Incidental Mutation 'R6772:Zfp429'
ID 532219
Institutional Source Beutler Lab
Gene Symbol Zfp429
Ensembl Gene ENSMUSG00000078994
Gene Name zinc finger protein 429
Synonyms 2810487A22Rik
MMRRC Submission 044888-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R6772 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 67536024-67547938 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 67538317 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 376 (C376R)
Ref Sequence ENSEMBL: ENSMUSP00000105354 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109732] [ENSMUST00000181071] [ENSMUST00000224684] [ENSMUST00000224825]
AlphaFold Q7M6Y0
Predicted Effect probably damaging
Transcript: ENSMUST00000109732
AA Change: C376R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000105354
Gene: ENSMUSG00000078994
AA Change: C376R

DomainStartEndE-ValueType
KRAB 15 75 7.16e-34 SMART
ZnF_C2H2 119 141 5.12e1 SMART
ZnF_C2H2 147 169 2.27e-4 SMART
ZnF_C2H2 175 197 1.28e-3 SMART
ZnF_C2H2 203 225 1.56e-2 SMART
ZnF_C2H2 259 281 4.62e1 SMART
ZnF_C2H2 287 309 5.14e-3 SMART
ZnF_C2H2 315 337 6.78e-3 SMART
ZnF_C2H2 343 365 3.11e-2 SMART
ZnF_C2H2 371 393 1.25e-1 SMART
ZnF_C2H2 399 421 6.32e-3 SMART
ZnF_C2H2 427 449 1.47e-3 SMART
ZnF_C2H2 455 477 5.42e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000181071
SMART Domains Protein: ENSMUSP00000137755
Gene: ENSMUSG00000078994

DomainStartEndE-ValueType
KRAB 15 75 7.16e-34 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000224684
Predicted Effect probably benign
Transcript: ENSMUST00000224825
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.8%
  • 20x: 96.7%
Validation Efficiency 97% (36/37)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 A T 7: 120,126,276 (GRCm39) D1144V probably damaging Het
Ankrd13a A G 5: 114,939,804 (GRCm39) H477R probably benign Het
Anxa3 A T 5: 96,958,972 (GRCm39) I27F probably damaging Het
Aplf T C 6: 87,640,781 (GRCm39) E76G possibly damaging Het
Bbs1 A G 19: 4,956,618 (GRCm39) probably benign Het
Camk2a T C 18: 61,102,092 (GRCm39) S332P probably benign Het
Casz1 T A 4: 149,027,663 (GRCm39) F1013L probably damaging Het
Cd109 A T 9: 78,588,092 (GRCm39) I707F possibly damaging Het
Cd4 G A 6: 124,849,421 (GRCm39) T202I probably benign Het
Celsr1 A G 15: 85,914,983 (GRCm39) S997P probably benign Het
Cfap77 T C 2: 28,944,951 (GRCm39) T24A probably damaging Het
Dscaml1 G A 9: 45,621,609 (GRCm39) R1019H probably damaging Het
Epb41l4b C A 4: 57,063,140 (GRCm39) V517F probably benign Het
Exosc10 G A 4: 148,665,591 (GRCm39) D818N probably damaging Het
Furin C T 7: 80,043,240 (GRCm39) G324S probably damaging Het
Idh2 TCCCAGG T 7: 79,748,079 (GRCm39) probably benign Het
Ifi206 T C 1: 173,308,773 (GRCm39) M408V unknown Het
Kdm4a T C 4: 117,999,752 (GRCm39) probably null Het
Neo1 T A 9: 58,810,259 (GRCm39) Q1064L probably damaging Het
Nphp4 G A 4: 152,628,863 (GRCm39) V750I probably benign Het
Pcdhac1 T C 18: 37,223,289 (GRCm39) V34A probably benign Het
Pdk4 T C 6: 5,487,141 (GRCm39) I302V probably benign Het
Prl6a1 A G 13: 27,503,031 (GRCm39) D209G probably damaging Het
Pspn T C 17: 57,306,515 (GRCm39) Q138R probably benign Het
Ptgs2 A G 1: 149,977,829 (GRCm39) Y134C probably damaging Het
Rlbp1 G A 7: 79,033,798 (GRCm39) probably benign Het
Rpia T C 6: 70,762,532 (GRCm39) I108V probably benign Het
Tcaf1 A T 6: 42,652,210 (GRCm39) H757Q probably damaging Het
Ttc8 A C 12: 98,909,848 (GRCm39) S143R probably damaging Het
Uba6 A G 5: 86,294,932 (GRCm39) probably benign Het
Ubr4 A T 4: 139,194,541 (GRCm39) K4280* probably null Het
Vmn2r15 C A 5: 109,434,238 (GRCm39) S822I probably damaging Het
Vps53 A T 11: 76,070,324 (GRCm39) M1K probably null Het
Zfp362 A G 4: 128,684,053 (GRCm39) M18T possibly damaging Het
Zfyve9 T C 4: 108,496,466 (GRCm39) N1395S probably damaging Het
Zmynd8 T A 2: 165,649,521 (GRCm39) Q857H probably benign Het
Other mutations in Zfp429
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01160:Zfp429 APN 13 67,539,132 (GRCm39) missense probably damaging 0.96
IGL01913:Zfp429 APN 13 67,544,793 (GRCm39) missense probably damaging 1.00
IGL02343:Zfp429 APN 13 67,538,844 (GRCm39) missense probably damaging 0.98
IGL02679:Zfp429 APN 13 67,547,855 (GRCm39) intron probably benign
IGL03396:Zfp429 APN 13 67,544,159 (GRCm39) splice site probably benign
FR4342:Zfp429 UTSW 13 67,544,769 (GRCm39) missense probably benign 0.02
R0012:Zfp429 UTSW 13 67,538,796 (GRCm39) missense probably benign 0.01
R1232:Zfp429 UTSW 13 67,538,751 (GRCm39) missense possibly damaging 0.47
R1330:Zfp429 UTSW 13 67,544,262 (GRCm39) splice site probably null
R1653:Zfp429 UTSW 13 67,538,043 (GRCm39) missense possibly damaging 0.87
R1761:Zfp429 UTSW 13 67,544,195 (GRCm39) missense probably benign 0.28
R1813:Zfp429 UTSW 13 67,538,505 (GRCm39) missense possibly damaging 0.55
R2356:Zfp429 UTSW 13 67,538,746 (GRCm39) missense probably benign
R4280:Zfp429 UTSW 13 67,538,914 (GRCm39) missense probably damaging 1.00
R4283:Zfp429 UTSW 13 67,538,914 (GRCm39) missense probably damaging 1.00
R4464:Zfp429 UTSW 13 67,538,617 (GRCm39) missense probably benign 0.13
R4789:Zfp429 UTSW 13 67,538,523 (GRCm39) missense probably benign 0.06
R5187:Zfp429 UTSW 13 67,538,959 (GRCm39) missense probably damaging 0.99
R5250:Zfp429 UTSW 13 67,538,638 (GRCm39) missense probably benign 0.00
R6688:Zfp429 UTSW 13 67,544,249 (GRCm39) missense probably damaging 0.98
R6989:Zfp429 UTSW 13 67,538,080 (GRCm39) missense probably benign 0.00
R7041:Zfp429 UTSW 13 67,538,830 (GRCm39) missense probably damaging 1.00
R7101:Zfp429 UTSW 13 67,538,931 (GRCm39) missense possibly damaging 0.88
R7593:Zfp429 UTSW 13 67,538,410 (GRCm39) missense probably damaging 1.00
R7792:Zfp429 UTSW 13 67,538,558 (GRCm39) nonsense probably null
R8500:Zfp429 UTSW 13 67,538,828 (GRCm39) nonsense probably null
R8721:Zfp429 UTSW 13 67,538,331 (GRCm39) missense probably damaging 0.98
R8891:Zfp429 UTSW 13 67,538,830 (GRCm39) missense probably damaging 1.00
R9364:Zfp429 UTSW 13 67,538,531 (GRCm39) missense probably benign 0.12
R9554:Zfp429 UTSW 13 67,538,531 (GRCm39) missense probably benign 0.12
Predicted Primers PCR Primer
(F):5'- TGATGTTGTACAAAGCATGAGGATG -3'
(R):5'- CCCTACAAGTGTGGAGAACG -3'

Sequencing Primer
(F):5'- TGATGCTCCTGAAGACTTCCAGAG -3'
(R):5'- TCTGAAGACAACCCTTACAAGTGTG -3'
Posted On 2018-08-29