Incidental Mutation 'R6775:Or7g30'
ID 532333
Institutional Source Beutler Lab
Gene Symbol Or7g30
Ensembl Gene ENSMUSG00000052182
Gene Name olfactory receptor family 7 subfamily G member 30
Synonyms Olfr849, GA_x6K02T2PVTD-13176842-13177780, MOR151-1
MMRRC Submission 044891-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.146) question?
Stock # R6775 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 19352211-19353149 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 19352718 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 170 (T170S)
Ref Sequence ENSEMBL: ENSMUSP00000149769 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063923] [ENSMUST00000217273]
AlphaFold Q8VFF6
Predicted Effect possibly damaging
Transcript: ENSMUST00000063923
AA Change: T170S

PolyPhen 2 Score 0.559 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000064123
Gene: ENSMUSG00000052182
AA Change: T170S

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.9e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 305 7.6e-6 PFAM
Pfam:7tm_1 41 290 2.6e-23 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000217273
AA Change: T170S

PolyPhen 2 Score 0.559 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts6 G A 13: 104,450,160 (GRCm39) V289M probably damaging Het
Atp10b A G 11: 43,113,040 (GRCm39) D862G possibly damaging Het
Ccn6 T C 10: 39,027,351 (GRCm39) T294A probably damaging Het
Colec10 A G 15: 54,298,419 (GRCm39) E60G possibly damaging Het
Cpne1 A G 2: 155,920,340 (GRCm39) V179A probably damaging Het
Galnt9 G A 5: 110,768,465 (GRCm39) R587H probably damaging Het
Gmip A G 8: 70,268,285 (GRCm39) D423G possibly damaging Het
Ints15 C A 5: 143,297,493 (GRCm39) V185L probably benign Het
Klk1b24 A G 7: 43,840,889 (GRCm39) M106V probably benign Het
Or14c39 A G 7: 86,344,357 (GRCm39) E231G probably benign Het
Or8k40 G A 2: 86,584,921 (GRCm39) R54C probably damaging Het
Orc1 T A 4: 108,460,652 (GRCm39) F496I probably damaging Het
Peg10 GC GCTCC 6: 4,756,452 (GRCm39) probably benign Het
Phf11b A T 14: 59,576,094 (GRCm39) N47K probably benign Het
Plscr4 G A 9: 92,364,858 (GRCm39) M94I probably benign Het
Ppip5k2 A T 1: 97,647,585 (GRCm39) V1047E possibly damaging Het
Scn3a A G 2: 65,352,159 (GRCm39) Y384H possibly damaging Het
Sgpp1 G C 12: 75,782,243 (GRCm39) P32R probably benign Het
Smc1b T C 15: 84,973,881 (GRCm39) E925G probably damaging Het
Sorl1 A G 9: 42,003,748 (GRCm39) Y183H possibly damaging Het
Tarbp1 A C 8: 127,163,568 (GRCm39) D1151E probably benign Het
Vmn2r3 T C 3: 64,183,039 (GRCm39) H220R possibly damaging Het
Wdr5 A G 2: 27,423,386 (GRCm39) Y260C probably damaging Het
Other mutations in Or7g30
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Or7g30 APN 9 19,352,266 (GRCm39) missense probably benign 0.01
IGL01599:Or7g30 APN 9 19,353,111 (GRCm39) missense probably benign 0.00
IGL01885:Or7g30 APN 9 19,352,760 (GRCm39) missense probably benign 0.01
IGL02258:Or7g30 APN 9 19,352,295 (GRCm39) missense probably benign 0.00
IGL02258:Or7g30 APN 9 19,352,293 (GRCm39) missense possibly damaging 0.66
IGL02282:Or7g30 APN 9 19,352,914 (GRCm39) missense probably benign 0.42
R1293:Or7g30 UTSW 9 19,352,728 (GRCm39) missense probably benign 0.27
R1931:Or7g30 UTSW 9 19,352,647 (GRCm39) missense possibly damaging 0.93
R2444:Or7g30 UTSW 9 19,352,311 (GRCm39) missense possibly damaging 0.78
R4181:Or7g30 UTSW 9 19,353,031 (GRCm39) missense possibly damaging 0.86
R4231:Or7g30 UTSW 9 19,352,886 (GRCm39) missense probably damaging 1.00
R4233:Or7g30 UTSW 9 19,352,886 (GRCm39) missense probably damaging 1.00
R4236:Or7g30 UTSW 9 19,352,886 (GRCm39) missense probably damaging 1.00
R4302:Or7g30 UTSW 9 19,352,295 (GRCm39) missense probably benign 0.00
R4651:Or7g30 UTSW 9 19,352,591 (GRCm39) nonsense probably null
R5006:Or7g30 UTSW 9 19,352,545 (GRCm39) missense probably benign 0.30
R5088:Or7g30 UTSW 9 19,353,067 (GRCm39) missense probably damaging 1.00
R5501:Or7g30 UTSW 9 19,352,290 (GRCm39) missense possibly damaging 0.93
R7038:Or7g30 UTSW 9 19,352,888 (GRCm39) missense possibly damaging 0.88
R8010:Or7g30 UTSW 9 19,352,988 (GRCm39) missense probably benign 0.02
R8850:Or7g30 UTSW 9 19,352,817 (GRCm39) missense probably damaging 0.96
R9154:Or7g30 UTSW 9 19,352,531 (GRCm39) missense probably benign 0.39
R9523:Or7g30 UTSW 9 19,352,580 (GRCm39) missense possibly damaging 0.73
Predicted Primers PCR Primer
(F):5'- TAGAAAACTGTCTCCTGGCAGTG -3'
(R):5'- AGACCCACATGTTGAAAAGGC -3'

Sequencing Primer
(F):5'- GATGGCCTATGACCGCTATG -3'
(R):5'- CCCACATGTTGAAAAGGCTTTATAC -3'
Posted On 2018-08-29