Incidental Mutation 'IGL01088:Olfr1461'
ID53238
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1461
Ensembl Gene ENSMUSG00000045883
Gene Nameolfactory receptor 1461
SynonymsGA_x6K02T2RE5P-3491834-3492772, MOR202-35
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.169) question?
Stock #IGL01088
Quality Score
Status
Chromosome19
Chromosomal Location13163000-13168130 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 13165371 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Threonine at position 119 (M119T)
Ref Sequence ENSEMBL: ENSMUSP00000146723 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053772] [ENSMUST00000207113] [ENSMUST00000208489]
Predicted Effect probably damaging
Transcript: ENSMUST00000053772
AA Change: M119T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000053269
Gene: ENSMUSG00000045883
AA Change: M119T

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 6e-55 PFAM
Pfam:7TM_GPCR_Srsx 36 306 8e-6 PFAM
Pfam:7tm_1 42 291 2e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207113
AA Change: M119T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000208489
AA Change: M119T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr6 C T 10: 89,725,841 V148I probably damaging Het
Aspn G T 13: 49,566,553 K348N probably benign Het
C1qtnf9 T C 14: 60,779,756 V245A probably benign Het
Chd4 T C 6: 125,122,468 probably benign Het
Clcn3 A T 8: 60,937,347 C187S probably damaging Het
Dcxr T C 11: 120,726,167 I123M possibly damaging Het
Fstl1 T C 16: 37,826,813 Y182H probably damaging Het
Ghrhr T C 6: 55,379,193 probably null Het
Gm4788 T C 1: 139,698,085 probably benign Het
Gpr179 T C 11: 97,337,801 E1176G probably damaging Het
H2-T22 A G 17: 36,041,919 S99P probably damaging Het
Igkv4-79 T A 6: 69,043,126 K68N probably damaging Het
Kpna6 C T 4: 129,655,483 V169I probably damaging Het
Krit1 G T 5: 3,812,844 V278F probably damaging Het
Mrpl4 T C 9: 21,003,331 S68P probably damaging Het
Mylk3 A C 8: 85,351,957 probably null Het
Nfasc A T 1: 132,642,776 probably benign Het
Ntsr1 T C 2: 180,542,542 F346S probably damaging Het
Olfr1333 A G 4: 118,829,792 V216A probably benign Het
Phox2a T C 7: 101,821,735 F145L probably damaging Het
Rbm7 A G 9: 48,490,849 V146A probably damaging Het
Sall3 A T 18: 80,973,232 Y494N probably damaging Het
Ssbp1 T A 6: 40,478,070 probably benign Het
Stard7 T C 2: 127,270,826 L4P probably damaging Het
Stk-ps2 A T 1: 46,029,850 noncoding transcript Het
Tmem67 G A 4: 12,063,126 R507C probably damaging Het
Unc13c A T 9: 73,932,281 D429E possibly damaging Het
Unc93b1 A G 19: 3,935,356 probably null Het
Vmn1r171 T C 7: 23,632,827 V159A probably damaging Het
Zfp608 T C 18: 54,898,087 E927G probably benign Het
Zfp820 T A 17: 21,821,181 K16* probably null Het
Zgrf1 T C 3: 127,588,141 probably benign Het
Other mutations in Olfr1461
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01370:Olfr1461 APN 19 13165299 missense possibly damaging 0.95
IGL01936:Olfr1461 APN 19 13165403 missense probably damaging 1.00
R0098:Olfr1461 UTSW 19 13165662 missense probably benign 0.12
R0270:Olfr1461 UTSW 19 13165887 missense probably damaging 1.00
R0575:Olfr1461 UTSW 19 13165387 nonsense probably null
R0627:Olfr1461 UTSW 19 13165250 missense probably benign 0.43
R1779:Olfr1461 UTSW 19 13165040 missense probably benign 0.00
R1956:Olfr1461 UTSW 19 13165196 missense probably damaging 1.00
R2446:Olfr1461 UTSW 19 13165447 missense probably benign 0.00
R3622:Olfr1461 UTSW 19 13165656 missense probably benign 0.06
R4485:Olfr1461 UTSW 19 13165491 missense possibly damaging 0.54
R4605:Olfr1461 UTSW 19 13165248 missense probably damaging 1.00
R4757:Olfr1461 UTSW 19 13165913 missense probably benign 0.01
R4816:Olfr1461 UTSW 19 13165124 missense probably benign 0.10
R5038:Olfr1461 UTSW 19 13165591 missense probably benign 0.39
R7026:Olfr1461 UTSW 19 13165415 missense probably benign 0.08
Posted On2013-06-21