Incidental Mutation 'R6785:Or1j10'
ID 531594
Institutional Source Beutler Lab
Gene Symbol Or1j10
Ensembl Gene ENSMUSG00000068950
Gene Name olfactory receptor family 1 subfamily J member 10
Synonyms GA_x6K02T2NLDC-33070879-33071799, Olfr338, MOR136-5
MMRRC Submission 044899-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R6785 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 36266790-36267710 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 36266854 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Arginine at position 22 (Q22R)
Ref Sequence ENSEMBL: ENSMUSP00000149146 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072114] [ENSMUST00000091006] [ENSMUST00000217511]
AlphaFold Q8VGK6
Predicted Effect probably benign
Transcript: ENSMUST00000072114
AA Change: Q22R

PolyPhen 2 Score 0.121 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000071985
Gene: ENSMUSG00000068950
AA Change: Q22R

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.3e-57 PFAM
Pfam:7TM_GPCR_Srsx 35 305 3.8e-8 PFAM
Pfam:7tm_1 41 290 1.1e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000091006
AA Change: Q22R

PolyPhen 2 Score 0.121 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000088528
Gene: ENSMUSG00000068950
AA Change: Q22R

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 3.9e-56 PFAM
Pfam:7tm_1 39 288 4.5e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217511
AA Change: Q22R

PolyPhen 2 Score 0.121 (Sensitivity: 0.93; Specificity: 0.86)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.3%
Validation Efficiency 98% (59/60)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi1 A G 2: 22,843,479 (GRCm39) V316A probably benign Het
Acad12 T C 5: 121,747,908 (GRCm39) Y170C probably damaging Het
Acss2 T C 2: 155,402,605 (GRCm39) V587A probably damaging Het
Adamtsl3 A G 7: 82,171,212 (GRCm39) I422V probably damaging Het
Aldh18a1 A G 19: 40,556,788 (GRCm39) L375P probably damaging Het
B020011L13Rik A G 1: 117,728,799 (GRCm39) D102G possibly damaging Het
Cfap74 T A 4: 155,538,481 (GRCm39) probably benign Het
Coa4 G A 7: 100,188,460 (GRCm39) V58M probably damaging Het
Crybg1 T C 10: 43,875,167 (GRCm39) N647S probably benign Het
Dync1h1 G A 12: 110,596,113 (GRCm39) G1547S probably damaging Het
Espnl A G 1: 91,249,943 (GRCm39) D30G probably benign Het
Fasl T A 1: 161,609,404 (GRCm39) Y194F probably benign Het
Fbxw8 T C 5: 118,230,754 (GRCm39) E349G probably damaging Het
Gen1 A G 12: 11,312,531 (GRCm39) V13A possibly damaging Het
Gm4559 A G 7: 141,827,845 (GRCm39) C86R unknown Het
H2-M9 T C 17: 36,953,125 (GRCm39) N61D probably damaging Het
H6pd C T 4: 150,067,247 (GRCm39) E380K possibly damaging Het
Herc1 TCCC TCC 9: 66,408,470 (GRCm39) probably null Het
Hnrnpd C A 5: 100,126,283 (GRCm39) K67N probably benign Het
Hspg2 T C 4: 137,235,709 (GRCm39) S170P probably damaging Het
Igsf10 G T 3: 59,226,665 (GRCm39) P2336Q probably damaging Het
Itih3 C T 14: 30,634,572 (GRCm39) probably null Het
Katnb1 T C 8: 95,822,270 (GRCm39) Y298H probably benign Het
Kif21a A T 15: 90,819,933 (GRCm39) N1610K probably damaging Het
Lce1l A T 3: 92,757,500 (GRCm39) C119* probably null Het
Lcn2 C T 2: 32,277,039 (GRCm39) probably null Het
Lmf2 A T 15: 89,236,236 (GRCm39) S588T probably benign Het
Mboat7 A G 7: 3,688,835 (GRCm39) L231P probably benign Het
Mier2 T C 10: 79,380,547 (GRCm39) R288G probably damaging Het
Mybbp1a T C 11: 72,338,392 (GRCm39) V694A probably benign Het
Ndnf C A 6: 65,680,047 (GRCm39) L109I probably benign Het
Nfkb1 C A 3: 135,321,064 (GRCm39) E230D probably benign Het
Nostrin A G 2: 69,014,271 (GRCm39) K409R probably benign Het
Or8k35 T A 2: 86,424,765 (GRCm39) M136L probably damaging Het
Pdpr C A 8: 111,851,243 (GRCm39) T534N probably benign Het
Plekhf1 G A 7: 37,921,488 (GRCm39) Q27* probably null Het
Ppp6c A T 2: 39,087,593 (GRCm39) H204Q probably benign Het
Prrc2c T C 1: 162,536,670 (GRCm39) probably benign Het
Prrg2 A G 7: 44,709,649 (GRCm39) F83L probably damaging Het
Rab11fip3 T G 17: 26,210,692 (GRCm39) D938A probably damaging Het
Rai1 A G 11: 60,079,620 (GRCm39) N1228S probably benign Het
Ryr1 G T 7: 28,764,299 (GRCm39) T3060K probably benign Het
Scube2 A G 7: 109,409,824 (GRCm39) I557T probably benign Het
Setdb1 C A 3: 95,233,712 (GRCm39) R1066L probably benign Het
Shoc1 T C 4: 59,049,066 (GRCm39) M1100V probably benign Het
Slc35f3 T C 8: 127,121,198 (GRCm39) V353A probably benign Het
Slfn3 A T 11: 83,105,427 (GRCm39) T475S possibly damaging Het
Snrnp200 T A 2: 127,071,085 (GRCm39) M1122K possibly damaging Het
Tead4 T A 6: 128,219,444 (GRCm39) K223* probably null Het
Tex2 A C 11: 106,424,776 (GRCm39) I334R probably damaging Het
Tfdp1 C T 8: 13,420,485 (GRCm39) R105W probably damaging Het
Tfdp1 G T 8: 13,427,233 (GRCm39) V393F possibly damaging Het
Thsd7b T C 1: 129,358,644 (GRCm39) L26P probably damaging Het
Trim80 T C 11: 115,332,027 (GRCm39) I73T probably damaging Het
Tssk4 T A 14: 55,887,932 (GRCm39) Y43N probably damaging Het
Ttn T C 2: 76,541,839 (GRCm39) T25389A probably damaging Het
Ttn A T 2: 76,578,288 (GRCm39) F24202I probably damaging Het
Vmn1r177 A G 7: 23,565,562 (GRCm39) S105P probably damaging Het
Vmn2r40 T A 7: 8,911,203 (GRCm39) T697S probably benign Het
Zfp267 T A 3: 36,219,601 (GRCm39) C541* probably null Het
Other mutations in Or1j10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Or1j10 APN 2 36,266,928 (GRCm39) missense probably damaging 0.99
IGL01089:Or1j10 APN 2 36,267,178 (GRCm39) missense probably damaging 1.00
IGL01298:Or1j10 APN 2 36,267,460 (GRCm39) missense probably benign 0.01
IGL01300:Or1j10 APN 2 36,267,054 (GRCm39) missense probably benign 0.13
IGL01632:Or1j10 APN 2 36,267,576 (GRCm39) missense probably benign 0.02
IGL02480:Or1j10 APN 2 36,267,504 (GRCm39) missense probably damaging 0.98
IGL02519:Or1j10 APN 2 36,267,325 (GRCm39) missense possibly damaging 0.84
IGL02658:Or1j10 APN 2 36,267,072 (GRCm39) missense probably damaging 0.97
IGL02716:Or1j10 APN 2 36,267,355 (GRCm39) missense possibly damaging 0.88
IGL02983:Or1j10 APN 2 36,267,649 (GRCm39) missense probably damaging 1.00
IGL03334:Or1j10 APN 2 36,267,063 (GRCm39) missense possibly damaging 0.66
IGL03054:Or1j10 UTSW 2 36,266,944 (GRCm39) missense possibly damaging 0.65
R0469:Or1j10 UTSW 2 36,267,474 (GRCm39) missense probably benign 0.02
R1263:Or1j10 UTSW 2 36,267,006 (GRCm39) missense probably damaging 0.99
R1500:Or1j10 UTSW 2 36,267,633 (GRCm39) missense probably benign 0.04
R2444:Or1j10 UTSW 2 36,267,625 (GRCm39) missense possibly damaging 0.59
R5571:Or1j10 UTSW 2 36,267,129 (GRCm39) missense probably benign 0.01
R5999:Or1j10 UTSW 2 36,267,322 (GRCm39) missense probably damaging 1.00
R6030:Or1j10 UTSW 2 36,267,556 (GRCm39) missense probably damaging 0.97
R6030:Or1j10 UTSW 2 36,267,556 (GRCm39) missense probably damaging 0.97
R6351:Or1j10 UTSW 2 36,267,208 (GRCm39) missense possibly damaging 0.78
R6695:Or1j10 UTSW 2 36,267,117 (GRCm39) missense probably benign 0.28
R6785:Or1j10 UTSW 2 36,266,963 (GRCm39) nonsense probably null
R7795:Or1j10 UTSW 2 36,267,453 (GRCm39) missense probably benign 0.05
R7814:Or1j10 UTSW 2 36,266,821 (GRCm39) missense possibly damaging 0.48
R7878:Or1j10 UTSW 2 36,267,145 (GRCm39) missense probably damaging 1.00
R8820:Or1j10 UTSW 2 36,267,006 (GRCm39) missense probably damaging 1.00
R8952:Or1j10 UTSW 2 36,267,402 (GRCm39) missense probably benign 0.01
R9512:Or1j10 UTSW 2 36,267,325 (GRCm39) missense possibly damaging 0.84
R9676:Or1j10 UTSW 2 36,266,848 (GRCm39) missense probably benign 0.01
R9705:Or1j10 UTSW 2 36,266,962 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GCTCATGATGAAAGTCTTCCTATTTGG -3'
(R):5'- ACGAGCATCTTTGGAGCTG -3'

Sequencing Primer
(F):5'- GTCTTCCTATTTGGATTAAAACACCC -3'
(R):5'- CTTTGGAGCTGTGACTGATGAGAAAG -3'
Posted On 2018-08-29