14: 121,780,926 (GRCm39) S2086P probably damaging Het
Espl1 C G 15: 102,207,660 (GRCm39) R375G probably benign Het
Fer1l6 C T 15: 58,443,275 (GRCm39) S526L possibly damaging Het
Galnt9 G A 5: 110,768,465 (GRCm39) R587H probably damaging Het
Gigyf2 G T 1: 87,371,396 (GRCm39) V1170L probably damaging Het
Gm14412 G T 2: 177,009,133 (GRCm39) T41K probably benign Het
Gm45861 A G 8: 27,990,086 (GRCm39) probably null Het
H2bc4 T C 13: 23,868,483 (GRCm39) I90T probably damaging Het
Hoxc5 A G 15: 102,922,322 (GRCm39) probably benign Het
Jkampl A T 6: 73,445,918 (GRCm39) Y210* probably null Het
Klra1 T C 6: 130,349,817 (GRCm39) D207G probably benign Het
Lancl2 A G 6: 57,680,240 (GRCm39) N57D probably benign Het
Map2k4 T C 11: 65,582,577 (GRCm39) probably benign Het
Mgat3 G T 15: 80,096,401 (GRCm39) Q409H probably damaging Het
Mpp3 T A 11: 101,892,974 (GRCm39) probably null Het
Myh1 T A 11: 67,105,396 (GRCm39) L1062Q probably damaging Het
Nebl T A 2: 17,439,725 (GRCm39) K183* probably null Het
Npat G C 9: 53,469,458 (GRCm39) D315H probably damaging Het
Nt5c2 A G 19: 46,912,766 (GRCm39) V63A probably damaging Het
Opn1sw T A 6: 29,379,846 (GRCm39) E129D probably damaging Het
Or10ag2 C T 2: 87,248,796 (GRCm39) R135C probably benign Het
Or1e29 T G 11: 73,667,676 (GRCm39) H159P probably damaging Het
Or5p1 A T 7: 107,916,989 (GRCm39) D296V probably damaging Het
Prdm16 T C 4: 154,407,764 (GRCm39) Y1153C probably damaging Het
Prdm6 T A 18: 53,669,698 (GRCm39) D105E probably benign Het
Pwwp4c C T X: 73,684,021 (GRCm39) R355H probably damaging Homo
Rbm27 T C 18: 42,434,929 (GRCm39) M331T probably benign Het
S1pr1 A G 3: 115,505,710 (GRCm39) Y295H probably damaging Het
Sgpp1 G C 12: 75,782,243 (GRCm39) P32R probably benign Het
Sla2 C T 2: 156,725,589 (GRCm39) S3N unknown Het
Slc10a6 A G 5: 103,776,896 (GRCm39) I68T probably damaging Het
Slc5a1 T C 5: 33,315,460 (GRCm39) F493S probably benign Het
Snx14 A T 9: 88,263,845 (GRCm39) Y847N probably benign Het
Tmc1 A G 19: 20,805,015 (GRCm39) probably null Het
Vps8 C A 16: 21,381,957 (GRCm39) Q1130K probably benign Het
Other mutations in Or51t4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01154:Or51t4 APN 7 102,598,046 (GRCm39) missense probably damaging 1.00
IGL01732:Or51t4 APN 7 102,598,446 (GRCm39) missense probably damaging 1.00
IGL02185:Or51t4 APN 7 102,597,721 (GRCm39) missense probably damaging 0.96
PIT4382001:Or51t4 UTSW 7 102,598,656 (GRCm39) missense probably benign
PIT4520001:Or51t4 UTSW 7 102,597,921 (GRCm39) missense probably damaging 1.00
R0765:Or51t4 UTSW 7 102,597,939 (GRCm39) missense probably damaging 1.00
R1616:Or51t4 UTSW 7 102,597,721 (GRCm39) missense probably damaging 0.96
R2041:Or51t4 UTSW 7 102,598,170 (GRCm39) missense probably damaging 0.98
R2079:Or51t4 UTSW 7 102,598,702 (GRCm39) missense probably benign 0.00
R2261:Or51t4 UTSW 7 102,598,464 (GRCm39) missense probably damaging 1.00
R2263:Or51t4 UTSW 7 102,598,464 (GRCm39) missense probably damaging 1.00
R2513:Or51t4 UTSW 7 102,598,700 (GRCm39) missense probably benign
R2903:Or51t4 UTSW 7 102,598,661 (GRCm39) missense probably benign 0.05
R4445:Or51t4 UTSW 7 102,598,005 (GRCm39) missense possibly damaging 0.93
R4512:Or51t4 UTSW 7 102,597,945 (GRCm39) missense probably damaging 1.00
R4513:Or51t4 UTSW 7 102,597,945 (GRCm39) missense probably damaging 1.00
R4528:Or51t4 UTSW 7 102,598,013 (GRCm39) missense probably damaging 1.00
R4904:Or51t4 UTSW 7 102,598,272 (GRCm39) missense probably damaging 1.00
R5935:Or51t4 UTSW 7 102,598,017 (GRCm39) missense probably benign 0.01
R6889:Or51t4 UTSW 7 102,597,975 (GRCm39) missense possibly damaging 0.94
R7082:Or51t4 UTSW 7 102,598,455 (GRCm39) missense probably damaging 1.00
R7125:Or51t4 UTSW 7 102,598,386 (GRCm39) missense probably damaging 0.99
R7549:Or51t4 UTSW 7 102,597,798 (GRCm39) missense possibly damaging 0.92
R7564:Or51t4 UTSW 7 102,598,473 (GRCm39) missense probably damaging 1.00
R7947:Or51t4 UTSW 7 102,598,278 (GRCm39) missense probably damaging 1.00
R8460:Or51t4 UTSW 7 102,598,531 (GRCm39) nonsense probably null
R8518:Or51t4 UTSW 7 102,597,804 (GRCm39) missense probably damaging 1.00
R8859:Or51t4 UTSW 7 102,598,373 (GRCm39) missense probably damaging 1.00
R9116:Or51t4 UTSW 7 102,598,527 (GRCm39) missense possibly damaging 0.87
R9327:Or51t4 UTSW 7 102,597,687 (GRCm39) missense probably benign 0.00
R9408:Or51t4 UTSW 7 102,598,443 (GRCm39) missense probably damaging 1.00
Z1177:Or51t4 UTSW 7 102,597,959 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGCTAAACTTGAAAGCAAAAGCTC -3'
(R):5'- ACATGGGCTTGTGGAGACTC -3'

Sequencing Primer
(F):5'- CCAGGCACTAGCAAAAATGGTTTAAG -3'
(R):5'- GTGGAGACTCCGTTCAATGATAATG -3'
Posted On 2018-08-29