Incidental Mutation 'R6769:Or5b120'
ID 532106
Institutional Source Beutler Lab
Gene Symbol Or5b120
Ensembl Gene ENSMUSG00000071629
Gene Name olfactory receptor family 5 subfamily B member 120
Synonyms Olfr1477, MOR202-10, GA_x6K02T2RE5P-3834960-3835907
MMRRC Submission 044885-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R6769 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 13477910-13480656 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 13480318 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 204 (F204I)
Ref Sequence ENSEMBL: ENSMUSP00000149565 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000214274] [ENSMUST00000217001]
AlphaFold Q7TQQ7
Predicted Effect possibly damaging
Transcript: ENSMUST00000214274
AA Change: F204I

PolyPhen 2 Score 0.831 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217001
AA Change: F204I

PolyPhen 2 Score 0.831 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 95.9%
Validation Efficiency 98% (39/40)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd8 G T 8: 71,914,105 (GRCm39) H174Q probably damaging Het
Alox5 C A 6: 116,392,145 (GRCm39) probably null Het
Amer3 C A 1: 34,627,330 (GRCm39) A523D possibly damaging Het
Apoa4 G A 9: 46,154,465 (GRCm39) M355I probably benign Het
Atp10b T C 11: 43,094,079 (GRCm39) probably null Het
Atp9a A T 2: 168,516,820 (GRCm39) Y340N probably damaging Het
C1rb T G 6: 124,554,364 (GRCm39) S382A probably benign Het
Csmd1 A G 8: 16,121,408 (GRCm39) V1763A possibly damaging Het
Ctnnd1 C A 2: 84,450,269 (GRCm39) R317L probably damaging Het
Ctnnd1 A T 2: 84,450,454 (GRCm39) D255E probably damaging Het
Dipk1b A G 2: 26,524,875 (GRCm39) R92G probably benign Het
Dmxl2 A T 9: 54,323,808 (GRCm39) I1192N probably damaging Het
Efcab5 A G 11: 76,996,258 (GRCm39) V1101A probably damaging Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Flg T C 3: 93,195,630 (GRCm39) probably benign Het
Fras1 A G 5: 96,746,800 (GRCm39) I623M possibly damaging Het
Gm7361 T A 5: 26,462,767 (GRCm39) L3* probably null Het
Gpr35 T A 1: 92,910,426 (GRCm39) M46K probably damaging Het
Ighv2-9 A T 12: 113,842,930 (GRCm39) F46I possibly damaging Het
Kdm4b C T 17: 56,658,754 (GRCm39) A33V possibly damaging Het
Klhl5 T A 5: 65,321,995 (GRCm39) Y534N probably damaging Het
Mccc1 C T 3: 36,043,992 (GRCm39) probably null Het
Memo1 A T 17: 74,508,273 (GRCm39) F270L probably damaging Het
Mnat1 A G 12: 73,319,196 (GRCm39) N273S probably benign Het
Niban2 C T 2: 32,785,666 (GRCm39) Het
Nxpe3 C A 16: 55,686,471 (GRCm39) G179V probably damaging Het
Otp A G 13: 95,012,294 (GRCm39) D6G probably damaging Het
Prdm5 T A 6: 65,839,920 (GRCm39) I265K probably damaging Het
Ptpn4 T A 1: 119,643,698 (GRCm39) N350I probably benign Het
Rassf10 A G 7: 112,553,635 (GRCm39) M79V probably benign Het
Rassf4 T A 6: 116,618,433 (GRCm39) D215V possibly damaging Het
Rbm12 A T 2: 155,939,375 (GRCm39) I299N possibly damaging Het
Scfd2 T C 5: 74,692,117 (GRCm39) H55R probably benign Het
Scn8a A G 15: 100,933,445 (GRCm39) N1550D probably benign Het
Skic2 G A 17: 35,064,166 (GRCm39) R507* probably null Het
Slc30a5 A C 13: 100,950,368 (GRCm39) S240A probably benign Het
Slc7a4 A G 16: 17,393,184 (GRCm39) V205A possibly damaging Het
Syde2 G A 3: 145,704,803 (GRCm39) G318E probably damaging Het
Ttn T A 2: 76,538,883 (GRCm39) D34649V possibly damaging Het
Vmn2r83 T A 10: 79,313,856 (GRCm39) S155T probably damaging Het
Other mutations in Or5b120
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01926:Or5b120 APN 19 13,480,105 (GRCm39) missense possibly damaging 0.55
IGL02394:Or5b120 APN 19 13,480,228 (GRCm39) missense probably damaging 0.97
R0047:Or5b120 UTSW 19 13,479,953 (GRCm39) missense probably benign 0.30
R0047:Or5b120 UTSW 19 13,479,953 (GRCm39) missense probably benign 0.30
R0356:Or5b120 UTSW 19 13,480,441 (GRCm39) missense possibly damaging 0.74
R0617:Or5b120 UTSW 19 13,479,900 (GRCm39) missense probably damaging 1.00
R1589:Or5b120 UTSW 19 13,480,121 (GRCm39) missense probably benign 0.03
R1725:Or5b120 UTSW 19 13,479,883 (GRCm39) missense probably damaging 1.00
R2153:Or5b120 UTSW 19 13,479,852 (GRCm39) missense probably damaging 1.00
R2362:Or5b120 UTSW 19 13,479,872 (GRCm39) missense probably damaging 1.00
R3402:Or5b120 UTSW 19 13,480,312 (GRCm39) missense probably benign 0.11
R4513:Or5b120 UTSW 19 13,479,986 (GRCm39) missense probably benign 0.05
R5197:Or5b120 UTSW 19 13,479,748 (GRCm39) missense possibly damaging 0.68
R5205:Or5b120 UTSW 19 13,480,163 (GRCm39) missense probably damaging 1.00
R5511:Or5b120 UTSW 19 13,480,556 (GRCm39) missense probably benign 0.12
R5838:Or5b120 UTSW 19 13,479,922 (GRCm39) missense probably damaging 1.00
R6023:Or5b120 UTSW 19 13,480,067 (GRCm39) missense probably damaging 1.00
R6232:Or5b120 UTSW 19 13,480,427 (GRCm39) missense probably damaging 1.00
R6700:Or5b120 UTSW 19 13,480,177 (GRCm39) missense probably damaging 0.97
R6771:Or5b120 UTSW 19 13,480,318 (GRCm39) missense possibly damaging 0.83
R7002:Or5b120 UTSW 19 13,480,039 (GRCm39) missense probably benign 0.00
R7057:Or5b120 UTSW 19 13,480,243 (GRCm39) missense probably damaging 1.00
R7320:Or5b120 UTSW 19 13,480,544 (GRCm39) missense possibly damaging 0.89
R7827:Or5b120 UTSW 19 13,480,587 (GRCm39) missense probably damaging 1.00
R7913:Or5b120 UTSW 19 13,480,571 (GRCm39) missense probably damaging 1.00
R9199:Or5b120 UTSW 19 13,480,436 (GRCm39) missense probably damaging 1.00
R9286:Or5b120 UTSW 19 13,479,791 (GRCm39) missense possibly damaging 0.88
R9523:Or5b120 UTSW 19 13,479,712 (GRCm39) missense probably benign
R9606:Or5b120 UTSW 19 13,479,943 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CTATGACCGTCATGCAGCAG -3'
(R):5'- GAGCTGGGCTGTAAGTACATG -3'

Sequencing Primer
(F):5'- GACAACTACGATATGTGTCTTGC -3'
(R):5'- GGGCTGTAAGTACATGAAGATAATTG -3'
Posted On 2018-08-29