Incidental Mutation 'R6786:Vmn2r17'
ID |
532365 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r17
|
Ensembl Gene |
ENSMUSG00000091879 |
Gene Name |
vomeronasal 2, receptor 17 |
Synonyms |
EG384221 |
MMRRC Submission |
044900-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.112)
|
Stock # |
R6786 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
5 |
Chromosomal Location |
109567879-109601253 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 109575695 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Serine
at position 189
(T189S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000131450
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171841]
|
AlphaFold |
E9PYF5 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000171841
AA Change: T189S
PolyPhen 2
Score 0.303 (Sensitivity: 0.90; Specificity: 0.89)
|
SMART Domains |
Protein: ENSMUSP00000131450 Gene: ENSMUSG00000091879 AA Change: T189S
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
76 |
465 |
7e-26 |
PFAM |
Pfam:NCD3G
|
508 |
562 |
3.5e-18 |
PFAM |
Pfam:7tm_3
|
593 |
830 |
4.8e-55 |
PFAM |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.5%
- 20x: 96.1%
|
Validation Efficiency |
96% (66/69) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 68 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Actl7a |
C |
A |
4: 56,744,116 (GRCm39) |
Y214* |
probably null |
Het |
Adnp2 |
A |
G |
18: 80,172,960 (GRCm39) |
V483A |
probably benign |
Het |
Aif1 |
C |
T |
17: 35,390,472 (GRCm39) |
V93M |
probably damaging |
Het |
Alpk2 |
A |
G |
18: 65,439,705 (GRCm39) |
S563P |
probably benign |
Het |
Ank2 |
A |
T |
3: 126,752,581 (GRCm39) |
N378K |
probably damaging |
Het |
Ano4 |
C |
T |
10: 88,828,732 (GRCm39) |
|
probably null |
Het |
Asxl3 |
G |
A |
18: 22,658,497 (GRCm39) |
C2169Y |
probably damaging |
Het |
Atp2b1 |
T |
C |
10: 98,852,821 (GRCm39) |
C101R |
probably damaging |
Het |
Bcs1l |
C |
T |
1: 74,629,844 (GRCm39) |
R224C |
probably damaging |
Het |
Car2 |
T |
C |
3: 14,951,710 (GRCm39) |
|
probably benign |
Het |
Cbln1 |
T |
C |
8: 88,198,657 (GRCm39) |
N71S |
probably benign |
Het |
Cdh8 |
T |
A |
8: 99,950,579 (GRCm39) |
T224S |
probably benign |
Het |
Cdin1 |
A |
G |
2: 115,462,462 (GRCm39) |
I65V |
probably benign |
Het |
Cep131 |
G |
A |
11: 119,956,218 (GRCm39) |
R1014W |
probably damaging |
Het |
Cfap61 |
T |
C |
2: 145,887,363 (GRCm39) |
S603P |
possibly damaging |
Het |
Chd8 |
G |
T |
14: 52,464,125 (GRCm39) |
L659I |
probably benign |
Het |
Ckap5 |
G |
A |
2: 91,387,920 (GRCm39) |
G255D |
probably benign |
Het |
Clec18a |
C |
A |
8: 111,807,572 (GRCm39) |
W126L |
probably benign |
Het |
Cux1 |
T |
A |
5: 136,596,085 (GRCm39) |
N4Y |
probably damaging |
Het |
Dgcr8 |
A |
T |
16: 18,101,693 (GRCm39) |
Y196* |
probably null |
Het |
Dnah14 |
A |
T |
1: 181,468,970 (GRCm39) |
I1267F |
probably benign |
Het |
Dock7 |
T |
C |
4: 98,949,529 (GRCm39) |
N438D |
probably benign |
Het |
Dock8 |
A |
T |
19: 25,160,386 (GRCm39) |
H1763L |
possibly damaging |
Het |
Elp1 |
T |
C |
4: 56,771,555 (GRCm39) |
D914G |
possibly damaging |
Het |
Fpr-rs6 |
A |
T |
17: 20,403,100 (GRCm39) |
M87K |
possibly damaging |
Het |
Gabrg1 |
A |
G |
5: 70,911,610 (GRCm39) |
S339P |
probably benign |
Het |
Gm10801 |
AAGT |
AAGTAGT |
2: 98,494,148 (GRCm39) |
|
probably null |
Het |
Gm12695 |
A |
G |
4: 96,651,058 (GRCm39) |
S132P |
probably damaging |
Het |
Gm3443 |
T |
A |
19: 21,533,128 (GRCm39) |
C31S |
probably damaging |
Het |
Gzmf |
A |
T |
14: 56,444,452 (GRCm39) |
F40L |
probably benign |
Het |
Herc1 |
TCCC |
TCC |
9: 66,408,470 (GRCm39) |
|
probably null |
Het |
Lrguk |
A |
G |
6: 34,072,522 (GRCm39) |
E604G |
probably benign |
Het |
Marveld3 |
C |
A |
8: 110,674,732 (GRCm39) |
K361N |
probably benign |
Het |
Mgat4b |
A |
T |
11: 50,121,525 (GRCm39) |
Y47F |
probably damaging |
Het |
Mmel1 |
G |
T |
4: 154,976,885 (GRCm39) |
E520* |
probably null |
Het |
Msantd5f6 |
A |
T |
4: 73,321,843 (GRCm39) |
M64K |
possibly damaging |
Het |
Muc21 |
T |
C |
17: 35,934,057 (GRCm39) |
|
probably benign |
Het |
Myod1 |
A |
G |
7: 46,027,741 (GRCm39) |
T294A |
probably benign |
Het |
Nfix |
A |
T |
8: 85,454,276 (GRCm39) |
S219T |
probably damaging |
Het |
Nr4a2 |
A |
G |
2: 57,001,920 (GRCm39) |
F115L |
probably benign |
Het |
Numa1 |
A |
C |
7: 101,641,845 (GRCm39) |
M98L |
probably benign |
Het |
Or5b105 |
T |
C |
19: 13,080,567 (GRCm39) |
I28V |
probably benign |
Het |
P3h1 |
C |
T |
4: 119,095,151 (GRCm39) |
L303F |
possibly damaging |
Het |
Pias4 |
G |
A |
10: 80,993,080 (GRCm39) |
T5I |
probably damaging |
Het |
Pik3ip1 |
A |
G |
11: 3,282,124 (GRCm39) |
N68S |
probably benign |
Het |
Pkdrej |
T |
C |
15: 85,702,850 (GRCm39) |
T1029A |
probably benign |
Het |
Recql |
A |
T |
6: 142,310,278 (GRCm39) |
D517E |
probably benign |
Het |
Sall2 |
G |
T |
14: 52,552,078 (GRCm39) |
H372Q |
probably damaging |
Het |
Scn8a |
A |
C |
15: 100,930,096 (GRCm39) |
I1436L |
probably benign |
Het |
Slc4a5 |
T |
C |
6: 83,273,729 (GRCm39) |
|
probably null |
Het |
Stox2 |
A |
C |
8: 47,639,500 (GRCm39) |
F898C |
probably damaging |
Het |
Sumo2 |
A |
T |
11: 115,414,601 (GRCm39) |
|
probably null |
Het |
Sycp2 |
C |
T |
2: 178,025,345 (GRCm39) |
E366K |
possibly damaging |
Het |
Tanc1 |
A |
G |
2: 59,622,150 (GRCm39) |
K423R |
probably benign |
Het |
Tbx21 |
T |
A |
11: 97,005,872 (GRCm39) |
Q31L |
possibly damaging |
Het |
Tfap2a |
T |
A |
13: 40,882,230 (GRCm39) |
N25I |
probably damaging |
Het |
Tfdp1 |
C |
T |
8: 13,420,485 (GRCm39) |
R105W |
probably damaging |
Het |
Trav18 |
G |
A |
14: 54,069,122 (GRCm39) |
V55I |
probably benign |
Het |
Trgc1 |
A |
T |
13: 19,400,646 (GRCm39) |
D125V |
unknown |
Het |
Trim55 |
A |
G |
3: 19,726,938 (GRCm39) |
D335G |
probably benign |
Het |
Trim71 |
T |
A |
9: 114,341,772 (GRCm39) |
T837S |
probably benign |
Het |
Vmn1r56 |
T |
C |
7: 5,198,961 (GRCm39) |
T219A |
probably benign |
Het |
Xaf1 |
A |
G |
11: 72,197,461 (GRCm39) |
T146A |
probably benign |
Het |
Zdbf2 |
T |
C |
1: 63,343,679 (GRCm39) |
V686A |
possibly damaging |
Het |
Zfp65 |
T |
C |
13: 67,856,130 (GRCm39) |
H383R |
probably damaging |
Het |
Zfp932 |
A |
G |
5: 110,157,606 (GRCm39) |
T435A |
probably damaging |
Het |
Zfp947 |
C |
T |
17: 22,364,750 (GRCm39) |
G308D |
probably benign |
Het |
Zswim3 |
T |
A |
2: 164,662,771 (GRCm39) |
V417E |
probably damaging |
Het |
|
Other mutations in Vmn2r17 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00325:Vmn2r17
|
APN |
5 |
109,575,858 (GRCm39) |
missense |
probably benign |
0.15 |
IGL01457:Vmn2r17
|
APN |
5 |
109,600,898 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01527:Vmn2r17
|
APN |
5 |
109,601,006 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01693:Vmn2r17
|
APN |
5 |
109,600,384 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01738:Vmn2r17
|
APN |
5 |
109,577,364 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01767:Vmn2r17
|
APN |
5 |
109,567,903 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01932:Vmn2r17
|
APN |
5 |
109,574,916 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01970:Vmn2r17
|
APN |
5 |
109,575,813 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL02009:Vmn2r17
|
APN |
5 |
109,600,714 (GRCm39) |
missense |
possibly damaging |
0.67 |
IGL02365:Vmn2r17
|
APN |
5 |
109,601,175 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02385:Vmn2r17
|
APN |
5 |
109,582,247 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02457:Vmn2r17
|
APN |
5 |
109,601,012 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02646:Vmn2r17
|
APN |
5 |
109,600,946 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02741:Vmn2r17
|
APN |
5 |
109,568,077 (GRCm39) |
missense |
probably benign |
|
IGL03213:Vmn2r17
|
APN |
5 |
109,582,256 (GRCm39) |
critical splice donor site |
probably null |
|
IGL03216:Vmn2r17
|
APN |
5 |
109,600,756 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03342:Vmn2r17
|
APN |
5 |
109,575,782 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03408:Vmn2r17
|
APN |
5 |
109,577,238 (GRCm39) |
splice site |
probably benign |
|
R0349:Vmn2r17
|
UTSW |
5 |
109,576,202 (GRCm39) |
missense |
probably damaging |
1.00 |
R0418:Vmn2r17
|
UTSW |
5 |
109,600,747 (GRCm39) |
missense |
probably damaging |
1.00 |
R0800:Vmn2r17
|
UTSW |
5 |
109,575,192 (GRCm39) |
splice site |
probably benign |
|
R0836:Vmn2r17
|
UTSW |
5 |
109,575,822 (GRCm39) |
missense |
possibly damaging |
0.89 |
R1715:Vmn2r17
|
UTSW |
5 |
109,576,110 (GRCm39) |
missense |
probably benign |
0.00 |
R1738:Vmn2r17
|
UTSW |
5 |
109,576,377 (GRCm39) |
missense |
probably benign |
0.10 |
R1801:Vmn2r17
|
UTSW |
5 |
109,576,344 (GRCm39) |
missense |
probably damaging |
1.00 |
R2054:Vmn2r17
|
UTSW |
5 |
109,600,352 (GRCm39) |
missense |
probably damaging |
0.98 |
R2060:Vmn2r17
|
UTSW |
5 |
109,575,075 (GRCm39) |
missense |
probably benign |
0.00 |
R2192:Vmn2r17
|
UTSW |
5 |
109,582,144 (GRCm39) |
missense |
possibly damaging |
0.81 |
R2315:Vmn2r17
|
UTSW |
5 |
109,575,897 (GRCm39) |
missense |
probably damaging |
1.00 |
R2374:Vmn2r17
|
UTSW |
5 |
109,575,104 (GRCm39) |
missense |
probably benign |
|
R3612:Vmn2r17
|
UTSW |
5 |
109,577,463 (GRCm39) |
missense |
probably benign |
0.00 |
R3832:Vmn2r17
|
UTSW |
5 |
109,576,262 (GRCm39) |
missense |
probably damaging |
1.00 |
R4273:Vmn2r17
|
UTSW |
5 |
109,600,832 (GRCm39) |
missense |
probably benign |
0.44 |
R4494:Vmn2r17
|
UTSW |
5 |
109,576,335 (GRCm39) |
missense |
probably damaging |
1.00 |
R4597:Vmn2r17
|
UTSW |
5 |
109,577,428 (GRCm39) |
missense |
probably benign |
0.01 |
R4675:Vmn2r17
|
UTSW |
5 |
109,575,049 (GRCm39) |
missense |
probably benign |
0.00 |
R4701:Vmn2r17
|
UTSW |
5 |
109,575,849 (GRCm39) |
missense |
probably damaging |
0.99 |
R4754:Vmn2r17
|
UTSW |
5 |
109,600,715 (GRCm39) |
missense |
probably damaging |
0.99 |
R4841:Vmn2r17
|
UTSW |
5 |
109,582,246 (GRCm39) |
missense |
probably damaging |
1.00 |
R4842:Vmn2r17
|
UTSW |
5 |
109,582,246 (GRCm39) |
missense |
probably damaging |
1.00 |
R4865:Vmn2r17
|
UTSW |
5 |
109,574,985 (GRCm39) |
missense |
probably damaging |
1.00 |
R4902:Vmn2r17
|
UTSW |
5 |
109,601,220 (GRCm39) |
missense |
probably benign |
0.14 |
R4989:Vmn2r17
|
UTSW |
5 |
109,575,739 (GRCm39) |
missense |
probably benign |
0.07 |
R5101:Vmn2r17
|
UTSW |
5 |
109,576,217 (GRCm39) |
missense |
probably damaging |
0.99 |
R5109:Vmn2r17
|
UTSW |
5 |
109,577,342 (GRCm39) |
missense |
probably benign |
0.06 |
R5123:Vmn2r17
|
UTSW |
5 |
109,575,774 (GRCm39) |
missense |
possibly damaging |
0.90 |
R5474:Vmn2r17
|
UTSW |
5 |
109,582,150 (GRCm39) |
missense |
probably damaging |
1.00 |
R5485:Vmn2r17
|
UTSW |
5 |
109,567,972 (GRCm39) |
missense |
probably benign |
0.06 |
R5611:Vmn2r17
|
UTSW |
5 |
109,576,030 (GRCm39) |
missense |
probably damaging |
0.97 |
R5652:Vmn2r17
|
UTSW |
5 |
109,577,430 (GRCm39) |
missense |
probably benign |
0.10 |
R5717:Vmn2r17
|
UTSW |
5 |
109,575,140 (GRCm39) |
missense |
possibly damaging |
0.94 |
R5735:Vmn2r17
|
UTSW |
5 |
109,600,716 (GRCm39) |
missense |
possibly damaging |
0.67 |
R5766:Vmn2r17
|
UTSW |
5 |
109,575,139 (GRCm39) |
missense |
possibly damaging |
0.46 |
R6645:Vmn2r17
|
UTSW |
5 |
109,576,247 (GRCm39) |
missense |
probably damaging |
1.00 |
R6821:Vmn2r17
|
UTSW |
5 |
109,577,331 (GRCm39) |
missense |
probably damaging |
1.00 |
R6979:Vmn2r17
|
UTSW |
5 |
109,576,265 (GRCm39) |
missense |
possibly damaging |
0.46 |
R6984:Vmn2r17
|
UTSW |
5 |
109,600,533 (GRCm39) |
missense |
probably benign |
0.10 |
R7269:Vmn2r17
|
UTSW |
5 |
109,576,337 (GRCm39) |
missense |
possibly damaging |
0.88 |
R7509:Vmn2r17
|
UTSW |
5 |
109,575,695 (GRCm39) |
missense |
probably benign |
0.30 |
R7736:Vmn2r17
|
UTSW |
5 |
109,600,757 (GRCm39) |
missense |
probably benign |
0.05 |
R7789:Vmn2r17
|
UTSW |
5 |
109,600,831 (GRCm39) |
missense |
possibly damaging |
0.77 |
R7814:Vmn2r17
|
UTSW |
5 |
109,575,739 (GRCm39) |
missense |
probably benign |
0.07 |
R7847:Vmn2r17
|
UTSW |
5 |
109,568,063 (GRCm39) |
missense |
probably damaging |
1.00 |
R7863:Vmn2r17
|
UTSW |
5 |
109,568,035 (GRCm39) |
missense |
probably benign |
|
R7893:Vmn2r17
|
UTSW |
5 |
109,575,944 (GRCm39) |
missense |
probably benign |
0.05 |
R8234:Vmn2r17
|
UTSW |
5 |
109,601,235 (GRCm39) |
missense |
probably benign |
0.01 |
R8382:Vmn2r17
|
UTSW |
5 |
109,576,387 (GRCm39) |
missense |
probably benign |
0.01 |
R8435:Vmn2r17
|
UTSW |
5 |
109,576,172 (GRCm39) |
missense |
probably benign |
0.01 |
R8465:Vmn2r17
|
UTSW |
5 |
109,600,691 (GRCm39) |
missense |
probably damaging |
0.99 |
R8555:Vmn2r17
|
UTSW |
5 |
109,600,810 (GRCm39) |
missense |
probably damaging |
0.99 |
R8900:Vmn2r17
|
UTSW |
5 |
109,575,863 (GRCm39) |
missense |
probably benign |
0.25 |
R9293:Vmn2r17
|
UTSW |
5 |
109,600,712 (GRCm39) |
missense |
probably damaging |
1.00 |
R9308:Vmn2r17
|
UTSW |
5 |
109,600,505 (GRCm39) |
missense |
probably damaging |
0.98 |
R9378:Vmn2r17
|
UTSW |
5 |
109,575,732 (GRCm39) |
missense |
possibly damaging |
0.94 |
R9597:Vmn2r17
|
UTSW |
5 |
109,575,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TGGGACTTGTCAGGAATAGCC -3'
(R):5'- CTGCATGTTTTCTGGGATCATATTCAC -3'
Sequencing Primer
(F):5'- AGCCTAGAATCTAATAGGGACAATTC -3'
(R):5'- TTCTGGGATCATATTCACAAAAGC -3'
|
Posted On |
2018-08-29 |