Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00508:Psg25'

5320

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Psg25

Ensembl Gene

ENSMUSG00000070798

Gene Name

pregnancy-specific glycoprotein 25

Synonyms

cea13

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

IGL00508

Quality Score

Status

Chromosome

Chromosomal Location

18519702-18532269 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 18529731 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 56 (Y56H)

Ref Sequence

ENSEMBL: ENSMUSP00000092389 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094795]

Predicted Effect

probably benign
Transcript: ENSMUST00000094795
AA Change: Y56H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000092389
Gene: ENSMUSG00000070798
AA Change: Y56H

Domain	Start	End	E-Value	Type
IG	40	141	2.15e-3	SMART
IG	160	261	1.55e0	SMART
IG	280	381	3.59e-5	SMART
IGc2	397	461	1.02e-9	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	A	C	13: 81,506,187	D2188E	probably damaging	Het
Atrx	A	G	X: 105,823,799	S2026P	probably damaging	Het
Cacna1b	A	C	2: 24,657,289		probably null	Het
Cfap46	C	T	7: 139,660,689	S56N	probably damaging	Het
Cfap57	C	T	4: 118,581,170		probably null	Het
Ckap5	T	G	2: 91,606,256	V1567G	probably damaging	Het
Cyp2c38	A	T	19: 39,460,725	Y61*	probably null	Het
D130052B06Rik	A	G	11: 33,599,402	E7G	unknown	Het
Dhx38	A	G	8: 109,556,934	L527P	possibly damaging	Het
Dnaaf5	A	G	5: 139,177,946	N653D	probably benign	Het
Dnah8	T	G	17: 30,855,930	M4541R	probably damaging	Het
Dpyd	A	T	3: 119,064,987	T617S	probably benign	Het
Fpr2	A	T	17: 17,892,772	N10I	probably damaging	Het
Frmd4a	A	T	2: 4,594,734	K524*	probably null	Het
Gpr45	C	T	1: 43,032,292	P32S	possibly damaging	Het
H2-Eb2	A	T	17: 34,334,367	I176F	probably damaging	Het
Hcrtr1	T	A	4: 130,137,269	N74I	probably damaging	Het
Ifi47	C	T	11: 49,095,414	Q3*	probably null	Het
Krt8	T	A	15: 101,998,025	M350L	probably benign	Het
Lilra6	A	G	7: 3,911,554	S533P	probably benign	Het
Map1b	A	T	13: 99,429,233	S2327T	unknown	Het
Mcoln3	T	A	3: 146,133,928	I345N	probably damaging	Het
Mettl3	C	A	14: 52,294,979		probably benign	Het
Mgat4a	G	A	1: 37,449,123	R472*	probably null	Het
Micall1	A	G	15: 79,130,568	K715E	probably damaging	Het
Pak1	G	T	7: 97,854,568	G37C	probably benign	Het
Pomt2	T	G	12: 87,119,627	H426P	probably damaging	Het
Pou2f3	G	A	9: 43,139,963	P155S	probably benign	Het
Rab9	G	T	X: 166,457,864	Y150*	probably null	Het
Rhox2g	T	A	X: 37,642,810	N152I	probably damaging	Het
Sema6d	T	C	2: 124,656,924		probably benign	Het
Simc1	C	A	13: 54,525,176	Q446K	probably benign	Het
Svs2	G	T	2: 164,237,042	T315K	possibly damaging	Het
Syt9	C	T	7: 107,425,367	R156*	probably null	Het
Tmem260	A	T	14: 48,509,121	Y618F	probably damaging	Het
Wdr44	A	G	X: 23,800,544	I719V	possibly damaging	Het
Zfp518a	T	G	19: 40,913,470	I614M	probably damaging	Het

Other mutations in Psg25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00231:Psg25	APN	7	18526181	splice site	probably benign
IGL01154:Psg25	APN	7	18524699	missense	probably benign	0.01
IGL01388:Psg25	APN	7	18529665	missense	possibly damaging	0.87
IGL02222:Psg25	APN	7	18529727	missense	probably damaging	1.00
IGL02261:Psg25	APN	7	18521343	missense	probably benign	0.09
IGL02309:Psg25	APN	7	18526424	missense	probably damaging	0.98
IGL02803:Psg25	APN	7	18526287	missense	possibly damaging	0.47
IGL03334:Psg25	APN	7	18529774	missense	probably benign	0.01
R0711:Psg25	UTSW	7	18529560	nonsense	probably null
R1458:Psg25	UTSW	7	18529587	missense	probably damaging	1.00
R1598:Psg25	UTSW	7	18532003	nonsense	probably null
R2064:Psg25	UTSW	7	18521253	missense	probably damaging	0.96
R2066:Psg25	UTSW	7	18529562	missense	probably damaging	1.00
R4485:Psg25	UTSW	7	18526278	missense	probably damaging	1.00
R4499:Psg25	UTSW	7	18524891	missense	possibly damaging	0.89
R4514:Psg25	UTSW	7	18529608	nonsense	probably null
R4547:Psg25	UTSW	7	18524704	missense	probably damaging	1.00
R4604:Psg25	UTSW	7	18529803	missense	probably benign	0.05
R4886:Psg25	UTSW	7	18524913	missense	probably benign	0.00
R5121:Psg25	UTSW	7	18526536	missense	possibly damaging	0.68
R5208:Psg25	UTSW	7	18526535	missense	probably benign	0.00
R5267:Psg25	UTSW	7	18524786	missense	possibly damaging	0.78
R5376:Psg25	UTSW	7	18526535	missense	probably benign	0.00
R5425:Psg25	UTSW	7	18524784	nonsense	probably null
R5749:Psg25	UTSW	7	18524851	missense	probably damaging	1.00
R6050:Psg25	UTSW	7	18526478	missense	probably benign	0.37
R6862:Psg25	UTSW	7	18521398	missense	probably benign	0.03
R6962:Psg25	UTSW	7	18529754	missense	probably damaging	1.00
R7238:Psg25	UTSW	7	18532202	start gained	probably benign
R7782:Psg25	UTSW	7	18521302	missense	probably benign	0.15
R7812:Psg25	UTSW	7	18521168	missense	possibly damaging	0.71
R8155:Psg25	UTSW	7	18526520	missense	probably benign	0.00
R8775:Psg25	UTSW	7	18521228	missense	probably damaging	1.00
R8775-TAIL:Psg25	UTSW	7	18521228	missense	probably damaging	1.00
R8865:Psg25	UTSW	7	18529594	missense	possibly damaging	0.71
R9013:Psg25	UTSW	7	18524765	missense	probably benign	0.02
Z1088:Psg25	UTSW	7	18529591	missense	probably benign	0.00

Posted On

2012-04-20