|Institutional Source||Beutler Lab|
|Gene Name||cerberus 1, DAN family BMP antagonist|
|Synonyms||Cerl1, Cerr1, Cerl, cer-1, Cerberus-like|
|Is this an essential gene?||Probably non essential (E-score: 0.133)|
|Stock #||R6807 (G1)|
|Chromosomal Location||82881751-82885148 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 82882815 bp|
|Amino Acid Change||Serine to Glycine at position 204 (S204G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000048607 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000048430]|
|Predicted Effect||probably benign
AA Change: S204G
PolyPhen 2 Score 0.079 (Sensitivity: 0.93; Specificity: 0.85)
AA Change: S204G
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||100% (72/72)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for most disruptions in this gene appear normal although one allele displays behavioral abnormalities and a mild increase in body weight with age. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cer1||
(F):5'- TAACCCTCACTTATTCTGTTGAGG -3'
(R):5'- TCATCCGTCTGTGCCTTGAG -3'
(F):5'- TCCAGGGATGAAGGAACCC -3'
(R):5'- AGTGGTCTGAAATGTCTCGAGATGAC -3'