Mutagenetix > Incidental Mutations

Incidental Mutation 'R6774:Vmn2r103'

532315

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

R6774 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

19773363-19812536 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19773511 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 50 (H50R)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

AlphaFold

E9PWW0

Predicted Effect

probably benign
Transcript: ENSMUST00000172203
AA Change: H50R

PolyPhen 2 Score 0.135 (Sensitivity: 0.92; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: H50R

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.5%
20x: 95.8%

Validation Efficiency

98% (53/54)

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017B05Rik	A	T	9: 57,256,625	I822N	probably damaging	Het
9930111J21Rik1	A	G	11: 48,947,316	S815P	possibly damaging	Het
A430033K04Rik	A	G	5: 138,646,450	Y199C	probably benign	Het
Afap1l1	A	T	18: 61,755,661	V113E	probably benign	Het
Ahnak2	C	T	12: 112,773,738	C494Y	possibly damaging	Het
Atr	A	T	9: 95,927,213	E1981D	probably benign	Het
Bmp7	A	G	2: 172,872,958	Y353H	probably damaging	Het
Capn11	C	T	17: 45,657,330		probably benign	Het
Ccdc103	T	C	11: 102,882,693	F47S	probably damaging	Het
Cmas	A	G	6: 142,764,421	Y130C	possibly damaging	Het
Cntn5	T	C	9: 10,144,217	Y149C	probably damaging	Het
Col12a1	A	C	9: 79,706,337	S75R	possibly damaging	Het
Crat	G	A	2: 30,413,183	H31Y	probably damaging	Het
Dnah7a	A	G	1: 53,698,651	V41A	probably benign	Het
F5	C	T	1: 164,186,878	R573C	probably damaging	Het
Gcc2	A	G	10: 58,281,439	N1170S	possibly damaging	Het
Gm29666	A	T	15: 84,914,059	C100*	probably null	Het
Gm3573	A	T	14: 42,187,515	Y158N	possibly damaging	Het
Gm5346	T	A	8: 43,625,183	H668L	probably benign	Het
Gm597	A	T	1: 28,776,893	I686N	probably benign	Het
Gtf3c1	G	T	7: 125,641,621	A1968E	possibly damaging	Het
Heg1	C	A	16: 33,738,268	T815K	probably damaging	Het
Herc1	TCCC	TCC	9: 66,501,188		probably null	Het
Kif17	A	G	4: 138,274,995	Y170C	probably damaging	Het
Kti12	G	A	4: 108,848,455	G189R	probably benign	Het
Lrp4	G	A	2: 91,511,504	A1821T	probably benign	Het
Mamdc4	T	C	2: 25,566,936	I610V	probably benign	Het
Mmp1b	T	C	9: 7,387,914	K27E	probably benign	Het
Mob4	A	G	1: 55,148,429		probably null	Het
Myc	G	A	15: 61,988,279		probably null	Het
Myo5c	A	T	9: 75,289,186	I1305F	probably benign	Het
Nprl3	A	G	11: 32,237,381	V292A	probably damaging	Het
Ntng2	T	C	2: 29,197,090	T373A	probably damaging	Het
Olfr1200	C	T	2: 88,767,884	V144I	probably benign	Het
Olfr161	T	A	16: 3,592,516	V40D	probably damaging	Het
Olfr469	T	A	7: 107,823,188	T94S	probably benign	Het
Olfr863-ps1	A	T	9: 19,941,774	L222H	unknown	Het
Pard3	T	C	8: 127,410,747	L859P	probably damaging	Het
Ppcs	T	C	4: 119,419,088	D100G	probably damaging	Het
Prkdc	G	T	16: 15,725,461		probably null	Het
Pwwp2b	T	C	7: 139,255,987	V448A	probably benign	Het
Rapgef4	A	G	2: 72,225,775	K624R	probably benign	Het
Synj2	C	T	17: 6,038,015	S1447L	possibly damaging	Het
Tfap2a	T	A	13: 40,728,754	N25I	probably damaging	Het
Tnxb	C	A	17: 34,709,632	Y2673*	probably null	Het
Trim27	T	A	13: 21,192,454	H457Q	probably damaging	Het
Trim72	T	G	7: 128,010,386	F453L	probably damaging	Het
Ubr5	A	T	15: 38,015,135	M877K	probably damaging	Het
Usp10	T	C	8: 119,951,972	L564P	probably benign	Het
Usp54	A	G	14: 20,577,228	V454A	probably damaging	Het
Uspl1	T	A	5: 149,214,094	D701E	probably benign	Het
Zfp35	G	A	18: 24,002,958	V120I	possibly damaging	Het
Zfp712	T	C	13: 67,041,504	T320A	probably benign	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	19793102	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	19794965	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	19792997	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	19792967	missense	probably benign
IGL01404:Vmn2r103	APN	17	19812434	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	19794068	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	19799208	missense	probably benign
IGL02251:Vmn2r103	APN	17	19793969	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19773369	missense	probably benign
IGL02555:Vmn2r103	APN	17	19811611	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	19794127	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	19793956	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	19812248	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19773520	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	19811979	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	19811641	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	19792859	missense	probably benign	0.06
R0375:Vmn2r103	UTSW	17	19793464	missense	probably benign	0.12
R0755:Vmn2r103	UTSW	17	19773568	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	19793927	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	19794247	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	19792968	missense	probably benign
R1488:Vmn2r103	UTSW	17	19793660	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19773400	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	19794234	missense	probably benign
R1928:Vmn2r103	UTSW	17	19811767	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	19812300	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	19793794	missense	probably benign
R2219:Vmn2r103	UTSW	17	19793647	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19773531	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	19793600	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	19812149	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	19794233	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	19811815	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	19811769	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	19812171	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	19793642	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	19792989	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	19794939	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	19812453	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	19794216	nonsense	probably null
R6114:Vmn2r103	UTSW	17	19812325	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	19812144	missense	probably benign
R6292:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	19794082	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	19811904	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	19811977	missense	probably damaging	1.00
R6981:Vmn2r103	UTSW	17	19793477	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	19812052	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	19794214	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	19793123	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	19799249	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	19793497	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	19811796	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	19811943	missense	probably damaging	1.00
R8559:Vmn2r103	UTSW	17	19812384	missense	probably benign	0.01
R9413:Vmn2r103	UTSW	17	19811896	missense	possibly damaging	0.54
Z1088:Vmn2r103	UTSW	17	19795047	missense	probably benign	0.08

Predicted Primers

PCR Primer
(F):5'- TGGCATTCTCAATCCCTTGG -3'
(R):5'- TGCCTGAGTGAGGAAAATGTTC -3'

Sequencing Primer
(F):5'- AACGATGAACCAAGCATATATGTAC -3'
(R):5'- CCTGAGTGAGGAAAATGTTCTAAATG -3'

Posted On

2018-08-29