Incidental Mutation 'IGL01082:Flrt1'
ID |
53231 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Flrt1
|
Ensembl Gene |
ENSMUSG00000047787 |
Gene Name |
fibronectin leucine rich transmembrane protein 1 |
Synonyms |
D630040I23Rik |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.185)
|
Stock # |
IGL01082
|
Quality Score |
|
Status
|
|
Chromosome |
19 |
Chromosomal Location |
7069366-7083094 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 7073339 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Alanine
at position 403
(T403A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000109010
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040261]
[ENSMUST00000113383]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably benign
Transcript: ENSMUST00000040261
|
SMART Domains |
Protein: ENSMUSP00000039507 Gene: ENSMUSG00000036278
Domain | Start | End | E-Value | Type |
low complexity region
|
9 |
21 |
N/A |
INTRINSIC |
low complexity region
|
25 |
41 |
N/A |
INTRINSIC |
low complexity region
|
59 |
74 |
N/A |
INTRINSIC |
A1pp
|
151 |
281 |
7.67e-46 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000113383
AA Change: T403A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000109010 Gene: ENSMUSG00000047787 AA Change: T403A
Domain | Start | End | E-Value | Type |
low complexity region
|
2 |
28 |
N/A |
INTRINSIC |
LRRNT
|
53 |
85 |
4.11e-6 |
SMART |
LRR
|
127 |
149 |
2.61e1 |
SMART |
LRR
|
150 |
175 |
4.71e1 |
SMART |
LRR
|
177 |
199 |
1.76e1 |
SMART |
LRR
|
200 |
220 |
7.36e0 |
SMART |
LRR
|
221 |
246 |
1.49e1 |
SMART |
LRR
|
247 |
270 |
9.77e1 |
SMART |
LRR
|
271 |
292 |
1.53e1 |
SMART |
LRR_TYP
|
293 |
316 |
3.55e-6 |
SMART |
LRRCT
|
328 |
379 |
5.19e-9 |
SMART |
low complexity region
|
381 |
392 |
N/A |
INTRINSIC |
FN3
|
434 |
515 |
1.49e0 |
SMART |
transmembrane domain
|
556 |
578 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008] PHENOTYPE: No notable phenotype was detected in a high-throughput screen of homozygous mice. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 33 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca12 |
G |
A |
1: 71,353,273 (GRCm39) |
S723F |
probably damaging |
Het |
Cacng5 |
C |
T |
11: 107,772,531 (GRCm39) |
V106I |
probably benign |
Het |
Ccdc116 |
A |
G |
16: 16,959,856 (GRCm39) |
S278P |
probably damaging |
Het |
Cep152 |
A |
T |
2: 125,411,465 (GRCm39) |
|
probably benign |
Het |
Cftr |
T |
C |
6: 18,226,102 (GRCm39) |
V350A |
probably damaging |
Het |
Dsc2 |
A |
T |
18: 20,176,849 (GRCm39) |
N399K |
probably damaging |
Het |
Eif3d |
T |
C |
15: 77,843,943 (GRCm39) |
T468A |
probably damaging |
Het |
Fam110b |
C |
T |
4: 5,799,461 (GRCm39) |
A293V |
possibly damaging |
Het |
H3c6 |
A |
G |
13: 23,746,548 (GRCm39) |
|
probably benign |
Het |
Ift140 |
T |
A |
17: 25,267,429 (GRCm39) |
V609E |
possibly damaging |
Het |
Klb |
G |
A |
5: 65,533,283 (GRCm39) |
V531I |
possibly damaging |
Het |
Krt73 |
T |
C |
15: 101,707,372 (GRCm39) |
|
probably null |
Het |
Mcm2 |
A |
G |
6: 88,864,859 (GRCm39) |
V539A |
probably benign |
Het |
Myb |
A |
G |
10: 21,028,843 (GRCm39) |
V85A |
probably damaging |
Het |
Ndufs1 |
T |
C |
1: 63,203,976 (GRCm39) |
E102G |
probably damaging |
Het |
Nr5a2 |
C |
A |
1: 136,773,206 (GRCm39) |
A499S |
probably benign |
Het |
Opa1 |
A |
T |
16: 29,436,933 (GRCm39) |
|
probably benign |
Het |
Or14j5 |
T |
A |
17: 38,161,514 (GRCm39) |
S10R |
probably benign |
Het |
Or4a47 |
A |
T |
2: 89,674,407 (GRCm39) |
|
probably benign |
Het |
Or4c11b |
T |
C |
2: 88,625,637 (GRCm39) |
F304L |
probably benign |
Het |
Pcnx1 |
G |
A |
12: 82,037,372 (GRCm39) |
E1877K |
possibly damaging |
Het |
Sel1l |
A |
G |
12: 91,778,682 (GRCm39) |
V711A |
probably benign |
Het |
Slc22a16 |
A |
G |
10: 40,449,860 (GRCm39) |
T120A |
probably benign |
Het |
Slc26a1 |
G |
T |
5: 108,819,744 (GRCm39) |
T485N |
possibly damaging |
Het |
Sp100 |
T |
C |
1: 85,597,741 (GRCm39) |
V201A |
possibly damaging |
Het |
Spz1 |
T |
G |
13: 92,712,029 (GRCm39) |
K149T |
probably damaging |
Het |
Stxbp5l |
A |
G |
16: 37,024,940 (GRCm39) |
S553P |
possibly damaging |
Het |
Szt2 |
A |
G |
4: 118,254,821 (GRCm39) |
S290P |
probably damaging |
Het |
Tbc1d10c |
A |
G |
19: 4,239,026 (GRCm39) |
Y165H |
probably damaging |
Het |
Tnxb |
C |
A |
17: 34,933,584 (GRCm39) |
Q2335K |
probably damaging |
Het |
Trim33 |
T |
C |
3: 103,234,175 (GRCm39) |
I471T |
possibly damaging |
Het |
Vsig10 |
A |
G |
5: 117,472,970 (GRCm39) |
I188V |
probably benign |
Het |
Zfp109 |
A |
T |
7: 23,933,784 (GRCm39) |
L45Q |
probably damaging |
Het |
|
Other mutations in Flrt1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00336:Flrt1
|
APN |
19 |
7,074,277 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02535:Flrt1
|
APN |
19 |
7,074,098 (GRCm39) |
missense |
probably benign |
0.00 |
R0240:Flrt1
|
UTSW |
19 |
7,074,475 (GRCm39) |
intron |
probably benign |
|
R0240:Flrt1
|
UTSW |
19 |
7,074,475 (GRCm39) |
intron |
probably benign |
|
R0403:Flrt1
|
UTSW |
19 |
7,073,284 (GRCm39) |
missense |
probably benign |
0.01 |
R0645:Flrt1
|
UTSW |
19 |
7,074,508 (GRCm39) |
intron |
probably benign |
|
R0677:Flrt1
|
UTSW |
19 |
7,073,544 (GRCm39) |
nonsense |
probably null |
|
R1818:Flrt1
|
UTSW |
19 |
7,072,711 (GRCm39) |
missense |
probably damaging |
1.00 |
R2191:Flrt1
|
UTSW |
19 |
7,073,194 (GRCm39) |
missense |
probably damaging |
0.99 |
R2228:Flrt1
|
UTSW |
19 |
7,072,723 (GRCm39) |
missense |
probably damaging |
1.00 |
R2471:Flrt1
|
UTSW |
19 |
7,073,856 (GRCm39) |
missense |
probably damaging |
1.00 |
R4978:Flrt1
|
UTSW |
19 |
7,074,241 (GRCm39) |
missense |
probably damaging |
1.00 |
R5460:Flrt1
|
UTSW |
19 |
7,073,105 (GRCm39) |
missense |
probably damaging |
0.99 |
R5630:Flrt1
|
UTSW |
19 |
7,073,830 (GRCm39) |
missense |
probably damaging |
1.00 |
R6326:Flrt1
|
UTSW |
19 |
7,073,974 (GRCm39) |
missense |
probably damaging |
1.00 |
R6734:Flrt1
|
UTSW |
19 |
7,073,524 (GRCm39) |
missense |
possibly damaging |
0.91 |
R6905:Flrt1
|
UTSW |
19 |
7,072,757 (GRCm39) |
nonsense |
probably null |
|
R7239:Flrt1
|
UTSW |
19 |
7,073,329 (GRCm39) |
missense |
probably benign |
0.12 |
R7799:Flrt1
|
UTSW |
19 |
7,073,229 (GRCm39) |
missense |
possibly damaging |
0.78 |
R8168:Flrt1
|
UTSW |
19 |
7,074,002 (GRCm39) |
missense |
probably damaging |
1.00 |
X0024:Flrt1
|
UTSW |
19 |
7,073,114 (GRCm39) |
missense |
probably damaging |
1.00 |
X0062:Flrt1
|
UTSW |
19 |
7,074,244 (GRCm39) |
missense |
probably benign |
0.00 |
|
Posted On |
2013-06-21 |