Incidental Mutation 'R6791:Mgst1'
ID 532582
Institutional Source Beutler Lab
Gene Symbol Mgst1
Ensembl Gene ENSMUSG00000008540
Gene Name microsomal glutathione S-transferase 1
Synonyms 1500002K10Rik
MMRRC Submission 044904-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.140) question?
Stock # R6791 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 138117525-138133753 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) G to A at 138118805 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000144912 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000008684] [ENSMUST00000118091] [ENSMUST00000120230] [ENSMUST00000120302] [ENSMUST00000120939] [ENSMUST00000125810] [ENSMUST00000140932] [ENSMUST00000204628]
AlphaFold Q91VS7
Predicted Effect probably benign
Transcript: ENSMUST00000008684
SMART Domains Protein: ENSMUSP00000008684
Gene: ENSMUSG00000008540

DomainStartEndE-ValueType
Pfam:MAPEG 16 150 9.2e-27 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000118091
AA Change: C39Y
SMART Domains Protein: ENSMUSP00000112923
Gene: ENSMUSG00000008540
AA Change: C39Y

DomainStartEndE-ValueType
Pfam:MAPEG 90 224 1.9e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000120230
SMART Domains Protein: ENSMUSP00000113859
Gene: ENSMUSG00000008540

DomainStartEndE-ValueType
Pfam:MAPEG 16 150 9.2e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000120302
SMART Domains Protein: ENSMUSP00000113257
Gene: ENSMUSG00000008540

DomainStartEndE-ValueType
Pfam:MAPEG 16 150 9.2e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000120939
SMART Domains Protein: ENSMUSP00000112646
Gene: ENSMUSG00000008540

DomainStartEndE-ValueType
PDB:2H8A|A 2 74 1e-45 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000125810
SMART Domains Protein: ENSMUSP00000114222
Gene: ENSMUSG00000008540

DomainStartEndE-ValueType
PDB:2H8A|A 42 92 6e-29 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000140932
SMART Domains Protein: ENSMUSP00000145306
Gene: ENSMUSG00000008540

DomainStartEndE-ValueType
Pfam:MAPEG 1 46 2.9e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204628
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.7%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,328,504 (GRCm39) C3526S probably damaging Het
Adgrf2 T C 17: 43,021,774 (GRCm39) N350S probably benign Het
Atp12a G A 14: 56,624,439 (GRCm39) probably null Het
AW551984 T G 9: 39,511,955 (GRCm39) S19R probably damaging Het
Bet1l A G 7: 140,434,418 (GRCm39) I77T possibly damaging Het
Cfap206 T C 4: 34,711,414 (GRCm39) I494M possibly damaging Het
Cog3 A G 14: 75,968,118 (GRCm39) I415T probably damaging Het
Col15a1 C T 4: 47,300,518 (GRCm39) P1060S probably damaging Het
Ctrb1 A G 8: 112,415,981 (GRCm39) V71A possibly damaging Het
Ddhd2 T C 8: 26,242,242 (GRCm39) Y211C probably benign Het
Fbxl20 T C 11: 98,000,336 (GRCm39) T128A probably benign Het
Fdps A G 3: 89,002,659 (GRCm39) probably null Het
Gm4302 TGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCA TGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCA 10: 100,177,361 (GRCm39) probably benign Het
Gm8369 T A 19: 11,489,200 (GRCm39) probably benign Het
Grm6 T C 11: 50,750,601 (GRCm39) V588A possibly damaging Het
Heatr6 T C 11: 83,649,167 (GRCm39) L174S probably benign Het
Kif1a G A 1: 92,993,859 (GRCm39) P364S probably damaging Het
Klk7 A G 7: 43,462,684 (GRCm39) D163G probably benign Het
Kmt2e TGCCGCCGCCGCCGCCACCGCCGCCGCCGC TGCCGCCGCCGCCGCCGCCACCGCCGCCGCCGC 5: 23,704,474 (GRCm39) probably benign Het
Lamb3 T C 1: 193,017,169 (GRCm39) S787P possibly damaging Het
Lrp5 C T 19: 3,650,753 (GRCm39) C1227Y probably damaging Het
Mllt6 T C 11: 97,571,428 (GRCm39) S1022P probably damaging Het
Mtmr2 T C 9: 13,716,678 (GRCm39) I521T probably benign Het
Naalad2 T C 9: 18,296,426 (GRCm39) T75A possibly damaging Het
Nadsyn1 A T 7: 143,372,845 (GRCm39) I83N probably damaging Het
Naip2 T C 13: 100,291,468 (GRCm39) S1157G probably benign Het
Neurl4 T A 11: 69,799,336 (GRCm39) L904Q probably damaging Het
Ngp A C 9: 110,249,017 (GRCm39) I30L probably benign Het
Or5af1 T C 11: 58,722,903 (GRCm39) Y308H probably benign Het
Or6c5c G A 10: 129,299,023 (GRCm39) M159I probably benign Het
Orm2 A T 4: 63,282,196 (GRCm39) M125L probably benign Het
Pax2 A T 19: 44,777,260 (GRCm39) D151V possibly damaging Het
Polg A G 7: 79,109,857 (GRCm39) V382A probably benign Het
Ppargc1b C A 18: 61,440,747 (GRCm39) G724W probably damaging Het
Pramel11 T A 4: 143,622,252 (GRCm39) I368F probably benign Het
Prss16 A T 13: 22,190,237 (GRCm39) V307E probably damaging Het
Prss54 T G 8: 96,291,283 (GRCm39) probably null Het
Rspo1 A G 4: 124,900,976 (GRCm39) H108R probably benign Het
Sh3bp5l C A 11: 58,237,098 (GRCm39) H352N probably damaging Het
Skor1 T C 9: 63,047,636 (GRCm39) probably null Het
Smad6 A G 9: 63,919,509 (GRCm39) Y289H probably benign Het
Spart G A 3: 55,034,982 (GRCm39) G456D probably damaging Het
Spg11 T C 2: 121,923,924 (GRCm39) E799G probably damaging Het
Tbc1d4 T G 14: 101,845,695 (GRCm39) K68Q probably damaging Het
Treml2 A G 17: 48,616,247 (GRCm39) M296V probably benign Het
Ugt2b1 C A 5: 87,067,116 (GRCm39) D436Y probably damaging Het
Usp9y A T Y: 1,325,042 (GRCm39) probably null Homo
Vmn2r6 T C 3: 64,445,580 (GRCm39) Y626C probably damaging Het
Xpc G A 6: 91,483,839 (GRCm39) A169V probably benign Het
Zfp131 A G 13: 120,228,129 (GRCm39) V506A probably damaging Het
Zfp74 A G 7: 29,633,860 (GRCm39) I616T probably benign Het
Other mutations in Mgst1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02135:Mgst1 APN 6 138,124,766 (GRCm39) missense probably damaging 0.99
R0319:Mgst1 UTSW 6 138,133,155 (GRCm39) missense possibly damaging 0.81
R0613:Mgst1 UTSW 6 138,133,243 (GRCm39) missense probably damaging 1.00
R0634:Mgst1 UTSW 6 138,133,329 (GRCm39) missense probably damaging 1.00
R0730:Mgst1 UTSW 6 138,124,667 (GRCm39) missense probably benign 0.03
R0862:Mgst1 UTSW 6 138,124,749 (GRCm39) missense probably damaging 1.00
R4447:Mgst1 UTSW 6 138,118,662 (GRCm39) intron probably benign
R4569:Mgst1 UTSW 6 138,133,213 (GRCm39) missense probably damaging 0.99
R4644:Mgst1 UTSW 6 138,133,368 (GRCm39) missense probably damaging 1.00
R4701:Mgst1 UTSW 6 138,127,836 (GRCm39) missense probably damaging 1.00
R4930:Mgst1 UTSW 6 138,130,507 (GRCm39) missense probably benign 0.00
R5688:Mgst1 UTSW 6 138,118,798 (GRCm39) intron probably benign
R6307:Mgst1 UTSW 6 138,127,827 (GRCm39) missense probably benign 0.44
R6468:Mgst1 UTSW 6 138,118,585 (GRCm39) splice site probably null
R6697:Mgst1 UTSW 6 138,124,751 (GRCm39) missense probably damaging 1.00
R6741:Mgst1 UTSW 6 138,127,836 (GRCm39) missense probably damaging 1.00
R6755:Mgst1 UTSW 6 138,124,770 (GRCm39) missense probably damaging 0.99
R7295:Mgst1 UTSW 6 138,124,754 (GRCm39) missense probably benign 0.11
R7440:Mgst1 UTSW 6 138,127,842 (GRCm39) missense probably benign
R7532:Mgst1 UTSW 6 138,130,504 (GRCm39) missense probably benign 0.29
R8486:Mgst1 UTSW 6 138,120,026 (GRCm39) missense probably benign 0.00
R8954:Mgst1 UTSW 6 138,119,967 (GRCm39) intron probably benign
R9326:Mgst1 UTSW 6 138,120,023 (GRCm39) missense probably benign 0.29
R9784:Mgst1 UTSW 6 138,124,799 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CACTGGGGCAAAATATGACAAC -3'
(R):5'- TTTGTAGCTCAGTGCCTGGC -3'

Sequencing Primer
(F):5'- CAGGAGTTACAGGAGAAGCTTCC -3'
(R):5'- TCAGTGCCTGGCCTGCTAG -3'
Posted On 2018-08-29