Incidental Mutation 'R6749:Vmn2r96'
ID 532911
Institutional Source Beutler Lab
Gene Symbol Vmn2r96
Ensembl Gene ENSMUSG00000091679
Gene Name vomeronasal 2, receptor 96
Synonyms EG433070
MMRRC Submission 044866-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.157) question?
Stock # R6749 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 18793282-18818419 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 18818352 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 643 (P643L)
Ref Sequence ENSEMBL: ENSMUSP00000131564 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165692] [ENSMUST00000177244] [ENSMUST00000231261] [ENSMUST00000231286]
AlphaFold E9PZU5
Predicted Effect probably damaging
Transcript: ENSMUST00000165692
AA Change: P643L

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000131564
Gene: ENSMUSG00000091679
AA Change: P643L

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 257 8.6e-20 PFAM
Pfam:NCD3G 317 370 3.7e-22 PFAM
Pfam:7tm_3 402 638 3.9e-53 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000177244
AA Change: P835L

PolyPhen 2 Score 0.798 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000135095
Gene: ENSMUSG00000091679
AA Change: P835L

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 245 4.2e-19 PFAM
Pfam:NCD3G 317 370 6.9e-21 PFAM
Pfam:7tm_3 400 639 3.4e-75 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231261
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231286
AA Change: P835L
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.9%
Validation Efficiency 100% (47/47)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk A G 11: 119,901,600 (GRCm39) V875A possibly damaging Het
Arhgef15 A T 11: 68,845,383 (GRCm39) F156L probably damaging Het
Bdh2 T A 3: 135,006,452 (GRCm39) S184T probably damaging Het
Bmp5 A T 9: 75,683,375 (GRCm39) M1L probably benign Het
Cacfd1 T C 2: 26,908,467 (GRCm39) Y134H probably damaging Het
Camk1 G A 6: 113,311,486 (GRCm39) P340L probably benign Het
Cdc14a T C 3: 116,090,807 (GRCm39) H424R possibly damaging Het
Cntfr T A 4: 41,663,232 (GRCm39) T192S possibly damaging Het
Erbin G T 13: 103,970,885 (GRCm39) S910R probably damaging Het
Esrp1 A T 4: 11,357,519 (GRCm39) V366E probably damaging Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Fsip2 T A 2: 82,808,738 (GRCm39) S1686T possibly damaging Het
Gata5 A G 2: 179,976,143 (GRCm39) L7S probably damaging Het
Hgf T A 5: 16,818,640 (GRCm39) probably null Het
Ift140 A G 17: 25,317,890 (GRCm39) E1458G probably damaging Het
Ift57 G A 16: 49,581,347 (GRCm39) G209R probably benign Het
Il12rb2 G T 6: 67,338,950 (GRCm39) probably benign Het
Krt78 G A 15: 101,859,358 (GRCm39) R280C probably damaging Het
Lipc A G 9: 70,730,668 (GRCm39) I88T probably damaging Het
Lrmda G T 14: 22,077,344 (GRCm39) R27L probably benign Het
Lrrc37a T G 11: 103,392,923 (GRCm39) E834A probably benign Het
Mmachc C A 4: 116,561,738 (GRCm39) R132L probably damaging Het
Myo10 T C 15: 25,714,196 (GRCm39) Y88H probably damaging Het
Myo5b G A 18: 74,834,574 (GRCm39) R878Q possibly damaging Het
Or2y1f A G 11: 49,184,877 (GRCm39) H243R probably damaging Het
Padi3 T C 4: 140,523,164 (GRCm39) T289A possibly damaging Het
Pcdhgb4 G T 18: 37,854,282 (GRCm39) A226S possibly damaging Het
Pde4c T C 8: 71,198,659 (GRCm39) V167A probably damaging Het
Pigr A G 1: 130,774,285 (GRCm39) T422A probably benign Het
Pmp2 T C 3: 10,247,542 (GRCm39) Y49C probably benign Het
Prpf39 A G 12: 65,103,048 (GRCm39) I441V possibly damaging Het
Ptprs A G 17: 56,744,884 (GRCm39) V284A probably damaging Het
Rsad1 T C 11: 94,434,166 (GRCm39) E354G probably damaging Het
Sema4b T A 7: 79,869,949 (GRCm39) D412E possibly damaging Het
Siglecg A G 7: 43,058,403 (GRCm39) I97V probably benign Het
Slc4a3 C T 1: 75,531,182 (GRCm39) R792* probably null Het
Slc6a20a A G 9: 123,466,135 (GRCm39) C569R probably damaging Het
Spata19 T C 9: 27,309,276 (GRCm39) V59A probably benign Het
Sult2a3 T A 7: 13,816,629 (GRCm39) Y183F probably benign Het
Tedc1 C T 12: 113,121,702 (GRCm39) T194M probably damaging Het
Tektl1 A C 10: 78,588,672 (GRCm39) M46R possibly damaging Het
Tmem63c T A 12: 87,122,439 (GRCm39) N412K probably damaging Het
Trav5-1 T C 14: 52,860,402 (GRCm39) I69T possibly damaging Het
Trim68 T C 7: 102,327,990 (GRCm39) D321G probably damaging Het
Ttn T C 2: 76,695,600 (GRCm39) probably benign Het
Vars2 A G 17: 35,977,605 (GRCm39) V109A probably damaging Het
Zfpm2 G T 15: 40,818,104 (GRCm39) V146F possibly damaging Het
Znfx1 T C 2: 166,898,519 (GRCm39) K135R probably benign Het
Other mutations in Vmn2r96
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00562:Vmn2r96 APN 17 18,804,077 (GRCm39) missense probably benign 0.00
IGL00563:Vmn2r96 APN 17 18,804,077 (GRCm39) missense probably benign 0.00
IGL00769:Vmn2r96 APN 17 18,804,081 (GRCm39) missense probably benign 0.00
IGL01314:Vmn2r96 APN 17 18,803,226 (GRCm39) missense probably benign 0.00
IGL01983:Vmn2r96 APN 17 18,817,527 (GRCm39) missense probably damaging 0.99
IGL02314:Vmn2r96 APN 17 18,804,221 (GRCm39) missense probably benign 0.01
IGL02600:Vmn2r96 APN 17 18,817,829 (GRCm39) missense probably benign
IGL02672:Vmn2r96 APN 17 18,818,376 (GRCm39) missense probably benign 0.02
IGL02750:Vmn2r96 APN 17 18,802,851 (GRCm39) missense probably benign 0.01
IGL03068:Vmn2r96 APN 17 18,803,137 (GRCm39) missense probably benign 0.00
IGL03411:Vmn2r96 APN 17 18,806,634 (GRCm39) missense possibly damaging 0.88
R0316:Vmn2r96 UTSW 17 18,802,827 (GRCm39) missense probably damaging 1.00
R0502:Vmn2r96 UTSW 17 18,804,262 (GRCm39) missense probably benign
R0580:Vmn2r96 UTSW 17 18,802,900 (GRCm39) missense probably damaging 1.00
R0652:Vmn2r96 UTSW 17 18,817,830 (GRCm39) missense probably benign 0.05
R0789:Vmn2r96 UTSW 17 18,802,738 (GRCm39) missense possibly damaging 0.81
R1462:Vmn2r96 UTSW 17 18,817,660 (GRCm39) missense possibly damaging 0.94
R1462:Vmn2r96 UTSW 17 18,817,660 (GRCm39) missense possibly damaging 0.94
R1660:Vmn2r96 UTSW 17 18,817,988 (GRCm39) missense probably benign 0.00
R1755:Vmn2r96 UTSW 17 18,802,915 (GRCm39) missense possibly damaging 0.50
R1843:Vmn2r96 UTSW 17 18,818,183 (GRCm39) missense probably benign 0.14
R1943:Vmn2r96 UTSW 17 18,806,664 (GRCm39) missense probably benign 0.09
R1993:Vmn2r96 UTSW 17 18,804,138 (GRCm39) missense probably damaging 1.00
R2018:Vmn2r96 UTSW 17 18,804,263 (GRCm39) missense probably benign
R2405:Vmn2r96 UTSW 17 18,818,102 (GRCm39) missense probably damaging 0.96
R3977:Vmn2r96 UTSW 17 18,817,941 (GRCm39) missense probably damaging 1.00
R3979:Vmn2r96 UTSW 17 18,817,941 (GRCm39) missense probably damaging 1.00
R4059:Vmn2r96 UTSW 17 18,818,339 (GRCm39) missense probably benign 0.20
R4693:Vmn2r96 UTSW 17 18,803,270 (GRCm39) missense probably benign 0.03
R4709:Vmn2r96 UTSW 17 18,803,088 (GRCm39) missense probably benign 0.36
R4776:Vmn2r96 UTSW 17 18,817,770 (GRCm39) missense probably damaging 1.00
R4882:Vmn2r96 UTSW 17 18,817,866 (GRCm39) missense probably damaging 1.00
R4920:Vmn2r96 UTSW 17 18,802,918 (GRCm39) missense probably benign 0.07
R5143:Vmn2r96 UTSW 17 18,804,120 (GRCm39) missense possibly damaging 0.65
R5301:Vmn2r96 UTSW 17 18,817,950 (GRCm39) missense probably damaging 0.98
R5507:Vmn2r96 UTSW 17 18,818,091 (GRCm39) missense probably damaging 1.00
R6151:Vmn2r96 UTSW 17 18,804,221 (GRCm39) missense probably benign 0.01
R6181:Vmn2r96 UTSW 17 18,804,126 (GRCm39) missense probably benign
R6339:Vmn2r96 UTSW 17 18,804,124 (GRCm39) missense possibly damaging 0.84
R6404:Vmn2r96 UTSW 17 18,817,793 (GRCm39) missense probably damaging 1.00
R6452:Vmn2r96 UTSW 17 18,804,117 (GRCm39) missense probably benign 0.07
R6813:Vmn2r96 UTSW 17 18,802,116 (GRCm39) missense probably benign 0.04
R6851:Vmn2r96 UTSW 17 18,802,800 (GRCm39) missense possibly damaging 0.95
R6944:Vmn2r96 UTSW 17 18,817,891 (GRCm39) missense probably benign 0.16
R6949:Vmn2r96 UTSW 17 18,818,100 (GRCm39) missense probably damaging 1.00
R6962:Vmn2r96 UTSW 17 18,818,283 (GRCm39) missense probably damaging 0.99
R6990:Vmn2r96 UTSW 17 18,804,082 (GRCm39) missense probably benign
R7149:Vmn2r96 UTSW 17 18,817,989 (GRCm39) missense possibly damaging 0.89
R7346:Vmn2r96 UTSW 17 18,803,029 (GRCm39) missense probably benign 0.15
R7385:Vmn2r96 UTSW 17 18,803,302 (GRCm39) missense probably damaging 1.00
R7442:Vmn2r96 UTSW 17 18,793,662 (GRCm39) missense probably benign 0.02
R7509:Vmn2r96 UTSW 17 18,802,995 (GRCm39) missense probably benign 0.02
R7652:Vmn2r96 UTSW 17 18,793,832 (GRCm39) missense probably benign
R7659:Vmn2r96 UTSW 17 18,793,749 (GRCm39) missense probably benign 0.00
R7753:Vmn2r96 UTSW 17 18,806,663 (GRCm39) missense possibly damaging 0.46
R7855:Vmn2r96 UTSW 17 18,818,130 (GRCm39) missense possibly damaging 0.59
R8166:Vmn2r96 UTSW 17 18,802,744 (GRCm39) missense probably damaging 1.00
R8260:Vmn2r96 UTSW 17 18,804,243 (GRCm39) missense probably benign 0.04
R8323:Vmn2r96 UTSW 17 18,803,023 (GRCm39) missense probably damaging 0.99
R8787:Vmn2r96 UTSW 17 18,818,250 (GRCm39) missense probably damaging 1.00
R8837:Vmn2r96 UTSW 17 18,802,888 (GRCm39) missense probably benign
R8933:Vmn2r96 UTSW 17 18,804,241 (GRCm39) missense probably benign 0.11
R9306:Vmn2r96 UTSW 17 18,803,226 (GRCm39) missense probably benign 0.00
R9481:Vmn2r96 UTSW 17 18,793,621 (GRCm39) start gained probably benign
R9626:Vmn2r96 UTSW 17 18,793,758 (GRCm39) missense probably benign 0.14
R9629:Vmn2r96 UTSW 17 18,803,257 (GRCm39) missense probably benign 0.15
Z1088:Vmn2r96 UTSW 17 18,817,628 (GRCm39) missense possibly damaging 0.86
Z1177:Vmn2r96 UTSW 17 18,818,376 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- ATGCTATGGCCTTCTTGTCTAG -3'
(R):5'- TAGGAATGGAGCCATCAGGTC -3'

Sequencing Primer
(F):5'- GGCCTTCTTGTCTAGAAATTTGCCAG -3'
(R):5'- GGAGCCATCAGGTCTTATACTCAG -3'
Posted On 2018-08-29