Incidental Mutation 'R6800:Or2n1'
ID 533306
Institutional Source Beutler Lab
Gene Symbol Or2n1
Ensembl Gene ENSMUSG00000096009
Gene Name olfactory receptor family 2 subfamily N member 1
Synonyms GA_x6K02T2PSCP-2623613-2624551, MOR256-5, Olfr134
MMRRC Submission 044913-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R6800 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 38485977-38486915 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38486013 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 13 (I13V)
Ref Sequence ENSEMBL: ENSMUSP00000151069 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074883] [ENSMUST00000215900]
AlphaFold Q8VG95
Predicted Effect probably benign
Transcript: ENSMUST00000074883
AA Change: I13V

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000074423
Gene: ENSMUSG00000096009
AA Change: I13V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.4e-50 PFAM
Pfam:7tm_1 41 290 2e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215900
AA Change: I13V

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.4%
Validation Efficiency 97% (66/68)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930486L24Rik G A 13: 60,992,948 (GRCm39) P244S probably damaging Het
9130023H24Rik C A 7: 127,836,742 (GRCm39) probably benign Het
Acoxl A T 2: 127,852,085 (GRCm39) Q129L probably damaging Het
Akna T C 4: 63,316,268 (GRCm39) T32A probably benign Het
Alox15 C T 11: 70,235,645 (GRCm39) probably null Het
Antxrl T C 14: 33,787,864 (GRCm39) S296P probably damaging Het
Arrb2 G T 11: 70,328,142 (GRCm39) G52* probably null Het
Bltp2 T C 11: 78,179,105 (GRCm39) F2091S probably benign Het
Capn2 A T 1: 182,309,045 (GRCm39) I499N probably damaging Het
Cfhr4 T A 1: 139,629,719 (GRCm39) D683V possibly damaging Het
Cspg4b T A 13: 113,504,686 (GRCm39) D396E probably benign Het
Cubn T A 2: 13,326,066 (GRCm39) I2700F probably damaging Het
Cypt4 A T 9: 24,536,965 (GRCm39) N152Y probably benign Het
Dmxl2 T C 9: 54,316,467 (GRCm39) N1640D probably damaging Het
Dnah7b A T 1: 46,379,377 (GRCm39) N3704Y possibly damaging Het
Dnah9 A G 11: 65,963,565 (GRCm39) probably null Het
Elac2 G A 11: 64,890,265 (GRCm39) probably null Het
Erich3 A T 3: 154,433,029 (GRCm39) probably null Het
Espnl T C 1: 91,270,351 (GRCm39) V386A probably damaging Het
Fbxl6 T A 15: 76,422,898 (GRCm39) probably benign Het
Fdps A C 3: 89,008,068 (GRCm39) F17V probably damaging Het
Gigyf2 T C 1: 87,346,898 (GRCm39) I576T possibly damaging Het
Gm20939 A G 17: 95,184,657 (GRCm39) E435G possibly damaging Het
Hivep1 G A 13: 42,310,852 (GRCm39) V1031I probably damaging Het
Hydin T G 8: 111,324,603 (GRCm39) S4655A probably benign Het
Ifrd1 T A 12: 40,273,157 (GRCm39) probably benign Het
Iqgap1 G T 7: 80,378,729 (GRCm39) T1219K possibly damaging Het
Lmtk3 G A 7: 45,443,233 (GRCm39) E639K possibly damaging Het
Map3k5 A G 10: 20,017,326 (GRCm39) *1373W probably null Het
Mia2 G A 12: 59,235,332 (GRCm39) probably null Het
Micu2 T C 14: 58,156,896 (GRCm39) D313G possibly damaging Het
Mrgpra4 A G 7: 47,631,371 (GRCm39) S77P probably damaging Het
Mrpl51 T C 6: 125,169,367 (GRCm39) V17A probably benign Het
Neurod4 A T 10: 130,106,661 (GRCm39) Y204* probably null Het
Or56a42-ps1 A T 7: 104,776,217 (GRCm39) V97E probably benign Het
Or5p67 G A 7: 107,922,460 (GRCm39) T141I probably benign Het
Or6c66b A T 10: 129,377,132 (GRCm39) H242L probably damaging Het
Pate2 T C 9: 35,596,941 (GRCm39) probably benign Het
Pcdhgb8 G A 18: 37,896,580 (GRCm39) R550Q probably benign Het
Phldb3 T C 7: 24,323,577 (GRCm39) L437P possibly damaging Het
Pianp C A 6: 124,978,565 (GRCm39) P257T possibly damaging Het
Rbbp6 T A 7: 122,584,287 (GRCm39) H140Q possibly damaging Het
Rfx2 A G 17: 57,087,804 (GRCm39) I529T probably damaging Het
Rnf113a1 A C X: 36,455,840 (GRCm39) T266P probably benign Het
Rp1l1 T C 14: 64,268,599 (GRCm39) I1395T possibly damaging Het
Rps6ka2 A C 17: 7,519,035 (GRCm39) K186Q probably damaging Het
Rsf1 CGGC CGGCGGCGGGGGC 7: 97,229,139 (GRCm39) probably benign Het
Rtel1 C A 2: 180,964,256 (GRCm39) T85N probably benign Het
Rtn4rl2 T C 2: 84,710,967 (GRCm39) N99S probably damaging Het
Ryr1 C T 7: 28,723,741 (GRCm39) G4106D possibly damaging Het
Scgb2b24 A G 7: 33,437,894 (GRCm39) V71A probably benign Het
Sgip1 A G 4: 102,778,225 (GRCm39) probably benign Het
Slc12a4 G A 8: 106,676,371 (GRCm39) T515I probably damaging Het
Spag1 C T 15: 36,197,895 (GRCm39) R286* probably null Het
Strbp C T 2: 37,515,228 (GRCm39) R266Q probably damaging Het
Strn G T 17: 78,977,787 (GRCm39) probably benign Het
Thnsl2 C A 6: 71,118,264 (GRCm39) V55L probably benign Het
Tmem178b A T 6: 40,231,858 (GRCm39) Q164L unknown Het
Tmprss6 C T 15: 78,324,457 (GRCm39) R786H probably damaging Het
Ttc21a T A 9: 119,770,268 (GRCm39) L113Q possibly damaging Het
Ttc21b T C 2: 66,038,994 (GRCm39) probably null Het
Vmn2r51 T C 7: 9,832,191 (GRCm39) D465G probably damaging Het
Vmp1 A C 11: 86,556,913 (GRCm39) probably null Het
Wdcp T C 12: 4,901,358 (GRCm39) F405L probably damaging Het
Zfhx3 A T 8: 109,676,149 (GRCm39) T2400S probably benign Het
Zfp27 T C 7: 29,593,860 (GRCm39) T702A probably benign Het
Zfp87 T C 13: 74,520,080 (GRCm39) S333G probably benign Het
Other mutations in Or2n1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01677:Or2n1 APN 17 38,486,766 (GRCm39) missense probably damaging 1.00
IGL01749:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01750:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01751:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01753:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01757:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01765:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01766:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01767:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01822:Or2n1 APN 17 38,486,339 (GRCm39) missense probably damaging 1.00
IGL02256:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02257:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02258:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02259:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02275:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02293:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02295:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02317:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02318:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
R0230:Or2n1 UTSW 17 38,486,841 (GRCm39) missense probably damaging 1.00
R0363:Or2n1 UTSW 17 38,486,338 (GRCm39) missense probably damaging 1.00
R1074:Or2n1 UTSW 17 38,486,331 (GRCm39) missense probably damaging 1.00
R1506:Or2n1 UTSW 17 38,486,091 (GRCm39) missense probably benign
R2300:Or2n1 UTSW 17 38,486,441 (GRCm39) nonsense probably null
R3743:Or2n1 UTSW 17 38,486,793 (GRCm39) missense probably damaging 1.00
R3975:Or2n1 UTSW 17 38,486,386 (GRCm39) missense probably benign 0.03
R4230:Or2n1 UTSW 17 38,486,772 (GRCm39) missense possibly damaging 0.67
R5158:Or2n1 UTSW 17 38,486,345 (GRCm39) nonsense probably null
R5439:Or2n1 UTSW 17 38,486,917 (GRCm39) splice site probably null
R6144:Or2n1 UTSW 17 38,486,116 (GRCm39) missense probably damaging 1.00
R6309:Or2n1 UTSW 17 38,486,410 (GRCm39) missense probably benign 0.00
R6675:Or2n1 UTSW 17 38,486,905 (GRCm39) missense probably benign
R6873:Or2n1 UTSW 17 38,486,259 (GRCm39) missense probably benign
R7193:Or2n1 UTSW 17 38,485,987 (GRCm39) missense probably benign 0.44
R7534:Or2n1 UTSW 17 38,486,188 (GRCm39) missense probably benign 0.22
R7869:Or2n1 UTSW 17 38,486,830 (GRCm39) missense possibly damaging 0.94
R7912:Or2n1 UTSW 17 38,486,158 (GRCm39) missense probably damaging 0.99
R8048:Or2n1 UTSW 17 38,486,419 (GRCm39) missense probably benign 0.11
R8305:Or2n1 UTSW 17 38,486,464 (GRCm39) missense probably damaging 1.00
R9396:Or2n1 UTSW 17 38,486,421 (GRCm39) missense probably damaging 1.00
R9445:Or2n1 UTSW 17 38,486,694 (GRCm39) missense probably damaging 1.00
X0011:Or2n1 UTSW 17 38,486,742 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCACAAAGCTCTATATGGACTG -3'
(R):5'- CATCTGAGGTACAATGCTTGTG -3'

Sequencing Primer
(F):5'- ATGGACTGATGTGTCTCCTAAC -3'
(R):5'- TGTGGTGTAGCACATGTCTAGAAAG -3'
Posted On 2018-09-12