Incidental Mutation 'IGL01139:Tex28'
ID53361
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tex28
Ensembl Gene ENSMUSG00000062564
Gene Nametestis expressed 28
SynonymsLOC385380
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL01139
Quality Score
Status
ChromosomeX
Chromosomal Location74150944-74167838 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 74151224 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 367 (M367K)
Ref Sequence ENSEMBL: ENSMUSP00000109967 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033771] [ENSMUST00000078060] [ENSMUST00000101457] [ENSMUST00000114328] [ENSMUST00000127445]
Predicted Effect probably benign
Transcript: ENSMUST00000033771
SMART Domains Protein: ENSMUSP00000033771
Gene: ENSMUSG00000031394

DomainStartEndE-ValueType
Pfam:7tm_1 65 317 1.1e-46 PFAM
low complexity region 335 357 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000078060
AA Change: M367K

PolyPhen 2 Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000077207
Gene: ENSMUSG00000062564
AA Change: M367K

DomainStartEndE-ValueType
Pfam:Tmemb_cc2 46 151 1.3e-28 PFAM
Pfam:Tmemb_cc2 131 380 2.3e-45 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000101457
SMART Domains Protein: ENSMUSP00000099000
Gene: ENSMUSG00000031394

DomainStartEndE-ValueType
Pfam:7tm_1 65 317 1.7e-46 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000114328
AA Change: M367K

PolyPhen 2 Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000109967
Gene: ENSMUSG00000062564
AA Change: M367K

DomainStartEndE-ValueType
Pfam:Tmemb_cc2 44 382 6.8e-112 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123401
Predicted Effect probably benign
Transcript: ENSMUST00000127445
SMART Domains Protein: ENSMUSP00000118631
Gene: ENSMUSG00000031394

DomainStartEndE-ValueType
Pfam:7tm_1 1 159 3.6e-20 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr3 A T 1: 125,405,885 I215N probably damaging Het
Ambn C T 5: 88,464,517 probably benign Het
Arhgef1 T A 7: 24,925,951 probably benign Het
Arid1a A C 4: 133,693,997 S832R unknown Het
Clca4a A T 3: 144,966,269 I304N probably damaging Het
Dmxl2 G A 9: 54,458,964 P274S probably damaging Het
Eif4enif1 T A 11: 3,221,143 D211E probably damaging Het
Eri2 A G 7: 119,786,737 probably null Het
Fhod3 C T 18: 25,066,344 P691S probably benign Het
Flnb A G 14: 7,945,989 S2465G probably damaging Het
Ftsj1 G A X: 8,246,592 R171C probably damaging Het
Glb1l3 G A 9: 26,818,227 T648I probably benign Het
Gm4222 T A 2: 90,148,545 probably benign Het
Gm438 A T 4: 144,777,689 Y297* probably null Het
Gm5475 G A 15: 100,424,215 probably benign Het
Jaml C A 9: 45,101,019 T268N possibly damaging Het
Kank3 G A 17: 33,817,401 G81E probably damaging Het
Lrba A G 3: 86,642,662 T217A possibly damaging Het
Ltn1 A G 16: 87,416,009 S555P probably benign Het
Map3k15 T A X: 160,072,879 M350K probably damaging Het
Mipol1 C A 12: 57,306,035 Y53* probably null Het
Mn1 A G 5: 111,421,449 D1095G probably damaging Het
Myh14 T C 7: 44,606,292 probably benign Het
Nrn1 A G 13: 36,730,216 C31R probably damaging Het
Nup210 A T 6: 91,030,097 L579H possibly damaging Het
Nxf2 T C X: 134,950,396 I578V probably benign Het
Obscn G A 11: 59,078,352 A172V probably damaging Het
Olfr1006 T G 2: 85,674,497 Y218S probably damaging Het
Olfr55 T A 17: 33,176,782 Y123N probably damaging Het
Phtf1 A G 3: 104,005,602 D748G probably damaging Het
Psd3 A T 8: 67,908,535 Y863N probably damaging Het
Psmc6 C T 14: 45,343,710 T321I probably benign Het
Rassf6 T C 5: 90,608,966 *31W probably null Het
Rictor A C 15: 6,778,268 K791Q probably damaging Het
Slc12a9 C T 5: 137,322,842 M470I probably damaging Het
Thnsl2 A T 6: 71,138,734 V163D probably damaging Het
Tmco3 G A 8: 13,319,887 R633Q possibly damaging Het
Trf A T 9: 103,223,604 V224D probably damaging Het
Ttc8 C T 12: 98,964,545 Q273* probably null Het
Usp9x A G X: 13,104,576 probably benign Het
Vmn2r117 A G 17: 23,477,804 W210R probably damaging Het
Vmn2r5 A G 3: 64,491,405 S718P probably benign Het
Vps13a T C 19: 16,640,625 D2932G probably damaging Het
Whamm T C 7: 81,595,914 L706P probably damaging Het
Yeats2 G A 16: 20,214,393 V45I probably damaging Het
Yipf3 G A 17: 46,250,457 probably null Het
Zeb1 T C 18: 5,705,061 V26A possibly damaging Het
Other mutations in Tex28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00535:Tex28 APN X 74161041 missense probably damaging 0.99
IGL01710:Tex28 APN X 74152333 nonsense probably null
Posted On2013-06-21