Incidental Mutation 'R6803:Hdac11'
ID 533434
Institutional Source Beutler Lab
Gene Symbol Hdac11
Ensembl Gene ENSMUSG00000034245
Gene Name histone deacetylase 11
Synonyms
MMRRC Submission 044916-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.284) question?
Stock # R6803 (G1)
Quality Score 150.008
Status Validated
Chromosome 6
Chromosomal Location 91133652-91151674 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 91143247 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 131 (R131L)
Ref Sequence ENSEMBL: ENSMUSP00000121624 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041736] [ENSMUST00000143621] [ENSMUST00000204776]
AlphaFold Q91WA3
Predicted Effect possibly damaging
Transcript: ENSMUST00000041736
AA Change: R131L

PolyPhen 2 Score 0.476 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000043828
Gene: ENSMUSG00000034245
AA Change: R131L

DomainStartEndE-ValueType
Pfam:Hist_deacetyl 24 321 1e-51 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000143621
AA Change: R131L

PolyPhen 2 Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000121624
Gene: ENSMUSG00000034245
AA Change: R131L

DomainStartEndE-ValueType
Pfam:Hist_deacetyl 23 141 1.6e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000155007
SMART Domains Protein: ENSMUSP00000120923
Gene: ENSMUSG00000034245

DomainStartEndE-ValueType
SCOP:d1c3pa_ 14 122 8e-16 SMART
low complexity region 124 140 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000204776
AA Change: R17L

PolyPhen 2 Score 0.104 (Sensitivity: 0.93; Specificity: 0.86)
Meta Mutation Damage Score 0.1614 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 98.0%
  • 20x: 94.7%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
PHENOTYPE: Mice homozygous for a knockout allele exhibit increased IL10 secretion from peritoneal elicited macrophages stimulated with LPS, more suppressive myeloid-derived suppressive cell population and enhanced tumor growth of injected tumor cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alg9 A C 9: 50,700,860 (GRCm39) D210A probably benign Het
As3mt T G 19: 46,698,020 (GRCm39) M120R probably benign Het
Baz1a T A 12: 54,988,340 (GRCm39) S270C probably null Het
Car5a A C 8: 122,650,504 (GRCm39) probably null Het
Ccdc187 T A 2: 26,179,791 (GRCm39) T223S probably benign Het
Cel T C 2: 28,448,060 (GRCm39) N322S probably benign Het
Chd6 T C 2: 160,802,279 (GRCm39) E2185G possibly damaging Het
Clcnkb T C 4: 141,132,639 (GRCm39) T597A probably benign Het
Cntnap1 A G 11: 101,068,060 (GRCm39) Y24C possibly damaging Het
Cog3 A G 14: 75,941,479 (GRCm39) S817P probably benign Het
Col8a2 A G 4: 126,205,793 (GRCm39) Y601C probably damaging Het
Cpm G T 10: 117,512,002 (GRCm39) probably null Het
Cpt2 T C 4: 107,769,861 (GRCm39) N79S probably damaging Het
Dnah17 T C 11: 118,016,198 (GRCm39) T314A probably benign Het
Dnm1 C A 2: 32,202,766 (GRCm39) V46F probably damaging Het
Fat3 C T 9: 15,908,083 (GRCm39) V2640M probably damaging Het
Fbxl2 A T 9: 113,813,617 (GRCm39) C296S probably damaging Het
Fcgbp A G 7: 27,802,637 (GRCm39) T1522A probably benign Het
Foxl2 A C 9: 98,837,985 (GRCm39) K91T probably damaging Het
Ipo11 T C 13: 106,993,766 (GRCm39) I723V probably benign Het
Klhl33 A G 14: 51,134,192 (GRCm39) L150P probably damaging Het
Klk1b11 A G 7: 43,647,261 (GRCm39) H65R probably damaging Het
Larp7 T C 3: 127,330,685 (GRCm39) probably null Het
Ldlrad3 T C 2: 101,943,892 (GRCm39) D60G possibly damaging Het
Mlip A T 9: 77,097,663 (GRCm39) H177Q probably damaging Het
Mrnip A G 11: 50,090,730 (GRCm39) D298G probably benign Het
Npas2 A C 1: 39,375,130 (GRCm39) S483R probably benign Het
Nrg3 C A 14: 38,733,957 (GRCm39) E310* probably null Het
Omg T A 11: 79,393,094 (GRCm39) T255S possibly damaging Het
Or2y12 T A 11: 49,426,432 (GRCm39) L140H probably damaging Het
Or56b1b G T 7: 108,164,620 (GRCm39) D127E probably damaging Het
Plekhg6 T C 6: 125,340,626 (GRCm39) D578G probably damaging Het
Pygo1 A G 9: 72,850,267 (GRCm39) K39E probably damaging Het
Rell2 A G 18: 38,089,994 (GRCm39) D66G probably damaging Het
Samd9l A T 6: 3,375,446 (GRCm39) I605K probably damaging Het
Sema6d T C 2: 124,505,970 (GRCm39) S593P probably damaging Het
Sf3b3 A G 8: 111,552,210 (GRCm39) V545A probably benign Het
Speer4f1 T A 5: 17,684,388 (GRCm39) probably null Het
Spem1 T C 11: 69,711,974 (GRCm39) E230G possibly damaging Het
Sphkap A G 1: 83,258,231 (GRCm39) F171L probably damaging Het
Tbc1d13 T C 2: 30,025,522 (GRCm39) probably benign Het
Tmem222 A T 4: 132,994,154 (GRCm39) N206K probably benign Het
Trnau1ap C T 4: 132,049,081 (GRCm39) V41M probably damaging Het
Ttn C T 2: 76,769,387 (GRCm39) probably null Het
Ubr3 T C 2: 69,766,368 (GRCm39) probably null Het
Uox T G 3: 146,318,264 (GRCm39) V55G possibly damaging Het
Vmn2r24 A T 6: 123,755,960 (GRCm39) I11F possibly damaging Het
Wasf2 T C 4: 132,922,220 (GRCm39) probably null Het
Wdr97 A G 15: 76,240,776 (GRCm39) Y488C probably damaging Het
Zbtb4 T C 11: 69,669,454 (GRCm39) S726P possibly damaging Het
Zfp534 C T 4: 147,758,926 (GRCm39) C581Y probably damaging Het
Zfp551 A T 7: 12,151,108 (GRCm39) C100* probably null Het
Other mutations in Hdac11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01452:Hdac11 APN 6 91,144,843 (GRCm39) missense probably damaging 1.00
IGL01556:Hdac11 APN 6 91,150,162 (GRCm39) missense probably benign 0.00
IGL02159:Hdac11 APN 6 91,150,084 (GRCm39) missense probably damaging 0.99
IGL03082:Hdac11 APN 6 91,150,085 (GRCm39) missense probably damaging 1.00
IGL03046:Hdac11 UTSW 6 91,145,827 (GRCm39) missense probably benign 0.02
R1791:Hdac11 UTSW 6 91,145,806 (GRCm39) missense probably benign
R5771:Hdac11 UTSW 6 91,146,364 (GRCm39) splice site probably null
R5877:Hdac11 UTSW 6 91,134,524 (GRCm39) missense probably damaging 1.00
R5974:Hdac11 UTSW 6 91,150,196 (GRCm39) missense probably benign
R7483:Hdac11 UTSW 6 91,136,214 (GRCm39) missense probably damaging 0.99
R7786:Hdac11 UTSW 6 91,150,158 (GRCm39) nonsense probably null
R8259:Hdac11 UTSW 6 91,149,210 (GRCm39) missense probably damaging 1.00
R8990:Hdac11 UTSW 6 91,145,799 (GRCm39) nonsense probably null
R9681:Hdac11 UTSW 6 91,150,068 (GRCm39) missense probably benign 0.11
Z1177:Hdac11 UTSW 6 91,144,816 (GRCm39) missense possibly damaging 0.64
Predicted Primers PCR Primer
(F):5'- TTGTTTTCCCCGTAAAACTGGG -3'
(R):5'- AGCAGATAGAGGTACCCGTG -3'

Sequencing Primer
(F):5'- TAAAACTGGGAGGGCCACTC -3'
(R):5'- TGGGGCCTACACAGGAAC -3'
Posted On 2018-09-12