Incidental Mutation 'R6792:Olfr69'
ID532648
Institutional Source Beutler Lab
Gene Symbol Olfr69
Ensembl Gene ENSMUSG00000058662
Gene Nameolfactory receptor 69
SynonymsMOR22-2, GA_x6K02T2PBJ9-6494485-6493535, 3'[b]3
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.064) question?
Stock #R6792 (G1)
Quality Score225.009
Status Validated
Chromosome7
Chromosomal Location103765805-103771594 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 103768139 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 86 (I86T)
Ref Sequence ENSEMBL: ENSMUSP00000102491 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106878]
Predicted Effect possibly damaging
Transcript: ENSMUST00000106878
AA Change: I86T

PolyPhen 2 Score 0.753 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000102491
Gene: ENSMUSG00000058662
AA Change: I86T

DomainStartEndE-ValueType
Pfam:7tm_4 33 313 1.9e-101 PFAM
Pfam:7TM_GPCR_Srx 34 237 1.1e-7 PFAM
Pfam:7TM_GPCR_Srsx 37 260 3.6e-7 PFAM
Pfam:7tm_1 43 295 6.6e-15 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.7%
Validation Efficiency 98% (51/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700123L14Rik T C 6: 96,165,115 E316G possibly damaging Het
4932438A13Rik A G 3: 37,011,566 probably null Het
A2ml1 G A 6: 128,546,329 Q1215* probably null Het
Akap2 A G 4: 57,855,880 D403G possibly damaging Het
Aldh2 C T 5: 121,580,649 G64R probably damaging Het
Atp11a G A 8: 12,861,939 probably benign Het
Bcl11b T C 12: 107,989,734 D52G probably damaging Het
Capg T A 6: 72,555,554 I34K possibly damaging Het
Card11 T A 5: 140,913,309 I37F probably damaging Het
Col27a1 G T 4: 63,317,503 R724L unknown Het
Cryl1 T C 14: 57,382,767 E47G probably damaging Het
Dgkb A T 12: 38,100,425 D70V possibly damaging Het
Dscam T C 16: 96,593,255 E1949G probably damaging Het
Dscam A G 16: 96,648,237 V1387A probably damaging Het
Exph5 G A 9: 53,375,317 V1233M possibly damaging Het
Fat3 A T 9: 16,375,644 V861E probably damaging Het
Fgfr4 T G 13: 55,156,898 D184E possibly damaging Het
Fkbp14 G T 6: 54,585,852 S49* probably null Het
Ginm1 T C 10: 7,773,983 D182G probably damaging Het
Gk2 T C 5: 97,455,729 I417V probably benign Het
Gm21677 A G Y: 3,298,867 Y206H possibly damaging Homo
Kmt2e TGCCGCCGCCGCCGCCACCGCCGCCGCCGC TGCCGCCGCCGCCGCCGCCACCGCCGCCGCCGC 5: 23,499,476 probably benign Het
Malrd1 C T 2: 16,150,756 P1992L unknown Het
Mapk6 A T 9: 75,395,548 I221N probably damaging Het
Mup9 A G 4: 60,421,355 V65A possibly damaging Het
Myo15b A G 11: 115,885,097 D805G probably damaging Het
Olfr1082 A T 2: 86,593,939 D296E probably benign Het
Otof T A 5: 30,375,634 H1588L probably damaging Het
Pde4a A G 9: 21,192,590 K145R probably benign Het
Pik3ap1 A T 19: 41,321,626 D418E probably benign Het
Pilrb2 C A 5: 137,868,590 R217M possibly damaging Het
Plcb2 T C 2: 118,719,441 N232S probably damaging Het
Ppargc1b C A 18: 61,307,676 G724W probably damaging Het
Ppp2r5d A G 17: 46,704,856 S2P probably benign Het
Prr5l T G 2: 101,717,424 N252T probably benign Het
Rilp A T 11: 75,512,775 K348* probably null Het
Slc17a7 A G 7: 45,174,875 E505G possibly damaging Het
Slc6a21 T A 7: 45,279,885 M1K probably null Het
Sorcs1 T C 19: 50,678,168 T101A probably benign Het
Sorl1 A T 9: 42,099,263 V137E probably damaging Het
Stam2 T C 2: 52,707,981 I270V probably benign Het
Synj2 G A 17: 5,990,290 A214T probably benign Het
Tarsl2 G T 7: 65,662,303 C321F probably damaging Het
Tcea1 T A 1: 4,892,045 D229E probably benign Het
Tdrd9 C T 12: 112,027,113 R692W probably benign Het
Tkfc T C 19: 10,594,524 T383A probably benign Het
Traf1 T C 2: 34,956,275 D43G probably benign Het
Tubgcp6 C T 15: 89,122,877 probably benign Het
Vit A T 17: 78,579,399 Y152F probably damaging Het
Vmn1r66 A T 7: 10,274,485 M207K possibly damaging Het
Other mutations in Olfr69
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03381:Olfr69 APN 7 103767837 missense probably benign 0.00
R0314:Olfr69 UTSW 7 103768181 missense probably damaging 1.00
R2158:Olfr69 UTSW 7 103767961 nonsense probably null
R4839:Olfr69 UTSW 7 103767754 missense possibly damaging 0.94
R5574:Olfr69 UTSW 7 103768116 missense possibly damaging 0.96
R6025:Olfr69 UTSW 7 103768209 missense probably benign 0.01
R6581:Olfr69 UTSW 7 103768221 missense probably benign 0.01
R7121:Olfr69 UTSW 7 103767733 nonsense probably null
R7178:Olfr69 UTSW 7 103767975 nonsense probably null
R7378:Olfr69 UTSW 7 103767930 missense probably benign 0.01
R7449:Olfr69 UTSW 7 103767819 missense probably benign
R7573:Olfr69 UTSW 7 103767470 missense probably benign
Predicted Primers PCR Primer
(F):5'- CCAAGGCAAGTGGTGAGTTG -3'
(R):5'- TTTAACACTAGTGGGGATCCCTGG -3'

Sequencing Primer
(F):5'- TTGTGGAGAGAAGATAGTAGCATGTC -3'
(R):5'- CCTGGAATCAGTGCAGTGCTG -3'
Posted On2018-08-29