Incidental Mutation 'R6749:Trim68'
ID 532889
Institutional Source Beutler Lab
Gene Symbol Trim68
Ensembl Gene ENSMUSG00000073968
Gene Name tripartite motif-containing 68
Synonyms SS-56, Rnf137, F730114J12Rik
MMRRC Submission 044866-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R6749 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 102326789-102336534 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 102327990 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 321 (D321G)
Ref Sequence ENSEMBL: ENSMUSP00000080813 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082175] [ENSMUST00000210855]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000082175
AA Change: D321G

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000080813
Gene: ENSMUSG00000073968
AA Change: D321G

DomainStartEndE-ValueType
RING 16 60 1.61e-8 SMART
BBOX 93 134 9.89e-9 SMART
coiled coil region 187 226 N/A INTRINSIC
PRY 302 354 1.91e-24 SMART
SPRY 355 482 3.03e-28 SMART
Predicted Effect silent
Transcript: ENSMUST00000210855
Meta Mutation Damage Score 0.7679 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.9%
Validation Efficiency 100% (47/47)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk A G 11: 119,901,600 (GRCm39) V875A possibly damaging Het
Arhgef15 A T 11: 68,845,383 (GRCm39) F156L probably damaging Het
Bdh2 T A 3: 135,006,452 (GRCm39) S184T probably damaging Het
Bmp5 A T 9: 75,683,375 (GRCm39) M1L probably benign Het
Cacfd1 T C 2: 26,908,467 (GRCm39) Y134H probably damaging Het
Camk1 G A 6: 113,311,486 (GRCm39) P340L probably benign Het
Cdc14a T C 3: 116,090,807 (GRCm39) H424R possibly damaging Het
Cntfr T A 4: 41,663,232 (GRCm39) T192S possibly damaging Het
Erbin G T 13: 103,970,885 (GRCm39) S910R probably damaging Het
Esrp1 A T 4: 11,357,519 (GRCm39) V366E probably damaging Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Fsip2 T A 2: 82,808,738 (GRCm39) S1686T possibly damaging Het
Gata5 A G 2: 179,976,143 (GRCm39) L7S probably damaging Het
Hgf T A 5: 16,818,640 (GRCm39) probably null Het
Ift140 A G 17: 25,317,890 (GRCm39) E1458G probably damaging Het
Ift57 G A 16: 49,581,347 (GRCm39) G209R probably benign Het
Il12rb2 G T 6: 67,338,950 (GRCm39) probably benign Het
Krt78 G A 15: 101,859,358 (GRCm39) R280C probably damaging Het
Lipc A G 9: 70,730,668 (GRCm39) I88T probably damaging Het
Lrmda G T 14: 22,077,344 (GRCm39) R27L probably benign Het
Lrrc37a T G 11: 103,392,923 (GRCm39) E834A probably benign Het
Mmachc C A 4: 116,561,738 (GRCm39) R132L probably damaging Het
Myo10 T C 15: 25,714,196 (GRCm39) Y88H probably damaging Het
Myo5b G A 18: 74,834,574 (GRCm39) R878Q possibly damaging Het
Or2y1f A G 11: 49,184,877 (GRCm39) H243R probably damaging Het
Padi3 T C 4: 140,523,164 (GRCm39) T289A possibly damaging Het
Pcdhgb4 G T 18: 37,854,282 (GRCm39) A226S possibly damaging Het
Pde4c T C 8: 71,198,659 (GRCm39) V167A probably damaging Het
Pigr A G 1: 130,774,285 (GRCm39) T422A probably benign Het
Pmp2 T C 3: 10,247,542 (GRCm39) Y49C probably benign Het
Prpf39 A G 12: 65,103,048 (GRCm39) I441V possibly damaging Het
Ptprs A G 17: 56,744,884 (GRCm39) V284A probably damaging Het
Rsad1 T C 11: 94,434,166 (GRCm39) E354G probably damaging Het
Sema4b T A 7: 79,869,949 (GRCm39) D412E possibly damaging Het
Siglecg A G 7: 43,058,403 (GRCm39) I97V probably benign Het
Slc4a3 C T 1: 75,531,182 (GRCm39) R792* probably null Het
Slc6a20a A G 9: 123,466,135 (GRCm39) C569R probably damaging Het
Spata19 T C 9: 27,309,276 (GRCm39) V59A probably benign Het
Sult2a3 T A 7: 13,816,629 (GRCm39) Y183F probably benign Het
Tedc1 C T 12: 113,121,702 (GRCm39) T194M probably damaging Het
Tektl1 A C 10: 78,588,672 (GRCm39) M46R possibly damaging Het
Tmem63c T A 12: 87,122,439 (GRCm39) N412K probably damaging Het
Trav5-1 T C 14: 52,860,402 (GRCm39) I69T possibly damaging Het
Ttn T C 2: 76,695,600 (GRCm39) probably benign Het
Vars2 A G 17: 35,977,605 (GRCm39) V109A probably damaging Het
Vmn2r96 C T 17: 18,818,352 (GRCm39) P643L probably damaging Het
Zfpm2 G T 15: 40,818,104 (GRCm39) V146F possibly damaging Het
Znfx1 T C 2: 166,898,519 (GRCm39) K135R probably benign Het
Other mutations in Trim68
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01133:Trim68 APN 7 102,328,348 (GRCm39) splice site probably null
IGL02703:Trim68 APN 7 102,333,286 (GRCm39) missense probably damaging 0.99
IGL02835:Trim68 UTSW 7 102,327,780 (GRCm39) missense probably benign 0.21
R1765:Trim68 UTSW 7 102,329,597 (GRCm39) missense possibly damaging 0.82
R1780:Trim68 UTSW 7 102,333,280 (GRCm39) missense possibly damaging 0.58
R4107:Trim68 UTSW 7 102,327,658 (GRCm39) missense probably benign 0.01
R4451:Trim68 UTSW 7 102,333,680 (GRCm39) start codon destroyed probably damaging 1.00
R5385:Trim68 UTSW 7 102,327,990 (GRCm39) missense probably damaging 1.00
R5793:Trim68 UTSW 7 102,333,560 (GRCm39) missense possibly damaging 0.74
R5980:Trim68 UTSW 7 102,328,038 (GRCm39) missense probably damaging 1.00
R6912:Trim68 UTSW 7 102,333,675 (GRCm39) missense probably damaging 1.00
R7396:Trim68 UTSW 7 102,327,569 (GRCm39) nonsense probably null
R7789:Trim68 UTSW 7 102,333,676 (GRCm39) missense possibly damaging 0.61
R7892:Trim68 UTSW 7 102,328,004 (GRCm39) missense unknown
R8096:Trim68 UTSW 7 102,327,649 (GRCm39) missense probably damaging 1.00
R8922:Trim68 UTSW 7 102,327,550 (GRCm39) missense probably benign 0.03
R8986:Trim68 UTSW 7 102,327,808 (GRCm39) nonsense probably null
R9026:Trim68 UTSW 7 102,329,447 (GRCm39) missense probably damaging 0.96
X0067:Trim68 UTSW 7 102,333,339 (GRCm39) missense probably benign 0.00
Z1176:Trim68 UTSW 7 102,328,020 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGGGATAAGTACACCACCTCC -3'
(R):5'- AATGGCTCAGTGCAATCTGG -3'

Sequencing Primer
(F):5'- GATAAGTACACCACCTCCTTCCGG -3'
(R):5'- CAGTGCAATCTGGATGCTTCATCTAG -3'
Posted On 2018-08-29