Incidental Mutation 'R6793:Zfp970'
ID532680
Institutional Source Beutler Lab
Gene Symbol Zfp970
Ensembl Gene ENSMUSG00000078866
Gene Namezinc finger protein 970
SynonymsGm14420
MMRRC Submission
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.262) question?
Stock #R6793 (G1)
Quality Score207.009
Status Not validated
Chromosome2
Chromosomal Location177464733-177478129 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 177475545 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Tyrosine at position 304 (C304Y)
Ref Sequence ENSEMBL: ENSMUSP00000104580 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099002] [ENSMUST00000108952]
Predicted Effect probably benign
Transcript: ENSMUST00000099002
SMART Domains Protein: ENSMUSP00000096600
Gene: ENSMUSG00000078866

DomainStartEndE-ValueType
KRAB 4 66 3.68e-13 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000108952
AA Change: C304Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000104580
Gene: ENSMUSG00000078866
AA Change: C304Y

DomainStartEndE-ValueType
KRAB 4 66 1.13e-13 SMART
ZnF_C2H2 78 97 1.53e2 SMART
ZnF_C2H2 103 125 8.75e0 SMART
ZnF_C2H2 131 153 1.28e-3 SMART
ZnF_C2H2 159 181 3.89e-3 SMART
ZnF_C2H2 187 209 3.63e-3 SMART
ZnF_C2H2 215 237 3.89e-3 SMART
ZnF_C2H2 243 265 1.58e-3 SMART
ZnF_C2H2 271 293 7.9e-4 SMART
ZnF_C2H2 299 321 3.69e-4 SMART
ZnF_C2H2 327 349 2.12e-4 SMART
ZnF_C2H2 355 377 1.56e-2 SMART
ZnF_C2H2 383 405 1.12e-3 SMART
ZnF_C2H2 411 433 1.79e-2 SMART
ZnF_C2H2 439 461 3.69e-4 SMART
ZnF_C2H2 467 489 3.21e-4 SMART
ZnF_C2H2 495 517 7.9e-4 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 96.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810011H11Rik A C 14: 32,806,821 I48L probably benign Het
2010315B03Rik A T 9: 124,295,422 N19K possibly damaging Het
A2ml1 G A 6: 128,546,329 Q1215* probably null Het
Abraxas2 T C 7: 132,874,834 I98T probably damaging Het
Ankrd17 G A 5: 90,265,512 T1181I probably damaging Het
Bsn T A 9: 108,114,615 K1313* probably null Het
C130060K24Rik C T 6: 65,381,421 A43V probably benign Het
Chst4 A T 8: 110,030,067 V388D probably damaging Het
Ckap5 T G 2: 91,568,709 W613G probably damaging Het
Clock GACTCACT GACT 5: 76,237,120 probably null Het
Enpp1 T C 10: 24,655,825 D520G probably damaging Het
Epha3 T C 16: 63,773,455 N90S probably benign Het
Esp36 A T 17: 38,417,114 M92K unknown Het
Fam135a A G 1: 24,067,925 V44A possibly damaging Het
Fndc8 T C 11: 82,897,586 S81P probably damaging Het
Fsip2 T G 2: 82,989,494 N5190K probably benign Het
Gabrr1 T G 4: 33,162,712 V426G possibly damaging Het
Igkv6-15 T A 6: 70,406,992 M1L probably benign Het
Lrrc36 A G 8: 105,458,433 E614G probably damaging Het
Man1a2 A T 3: 100,632,597 I176K possibly damaging Het
Mapk4 T A 18: 73,930,468 N561I probably damaging Het
Med15 A T 16: 17,652,703 probably benign Het
Mfsd2a A G 4: 122,950,705 V258A probably benign Het
Micu3 G A 8: 40,380,695 V457I probably damaging Het
Mov10l1 T A 15: 88,996,184 V291E possibly damaging Het
Naip2 T C 13: 100,154,960 S1157G probably benign Het
Ncbp1 T C 4: 46,157,827 I355T probably damaging Het
Olfr571 A G 7: 102,909,728 V37A probably benign Het
Olfr600 T C 7: 103,346,266 T221A probably benign Het
Otub2 A G 12: 103,389,019 probably benign Het
Pcdh15 T C 10: 74,631,139 S1666P probably damaging Het
Pcdha12 T A 18: 37,022,181 V651E probably damaging Het
Pomt1 T C 2: 32,242,949 F186L probably damaging Het
Prl3d3 G A 13: 27,161,061 A140T probably benign Het
Ptprn G A 1: 75,258,142 T267I probably benign Het
Rhbdd2 T A 5: 135,636,154 I113N probably damaging Het
Saraf T A 8: 34,168,613 probably null Het
Slc41a2 T C 10: 83,301,158 probably null Het
Slc47a1 A G 11: 61,359,403 V352A probably benign Het
Tmem237 T C 1: 59,114,216 T49A probably benign Het
Tmprss11e C T 5: 86,715,555 C217Y probably damaging Het
Ubfd1 T C 7: 122,067,880 V140A probably benign Het
Utrn A G 10: 12,640,925 probably null Het
Utrn T A 10: 12,699,100 I1028F possibly damaging Het
Virma C T 4: 11,539,968 T1479M probably damaging Het
Vwa7 G T 17: 35,024,891 R767L probably benign Het
Wdfy3 A T 5: 101,917,431 Y1290* probably null Het
Other mutations in Zfp970
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02900:Zfp970 APN 2 177474817 splice site probably benign
R1817:Zfp970 UTSW 2 177476183 missense probably damaging 1.00
R1992:Zfp970 UTSW 2 177474870 missense possibly damaging 0.55
R2252:Zfp970 UTSW 2 177474821 splice site probably null
R2253:Zfp970 UTSW 2 177474821 splice site probably null
R4576:Zfp970 UTSW 2 177475680 missense probably damaging 0.99
R4617:Zfp970 UTSW 2 177476168 missense probably benign 0.16
R4828:Zfp970 UTSW 2 177475353 missense probably damaging 0.98
R5801:Zfp970 UTSW 2 177473358 missense probably damaging 1.00
R6198:Zfp970 UTSW 2 177475460 missense probably damaging 1.00
R6540:Zfp970 UTSW 2 177475595 missense probably damaging 1.00
R7092:Zfp970 UTSW 2 177475292 missense probably damaging 1.00
R7289:Zfp970 UTSW 2 177475293 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGCCTTTACACGAAGCAGT -3'
(R):5'- GTGCAAAGGCTTTACCACATTG -3'

Sequencing Primer
(F):5'- TTTACACGAAGCAGTCATCTCGG -3'
(R):5'- CATGTATTCGGAGAGCAATGCATC -3'
Posted On2018-08-29