Incidental Mutation 'R6744:Or10al3'
ID 532808
Institutional Source Beutler Lab
Gene Symbol Or10al3
Ensembl Gene ENSMUSG00000059964
Gene Name olfactory receptor family 10 subfamily AL member 3
Synonyms GA_x6K02T2PSCP-2159633-2160598, MOR263-7, Olfr119
MMRRC Submission 044861-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R6744 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 38007576-38012611 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 38012336 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 258 (Y258*)
Ref Sequence ENSEMBL: ENSMUSP00000150099 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080483] [ENSMUST00000213732]
AlphaFold Q7TRJ5
Predicted Effect probably null
Transcript: ENSMUST00000080483
AA Change: Y258*
SMART Domains Protein: ENSMUSP00000092919
Gene: ENSMUSG00000059964
AA Change: Y258*

Pfam:7tm_4 37 314 5.6e-59 PFAM
Pfam:7TM_GPCR_Srsx 41 311 1.7e-5 PFAM
Pfam:7tm_1 47 296 3.1e-23 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213732
AA Change: Y258*
Meta Mutation Damage Score 0.9666 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.6%
Validation Efficiency 98% (47/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahi1 T A 10: 20,841,466 (GRCm39) L251H probably damaging Het
Alk A T 17: 72,910,077 (GRCm39) S210T probably benign Het
Arap2 A G 5: 62,906,281 (GRCm39) F246S probably damaging Het
Atad5 T A 11: 80,024,858 (GRCm39) N1749K probably benign Het
C87436 T A 6: 86,423,046 (GRCm39) S207T probably damaging Het
C8b C T 4: 104,631,543 (GRCm39) R53W probably damaging Het
Catsperg2 A G 7: 29,409,244 (GRCm39) V619A probably benign Het
Cdc73 G A 1: 143,577,887 (GRCm39) probably benign Het
Cdh4 C A 2: 179,489,180 (GRCm39) H297Q possibly damaging Het
Col3a1 G T 1: 45,377,782 (GRCm39) probably benign Het
Crybg2 A G 4: 133,816,207 (GRCm39) N1328S probably damaging Het
Ctnnb1 T A 9: 120,782,025 (GRCm39) V346E probably damaging Het
Ctns C T 11: 73,076,111 (GRCm39) G308E probably damaging Het
Dnah6 A G 6: 73,014,532 (GRCm39) I3685T probably damaging Het
Dock6 T C 9: 21,742,770 (GRCm39) H775R probably damaging Het
Eef1ece2 A T 16: 20,449,116 (GRCm39) K165N probably damaging Het
Fbxl3 A T 14: 103,320,730 (GRCm39) V239D probably damaging Het
Gh T A 11: 106,192,230 (GRCm39) K55* probably null Het
Havcr2 T G 11: 46,345,887 (GRCm39) probably null Het
Kcnq2 T A 2: 180,727,099 (GRCm39) H576L possibly damaging Het
Kifap3 A G 1: 163,676,239 (GRCm39) N398S probably benign Het
Lama5 G A 2: 179,833,455 (GRCm39) P1519L probably damaging Het
Mblac1 A G 5: 138,192,682 (GRCm39) E8G possibly damaging Het
Mtor C T 4: 148,543,112 (GRCm39) T290I probably benign Het
Nceh1 T C 3: 27,295,938 (GRCm39) Y400H probably damaging Het
Nek9 A G 12: 85,376,703 (GRCm39) V226A probably benign Het
Or10a3 T C 7: 108,480,037 (GRCm39) T259A probably damaging Het
Or2d4 A G 7: 106,543,741 (GRCm39) S156P probably damaging Het
Otud4 C A 8: 80,400,407 (GRCm39) Y1039* probably null Het
Pax4 T C 6: 28,442,396 (GRCm39) H331R probably benign Het
Piezo2 A T 18: 63,165,960 (GRCm39) Y2090* probably null Het
Ppp1r12a T A 10: 108,066,395 (GRCm39) H195Q probably damaging Het
Ppp6r2 A G 15: 89,140,864 (GRCm39) probably null Het
Prodh A G 16: 17,897,064 (GRCm39) V23A probably benign Het
Psg20 G A 7: 18,408,505 (GRCm39) T405I probably damaging Het
Ptprf T C 4: 118,093,562 (GRCm39) D360G probably benign Het
Qrfprl T A 6: 65,418,324 (GRCm39) M164K possibly damaging Het
Rad18 A T 6: 112,652,745 (GRCm39) M284K probably damaging Het
Rgs17 T C 10: 5,792,567 (GRCm39) K60E possibly damaging Het
Sec31a G T 5: 100,540,358 (GRCm39) Q39K possibly damaging Het
Slc22a22 G T 15: 57,117,668 (GRCm39) T291K possibly damaging Het
Sult2a6 C T 7: 13,956,470 (GRCm39) E264K probably damaging Het
Syne2 C T 12: 76,121,221 (GRCm39) R5896C probably damaging Het
Tctn1 A T 5: 122,402,209 (GRCm39) V75D probably damaging Het
Tmem214 A G 5: 31,031,372 (GRCm39) K409E probably damaging Het
Vcan T C 13: 89,853,301 (GRCm39) Y553C probably damaging Het
Vmn1r49 C T 6: 90,049,184 (GRCm39) V273I probably benign Het
Other mutations in Or10al3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02209:Or10al3 APN 17 38,011,883 (GRCm39) missense probably damaging 1.00
IGL03339:Or10al3 APN 17 38,011,682 (GRCm39) missense probably damaging 0.99
R0092:Or10al3 UTSW 17 38,011,696 (GRCm39) missense probably damaging 0.98
R0207:Or10al3 UTSW 17 38,011,949 (GRCm39) nonsense probably null
R0378:Or10al3 UTSW 17 38,011,932 (GRCm39) missense probably damaging 1.00
R0408:Or10al3 UTSW 17 38,012,190 (GRCm39) missense probably benign
R0483:Or10al3 UTSW 17 38,012,188 (GRCm39) missense probably benign 0.01
R1595:Or10al3 UTSW 17 38,012,004 (GRCm39) missense probably benign 0.03
R1901:Or10al3 UTSW 17 38,012,312 (GRCm39) missense probably damaging 1.00
R1902:Or10al3 UTSW 17 38,012,312 (GRCm39) missense probably damaging 1.00
R2845:Or10al3 UTSW 17 38,011,714 (GRCm39) missense probably damaging 1.00
R2846:Or10al3 UTSW 17 38,011,714 (GRCm39) missense probably damaging 1.00
R4356:Or10al3 UTSW 17 38,011,790 (GRCm39) missense probably damaging 0.97
R4381:Or10al3 UTSW 17 38,011,790 (GRCm39) missense probably damaging 0.97
R7674:Or10al3 UTSW 17 38,011,573 (GRCm39) missense probably benign 0.03
R7677:Or10al3 UTSW 17 38,011,957 (GRCm39) missense probably damaging 1.00
R7994:Or10al3 UTSW 17 38,012,326 (GRCm39) missense probably damaging 0.99
R8305:Or10al3 UTSW 17 38,012,389 (GRCm39) missense probably benign 0.10
R8512:Or10al3 UTSW 17 38,012,071 (GRCm39) missense probably damaging 1.00
R9300:Or10al3 UTSW 17 38,011,815 (GRCm39) missense probably damaging 1.00
R9760:Or10al3 UTSW 17 38,012,434 (GRCm39) missense probably damaging 1.00
Z1177:Or10al3 UTSW 17 38,011,944 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2018-08-29