Incidental Mutation 'IGL01152:Pim2'
ID 53371
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pim2
Ensembl Gene ENSMUSG00000031155
Gene Name proviral integration site 2
Synonyms Pim-2, DXCch3
Accession Numbers
Essential gene? Not available question?
Stock # IGL01152
Quality Score
Status
Chromosome X
Chromosomal Location 7744545-7749671 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) C to A at 7744661 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000111332 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033494] [ENSMUST00000115665] [ENSMUST00000115666] [ENSMUST00000115667] [ENSMUST00000115668] [ENSMUST00000223553]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000033494
SMART Domains Protein: ENSMUSP00000033494
Gene: ENSMUSG00000031154

DomainStartEndE-ValueType
low complexity region 9 53 N/A INTRINSIC
low complexity region 58 78 N/A INTRINSIC
low complexity region 84 98 N/A INTRINSIC
low complexity region 100 114 N/A INTRINSIC
low complexity region 118 141 N/A INTRINSIC
low complexity region 157 164 N/A INTRINSIC
Pfam:OTU 219 331 1.4e-22 PFAM
low complexity region 425 438 N/A INTRINSIC
low complexity region 445 457 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000033495
AA Change: A40D
SMART Domains Protein: ENSMUSP00000033495
Gene: ENSMUSG00000031155
AA Change: A40D

DomainStartEndE-ValueType
low complexity region 6 41 N/A INTRINSIC
low complexity region 69 79 N/A INTRINSIC
S_TKc 91 345 1.19e-71 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115665
SMART Domains Protein: ENSMUSP00000111329
Gene: ENSMUSG00000031154

DomainStartEndE-ValueType
low complexity region 9 53 N/A INTRINSIC
low complexity region 58 78 N/A INTRINSIC
low complexity region 84 98 N/A INTRINSIC
low complexity region 100 114 N/A INTRINSIC
Pfam:OTU 176 288 2.8e-23 PFAM
low complexity region 376 389 N/A INTRINSIC
low complexity region 396 408 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115666
SMART Domains Protein: ENSMUSP00000111330
Gene: ENSMUSG00000031154

DomainStartEndE-ValueType
low complexity region 9 53 N/A INTRINSIC
low complexity region 58 78 N/A INTRINSIC
low complexity region 84 98 N/A INTRINSIC
low complexity region 100 114 N/A INTRINSIC
low complexity region 118 141 N/A INTRINSIC
low complexity region 157 164 N/A INTRINSIC
Pfam:OTU 219 331 3.2e-23 PFAM
low complexity region 425 438 N/A INTRINSIC
low complexity region 445 457 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115667
SMART Domains Protein: ENSMUSP00000111331
Gene: ENSMUSG00000031154

DomainStartEndE-ValueType
low complexity region 9 53 N/A INTRINSIC
low complexity region 58 78 N/A INTRINSIC
low complexity region 84 98 N/A INTRINSIC
low complexity region 100 114 N/A INTRINSIC
low complexity region 118 141 N/A INTRINSIC
low complexity region 157 164 N/A INTRINSIC
Pfam:OTU 219 338 3.4e-20 PFAM
low complexity region 430 443 N/A INTRINSIC
low complexity region 450 462 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115668
SMART Domains Protein: ENSMUSP00000111332
Gene: ENSMUSG00000031154

DomainStartEndE-ValueType
low complexity region 9 53 N/A INTRINSIC
low complexity region 58 78 N/A INTRINSIC
low complexity region 84 98 N/A INTRINSIC
low complexity region 100 114 N/A INTRINSIC
Pfam:OTU 176 288 1.2e-22 PFAM
low complexity region 382 395 N/A INTRINSIC
low complexity region 402 414 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000190448
AA Change: A35D
SMART Domains Protein: ENSMUSP00000140602
Gene: ENSMUSG00000031155
AA Change: A35D

DomainStartEndE-ValueType
low complexity region 6 41 N/A INTRINSIC
low complexity region 69 79 N/A INTRINSIC
S_TKc 91 345 1.19e-71 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126715
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150644
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145177
Predicted Effect unknown
Transcript: ENSMUST00000223553
AA Change: A35D
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]
PHENOTYPE: Homozygous null mice display reduced T cell proliferation in response to suboptimal alphaCD3 activation. Mice homozygous for a null allele exhibit reduced LPS-stimulated IL6 production from splenotcytes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A730013G03Rik T G 1: 192,515,947 (GRCm39) noncoding transcript Het
Abcb4 G A 5: 9,000,678 (GRCm39) V1031M probably benign Het
Abcc4 A G 14: 118,836,797 (GRCm39) S655P probably damaging Het
Actn1 T C 12: 80,245,820 (GRCm39) K121R probably damaging Het
Aldh1l2 T A 10: 83,358,750 (GRCm39) R82* probably null Het
Arhgap31 T A 16: 38,422,601 (GRCm39) H1155L possibly damaging Het
Atp8a1 G T 5: 68,004,549 (GRCm39) P2Q probably damaging Het
Bcs1l A G 1: 74,631,174 (GRCm39) M401V possibly damaging Het
Brca2 A T 5: 150,465,855 (GRCm39) N1873I probably damaging Het
Cenpj T C 14: 56,789,757 (GRCm39) N764S probably benign Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Clk1 A T 1: 58,452,611 (GRCm39) C359S possibly damaging Het
Clk2 T A 3: 89,083,818 (GRCm39) F479I probably damaging Het
Cul4b T C X: 37,632,247 (GRCm39) M709V probably damaging Het
D130052B06Rik G T 11: 33,573,620 (GRCm39) probably null Het
Dgkb T A 12: 38,134,233 (GRCm39) N46K probably damaging Het
Dnah9 C T 11: 65,962,882 (GRCm39) R1811H probably damaging Het
Dnajc18 T C 18: 35,813,926 (GRCm39) N281S probably benign Het
Galnt5 A T 2: 57,915,405 (GRCm39) I654L probably benign Het
Gm9989 T G 3: 81,829,518 (GRCm39) noncoding transcript Het
Gpr179 T C 11: 97,228,237 (GRCm39) E1306G probably benign Het
Gsc C A 12: 104,437,864 (GRCm39) K219N probably damaging Het
Gsx2 A T 5: 75,236,452 (GRCm39) I11F probably damaging Het
Igdcc4 A C 9: 65,042,446 (GRCm39) E121A probably damaging Het
Lama2 C T 10: 27,084,425 (GRCm39) R915H probably benign Het
Large2 A G 2: 92,200,984 (GRCm39) L64P probably damaging Het
Lztr1 C A 16: 17,340,317 (GRCm39) Q136K probably damaging Het
Mageb18 A G X: 91,163,430 (GRCm39) W271R possibly damaging Het
Magoh A C 4: 107,742,203 (GRCm39) probably benign Het
Matcap2 A T 9: 22,346,460 (GRCm39) H356L probably benign Het
Mrgprx1 T C 7: 47,671,234 (GRCm39) H171R probably benign Het
Muc1 C A 3: 89,138,061 (GRCm39) T301K probably benign Het
Nbas C T 12: 13,410,959 (GRCm39) L868F probably damaging Het
Nwd2 A G 5: 63,963,872 (GRCm39) D1152G possibly damaging Het
Or5p68 C T 7: 107,946,156 (GRCm39) A11T probably benign Het
Or7d10 G A 9: 19,832,245 (GRCm39) V247M possibly damaging Het
Ovgp1 T A 3: 105,893,488 (GRCm39) D420E possibly damaging Het
Pacsin3 A G 2: 91,094,121 (GRCm39) D350G probably benign Het
Pcolce2 A T 9: 95,574,976 (GRCm39) N309Y probably damaging Het
Plcb1 A G 2: 134,655,579 (GRCm39) Y53C probably damaging Het
Pogk T C 1: 166,236,047 (GRCm39) E18G probably damaging Het
Pxdn T A 12: 30,051,936 (GRCm39) D704E probably damaging Het
Rb1 C A 14: 73,443,310 (GRCm39) S781I probably damaging Het
Rnpepl1 A G 1: 92,843,621 (GRCm39) H247R possibly damaging Het
Scube1 A T 15: 83,497,771 (GRCm39) F697I probably damaging Het
Sel1l3 G T 5: 53,273,675 (GRCm39) H1064N probably damaging Het
Serinc3 A G 2: 163,478,831 (GRCm39) Y99H probably damaging Het
Slc36a2 T A 11: 55,060,673 (GRCm39) probably benign Het
Smarcc1 A C 9: 109,968,693 (GRCm39) E130A possibly damaging Het
Strc A G 2: 121,201,276 (GRCm39) M1273T probably benign Het
Tmem116 A G 5: 121,601,862 (GRCm39) I21V probably benign Het
Tmem190 T C 7: 4,787,025 (GRCm39) probably benign Het
Trim63 C T 4: 134,052,987 (GRCm39) A316V probably benign Het
Ugt2b34 T C 5: 87,049,062 (GRCm39) E321G probably damaging Het
Zfat T A 15: 67,982,353 (GRCm39) R1053S probably damaging Het
Posted On 2013-06-21