Incidental Mutation 'R6774:Vmn2r103'
| ID |
532315 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r103
|
| Ensembl Gene |
ENSMUSG00000091771 |
| Gene Name |
vomeronasal 2, receptor 103 |
| Synonyms |
EG627636 |
| MMRRC Submission |
044890-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
R6774 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19773363-19812536 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 19773511 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Arginine
at position 50
(H50R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126756
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172203]
|
| AlphaFold |
E9PWW0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172203
AA Change: H50R
PolyPhen 2
Score 0.135 (Sensitivity: 0.92; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: H50R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
449 |
1.3e-37 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
3.5e-22 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.1e-51 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.5%
- 20x: 95.8%
|
| Validation Efficiency |
98% (53/54) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 53 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700017B05Rik |
A |
T |
9: 57,256,625 (GRCm38) |
I822N |
probably damaging |
Het |
| 9930111J21Rik1 |
A |
G |
11: 48,947,316 (GRCm38) |
S815P |
possibly damaging |
Het |
| A430033K04Rik |
A |
G |
5: 138,646,450 (GRCm38) |
Y199C |
probably benign |
Het |
| Afap1l1 |
A |
T |
18: 61,755,661 (GRCm38) |
V113E |
probably benign |
Het |
| Ahnak2 |
C |
T |
12: 112,773,738 (GRCm38) |
C494Y |
possibly damaging |
Het |
| Atr |
A |
T |
9: 95,927,213 (GRCm38) |
E1981D |
probably benign |
Het |
| Bmp7 |
A |
G |
2: 172,872,958 (GRCm38) |
Y353H |
probably damaging |
Het |
| Capn11 |
C |
T |
17: 45,657,330 (GRCm38) |
|
probably benign |
Het |
| Ccdc103 |
T |
C |
11: 102,882,693 (GRCm38) |
F47S |
probably damaging |
Het |
| Cmas |
A |
G |
6: 142,764,421 (GRCm38) |
Y130C |
possibly damaging |
Het |
| Cntn5 |
T |
C |
9: 10,144,217 (GRCm38) |
Y149C |
probably damaging |
Het |
| Col12a1 |
A |
C |
9: 79,706,337 (GRCm38) |
S75R |
possibly damaging |
Het |
| Crat |
G |
A |
2: 30,413,183 (GRCm38) |
H31Y |
probably damaging |
Het |
| Dnah7a |
A |
G |
1: 53,698,651 (GRCm38) |
V41A |
probably benign |
Het |
| F5 |
C |
T |
1: 164,186,878 (GRCm38) |
R573C |
probably damaging |
Het |
| Gcc2 |
A |
G |
10: 58,281,439 (GRCm38) |
N1170S |
possibly damaging |
Het |
| Gm29666 |
A |
T |
15: 84,914,059 (GRCm38) |
C100* |
probably null |
Het |
| Gm3573 |
A |
T |
14: 42,187,515 (GRCm38) |
Y158N |
possibly damaging |
Het |
| Gm5346 |
T |
A |
8: 43,625,183 (GRCm38) |
H668L |
probably benign |
Het |
| Gm597 |
A |
T |
1: 28,776,893 (GRCm38) |
I686N |
probably benign |
Het |
| Gtf3c1 |
G |
T |
7: 125,641,621 (GRCm38) |
A1968E |
possibly damaging |
Het |
| Heg1 |
C |
A |
16: 33,738,268 (GRCm38) |
T815K |
probably damaging |
Het |
| Herc1 |
TCCC |
TCC |
9: 66,501,188 (GRCm38) |
|
probably null |
Het |
| Kif17 |
A |
G |
4: 138,274,995 (GRCm38) |
Y170C |
probably damaging |
Het |
| Kti12 |
G |
A |
4: 108,848,455 (GRCm38) |
G189R |
probably benign |
Het |
| Lrp4 |
G |
A |
2: 91,511,504 (GRCm38) |
A1821T |
probably benign |
Het |
| Mamdc4 |
T |
C |
2: 25,566,936 (GRCm38) |
I610V |
probably benign |
Het |
| Mmp1b |
T |
C |
9: 7,387,914 (GRCm38) |
K27E |
probably benign |
Het |
| Mob4 |
A |
G |
1: 55,148,429 (GRCm38) |
|
probably null |
Het |
| Myc |
G |
A |
15: 61,988,279 (GRCm38) |
|
probably null |
Het |
| Myo5c |
A |
T |
9: 75,289,186 (GRCm38) |
I1305F |
probably benign |
Het |
| Nprl3 |
A |
G |
11: 32,237,381 (GRCm38) |
V292A |
probably damaging |
Het |
| Ntng2 |
T |
C |
2: 29,197,090 (GRCm38) |
T373A |
probably damaging |
Het |
| Olfr1200 |
C |
T |
2: 88,767,884 (GRCm38) |
V144I |
probably benign |
Het |
| Olfr161 |
T |
A |
16: 3,592,516 (GRCm38) |
V40D |
probably damaging |
Het |
| Olfr469 |
T |
A |
7: 107,823,188 (GRCm38) |
T94S |
probably benign |
Het |
| Olfr863-ps1 |
A |
T |
9: 19,941,774 (GRCm38) |
L222H |
unknown |
Het |
| Pard3 |
T |
C |
8: 127,410,747 (GRCm38) |
L859P |
probably damaging |
Het |
| Ppcs |
T |
C |
4: 119,419,088 (GRCm38) |
D100G |
probably damaging |
Het |
| Prkdc |
G |
T |
16: 15,725,461 (GRCm38) |
|
probably null |
Het |
| Pwwp2b |
T |
C |
7: 139,255,987 (GRCm38) |
V448A |
probably benign |
Het |
| Rapgef4 |
A |
G |
2: 72,225,775 (GRCm38) |
K624R |
probably benign |
Het |
| Synj2 |
C |
T |
17: 6,038,015 (GRCm38) |
S1447L |
possibly damaging |
Het |
| Tfap2a |
T |
A |
13: 40,728,754 (GRCm38) |
N25I |
probably damaging |
Het |
| Tnxb |
C |
A |
17: 34,709,632 (GRCm38) |
Y2673* |
probably null |
Het |
| Trim27 |
T |
A |
13: 21,192,454 (GRCm38) |
H457Q |
probably damaging |
Het |
| Trim72 |
T |
G |
7: 128,010,386 (GRCm38) |
F453L |
probably damaging |
Het |
| Ubr5 |
A |
T |
15: 38,015,135 (GRCm38) |
M877K |
probably damaging |
Het |
| Usp10 |
T |
C |
8: 119,951,972 (GRCm38) |
L564P |
probably benign |
Het |
| Usp54 |
A |
G |
14: 20,577,228 (GRCm38) |
V454A |
probably damaging |
Het |
| Uspl1 |
T |
A |
5: 149,214,094 (GRCm38) |
D701E |
probably benign |
Het |
| Zfp35 |
G |
A |
18: 24,002,958 (GRCm38) |
V120I |
possibly damaging |
Het |
| Zfp712 |
T |
C |
13: 67,041,504 (GRCm38) |
T320A |
probably benign |
Het |
|
| Other mutations in Vmn2r103 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00333:Vmn2r103
|
APN |
17 |
19,793,102 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL00939:Vmn2r103
|
APN |
17 |
19,794,965 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01120:Vmn2r103
|
APN |
17 |
19,792,997 (GRCm38) |
missense |
probably benign |
0.06 |
|
IGL01403:Vmn2r103
|
APN |
17 |
19,792,967 (GRCm38) |
missense |
probably benign |
|
|
IGL01404:Vmn2r103
|
APN |
17 |
19,812,434 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01713:Vmn2r103
|
APN |
17 |
19,794,068 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01802:Vmn2r103
|
APN |
17 |
19,799,208 (GRCm38) |
missense |
probably benign |
|
|
IGL02251:Vmn2r103
|
APN |
17 |
19,793,969 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
IGL02466:Vmn2r103
|
APN |
17 |
19,773,369 (GRCm38) |
missense |
probably benign |
|
|
IGL02555:Vmn2r103
|
APN |
17 |
19,811,611 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02668:Vmn2r103
|
APN |
17 |
19,794,127 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02715:Vmn2r103
|
APN |
17 |
19,793,956 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL02735:Vmn2r103
|
APN |
17 |
19,812,248 (GRCm38) |
missense |
probably benign |
0.27 |
|
IGL03101:Vmn2r103
|
APN |
17 |
19,773,520 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0003:Vmn2r103
|
UTSW |
17 |
19,811,979 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0052:Vmn2r103
|
UTSW |
17 |
19,811,641 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0375:Vmn2r103
|
UTSW |
17 |
19,793,464 (GRCm38) |
missense |
probably benign |
0.12 |
|
R0375:Vmn2r103
|
UTSW |
17 |
19,792,859 (GRCm38) |
missense |
probably benign |
0.06 |
|
R0755:Vmn2r103
|
UTSW |
17 |
19,773,568 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0837:Vmn2r103
|
UTSW |
17 |
19,793,927 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1345:Vmn2r103
|
UTSW |
17 |
19,794,247 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1396:Vmn2r103
|
UTSW |
17 |
19,792,968 (GRCm38) |
missense |
probably benign |
|
|
R1488:Vmn2r103
|
UTSW |
17 |
19,793,660 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1533:Vmn2r103
|
UTSW |
17 |
19,773,400 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1590:Vmn2r103
|
UTSW |
17 |
19,794,234 (GRCm38) |
missense |
probably benign |
|
|
R1928:Vmn2r103
|
UTSW |
17 |
19,811,767 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1942:Vmn2r103
|
UTSW |
17 |
19,812,300 (GRCm38) |
missense |
probably benign |
0.02 |
|
R2071:Vmn2r103
|
UTSW |
17 |
19,793,794 (GRCm38) |
missense |
probably benign |
|
|
R2219:Vmn2r103
|
UTSW |
17 |
19,793,647 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2442:Vmn2r103
|
UTSW |
17 |
19,773,531 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2889:Vmn2r103
|
UTSW |
17 |
19,793,600 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3762:Vmn2r103
|
UTSW |
17 |
19,812,149 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4014:Vmn2r103
|
UTSW |
17 |
19,793,604 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R4331:Vmn2r103
|
UTSW |
17 |
19,794,233 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4630:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4631:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4632:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4660:Vmn2r103
|
UTSW |
17 |
19,811,815 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4801:Vmn2r103
|
UTSW |
17 |
19,795,076 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4802:Vmn2r103
|
UTSW |
17 |
19,795,076 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4931:Vmn2r103
|
UTSW |
17 |
19,811,769 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4995:Vmn2r103
|
UTSW |
17 |
19,773,511 (GRCm38) |
missense |
probably benign |
0.14 |
|
R5309:Vmn2r103
|
UTSW |
17 |
19,793,034 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5312:Vmn2r103
|
UTSW |
17 |
19,793,034 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5329:Vmn2r103
|
UTSW |
17 |
19,812,171 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5611:Vmn2r103
|
UTSW |
17 |
19,793,642 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5684:Vmn2r103
|
UTSW |
17 |
19,792,989 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5715:Vmn2r103
|
UTSW |
17 |
19,794,939 (GRCm38) |
missense |
probably benign |
0.17 |
|
R5907:Vmn2r103
|
UTSW |
17 |
19,812,453 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R6029:Vmn2r103
|
UTSW |
17 |
19,794,216 (GRCm38) |
nonsense |
probably null |
|
|
R6114:Vmn2r103
|
UTSW |
17 |
19,812,325 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6285:Vmn2r103
|
UTSW |
17 |
19,812,144 (GRCm38) |
missense |
probably benign |
|
|
R6292:Vmn2r103
|
UTSW |
17 |
19,793,604 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R6334:Vmn2r103
|
UTSW |
17 |
19,794,082 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6501:Vmn2r103
|
UTSW |
17 |
19,811,904 (GRCm38) |
missense |
probably benign |
0.29 |
|
R6710:Vmn2r103
|
UTSW |
17 |
19,811,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6981:Vmn2r103
|
UTSW |
17 |
19,793,477 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7768:Vmn2r103
|
UTSW |
17 |
19,812,052 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7816:Vmn2r103
|
UTSW |
17 |
19,794,214 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7885:Vmn2r103
|
UTSW |
17 |
19,793,123 (GRCm38) |
missense |
probably benign |
0.25 |
|
R8002:Vmn2r103
|
UTSW |
17 |
19,799,249 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8031:Vmn2r103
|
UTSW |
17 |
19,793,497 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8140:Vmn2r103
|
UTSW |
17 |
19,811,796 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8186:Vmn2r103
|
UTSW |
17 |
19,811,943 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8559:Vmn2r103
|
UTSW |
17 |
19,812,384 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9413:Vmn2r103
|
UTSW |
17 |
19,811,896 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R9591:Vmn2r103
|
UTSW |
17 |
19,811,659 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R9652:Vmn2r103
|
UTSW |
17 |
19,793,765 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9680:Vmn2r103
|
UTSW |
17 |
19,799,263 (GRCm38) |
nonsense |
probably null |
|
|
R9743:Vmn2r103
|
UTSW |
17 |
19,812,213 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r103
|
UTSW |
17 |
19,795,047 (GRCm38) |
missense |
probably benign |
0.08 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGCATTCTCAATCCCTTGG -3'
(R):5'- TGCCTGAGTGAGGAAAATGTTC -3'
Sequencing Primer
(F):5'- AACGATGAACCAAGCATATATGTAC -3'
(R):5'- CCTGAGTGAGGAAAATGTTCTAAATG -3'
|
| Posted On |
2018-08-29 |
Incidental Mutation