Mutagenetix > Incidental Mutations

Incidental Mutation 'R6762:Taar2'

531747

Institutional Source

Beutler Lab

Gene Symbol

Taar2

Ensembl Gene

ENSMUSG00000059763

Gene Name

trace amine-associated receptor 2

Synonyms

Gpr58

MMRRC Submission

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6762 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

23938572-23941583 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 23941402 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Methionine at position 280 (T280M)

Ref Sequence

ENSEMBL: ENSMUSP00000078137 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079134]

Predicted Effect

probably damaging
Transcript: ENSMUST00000079134
AA Change: T280M

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000078137
Gene: ENSMUSG00000059763
AA Change: T280M

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	42	318	2.4e-10	PFAM
Pfam:7tm_1	48	303	2.9e-54	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.4%
20x: 95.7%

Validation Efficiency

100% (45/45)

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ackr4	A	G	9: 104,099,668	Y27H	probably benign	Het
Angptl3	T	A	4: 99,037,417	S327T	possibly damaging	Het
Arl6ip4	GGAAGAAGAAGAAGAAGAA	GGAAGAAGAAGAAGAAGAAGAA	5: 124,117,050		probably benign	Het
Cyp2s1	A	T	7: 25,808,070	L318H	probably damaging	Het
Dnah14	T	C	1: 181,757,259	L3185P	probably damaging	Het
Dnah7b	T	C	1: 46,224,742	V2128A	probably benign	Het
Ehhadh	A	T	16: 21,762,459	F594L	probably benign	Het
En2	A	G	5: 28,170,353	N298S	possibly damaging	Het
Epha5	T	A	5: 84,331,726	N140Y	probably damaging	Het
Fam151b	C	T	13: 92,468,050	V144I	possibly damaging	Het
Fanca	C	A	8: 123,271,303	A1215S	probably benign	Het
Fancd2	T	A	6: 113,586,016		probably null	Het
Fat2	T	C	11: 55,253,482		probably null	Het
Gm4513	T	C	7: 20,594,193	N31S	probably benign	Het
Hspg2	A	T	4: 137,551,803	I3066F	possibly damaging	Het
Krt10	T	C	11: 99,387,057	T355A	possibly damaging	Het
Lims1	C	A	10: 58,412,545	H275N	probably damaging	Het
Map3k19	C	T	1: 127,847,264	G112D	probably damaging	Het
Mdn1	T	A	4: 32,676,786	N619K	possibly damaging	Het
Mpp6	T	A	6: 50,180,438		probably null	Het
Mtor	A	G	4: 148,538,481	T1977A	possibly damaging	Het
Nos2	T	G	11: 78,959,748	L1144R	possibly damaging	Het
Olfr1085	A	T	2: 86,657,844	F205I	probably benign	Het
Olfr608	G	C	7: 103,470,389	V117L	probably benign	Het
Olfr780	G	A	10: 129,322,256	C211Y	probably damaging	Het
Pcdhga9	C	A	18: 37,737,268	S50Y	probably damaging	Het
Pfn4	T	A	12: 4,775,487	M108K	probably damaging	Het
Prep	T	C	10: 45,148,123		probably null	Het
Qtrt1	T	A	9: 21,412,082	H76Q	probably damaging	Het
Rpa1	T	A	11: 75,340,345	S73C	possibly damaging	Het
Senp5	A	G	16: 31,989,884	V157A	probably damaging	Het
Snapc3	T	C	4: 83,435,258	L178P	probably damaging	Het
Sptbn4	A	G	7: 27,394,208	F1340L	probably damaging	Het
Srd5a3	T	A	5: 76,153,551	I85K	probably benign	Het
Tgfb3	T	C	12: 86,069,463	D177G	probably benign	Het
Tpt1	A	G	14: 75,846,381	D94G	probably benign	Het
Trpm4	A	G	7: 45,304,816		probably benign	Het
Trpv4	C	T	5: 114,625,110	R746H	probably benign	Het
Txndc2	T	C	17: 65,638,972	D70G	probably damaging	Het
Ugcg	T	A	4: 59,219,530	I289N	possibly damaging	Het
Vmn2r2	C	G	3: 64,134,449	D282H	probably damaging	Het
Vmn2r50	A	T	7: 10,053,083	N32K	probably benign	Het
Wdpcp	C	T	11: 21,721,244	T495I	probably benign	Het
Zfp961	T	A	8: 71,966,114	C51S	possibly damaging	Het
Zxdc	C	T	6: 90,382,183	A599V	probably benign	Het

Other mutations in Taar2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Taar2	APN	10	23941368	missense	possibly damaging	0.50
IGL00807:Taar2	APN	10	23940675	missense	probably benign	0.00
IGL01346:Taar2	APN	10	23941099	missense	probably damaging	1.00
IGL01433:Taar2	APN	10	23940759	missense	probably benign	0.02
IGL01782:Taar2	APN	10	23941144	missense	probably damaging	1.00
IGL03106:Taar2	APN	10	23941297	missense	probably damaging	0.99
IGL03372:Taar2	APN	10	23941171	missense	probably benign	0.03
R0046:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0046:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0090:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0101:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0101:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0103:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0157:Taar2	UTSW	10	23941491	missense	probably damaging	1.00
R0189:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0190:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0226:Taar2	UTSW	10	23941063	missense	probably damaging	1.00
R0226:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0265:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0267:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0349:Taar2	UTSW	10	23941429	missense	possibly damaging	0.79
R0349:Taar2	UTSW	10	23941509	missense	probably benign	0.01
R0426:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0556:Taar2	UTSW	10	23940895	missense	probably damaging	1.00
R0698:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R1191:Taar2	UTSW	10	23941029	missense	probably damaging	1.00
R2919:Taar2	UTSW	10	23941556	missense	probably benign	0.00
R4615:Taar2	UTSW	10	23941365	missense	probably benign	0.43
R4658:Taar2	UTSW	10	23941503	missense	probably benign	0.04
R4766:Taar2	UTSW	10	23940771	missense	probably damaging	0.98
R4872:Taar2	UTSW	10	23940693	missense	probably benign	0.02
R5205:Taar2	UTSW	10	23940976	missense	probably benign	0.42
R5271:Taar2	UTSW	10	23941032	missense	probably damaging	0.97
R5517:Taar2	UTSW	10	23940729	missense	possibly damaging	0.92
R6033:Taar2	UTSW	10	23940976	missense	probably benign
R6033:Taar2	UTSW	10	23940976	missense	probably benign
R6325:Taar2	UTSW	10	23940717	missense	probably benign	0.05
R6398:Taar2	UTSW	10	23941279	missense	probably benign	0.00
R7121:Taar2	UTSW	10	23940827	missense	probably damaging	1.00
R7209:Taar2	UTSW	10	23940699	missense	possibly damaging	0.57
R7709:Taar2	UTSW	10	23940723	missense	probably benign	0.00
R8045:Taar2	UTSW	10	23941488	missense	probably damaging	1.00
R8223:Taar2	UTSW	10	23941350	missense	probably damaging	1.00
Z1176:Taar2	UTSW	10	23941186	missense	possibly damaging	0.94

Predicted Primers

PCR Primer
(F):5'- CGGCAAAATTTTCGCTGTATCC -3'
(R):5'- AGTGCCAGTCGTTGATGAC -3'

Sequencing Primer
(F):5'- ACGCTCGCGTAATTGAC -3'
(R):5'- GTCGTTGATGACTAGTACAGATCAAG -3'

Posted On

2018-08-29