Incidental Mutation 'R6802:Or12k7'
ID 533368
Institutional Source Beutler Lab
Gene Symbol Or12k7
Ensembl Gene ENSMUSG00000083361
Gene Name olfactory receptor family 12 subfamily K member 7
Synonyms MOR159-1, Olfr360, GA_x6K02T2NLDC-33760081-33761034
MMRRC Submission 044915-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R6802 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 36958319-36959272 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 36958427 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 37 (M37V)
Ref Sequence ENSEMBL: ENSMUSP00000149581 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000120704] [ENSMUST00000216706]
AlphaFold Q8VFP3
Predicted Effect probably benign
Transcript: ENSMUST00000120704
AA Change: M37V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000114121
Gene: ENSMUSG00000083361
AA Change: M37V

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2e-45 PFAM
Pfam:7TM_GPCR_Srsx 35 206 6e-7 PFAM
Pfam:7tm_1 41 289 5.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216706
AA Change: M37V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.2%
Validation Efficiency 100% (54/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110004F10Rik A T 7: 115,698,725 (GRCm39) K38N probably damaging Het
Agap3 T A 5: 24,692,791 (GRCm39) I408N possibly damaging Het
Apold1 G A 6: 134,960,693 (GRCm39) R49H probably damaging Het
Arfgef1 A T 1: 10,259,677 (GRCm39) M597K probably benign Het
Bsn C T 9: 107,987,823 (GRCm39) probably benign Het
Ccdc177 A T 12: 80,806,057 (GRCm39) D72E probably damaging Het
Coa8 G T 12: 111,717,625 (GRCm39) G162W probably benign Het
Ctdp1 A T 18: 80,463,656 (GRCm39) probably null Het
Ctsj A T 13: 61,150,888 (GRCm39) L190M probably benign Het
Dhx57 A G 17: 80,582,750 (GRCm39) F285S probably benign Het
Dnah2 A T 11: 69,314,516 (GRCm39) V4051E probably damaging Het
F5 A T 1: 164,006,925 (GRCm39) D243V probably damaging Het
Fat3 C T 9: 15,826,357 (GRCm39) E4532K possibly damaging Het
Fbxo30 G T 10: 11,167,224 (GRCm39) G649C probably damaging Het
Focad T C 4: 88,192,440 (GRCm39) S590P unknown Het
Focad G A 4: 88,262,921 (GRCm39) V973I unknown Het
Glb1l3 T C 9: 26,770,648 (GRCm39) probably null Het
Gli2 G A 1: 118,769,795 (GRCm39) R586C probably damaging Het
Gm6401 T A 14: 41,788,874 (GRCm39) E65V probably damaging Het
Gml2 T A 15: 74,696,095 (GRCm39) L163H probably damaging Het
Grm6 A T 11: 50,744,216 (GRCm39) Q229L probably benign Het
Gtf2h2 T C 13: 100,617,051 (GRCm39) M252V probably benign Het
Hsf4 G A 8: 106,001,300 (GRCm39) G309S probably damaging Het
Iglc1 T C 16: 18,880,660 (GRCm39) probably benign Het
Irgq A G 7: 24,231,076 (GRCm39) E89G probably benign Het
Kcnj6 T C 16: 94,563,436 (GRCm39) N354S probably benign Het
Lrguk A G 6: 34,039,392 (GRCm39) H301R probably damaging Het
Mc4r C A 18: 66,992,488 (GRCm39) M208I probably benign Het
Mrpl15 A G 1: 4,846,953 (GRCm39) S208P probably benign Het
Neil2 A G 14: 63,429,263 (GRCm39) F10S probably damaging Het
Nrg1 T C 8: 32,311,292 (GRCm39) R476G probably damaging Het
Or4c100 A G 2: 88,355,941 (GRCm39) T5A probably benign Het
Or8k22 G T 2: 86,163,529 (GRCm39) T57K possibly damaging Het
Pacs1 T C 19: 5,202,812 (GRCm39) I357V probably damaging Het
Pla2g15 T C 8: 106,877,213 (GRCm39) L32P probably damaging Het
Pms1 A T 1: 53,245,951 (GRCm39) S529R probably benign Het
Prkra A T 2: 76,463,881 (GRCm39) D260E probably damaging Het
Qsox1 A C 1: 155,671,139 (GRCm39) F127V probably damaging Het
Rabgap1l A T 1: 160,561,250 (GRCm39) V161E probably benign Het
Robo1 T G 16: 72,730,201 (GRCm39) V214G probably benign Het
Ryr2 G A 13: 11,701,852 (GRCm39) A2935V probably damaging Het
Sgtb A T 13: 104,268,558 (GRCm39) Q198L probably benign Het
Slc39a12 C T 2: 14,424,896 (GRCm39) L376F probably benign Het
Socs1 C A 16: 10,602,222 (GRCm39) V172L probably benign Het
Sprr2k A G 3: 92,340,671 (GRCm39) probably benign Het
Tgm1 C T 14: 55,949,939 (GRCm39) probably benign Het
Tph2 A T 10: 115,020,778 (GRCm39) M6K probably damaging Het
Trav16 T A 14: 53,980,941 (GRCm39) C43* probably null Het
Ttll5 A G 12: 85,926,160 (GRCm39) E318G probably damaging Het
Vmn2r90 T A 17: 17,932,351 (GRCm39) I86N probably damaging Het
Zdhhc19 T C 16: 32,325,176 (GRCm39) S165P possibly damaging Het
Zfp352 A T 4: 90,113,437 (GRCm39) T526S probably benign Het
Other mutations in Or12k7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02394:Or12k7 APN 2 36,958,497 (GRCm39) missense probably damaging 1.00
H8786:Or12k7 UTSW 2 36,958,341 (GRCm39) missense probably benign 0.41
R4551:Or12k7 UTSW 2 36,958,355 (GRCm39) missense probably benign 0.03
R4896:Or12k7 UTSW 2 36,958,422 (GRCm39) missense probably damaging 1.00
R5004:Or12k7 UTSW 2 36,958,422 (GRCm39) missense probably damaging 1.00
R5828:Or12k7 UTSW 2 36,959,001 (GRCm39) missense probably benign 0.00
R6173:Or12k7 UTSW 2 36,959,091 (GRCm39) missense possibly damaging 0.78
R6859:Or12k7 UTSW 2 36,958,794 (GRCm39) missense probably damaging 0.98
R7171:Or12k7 UTSW 2 36,958,400 (GRCm39) missense possibly damaging 0.91
R7712:Or12k7 UTSW 2 36,958,916 (GRCm39) missense probably damaging 1.00
R7798:Or12k7 UTSW 2 36,959,186 (GRCm39) missense probably damaging 1.00
R8492:Or12k7 UTSW 2 36,958,695 (GRCm39) missense probably damaging 1.00
R8815:Or12k7 UTSW 2 36,958,429 (GRCm39) missense probably benign
R8870:Or12k7 UTSW 2 36,958,982 (GRCm39) missense probably benign
R9115:Or12k7 UTSW 2 36,959,052 (GRCm39) missense probably damaging 0.96
T0722:Or12k7 UTSW 2 36,958,449 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATAAGATGTGCTTGAGCCTTGG -3'
(R):5'- TGCTGCCCACTGCCATAAAG -3'

Sequencing Primer
(F):5'- GGTATTGTTCTCTTTTCCAACTGTG -3'
(R):5'- GCAACGATTATAGGAAATGCTCC -3'
Posted On 2018-09-12