Incidental Mutation 'R6743:Or5b3'
ID 532762
Institutional Source Beutler Lab
Gene Symbol Or5b3
Ensembl Gene ENSMUSG00000063777
Gene Name olfactory receptor family 5 subfamily B member 3
Synonyms MOR202-11, Olfr1469, GA_x6K02T2RE5P-3743369-3744289
MMRRC Submission 044860-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R6743 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 13387935-13388864 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 13387957 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 8 (T8I)
Ref Sequence ENSEMBL: ENSMUSP00000150006 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077538] [ENSMUST00000216910]
AlphaFold Q8VFW5
Predicted Effect probably damaging
Transcript: ENSMUST00000077538
AA Change: T8I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000076741
Gene: ENSMUSG00000063777
AA Change: T8I

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 2e-47 PFAM
Pfam:7tm_1 42 290 2.3e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216910
AA Change: T8I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.2%
Validation Efficiency 100% (39/39)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg1 C T 17: 31,327,321 (GRCm39) R339C possibly damaging Het
Adamts6 G A 13: 104,565,436 (GRCm39) G721R probably damaging Het
Adnp2 A G 18: 80,171,274 (GRCm39) V1045A probably benign Het
Agbl3 T C 6: 34,823,888 (GRCm39) I856T probably benign Het
Anapc1 T A 2: 128,526,454 (GRCm39) K115* probably null Het
Arc A G 15: 74,543,636 (GRCm39) S196P probably benign Het
Atp10a T C 7: 58,447,562 (GRCm39) I768T possibly damaging Het
Blk C T 14: 63,622,375 (GRCm39) R55H probably benign Het
Ccdc158 T C 5: 92,810,005 (GRCm39) S168G probably benign Het
Cda G T 4: 138,066,253 (GRCm39) T128K probably benign Het
Celsr1 T A 15: 85,791,799 (GRCm39) T2601S probably damaging Het
Dmxl1 T C 18: 50,013,847 (GRCm39) V1545A possibly damaging Het
Dst T A 1: 34,309,971 (GRCm39) N6264K probably damaging Het
Ednra T C 8: 78,401,718 (GRCm39) S191G probably damaging Het
Elk3 A T 10: 93,100,912 (GRCm39) S280T possibly damaging Het
Etnk1 A G 6: 143,126,343 (GRCm39) I63V possibly damaging Het
Fscb A G 12: 64,518,347 (GRCm39) S1040P unknown Het
Gm14295 T G 2: 176,502,420 (GRCm39) C637G probably damaging Het
Gm5114 T C 7: 39,057,997 (GRCm39) T541A probably benign Het
Man2c1 T C 9: 57,042,849 (GRCm39) F240L probably benign Het
Map2 A T 1: 66,454,766 (GRCm39) I1219L probably benign Het
Map3k13 A G 16: 21,711,173 (GRCm39) Y152C probably damaging Het
Morc1 G A 16: 48,322,683 (GRCm39) A327T probably damaging Het
Myo3a A T 2: 22,366,475 (GRCm39) Y553F probably benign Het
Myo9b T A 8: 71,804,803 (GRCm39) probably null Het
Or14j1 A C 17: 38,146,694 (GRCm39) D268A probably damaging Het
Pam A G 1: 97,823,774 (GRCm39) V219A probably benign Het
Panx1 A G 9: 14,918,929 (GRCm39) I310T possibly damaging Het
Pde6a T A 18: 61,397,057 (GRCm39) F634L possibly damaging Het
Pkd1l2 C A 8: 117,757,370 (GRCm39) C1556F probably damaging Het
Prdm5 G A 6: 65,860,635 (GRCm39) V440I probably damaging Het
Rasa2 T C 9: 96,493,493 (GRCm39) T64A probably damaging Het
Sec24b A T 3: 129,834,881 (GRCm39) Y106N probably damaging Het
Sfswap C T 5: 129,627,883 (GRCm39) Q689* probably null Het
Slamf8 C T 1: 172,417,965 (GRCm39) probably null Het
Tektl1 G A 10: 78,588,726 (GRCm39) T28M probably benign Het
Tmt1a3 A G 15: 100,233,123 (GRCm39) K105E probably benign Het
Tsr1 T C 11: 74,799,177 (GRCm39) V786A probably benign Het
Yod1 G A 1: 130,645,275 (GRCm39) G19S probably damaging Het
Zmynd10 T C 9: 107,425,079 (GRCm39) I58T possibly damaging Het
Other mutations in Or5b3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01064:Or5b3 APN 19 13,388,590 (GRCm39) missense probably benign 0.01
IGL01520:Or5b3 APN 19 13,388,114 (GRCm39) missense probably damaging 0.97
IGL01671:Or5b3 APN 19 13,388,255 (GRCm39) missense probably benign 0.29
IGL02247:Or5b3 APN 19 13,388,831 (GRCm39) missense probably benign 0.01
IGL02297:Or5b3 APN 19 13,388,839 (GRCm39) missense probably benign 0.00
IGL02417:Or5b3 APN 19 13,388,259 (GRCm39) missense possibly damaging 0.52
IGL02442:Or5b3 APN 19 13,388,351 (GRCm39) missense probably benign 0.00
IGL02989:Or5b3 APN 19 13,388,850 (GRCm39) missense probably benign
IGL03269:Or5b3 APN 19 13,388,792 (GRCm39) missense probably damaging 0.99
IGL02988:Or5b3 UTSW 19 13,388,826 (GRCm39) missense possibly damaging 0.75
R0707:Or5b3 UTSW 19 13,388,784 (GRCm39) missense probably benign 0.22
R1055:Or5b3 UTSW 19 13,388,754 (GRCm39) missense probably benign 0.10
R1102:Or5b3 UTSW 19 13,388,454 (GRCm39) missense probably damaging 1.00
R1946:Or5b3 UTSW 19 13,388,143 (GRCm39) missense possibly damaging 0.64
R2111:Or5b3 UTSW 19 13,388,307 (GRCm39) missense probably damaging 0.99
R4072:Or5b3 UTSW 19 13,388,299 (GRCm39) missense possibly damaging 0.49
R4073:Or5b3 UTSW 19 13,388,299 (GRCm39) missense possibly damaging 0.49
R4076:Or5b3 UTSW 19 13,388,299 (GRCm39) missense possibly damaging 0.49
R4726:Or5b3 UTSW 19 13,388,469 (GRCm39) missense probably damaging 1.00
R4939:Or5b3 UTSW 19 13,388,219 (GRCm39) missense probably benign 0.10
R5914:Or5b3 UTSW 19 13,388,326 (GRCm39) missense probably benign 0.31
R6003:Or5b3 UTSW 19 13,388,403 (GRCm39) missense probably benign 0.34
R6825:Or5b3 UTSW 19 13,388,514 (GRCm39) missense probably benign 0.01
R6826:Or5b3 UTSW 19 13,388,452 (GRCm39) missense probably benign 0.05
R6970:Or5b3 UTSW 19 13,388,792 (GRCm39) missense probably damaging 0.99
R7558:Or5b3 UTSW 19 13,388,355 (GRCm39) missense probably damaging 1.00
R7596:Or5b3 UTSW 19 13,388,511 (GRCm39) missense probably benign 0.01
R7923:Or5b3 UTSW 19 13,388,182 (GRCm39) missense probably benign 0.17
R8014:Or5b3 UTSW 19 13,388,175 (GRCm39) missense not run
R8506:Or5b3 UTSW 19 13,388,604 (GRCm39) missense possibly damaging 0.49
R8746:Or5b3 UTSW 19 13,388,092 (GRCm39) missense probably benign 0.44
R8803:Or5b3 UTSW 19 13,388,037 (GRCm39) missense probably damaging 0.99
R9112:Or5b3 UTSW 19 13,388,475 (GRCm39) missense probably benign 0.05
R9721:Or5b3 UTSW 19 13,388,334 (GRCm39) missense probably benign 0.17
Z1177:Or5b3 UTSW 19 13,388,083 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- AACCCCTTGTTTCCTAGTACAATAG -3'
(R):5'- ATGACTGTGGGTGTGACAGC -3'

Sequencing Primer
(F):5'- ACTTTGTAGACAACGCTGGC -3'
(R):5'- TCAACCAAGGACAGATTACCTAG -3'
Posted On 2018-08-29