Incidental Mutation 'R6842:Ocm'
ID 533900
Institutional Source Beutler Lab
Gene Symbol Ocm
Ensembl Gene ENSMUSG00000029618
Gene Name oncomodulin
Synonyms
MMRRC Submission 044948-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6842 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 143956622-143963488 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 143962509 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 6 (I6F)
Ref Sequence ENSEMBL: ENSMUSP00000106330 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031622] [ENSMUST00000085704] [ENSMUST00000110702]
AlphaFold P51879
Predicted Effect unknown
Transcript: ENSMUST00000031622
AA Change: I6F
SMART Domains Protein: ENSMUSP00000031622
Gene: ENSMUSG00000029618
AA Change: I6F

DomainStartEndE-ValueType
low complexity region 2 16 N/A INTRINSIC
EFh 43 71 2.41e-4 SMART
EFh 82 109 1.09e0 SMART
Predicted Effect unknown
Transcript: ENSMUST00000085704
AA Change: I6F
SMART Domains Protein: ENSMUSP00000082848
Gene: ENSMUSG00000029618
AA Change: I6F

DomainStartEndE-ValueType
low complexity region 2 16 N/A INTRINSIC
EFh 43 71 2.41e-4 SMART
EFh 82 109 1.09e0 SMART
Predicted Effect unknown
Transcript: ENSMUST00000110702
AA Change: I6F
SMART Domains Protein: ENSMUSP00000106330
Gene: ENSMUSG00000029618
AA Change: I6F

DomainStartEndE-ValueType
SCOP:d2pvba_ 7 60 5e-7 SMART
PDB:2NLN|A 17 60 6e-25 PDB
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Oncomodulin is a high-affinity calcium ion-binding protein. It belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. Oncomodulin is an oncodevelopmental protein found in early embryonic cells in the placenta and also in tumors. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibti deafness. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsbg3 A G 17: 57,184,432 (GRCm39) N69S probably benign Het
Adgrl3 C T 5: 81,888,927 (GRCm39) A1042V probably damaging Het
Armh3 A G 19: 45,807,416 (GRCm39) V660A probably benign Het
C1s2 T A 6: 124,604,461 (GRCm39) H395L probably benign Het
Cacna1e A G 1: 154,358,863 (GRCm39) I307T probably damaging Het
Cap2 T C 13: 46,800,101 (GRCm39) S381P probably damaging Het
Cbfa2t2 A G 2: 154,365,965 (GRCm39) T392A probably benign Het
Ccdc127 T C 13: 74,505,088 (GRCm39) I212T probably damaging Het
Cela3a A G 4: 137,132,979 (GRCm39) V91A probably benign Het
Cep85 C G 4: 133,883,167 (GRCm39) A241P probably benign Het
Csmd2 T C 4: 128,402,952 (GRCm39) F2347L possibly damaging Het
Ddx19a A G 8: 111,705,257 (GRCm39) V288A possibly damaging Het
Fbxl5 T C 5: 43,930,928 (GRCm39) E53G probably damaging Het
Fbxw26 A T 9: 109,553,988 (GRCm39) I217N probably damaging Het
Fgfr1op2 T A 6: 146,491,536 (GRCm39) probably null Het
Ighv1-37 A T 12: 114,860,275 (GRCm39) I6N probably damaging Het
Klhdc10 T C 6: 30,439,781 (GRCm39) L128P probably damaging Het
Lypla1 C T 1: 4,902,563 (GRCm39) S24F probably benign Het
Mme T A 3: 63,269,465 (GRCm39) D591E probably damaging Het
Mmp1b T A 9: 7,384,888 (GRCm39) I254F probably damaging Het
Msr1 T C 8: 40,085,866 (GRCm39) M5V probably benign Het
Myh8 A G 11: 67,175,481 (GRCm39) D312G probably damaging Het
Nav2 T C 7: 49,107,917 (GRCm39) Y709H possibly damaging Het
Oas1g T C 5: 121,025,621 (GRCm39) E2G probably benign Het
Odad2 C T 18: 7,268,401 (GRCm39) D373N probably benign Het
Or13f5 T C 4: 52,825,576 (GRCm39) Y60H probably damaging Het
Or2ag12 T C 7: 106,277,093 (GRCm39) Y200C probably damaging Het
Or8a1b T C 9: 37,622,885 (GRCm39) N230S probably benign Het
Or8b12i A G 9: 20,082,549 (GRCm39) L106P possibly damaging Het
Pax1 A G 2: 147,215,640 (GRCm39) D419G probably benign Het
Plbd1 T A 6: 136,612,612 (GRCm39) I194F probably benign Het
Prdx6 A T 1: 161,074,940 (GRCm39) C47S probably damaging Het
Sec24d T C 3: 123,136,868 (GRCm39) S534P probably benign Het
Sgk3 T C 1: 9,968,979 (GRCm39) V452A probably benign Het
Sipa1l1 T C 12: 82,467,320 (GRCm39) V1177A probably benign Het
Tgfbr1 T C 4: 47,383,757 (GRCm39) C32R probably damaging Het
Trim66 T C 7: 109,059,983 (GRCm39) N801S probably benign Het
Utp6 C T 11: 79,831,775 (GRCm39) S504N probably benign Het
Wdsub1 A C 2: 59,708,532 (GRCm39) S114A probably benign Het
Wfikkn2 T C 11: 94,128,866 (GRCm39) E425G probably damaging Het
Zfp956 C T 6: 47,940,763 (GRCm39) T374I possibly damaging Het
Other mutations in Ocm
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0304:Ocm UTSW 5 143,961,352 (GRCm39) missense probably damaging 1.00
R2423:Ocm UTSW 5 143,961,388 (GRCm39) splice site probably null
R4718:Ocm UTSW 5 143,961,375 (GRCm39) missense possibly damaging 0.93
R4803:Ocm UTSW 5 143,960,686 (GRCm39) missense possibly damaging 0.63
R5362:Ocm UTSW 5 143,960,674 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TATCATCAACTGAGCTCCAGC -3'
(R):5'- CATGTAGTCAAGAGGTGGCTG -3'

Sequencing Primer
(F):5'- GCTCCAGCTACATGCCC -3'
(R):5'- TCAAGAGGTGGCTGGAGTC -3'
Posted On 2018-09-12