Incidental Mutation 'R6743:Tektl1'
ID 532746
Institutional Source Beutler Lab
Gene Symbol Tektl1
Ensembl Gene ENSMUSG00000078442
Gene Name tektin like 1
Synonyms Ccdc105, 4931413A09Rik
MMRRC Submission 044860-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R6743 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 78582760-78588899 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 78588726 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 28 (T28M)
Ref Sequence ENSEMBL: ENSMUSP00000101022 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105383]
AlphaFold Q9D4K7
Predicted Effect probably benign
Transcript: ENSMUST00000105383
AA Change: T28M

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000101022
Gene: ENSMUSG00000078442
AA Change: T28M

DomainStartEndE-ValueType
Pfam:Tektin 115 470 1.6e-19 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.2%
Validation Efficiency 100% (39/39)
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg1 C T 17: 31,327,321 (GRCm39) R339C possibly damaging Het
Adamts6 G A 13: 104,565,436 (GRCm39) G721R probably damaging Het
Adnp2 A G 18: 80,171,274 (GRCm39) V1045A probably benign Het
Agbl3 T C 6: 34,823,888 (GRCm39) I856T probably benign Het
Anapc1 T A 2: 128,526,454 (GRCm39) K115* probably null Het
Arc A G 15: 74,543,636 (GRCm39) S196P probably benign Het
Atp10a T C 7: 58,447,562 (GRCm39) I768T possibly damaging Het
Blk C T 14: 63,622,375 (GRCm39) R55H probably benign Het
Ccdc158 T C 5: 92,810,005 (GRCm39) S168G probably benign Het
Cda G T 4: 138,066,253 (GRCm39) T128K probably benign Het
Celsr1 T A 15: 85,791,799 (GRCm39) T2601S probably damaging Het
Dmxl1 T C 18: 50,013,847 (GRCm39) V1545A possibly damaging Het
Dst T A 1: 34,309,971 (GRCm39) N6264K probably damaging Het
Ednra T C 8: 78,401,718 (GRCm39) S191G probably damaging Het
Elk3 A T 10: 93,100,912 (GRCm39) S280T possibly damaging Het
Etnk1 A G 6: 143,126,343 (GRCm39) I63V possibly damaging Het
Fscb A G 12: 64,518,347 (GRCm39) S1040P unknown Het
Gm14295 T G 2: 176,502,420 (GRCm39) C637G probably damaging Het
Gm5114 T C 7: 39,057,997 (GRCm39) T541A probably benign Het
Man2c1 T C 9: 57,042,849 (GRCm39) F240L probably benign Het
Map2 A T 1: 66,454,766 (GRCm39) I1219L probably benign Het
Map3k13 A G 16: 21,711,173 (GRCm39) Y152C probably damaging Het
Morc1 G A 16: 48,322,683 (GRCm39) A327T probably damaging Het
Myo3a A T 2: 22,366,475 (GRCm39) Y553F probably benign Het
Myo9b T A 8: 71,804,803 (GRCm39) probably null Het
Or14j1 A C 17: 38,146,694 (GRCm39) D268A probably damaging Het
Or5b3 C T 19: 13,387,957 (GRCm39) T8I probably damaging Het
Pam A G 1: 97,823,774 (GRCm39) V219A probably benign Het
Panx1 A G 9: 14,918,929 (GRCm39) I310T possibly damaging Het
Pde6a T A 18: 61,397,057 (GRCm39) F634L possibly damaging Het
Pkd1l2 C A 8: 117,757,370 (GRCm39) C1556F probably damaging Het
Prdm5 G A 6: 65,860,635 (GRCm39) V440I probably damaging Het
Rasa2 T C 9: 96,493,493 (GRCm39) T64A probably damaging Het
Sec24b A T 3: 129,834,881 (GRCm39) Y106N probably damaging Het
Sfswap C T 5: 129,627,883 (GRCm39) Q689* probably null Het
Slamf8 C T 1: 172,417,965 (GRCm39) probably null Het
Tmt1a3 A G 15: 100,233,123 (GRCm39) K105E probably benign Het
Tsr1 T C 11: 74,799,177 (GRCm39) V786A probably benign Het
Yod1 G A 1: 130,645,275 (GRCm39) G19S probably damaging Het
Zmynd10 T C 9: 107,425,079 (GRCm39) I58T possibly damaging Het
Other mutations in Tektl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00858:Tektl1 APN 10 78,586,403 (GRCm39) missense probably damaging 1.00
IGL01632:Tektl1 APN 10 78,584,536 (GRCm39) missense probably benign 0.01
IGL02473:Tektl1 APN 10 78,586,428 (GRCm39) missense probably benign 0.05
IGL02606:Tektl1 APN 10 78,584,300 (GRCm39) missense probably benign 0.01
IGL03356:Tektl1 APN 10 78,582,966 (GRCm39) missense possibly damaging 0.52
R0096:Tektl1 UTSW 10 78,584,539 (GRCm39) missense probably benign 0.01
R0096:Tektl1 UTSW 10 78,584,539 (GRCm39) missense probably benign 0.01
R0666:Tektl1 UTSW 10 78,586,381 (GRCm39) missense probably benign 0.04
R1756:Tektl1 UTSW 10 78,583,031 (GRCm39) missense probably damaging 0.96
R1757:Tektl1 UTSW 10 78,583,058 (GRCm39) missense probably benign 0.02
R1765:Tektl1 UTSW 10 78,584,502 (GRCm39) missense probably benign 0.21
R1956:Tektl1 UTSW 10 78,586,373 (GRCm39) critical splice donor site probably null
R2305:Tektl1 UTSW 10 78,584,336 (GRCm39) missense probably damaging 1.00
R3802:Tektl1 UTSW 10 78,584,314 (GRCm39) missense probably damaging 1.00
R3845:Tektl1 UTSW 10 78,584,532 (GRCm39) missense probably benign
R4023:Tektl1 UTSW 10 78,588,727 (GRCm39) missense probably benign 0.03
R4808:Tektl1 UTSW 10 78,588,698 (GRCm39) missense probably benign 0.02
R4812:Tektl1 UTSW 10 78,585,050 (GRCm39) missense probably benign 0.01
R5391:Tektl1 UTSW 10 78,588,688 (GRCm39) nonsense probably null
R5434:Tektl1 UTSW 10 78,584,484 (GRCm39) nonsense probably null
R6382:Tektl1 UTSW 10 78,588,675 (GRCm39) missense possibly damaging 0.90
R6749:Tektl1 UTSW 10 78,588,672 (GRCm39) missense possibly damaging 0.95
R7177:Tektl1 UTSW 10 78,588,324 (GRCm39) missense probably damaging 1.00
R8158:Tektl1 UTSW 10 78,584,509 (GRCm39) missense probably benign 0.01
R8504:Tektl1 UTSW 10 78,586,463 (GRCm39) missense probably damaging 1.00
R8504:Tektl1 UTSW 10 78,585,038 (GRCm39) missense probably benign 0.00
R8558:Tektl1 UTSW 10 78,583,035 (GRCm39) missense probably damaging 1.00
R8806:Tektl1 UTSW 10 78,588,306 (GRCm39) missense probably damaging 1.00
R8925:Tektl1 UTSW 10 78,588,258 (GRCm39) missense probably damaging 1.00
R8927:Tektl1 UTSW 10 78,588,258 (GRCm39) missense probably damaging 1.00
R9285:Tektl1 UTSW 10 78,588,234 (GRCm39) splice site probably benign
R9407:Tektl1 UTSW 10 78,583,128 (GRCm39) missense probably damaging 0.99
X0057:Tektl1 UTSW 10 78,586,375 (GRCm39) missense probably null 1.00
Predicted Primers PCR Primer
(F):5'- TTCCATAGGGTGACGCCTTCTC -3'
(R):5'- ATGGTTGTCCTGGTTGCCAC -3'

Sequencing Primer
(F):5'- CGGGCGGTGGCTTTTCC -3'
(R):5'- TCTGGGAGCACGCATTCTAG -3'
Posted On 2018-08-29