Mutagenetix > Incidental Mutation

Incidental Mutation 'R6804:Vmn2r11'

533479

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r11

Ensembl Gene

ENSMUSG00000091450

Gene Name

vomeronasal 2, receptor 11

Synonyms

EG384219

MMRRC Submission

044917-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

R6804 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

109194739-109207318 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 109201350 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Tyrosine at position 385 (N385Y)

Ref Sequence

ENSEMBL: ENSMUSP00000133218 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164875]

AlphaFold

E9Q4X4

Predicted Effect

probably damaging
Transcript: ENSMUST00000164875
AA Change: N385Y

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000133218
Gene: ENSMUSG00000091450
AA Change: N385Y

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	167	475	1.6e-29	PFAM
Pfam:NCD3G	520	574	9.1e-19	PFAM
Pfam:7tm_3	607	842	4.6e-55	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.4%
20x: 95.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aox1	A	T	1: 58,343,757 (GRCm39)	Q480L	probably benign	Het
Arid4b	T	A	13: 14,303,792 (GRCm39)	D72E	probably benign	Het
Avil	C	T	10: 126,844,175 (GRCm39)	Q245*	probably null	Het
BC048679	T	C	7: 81,146,612 (GRCm39)	S2G	possibly damaging	Het
C1ra	G	A	6: 124,494,684 (GRCm39)	E316K	probably benign	Het
Cacna1d	T	C	14: 29,773,622 (GRCm39)	T1723A	probably benign	Het
Cfap91	T	C	16: 38,152,604 (GRCm39)	D202G	probably damaging	Het
Chil3	A	T	3: 106,071,495 (GRCm39)	Y56*	probably null	Het
Clec2i	A	G	6: 128,872,384 (GRCm39)	E172G	probably damaging	Het
Crybg1	C	T	10: 43,842,337 (GRCm39)	D1785N	probably damaging	Het
Csmd1	G	A	8: 16,087,260 (GRCm39)	R1930W	probably damaging	Het
D430041D05Rik	A	C	2: 103,979,371 (GRCm39)	S2019A	possibly damaging	Het
Ep300	T	A	15: 81,525,512 (GRCm39)	Y1445*	probably null	Het
Gne	A	G	4: 44,060,210 (GRCm39)	I61T	probably damaging	Het
Ifit3b	A	T	19: 34,588,947 (GRCm39)	Q41L	possibly damaging	Het
Kplce	T	C	3: 92,776,354 (GRCm39)	T110A	possibly damaging	Het
Llgl2	A	G	11: 115,734,141 (GRCm39)		probably null	Het
Mast3	T	C	8: 71,239,376 (GRCm39)	I417V	probably benign	Het
Mettl21e	T	A	1: 44,257,295 (GRCm39)	I8F	probably benign	Het
Ms4a2	A	G	19: 11,594,899 (GRCm39)	Y183H	probably damaging	Het
Naip6	C	G	13: 100,435,675 (GRCm39)	E949D	probably benign	Het
Nbea	T	C	3: 55,994,874 (GRCm39)	T181A	probably benign	Het
Nrg1	T	C	8: 32,311,292 (GRCm39)	R476G	probably damaging	Het
Olfm3	A	T	3: 114,916,328 (GRCm39)	Y400F	probably benign	Het
Or12d2	A	G	17: 37,625,021 (GRCm39)	S85P	probably damaging	Het
Or1e33	A	G	11: 73,738,240 (GRCm39)	V237A	probably benign	Het
Or2a25	A	T	6: 42,888,852 (GRCm39)	T132S	probably benign	Het
Or2y1e	A	G	11: 49,218,808 (GRCm39)	D190G	probably benign	Het
Pappa2	T	C	1: 158,764,438 (GRCm39)	S358G	probably benign	Het
Pde4dip	C	A	3: 97,700,564 (GRCm39)	E259*	probably null	Het
Phlpp2	T	A	8: 110,655,197 (GRCm39)	L664Q	probably damaging	Het
Prpf8	A	G	11: 75,390,635 (GRCm39)	K1262R	possibly damaging	Het
Rsf1	ATGGCG	ATGGCGACGGTGGCG	7: 97,229,111 (GRCm39)		probably benign	Het
Saal1	GGCTTGCACGCCGT	G	7: 46,349,064 (GRCm39)		probably null	Het
Sec31a	C	T	5: 100,530,671 (GRCm39)	V701I	probably benign	Het
Smarca2	A	T	19: 26,729,286 (GRCm39)	R12S	possibly damaging	Het
Spocd1	T	A	4: 129,847,423 (GRCm39)	C537*	probably null	Het
Syt14	T	C	1: 192,584,161 (GRCm39)	E701G	probably damaging	Het
Taf3	T	C	2: 9,923,028 (GRCm39)	Y32C	possibly damaging	Het
Tfeb	T	C	17: 48,100,735 (GRCm39)		probably null	Het
Ttc13	C	A	8: 125,426,426 (GRCm39)	R168L	probably damaging	Het
Vmn2r54	T	C	7: 12,363,792 (GRCm39)	K367R	probably benign	Het

Other mutations in Vmn2r11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00925:Vmn2r11	APN	5	109,194,885 (GRCm39)	missense	probably benign	0.00
IGL01677:Vmn2r11	APN	5	109,201,823 (GRCm39)	missense	possibly damaging	0.50
IGL02048:Vmn2r11	APN	5	109,202,658 (GRCm39)	missense	probably benign	0.00
IGL02559:Vmn2r11	APN	5	109,200,046 (GRCm39)	missense	probably damaging	0.98
IGL02879:Vmn2r11	APN	5	109,201,704 (GRCm39)	missense	possibly damaging	0.95
IGL03084:Vmn2r11	APN	5	109,207,209 (GRCm39)	missense	probably benign	0.00
IGL03163:Vmn2r11	APN	5	109,201,692 (GRCm39)	missense	probably benign	0.41
IGL03289:Vmn2r11	APN	5	109,196,788 (GRCm39)	splice site	probably benign
IGL03294:Vmn2r11	APN	5	109,201,935 (GRCm39)	missense	probably benign	0.22
R0233:Vmn2r11	UTSW	5	109,201,968 (GRCm39)	missense	probably benign	0.16
R0233:Vmn2r11	UTSW	5	109,201,968 (GRCm39)	missense	probably benign	0.16
R0421:Vmn2r11	UTSW	5	109,207,294 (GRCm39)	missense	probably benign	0.00
R0549:Vmn2r11	UTSW	5	109,199,963 (GRCm39)	missense	possibly damaging	0.80
R0628:Vmn2r11	UTSW	5	109,195,597 (GRCm39)	missense	possibly damaging	0.88
R1523:Vmn2r11	UTSW	5	109,201,707 (GRCm39)	missense	probably benign	0.25
R1660:Vmn2r11	UTSW	5	109,201,724 (GRCm39)	missense	possibly damaging	0.79
R1827:Vmn2r11	UTSW	5	109,199,938 (GRCm39)	missense	probably benign	0.01
R1913:Vmn2r11	UTSW	5	109,202,654 (GRCm39)	missense	probably benign
R2260:Vmn2r11	UTSW	5	109,201,657 (GRCm39)	nonsense	probably null
R2400:Vmn2r11	UTSW	5	109,199,928 (GRCm39)	missense	probably benign	0.03
R3933:Vmn2r11	UTSW	5	109,201,260 (GRCm39)	missense	probably damaging	0.97
R4091:Vmn2r11	UTSW	5	109,202,616 (GRCm39)	critical splice donor site	probably null
R4624:Vmn2r11	UTSW	5	109,200,101 (GRCm39)	missense	probably damaging	0.99
R4762:Vmn2r11	UTSW	5	109,195,436 (GRCm39)	missense	probably damaging	1.00
R5256:Vmn2r11	UTSW	5	109,202,658 (GRCm39)	missense	probably benign	0.26
R5370:Vmn2r11	UTSW	5	109,195,421 (GRCm39)	missense	probably damaging	1.00
R5419:Vmn2r11	UTSW	5	109,207,224 (GRCm39)	missense	possibly damaging	0.55
R5516:Vmn2r11	UTSW	5	109,195,032 (GRCm39)	missense	probably damaging	0.98
R5643:Vmn2r11	UTSW	5	109,194,869 (GRCm39)	missense	probably damaging	1.00
R5671:Vmn2r11	UTSW	5	109,202,772 (GRCm39)	missense	probably benign	0.03
R5679:Vmn2r11	UTSW	5	109,202,708 (GRCm39)	missense	probably benign	0.00
R5739:Vmn2r11	UTSW	5	109,207,114 (GRCm39)	critical splice donor site	probably null
R5746:Vmn2r11	UTSW	5	109,201,560 (GRCm39)	missense	probably benign	0.41
R5995:Vmn2r11	UTSW	5	109,194,921 (GRCm39)	missense	probably damaging	1.00
R6147:Vmn2r11	UTSW	5	109,202,700 (GRCm39)	missense	probably benign	0.04
R6220:Vmn2r11	UTSW	5	109,201,434 (GRCm39)	missense	probably benign	0.09
R6374:Vmn2r11	UTSW	5	109,201,679 (GRCm39)	missense	possibly damaging	0.65
R6491:Vmn2r11	UTSW	5	109,196,800 (GRCm39)	missense	possibly damaging	0.95
R6814:Vmn2r11	UTSW	5	109,194,976 (GRCm39)	missense	possibly damaging	0.81
R6872:Vmn2r11	UTSW	5	109,194,976 (GRCm39)	missense	possibly damaging	0.81
R7014:Vmn2r11	UTSW	5	109,201,289 (GRCm39)	missense	probably damaging	1.00
R7041:Vmn2r11	UTSW	5	109,202,816 (GRCm39)	missense	probably damaging	1.00
R7043:Vmn2r11	UTSW	5	109,200,098 (GRCm39)	missense	probably benign	0.00
R7050:Vmn2r11	UTSW	5	109,202,657 (GRCm39)	missense	probably benign	0.05
R7184:Vmn2r11	UTSW	5	109,201,281 (GRCm39)	missense	probably damaging	1.00
R7388:Vmn2r11	UTSW	5	109,202,742 (GRCm39)	missense	probably benign	0.05
R7477:Vmn2r11	UTSW	5	109,207,214 (GRCm39)	missense	possibly damaging	0.67
R7524:Vmn2r11	UTSW	5	109,201,848 (GRCm39)	missense	probably benign	0.01
R7682:Vmn2r11	UTSW	5	109,195,481 (GRCm39)	missense	probably benign	0.02
R7715:Vmn2r11	UTSW	5	109,195,307 (GRCm39)	missense	probably damaging	0.99
R7869:Vmn2r11	UTSW	5	109,199,986 (GRCm39)	missense	probably damaging	1.00
R8094:Vmn2r11	UTSW	5	109,201,626 (GRCm39)	missense	probably damaging	1.00
R8277:Vmn2r11	UTSW	5	109,202,833 (GRCm39)	missense	probably benign	0.00
R8506:Vmn2r11	UTSW	5	109,207,270 (GRCm39)	missense	probably benign	0.00
R8676:Vmn2r11	UTSW	5	109,201,626 (GRCm39)	missense	probably damaging	1.00
R8701:Vmn2r11	UTSW	5	109,195,556 (GRCm39)	missense	probably damaging	1.00
R8749:Vmn2r11	UTSW	5	109,195,319 (GRCm39)	missense	probably damaging	0.97
R9046:Vmn2r11	UTSW	5	109,202,850 (GRCm39)	missense	probably benign	0.00
R9138:Vmn2r11	UTSW	5	109,201,904 (GRCm39)	missense	probably damaging	1.00
R9267:Vmn2r11	UTSW	5	109,199,929 (GRCm39)	missense	possibly damaging	0.93
R9306:Vmn2r11	UTSW	5	109,196,831 (GRCm39)	missense	probably damaging	1.00
R9384:Vmn2r11	UTSW	5	109,201,266 (GRCm39)	missense	probably damaging	1.00
R9443:Vmn2r11	UTSW	5	109,195,159 (GRCm39)	nonsense	probably null
R9520:Vmn2r11	UTSW	5	109,201,455 (GRCm39)	missense	probably benign	0.35
R9596:Vmn2r11	UTSW	5	109,201,563 (GRCm39)	missense	possibly damaging	0.67
R9677:Vmn2r11	UTSW	5	109,201,332 (GRCm39)	missense

Predicted Primers

PCR Primer
(F):5'- CAATCAGTGAATGTTCCTTTGGG -3'
(R):5'- CACAACCTCACAATGGGATGTTATC -3'

Sequencing Primer
(F):5'- GGTACTGCCATTTGCTGAGATTCTAC -3'
(R):5'- AGCCTTGATTTCTTTCACGGGAC -3'

Posted On

2018-09-12