Incidental Mutation 'R6809:Bloc1s5'
ID 533722
Institutional Source Beutler Lab
Gene Symbol Bloc1s5
Ensembl Gene ENSMUSG00000038982
Gene Name biogenesis of lysosomal organelles complex-1, subunit 5, muted
Synonyms 1810074A19Rik, Muted, BLOC-1 subunit, mu
MMRRC Submission 044922-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6809 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 38786674-38821093 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38787961 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 141 (V141A)
Ref Sequence ENSEMBL: ENSMUSP00000036614 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035899] [ENSMUST00000224115]
AlphaFold Q8R015
Predicted Effect probably benign
Transcript: ENSMUST00000035899
AA Change: V141A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000036614
Gene: ENSMUSG00000038982
AA Change: V141A

DomainStartEndE-ValueType
Pfam:Muted 34 179 6.6e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000224115
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.1%
Validation Efficiency 96% (51/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a component of BLOC-1 (biogenesis of lysosome-related organelles complex 1). Components of this complex are involved in the biogenesis of organelles such as melanosomes and platelet-dense granules. A mouse model for Hermansky-Pudlak Syndrome is mutated in the murine version of this gene. Alternative splicing results in multiple transcript variants. Read-through transcription exists between this gene and the upstream EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1) gene, as well as with the downstream TXNDC5 (thioredoxin domain containing 5) gene. [provided by RefSeq, Dec 2010]
PHENOTYPE: Mutations at this locus cause pigment dilution, prolonged bleeding time, and inner ear abnormalities, modeling Hermansky-Pudlak Syndrome. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A130010J15Rik T A 1: 192,857,089 (GRCm39) V147E possibly damaging Het
Abtb3 A G 10: 85,467,240 (GRCm39) T732A probably benign Het
Adgrv1 A T 13: 81,621,072 (GRCm39) M3893K probably benign Het
Aox3 T C 1: 58,157,840 (GRCm39) S66P probably damaging Het
Apeh G A 9: 107,969,878 (GRCm39) H186Y probably damaging Het
Bltp1 A G 3: 36,928,431 (GRCm39) N61S probably damaging Het
Col28a1 T C 6: 7,999,468 (GRCm39) Y1083C probably damaging Het
Crb1 A G 1: 139,170,864 (GRCm39) V842A probably benign Het
Dapk1 A G 13: 60,899,103 (GRCm39) S858G probably benign Het
Dlgap2 G T 8: 14,229,619 (GRCm39) probably benign Het
Dpysl4 A G 7: 138,673,576 (GRCm39) D199G probably benign Het
Eml6 C T 11: 29,753,161 (GRCm39) V917I probably benign Het
Fut9 T A 4: 25,620,647 (GRCm39) T56S probably benign Het
Gtdc1 G C 2: 44,465,563 (GRCm39) S214* probably null Het
Gtdc1 A G 2: 44,715,396 (GRCm39) F49S probably damaging Het
Hoxd9 A G 2: 74,529,590 (GRCm39) Y282C probably damaging Het
Hrc A G 7: 44,985,803 (GRCm39) E318G probably benign Het
Ikzf2 T C 1: 69,609,661 (GRCm39) T195A probably damaging Het
Krt36 A T 11: 99,996,335 (GRCm39) S30T probably benign Het
Lrp1 A G 10: 127,390,925 (GRCm39) F2991L probably benign Het
Lrrc34 T A 3: 30,688,749 (GRCm39) Q184L possibly damaging Het
Mapk1 A T 16: 16,853,326 (GRCm39) M49L probably benign Het
Mroh2a G T 1: 88,162,938 (GRCm39) Q360H probably benign Het
Mrpl48 A G 7: 100,195,574 (GRCm39) probably benign Het
Ncln A G 10: 81,323,512 (GRCm39) probably null Het
Nol4 T A 18: 23,053,882 (GRCm39) Q96L probably damaging Het
Or2y1e G T 11: 49,218,687 (GRCm39) V150L probably benign Het
Or5g25 G A 2: 85,478,317 (GRCm39) A116V probably damaging Het
Padi2 A G 4: 140,674,077 (GRCm39) probably null Het
Pak5 T G 2: 135,939,501 (GRCm39) I545L possibly damaging Het
Paqr5 T A 9: 61,876,064 (GRCm39) R157W probably null Het
Pard3b G A 1: 62,200,340 (GRCm39) R293H probably damaging Het
Phf11d C A 14: 59,593,844 (GRCm39) C110F probably damaging Het
Pkn2 G A 3: 142,504,765 (GRCm39) P804S probably damaging Het
Pnpla6 G A 8: 3,584,611 (GRCm39) C743Y possibly damaging Het
Pramel14 A G 4: 143,719,651 (GRCm39) V238A probably benign Het
Pramel58 C A 5: 94,831,277 (GRCm39) Q95K probably benign Het
Psip1 A G 4: 83,386,879 (GRCm39) M164T probably benign Het
Rgs22 C G 15: 36,048,910 (GRCm39) S914T probably damaging Het
Rufy4 G A 1: 74,172,206 (GRCm39) V310I probably benign Het
Ryr2 G A 13: 11,741,816 (GRCm39) L2122F probably damaging Het
Sgcb T G 5: 73,798,036 (GRCm39) N142T probably benign Het
Slc27a6 A G 18: 58,738,126 (GRCm39) E394G probably benign Het
Slc29a2 T C 19: 5,079,271 (GRCm39) V298A probably damaging Het
Slf2 C A 19: 44,931,907 (GRCm39) T654N probably damaging Het
Spata4 A C 8: 55,055,368 (GRCm39) K123Q possibly damaging Het
Taar7b T C 10: 23,876,756 (GRCm39) V307A probably benign Het
Tenm4 G A 7: 96,202,703 (GRCm39) R106H probably benign Het
Ttn T C 2: 76,693,983 (GRCm39) E295G possibly damaging Het
Ubqln4 A T 3: 88,462,679 (GRCm39) Q48L possibly damaging Het
Ugt1a10 T A 1: 87,983,647 (GRCm39) D148E probably damaging Het
Vmn2r85 T A 10: 130,261,795 (GRCm39) N181Y probably benign Het
Wdfy3 C T 5: 102,071,813 (GRCm39) V1026I possibly damaging Het
Other mutations in Bloc1s5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00813:Bloc1s5 APN 13 38,803,158 (GRCm39) missense probably damaging 1.00
IGL02530:Bloc1s5 APN 13 38,787,859 (GRCm39) missense probably damaging 1.00
minnie UTSW 13 38,790,710 (GRCm39) intron probably benign
R0685:Bloc1s5 UTSW 13 38,787,895 (GRCm39) missense probably benign
R1763:Bloc1s5 UTSW 13 38,803,060 (GRCm39) splice site probably benign
R4852:Bloc1s5 UTSW 13 38,818,960 (GRCm39) missense probably damaging 1.00
R6923:Bloc1s5 UTSW 13 38,815,040 (GRCm39) missense probably damaging 1.00
R7702:Bloc1s5 UTSW 13 38,787,850 (GRCm39) missense probably benign 0.15
Predicted Primers PCR Primer
(F):5'- TGCTAAGCTTGAAGGAGAGACTAC -3'
(R):5'- GAAAGAAACATCTTCTGCTTGTTGC -3'

Sequencing Primer
(F):5'- GGGAATGAGAAAGCACTTCCTCATTC -3'
(R):5'- GCAGTAACGTTCAGTGGATAAAGTTC -3'
Posted On 2018-09-12