Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01124:Cyp2c65'

53278

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2c65

Ensembl Gene

ENSMUSG00000067231

Gene Name

cytochrome P450, family 2, subfamily c, polypeptide 65

Synonyms

2210009K14Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.082) question?

Stock #

IGL01124

Quality Score

Status

Chromosome

Chromosomal Location

39049459-39082388 bp(+) (GRCm39)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

T to A at 39081954 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000084489 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087236]

AlphaFold

Q148B1

Predicted Effect

probably benign
Transcript: ENSMUST00000087236

SMART Domains

Protein: ENSMUSP00000084489
Gene: ENSMUSG00000067231

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:p450	30	487	2.1e-160	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ascc3	T	C	10: 50,608,569 (GRCm39)	I1477T	probably damaging	Het
Baat	A	G	4: 49,490,391 (GRCm39)	I231T	possibly damaging	Het
Cactin	T	C	10: 81,160,184 (GRCm39)	S426P	possibly damaging	Het
Cfh	A	T	1: 140,110,999 (GRCm39)	F6I	probably benign	Het
Clec4a2	C	T	6: 123,116,037 (GRCm39)		probably benign	Het
Col12a1	A	G	9: 79,611,129 (GRCm39)	S148P	probably damaging	Het
Cubn	G	T	2: 13,482,904 (GRCm39)	Q281K	possibly damaging	Het
Dennd4b	A	T	3: 90,176,381 (GRCm39)	T243S	possibly damaging	Het
Epha8	C	T	4: 136,663,394 (GRCm39)	G518D	probably damaging	Het
Fmo3	G	A	1: 162,785,830 (GRCm39)	R387C	probably damaging	Het
Foxo6	T	C	4: 120,126,349 (GRCm39)	T149A	probably benign	Het
Fthl17d	T	C	X: 8,852,827 (GRCm39)	E3G	probably benign	Het
Gm10521	A	G	1: 171,724,010 (GRCm39)	Y107C	unknown	Het
Ipo8	T	A	6: 148,678,874 (GRCm39)	E908V	probably benign	Het
Kcnd2	T	C	6: 21,217,216 (GRCm39)	S307P	probably damaging	Het
Klf3	A	G	5: 64,974,123 (GRCm39)	M3V	possibly damaging	Het
Ldb3	T	A	14: 34,266,157 (GRCm39)	E417D	probably damaging	Het
Lrch1	A	T	14: 74,994,503 (GRCm39)	D673E	probably benign	Het
Map3k4	T	C	17: 12,474,087 (GRCm39)	K865E	probably benign	Het
Muc4	G	A	16: 32,589,104 (GRCm39)	V754I	possibly damaging	Het
Nek4	A	G	14: 30,692,219 (GRCm39)	N223D	probably benign	Het
Nell2	G	A	15: 95,194,060 (GRCm39)	T551M	probably damaging	Het
Nup155	T	A	15: 8,183,163 (GRCm39)	M1241K	probably damaging	Het
Or2t49	A	T	11: 58,393,020 (GRCm39)	S121T	possibly damaging	Het
Or5i1	T	C	2: 87,613,720 (GRCm39)	F279L	probably benign	Het
Orc1	T	C	4: 108,445,984 (GRCm39)		probably benign	Het
Pclo	T	C	5: 14,764,343 (GRCm39)	I4272T	unknown	Het
Ppp1r12c	A	G	7: 4,500,344 (GRCm39)		probably benign	Het
Prcp	A	G	7: 92,559,416 (GRCm39)	E160G	probably benign	Het
Prl3d3	G	A	13: 27,343,090 (GRCm39)	R92Q	possibly damaging	Het
Prl6a1	T	A	13: 27,500,347 (GRCm39)	M106K	possibly damaging	Het
Slc22a1	T	A	17: 12,869,749 (GRCm39)		probably benign	Het
Slco3a1	A	G	7: 73,934,295 (GRCm39)	Y626H	probably damaging	Het
Smtn	A	G	11: 3,476,326 (GRCm39)		probably null	Het
Snx30	T	C	4: 59,886,404 (GRCm39)		probably benign	Het
Spock2	A	G	10: 59,967,209 (GRCm39)	D393G	unknown	Het
Trem3	T	G	17: 48,556,829 (GRCm39)	L100R	probably damaging	Het
Trpm2	A	T	10: 77,781,659 (GRCm39)		probably benign	Het
Ubr1	T	C	2: 120,745,386 (GRCm39)	M901V	probably benign	Het
Usp28	T	A	9: 48,948,513 (GRCm39)	S873T	probably damaging	Het
Vmn1r86	T	C	7: 12,836,856 (GRCm39)	I7V	probably benign	Het
Xirp2	T	C	2: 67,338,959 (GRCm39)	L400P	probably damaging	Het

Other mutations in Cyp2c65

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01122:Cyp2c65	APN	19	39,060,621 (GRCm39)	critical splice acceptor site	probably null
IGL01895:Cyp2c65	APN	19	39,060,676 (GRCm39)	missense	possibly damaging	0.90
IGL02544:Cyp2c65	APN	19	39,079,082 (GRCm39)	missense	probably damaging	1.00
R0172:Cyp2c65	UTSW	19	39,076,100 (GRCm39)	missense	possibly damaging	0.86
R0378:Cyp2c65	UTSW	19	39,061,662 (GRCm39)	missense	probably benign	0.19
R0517:Cyp2c65	UTSW	19	39,070,792 (GRCm39)	splice site	probably benign
R0585:Cyp2c65	UTSW	19	39,057,686 (GRCm39)	missense	probably benign	0.00
R1770:Cyp2c65	UTSW	19	39,070,642 (GRCm39)	missense	probably benign	0.07
R2051:Cyp2c65	UTSW	19	39,070,675 (GRCm39)	missense	probably benign	0.12
R2310:Cyp2c65	UTSW	19	39,081,826 (GRCm39)	missense	probably benign	0.02
R2911:Cyp2c65	UTSW	19	39,076,126 (GRCm39)	missense	probably damaging	0.96
R4208:Cyp2c65	UTSW	19	39,079,099 (GRCm39)	missense	probably damaging	1.00
R4258:Cyp2c65	UTSW	19	39,081,872 (GRCm39)	missense	probably benign	0.41
R4734:Cyp2c65	UTSW	19	39,060,778 (GRCm39)	missense	probably benign	0.00
R4821:Cyp2c65	UTSW	19	39,060,635 (GRCm39)	missense	probably damaging	1.00
R4926:Cyp2c65	UTSW	19	39,049,597 (GRCm39)	missense	probably benign	0.00
R5060:Cyp2c65	UTSW	19	39,049,514 (GRCm39)	missense	unknown
R5091:Cyp2c65	UTSW	19	39,076,009 (GRCm39)	critical splice acceptor site	probably null
R5433:Cyp2c65	UTSW	19	39,081,928 (GRCm39)	missense	probably benign	0.00
R6051:Cyp2c65	UTSW	19	39,049,610 (GRCm39)	missense	probably benign	0.29
R6182:Cyp2c65	UTSW	19	39,049,606 (GRCm39)	missense	probably benign	0.18
R6400:Cyp2c65	UTSW	19	39,049,558 (GRCm39)	missense	possibly damaging	0.80
R6586:Cyp2c65	UTSW	19	39,070,662 (GRCm39)	missense	possibly damaging	0.89
R6672:Cyp2c65	UTSW	19	39,076,118 (GRCm39)	missense	probably damaging	1.00
R6850:Cyp2c65	UTSW	19	39,057,535 (GRCm39)	missense	probably benign	0.15
R8075:Cyp2c65	UTSW	19	39,060,682 (GRCm39)	missense	probably benign	0.10
R8756:Cyp2c65	UTSW	19	39,049,552 (GRCm39)	nonsense	probably null
R9006:Cyp2c65	UTSW	19	39,070,714 (GRCm39)	missense	probably damaging	1.00
R9031:Cyp2c65	UTSW	19	39,061,663 (GRCm39)	nonsense	probably null
R9231:Cyp2c65	UTSW	19	39,060,661 (GRCm39)	missense	possibly damaging	0.92
R9663:Cyp2c65	UTSW	19	39,079,070 (GRCm39)	critical splice acceptor site	probably null

Posted On

2013-06-21